Month: April 2022

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs, published in 2015, which mentions a compound: 56621-48-8, mainly applied to Edecrin phosphorus dendrimer dendron antiproliferative epidermal carcinoma leukemia growth, Reference of 4-(Piperazin-1-yl)phenol.

The well-known reactive diuretic ethacrynic acid (EA, Edecrin), with low antiproliferative activities, was chem. modified and grafted onto phosphorus dendrimers and the corresponding simple branched phosphorus dendron-like derivatives affording novel nanodevices showing moderate to strong antiproliferative activities against liquid and solid tumor cell lines, resp.

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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors, published in 2010-03-01, which mentions a compound: 56621-48-8, Name is 4-(Piperazin-1-yl)phenol, Molecular C10H14N2O, Recommanded Product: 56621-48-8.

The authors described herein the design, synthesis, and pharmacol. evaluation of N-phenylpiperazine heterocyclic derivatives as multi-target compounds potentially useful for the treatment of schizophrenia. The isosteric replacement of the heterocyclic ring at the biaryl motif generating pyrazole, 1,2,3-triazole, and 2-methylimidazole[1,2-a]pyridine derivatives resulted in 21 analogs with different substitutions at the para-biaryl and para-phenylpiperazine positions. Among the compounds prepared, 4 (LASSBio-579) and 10 (LASSBio-664) exhibited an adequate binding profile and a potential for schizophrenia pos. symptoms treatment without cataleptogenic effects. Structural features of this mol. scaffold are discussed regarding binding affinity and selectivity for D2-like, 5-HT1A, and 5-HT2A receptors.

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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

COA of Formula: C10H14N2O. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Synthesis and biological evaluation of novel carbazole derivatives. Author is Hedapara, K. R.; Kharadi, G. J..

The series of carbazole derivatives were synthesized in high yield and quality through simple straight forward reaction of 4-(oxiran-2-ylmethoxy)-9H-carbazole with various nucleophiles like piperazine containing heterocyclic derivatives or quinoline derivatives without using any base. All the compounds were screened for their antibacterial and antifungal activities. The compound 1-((9H-carbazol-4-yl)oxy)-3-(4-(benzo[d]isothiazol-3-yl)piperazin-1yl)propan-2-ol exhibited good inhibition towards antimicrobial activity compared to the other compounds

After consulting a lot of data, we found that this compound(56621-48-8)COA of Formula: C10H14N2O can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

SDS of cas: 73590-85-9. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, is researched, Molecular C17H19N3O2S, CAS is 73590-85-9, about Design of experiment (DOE) utilization to develop a simple and robust reversed-phase HPLC technique for related substances’ estimation of omeprazole formulations. Author is Manranjan, Vayeda Chintan; Yadav, Devendra Singh; Jogia, Hitesh Amrutlal; Chauhan, Praful Lalitkumar.

A simple, fast, and sensitive reversed-phase HPLC method with UV detection was developed for the quantitation of omeprazole and its eleven related compounds (impurities) in pharmaceutical formulation using the Thermo Accucore C-18 (50 mm × 4.6 mm, 2.6 μm) column. The separation among all the compounds was achieved with a flow rate of 0.8 mL min-1 employing a gradient program of mobile phase A [0.08 M glycine buffer pH 9.0: acetonitrile; 95:05 (volume/volume)] and mobile phase B [acetonitrile: MeOH; 65:35 (volume/volume)]. The chromatog. detection was carried out at a wavelength of 305 nm. The method was validated for specificity, linearity, and recovery. The huskiness of the method was determined prior to validation using the Design of Experiments (DOE). The ANOVA anal. of DOE with a 95% confidence interval (CI) confirmed the buffer pH of mobile phase A and column temperature as significant Critical Method Parameters (CMPs).

After consulting a lot of data, we found that this compound(73590-85-9)SDS of cas: 73590-85-9 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Seenivasaperumal, Muthu; Federsel, Hans-Jurgen; Szabo, Kalman J. published an article about the compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole( cas:73590-85-9,SMILESS:CC1=CN=C(CSC2=NC3=CC(OC)=CC=C3N2)C(C)=C1OC ).Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:73590-85-9) through the article.

