In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1077-01-6, name is 1-Fluoro-3-(trifluoromethoxy)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 1-Fluoro-3-(trifluoromethoxy)benzene
(Comparative Example 6); 4-Fluoro-l-nitro-2- (trifluoromethoxy) benzeneFuming nitric acid (20 mL) was added dropwise to concentrated sulfuric acid (40 ml) under cooling (-100C), and subsequently, 1- fluoro-3- (trifluoromethoxy) benzene (15 g, 83 mmol) was added to the mixture at -100C, and the mixture was stirred for 0.5 hours. After the mixture was added into ice-water to stop the reaction, it was extracted with dichloromethane . After the obtained organic layer was washed with a IN aqueous sodium hydroxide solution and water, it was dried with anhydrous sodium sulfate. After filtration, the solution was concentrated and the residue was purified by silica gel column chromatography (100:0-97:3, hexane : ethyl acetate) to give the title compound (3.1 g, 16%) as an oil.1H-NMR (400 MHz, CDCl3) delta: 8.10 (IH, dd, J = 5.5, 9.4 Hz) , 7.23-7.15 (2H, m) .
The synthetic route of 1077-01-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EXELIXIS, INC.; Daiichi Sankyo Company, Limited; NUSS, John; WILLIAMS, Matthew; MOHAN, Raju; MARTIN, Richard; WANG, Tie-lin; TSURUOKA, Hiroyuki; AOKI, Kazumasa; HONZUMI, Masatoshi; ASOH, Yusuke; SAITO, Keiji; HOMMA, Tsuyoshi; WO2010/42626; (2010); A1;,
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