Antibacterial activities of some arylidene barbiturate derivatives was written by Khan, Khalid Mohammed;Ali, Muhammad;Ahmad, Aqeel;Amyn, Afroze;Karim, Aneela;Khan, Momin;Parveen, Shahnaz. And the article was included in Journal of the Chemical Society of Pakistan in 2013.Reference of 57179-35-8 This article mentions the following:
A series of arylidene barbiturates 1-18 has been synthesized and evaluated against a number of Gram-pos. and Gram-neg. bacterial strains. Chromenopyrimidinedione derivatives 16 and 18 were found to be the most active against a number of Gram-pos. organisms while compound 13 also showed antimicrobial activity against four Gram-pos. strains. No significant activity was observed against Gram-neg. bacterial strains. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8Reference of 57179-35-8).
3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Reference of 57179-35-8