Lanier, Marion published the artcileRepurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes, Safety of (2-((3-Chlorobenzyl)oxy)phenyl)boronic acid, the publication is Journal of Medicinal Chemistry (2017), 60(12), 5209-5215, database is CAplus and MEDLINE.
Serine hydrolases are susceptible to potent reversible inhibition by boronic acids. Large collections of chem. diverse boronic acid fragments are com. available because of their utility in coupling chem. The authors repurposed the approx. 650 boronic acid reagents in the collection as a directed fragment library targeting serine hydrolases and related enzymes. Highly efficient hits (LE > 0.6) often result. The utility of the approach is illustrated with the results against autotaxin, a phospholipase implicated in cardiovascular disease.
Journal of Medicinal Chemistry published new progress about 849062-32-4. 849062-32-4 belongs to ethers-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-((3-Chlorobenzyl)oxy)phenyl)boronic acid, and the molecular formula is C13H12BClO3, Safety of (2-((3-Chlorobenzyl)oxy)phenyl)boronic acid.
Ether | (C2H5)2O – PubChem