The asym. sulfoxidation reaction of imidazole-based prochiral sulfides was studied to explore the mechanistic details of the highly efficient esomeprazole process, which is one of the few industrial scale catalytic asym. procedures. The synthetic studies revealed that the smallest subunit governing the selectivity in the esomeprazole process is an imidazole ring. Thus, by using the esomeprazole procedure Me imidazole sulfide could be oxidized as efficiently as its several functionalized derivatives, including pyrmetazol. However, alkylation of the imidazole nitrogen led to a major drop of the enantioselectivity. Our atm. pressure chem. ionization-mass spectrometry (APCI/MS) studies indicate that addition of small amounts of water to the reaction mixture facilitates the formation of mononuclear titanium species, which are the active catalytic intermediates of the selective oxidation reaction. One of the most important features of the esomeprazole procedure is that amine additives increase the enantioselectivity of the oxidation process. The NMR studies of the presumed reaction intermediates show that under catalytic conditions the amines are able to coordinate to titanium and dissociate the coordinated imidazole substrate. The d. functional theory (DFT) modeling studies provided new insights in the mechanism of the asym. induction. It was found that the oxidation requires a lower activation energy if the imidazole sulfide precursor does not coordinate to titanium. Two possible reaction paths were explored for this out of sphere oxidation mechanism. The most important interaction governing the enantioselection is hydrogen bonding between the N-H of the imidazole ring and the chiral tartrate ligand on titanium. Furthermore, the oxidation reaction imposes an important structural constraint to the TS structure involving a linear arrangement of the peroxide oxygens and the sulfur atom. This constraint and the N coordination of imidazole leads to a very strained structure for the inner sphere mechanism of the oxidation, which leads to a much higher activation barrier than the corresponding out of sphere process, and therefore it is unlikely.

After consulting a lot of data, we found that this compound(73590-85-9)Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 56621-48-8, is researched, Molecular C10H14N2O, about Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists, the main research direction is naphtosultam preparation receptor binding; antagonist 5HT2 naphtosultam; naphthoisothiazole dioxide aminoalkyl.COA of Formula: C10H14N2O.

A series of 2-(aminoalkyl)naphtho[1,8-cd]isothiazole 1,1-dioxides I (R = aminoalkyl) was synthesized from I (R = H) and examined in various receptor binding tests. Most compounds demonstrated high affinity for the 5-HT2 receptor with moderate to high selectivity. A member of this series, compound I [R = 3-[4-(p-fluorophenyl)piperazino]propyl] (RP 62203), displays high 5-HT2 receptor affinity (Ki = 0.26 nM), which is resp. more than 100 and 1000 times higher than its affinity for α1 (Ki = 38 nM) and D2 (Ki >1000 nM) receptors. This compound is a potent orally effective and long lasting 5-HT2 antagonist in the mescaline-induced head-twitches test in mice and rats.

After consulting a lot of data, we found that this compound(56621-48-8)COA of Formula: C10H14N2O can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gao, Mei-Ling; Zeng, Jie; Fang, Xi; Luo, Jian; Jin, Zhen; Liu, Ya-Hong; Tang, You-Zhi published an article about the compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8,SMILESS:OC1=CC=C(N2CCNCC2)C=C1 ).Related Products of 56621-48-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:56621-48-8) through the article.

A series of pleuromutilin derivatives bearing piperazine ring have been reported. The in vitro antibacterial activities of the synthetic derivatives against MRSA (ATCC 43300), Staphylococcus aureus (ATCC 29213), Enterococcus faecalis (ATCC 29212), Enterococcus faecium (ATCC35667) and Escherichia coli (ATCC25922) were evaluated by the broth dilution method. Most of the synthesized derivatives displayed potent activities. Compounds 11c, 12a and 12c were found to be the most active antibacterial derivatives against MRSA (min. inhibitory concentration = 0.015 μg/mL). The binding of compounds 11c, 12a and 12c (I – III, resp.) to the 50s ribosome were investigated by mol. modeling. Compound 11c possessed lower binding free energy compared with compounds 12a and 12c. Compound 11c was further evaluated in MRSA systemic infection model and displayed superior in vivo efficacy to that of tiamulin.

After consulting a lot of data, we found that this compound(56621-48-8)Related Products of 56621-48-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, is researched, Molecular C17H19N3O2S, CAS is 73590-85-9, about Going Green in Process Chemistry: Optimizing an Asymmetric Oxidation Reaction To Synthesize the Antiulcer Drug Esomeprazole. Author is McAllister, Graeme D.; Parsons, Andrew F..

Sustainable practices in process chem. are highlighted by a novel, 9 wk team project of 8-12 students, in collaboration with AstraZeneca chemists, in an organic chem. laboratory Students synthesize the antiulcer medicine esomeprazole, which involves the asym. oxidation of pyrmetazole. To provide insight into the modern process chem. industry, they propose environmentally friendly modifications to the asym. oxidation Students first synthesize pyrmetazole and then follow a standard oxidation procedure and carry out modified, greener reactions of their choice. They investigate how a change in reaction conditions affects both the yield and enantioselectivity of esomeprazole. Pos. student feedback was received and student postlab reports were analyzed over a 4 yr period (2015-2018). Results consistently showed that the project provided students with the key tools to develop greener syntheses. This contextual approach not only offers the opportunity to develop valuable communication and team-working skills, but it also gives students creative input into their exptl. work. It teaches the important research skills involved in sustainable process chem., from reproducing and modifying a literature procedure to identifying green metrics.

After consulting a lot of data, we found that this compound(73590-85-9)Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ibis, Cemil; Aydinli, Goeksin published an article about the compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8,SMILESS:OC1=CC=C(N2CCNCC2)C=C1 ).Related Products of 56621-48-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:56621-48-8) through the article.

2-Nitro diene Cl2C:CClC(NO2):CCl2 reacted with 3-mercapto-1,2,4-triazole (I) and cyclohexanethiol to yield the resp. dithioacetals Cl2C:CClC(NO2):C(SR)R1 (II; R = 1,2,4-triazol-3-yl, cyclohexyl; R1 = SR). Dithioacetals II (R = 1,2,4-triazol-3-yl; R1 = octylthio, decylthio, hexdecylthio, cyclohexylthio) were obtained by reactions of appropriate vinyl sulfides with I. Novel N,S-substituted dienes were obtained by treatment of II [R = decyl, R1 = Cl (III)] with piperazines. Compound III was reacted with N-(2-aminoethyl)morpholine to give the corresponding N,S-substituted diene. Compound III gave a new N-butadienylhomopiperazine on reaction with homopiperazine in CH2Cl2. Compound II (R = cyclohexyl, R1 = cyclohexylthio) was characterized by single-crystal x-ray diffraction [monoclinic, space group P21/n, a 12.0862(12), b 11.1625(8), c 16.337(1) Å, β 110.840(4)°, V 2059.9(3) Å3, Z 4].

After consulting a lot of data, we found that this compound(56621-48-8)Related Products of 56621-48-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 73590-85-9, is researched, Molecular C17H19N3O2S, about High-performance liquid chromatographic assay for human liver microsomal omeprazole metabolism, the main research direction is omeprazole metabolism liver microsome determination HPLC; liquid chromatog omeprazole metabolite liver microsome.Computed Properties of C17H19N3O2S.

Assays for the measurement of omeprazole metabolites in plasma and urine were reported, but when applied to the determination of omeprazole metabolites formed by human liver microsomal incubations, there were obvious limitations in sensitivity. The present HPLC assay, which comprises extraction, evaporation and reconstitution, is several-fold more sensitive with a limit of detection of ∼ 2 pmol (2 nM in incubate) for omeprazole sulfone and 25 pmol (25 nM in incubate) for hydroxyomeprazole. Extraction efficiency is essentially quant. and is highly reproducible (coefficient of variation = 2.1% for both metabolites). The assay is linear over a wide range of concentrations and the formation of the metabolites is linear with respect to both time (to 15 min) and protein concentration (to 1.5 mg/mL). Two minor metabolites, 1 of which was identified tentatively as 5-O-desmethylomeprazole, were also formed by human liver microsomes and could be determined by this method. Preliminary studies of the formation of omeprazole sulfone and hydroxyomeprazole showed that the formation kinetics in human liver microsomes were biphasic for both metabolites, suggesting that at least 2 different cytochrome P 450 isoforms are involved in their formation.

After consulting a lot of data, we found that this compound(73590-85-9)Computed Properties of C17H19N3O2S can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem