Month: April 2022

Computed Properties of C17H19N3O2S. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, is researched, Molecular C17H19N3O2S, CAS is 73590-85-9, about An efficient procedure for the synthesis of Esomeprazole using a titanium complex with two chiral ligands.

A procedure has been proposed for the selective preparation of Esomeprazole [(S)-I] via asym. oxidation of the corresponding prochiral sulfide in the presence of a catalytic complex derived from titanium(IV) isopropoxide and two different chiral ligands, di-Et D-tartrate and (R)-N,N-dimethyl-1-phenylethanamine.

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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, is researched, Molecular C17H19N3O2S, CAS is 73590-85-9, about Evidence for acid-induced transformation of omeprazole into an active inhibitor of proton-potassium ATPase within the parietal cell. Author is Wallmark, Bjorn; Brandstrom, Arne; Larsson, Hakan.

The chem. reactions of omeprazole (I) [73590-58-6], leading to inhibition of gastric acid secretion, were investigated. In acid buffer solutions, omeprazole was found to be labile, whereas at physiol. pH it was stable (t1/2 > 17 h at pH 7.4). The stability of omeprazole was also studied in isolated, acid producing, gastric glands under conditions where acid formation was either stimulated or inhibited. The rate of transformation of omeprazole was high (t1/2 ≈ 3 min) under stimulation. Inhibition of acid formation in the gland greatly retarded the decomposition of omeprazole (t1/2 ≈ 73 min). The time-course for inhibition of acid formation by omeprazole was parallel to that for decomposition The major product formed from omeprazole was the reduced form, H 168/22 (II) [73590-85-9]. The inhibitory action of omeprazole was shown to depend on acid-induced transformation, since no inhibition was obtained when omeprazole was incubated under neutral conditions, both in the isolated gastric mucosal- and the (H+ + K+)-ATPase  [9000-83-3] preparations Despite the fact that H 168/22 was the major product formed in the glandular preparation, it was found to be virtually inactive in both the glandular and (H+ and K+)-ATPase preparations Therefore, a model is proposed in which the inhibition of acid formation by omeprazole is mediated by a compound formed during the reduction of omeprazole to H 168/22 within the acid compartments of the parietal cell. Furthermore, mercaptans, such as β-mercaptoethanol, were found to prevent as well as reverse inhibition by omeprazole in both the glandular- and (H+ + K+)-ATPase preparations This indicates that -SH groups are most likely involved in the chem. reactions leading to inhibition of acid secretion.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Computed Properties of C10H14N2O. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Modifications to five-substituted 3,3-diethyl-4,5-dihydro-2(3H)-furanones en route to novel muscarinic receptor ligands. Author is Bhandare, Richie R.; Canney, Daniel J..

Lead lactone-based ligands with modest affinity for muscarinic receptors were modified based on structure-activity relationship data in the literature to provide a new series of 5-substituted 4,5-dihydro-2(3H)-furanones. The modifications included the addition of various nitrogen-containing heterocycles attached to substituted and unsubstituted aromatic rings. The target compounds, e.g. I, were synthesized in modest yields and evaluated in preliminary muscarinic binding assays. A lactone-based ligand containing a diphenylmethylpiperazine moiety was identified as a nonselective muscarinic ligand with IC50 of 340 nM. The design of future ligands will be based, in part, on structure-activity data reported herein.

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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Name: 4-(Piperazin-1-yl)phenol. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about A novel class of ethacrynic acid derivatives as promising drug-like potent generation of anticancer agents with established mechanism of action. Author is Mignani, Serge; El Brahmi, Nabil; El Kazzouli, Said; Eloy, Laure; Courilleau, Delphine; Caron, Joachim; Bousmina, Mosto M.; Caminade, Anne-Marie; Cresteil, Thierry; Majoral, Jean-Pierre.

The well-known diuretic Ethacrynic acid (EA, Edecrin), showing low anti-proliferative activities, was chem. modified at different positions. The new EA derivatives have been tested in vitro in anti-proliferative assays on both tumor KB (epidermal carcinoma) and leukemia HL60 (promyelocytic) cells suitable targets for anticancer activity. Reduction of the α-β double bond of EA completely abolished anti-cancer activities, whereas introduction of either 2-(4-substituted phenyl)ethanamine (series A) or 4-(4-substituted phenyl)piperazine (series B) moieties generated compounds showing moderate to strong anti-proliferative activities against human cancer cell lines. Several substitutions on the Ph of these two moieties are tolerated. The mechanism of action of the EA derivatives prepared in this study is more complex than the inhibition of glutathione S-transferase π ascribed as unique effect to EA and might help to overcome tumor resistances.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(Piperazin-1-yl)phenol(SMILESS: OC1=CC=C(N2CCNCC2)C=C1,cas:56621-48-8) is researched.Related Products of 77341-67-4. The article 《Electrochemical oxidation of 4-(piperazin-1-yl)phenol in the presence of aryl sulfinic acids》 in relation to this compound, is published in Journal of the Electrochemical Society. Let’s take a look at the latest research on this compound (cas:56621-48-8).

Electrochem. oxidation of 4-(piperazin-1-yl)phenol was studied in the presence of aryl sulfinic acids as nucleophiles in EtOH/H2O mixture (10/90) using cyclic voltammetry and controlled-potential coulometry methods. The electrochem. generated p-quinone-imine participates in Michael type addition reaction with aryl sulfinic acids and via an EC mechanism converts to the new 2-(phenylsulfonyl)-4-(piperazin-1-yl)phenol derivatives The present work led to the development of a facile and environmentally friendly electrochem. method for the synthesis of some new 2-(phenylsulfonyl)-4-(piperazin-1-yl)phenol derivatives under green conditions.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 56621-48-8, is researched, Molecular C10H14N2O, about N-Substituted S-Alkyl Carbamothioates in the Synthesis of Nitrogen-containing Functional Derivatives of the Adamantane Series, the main research direction is urea adamantyl preparation; urethane adamantyl preparation.Application In Synthesis of 4-(Piperazin-1-yl)phenol.

A series of new asym. ureas, urethanes, and other derivatives of the framework structure I [R = OCH2C2OH, (2-methylquinolin-4-yl)aminyl, 4-methylpiperazin-1-yl.HCl, etc.] have been synthesized by the reactions of adamantan-1-yl isocyanate generated in situ by the thermolysis of S-Et (adamantan-1-yl)carbamothioate with nitrogen-containing nucleophiles and alcs.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ochiai, Hiroshi; Ishida, Akiharu; Ohtani, Tazumi; Kusumi, Kensuke; Kishikawa, Katuya; Yamamoto, Susumu; Takeda, Hiroshi; Obata, Takaaki; Nakai, Hisao; Toda, Masaaki published an article about the compound: 1-Methyl-3-(thiophen-2-yl)-1H-pyrazol-5-amine( cas:118430-78-7,SMILESS:NC1=CC(C2=CC=CS2)=NN1C ).SDS of cas: 118430-78-7. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:118430-78-7) through the article.

A series of 4-anilinopyrazolopyridine derivatives were synthesized and biol. evaluated as inhibitors of phosphodiesterase (PDE4). Chem. modification of 3, a structurally new chem. lead that was found in our inhouse library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chem. lead 5 are presented. Structure-activity relationship data, pharmacol. evaluation, and the subtype selectivity study are also presented.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Design, synthesis and biological evaluation of novel pleuromutilin derivatives possessing acetamine phenyl linker, published in 2019-11-01, which mentions a compound: 56621-48-8, mainly applied to acetamine phenyl pleuromutilin preparation antibacterial pharmacokinetic; Antibiotics; In vivo; MRSA; Pleuromutilin; Synthesis, Recommanded Product: 4-(Piperazin-1-yl)phenol.

A series of novel acetamine Ph pleuromutilin derivatives incorporating 2-aminothiophenol moieties into the C14 side chain were synthesized via acylation reactions under mild conditions. The in vitro antibacterial activities of the synthesized derivatives against three Staphylococcus aureus (MRSA ATCC 43300, ATCC 29213 and AD 3) and two Escherichia coli (ATCC 25922 and 9-1) were evaluated by the broth dilution method. Most of the synthesized derivatives displayed potent activities. Compound I was found to be the most active antibacterial derivative against MRSA (minimal inhibitory concentration = 0.015 μg/mL) which may lead to a promising antibacterial drug. Furthermore, compound I displayed more rapid bactericidal kinetic than tiamulin in in vitro time-kill studies and possessed a longer PAE than tiamulin against MRSA. The PK properties of compound I were then measured. The half life (t1/2), clearance rate (Cl) and the area under the plasma concentration-time curve (AUC0→∞) of compound I were 6.88 h, 21.64 L/h/kg and 0.48 μg h/mL, resp. The in vivo antibacterial activities of compound I against MRSA were further evaluated using thigh infection model and systemic infection model. Compound I possessed superior antibacterial efficacy to tiamulin against MRSA infection in both model.

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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C10H14N2O. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Development of 1,3,4-Thiadiazole and Piperazine Fused Hybrid Quinazoline Derivatives as Dynamic Antimycobacterial Agents. Author is Patel, Amit B.; Rohit, Jignesh V..

Novel series of 1,3,4-thiadiazole and piperazine substituted quinazoline derivatives I [R = H, Cl, CF3, etc] were designed, synthesized, and tested in vitro for antimycobacterial activity. The synthetic procedure involved Suzuki C-C cross-coupling on a quinazoline ring and subsequently by the formation of 1,3,4-thiadiazole based piperazines. Many synthesized analogs were observed active against Mycobacterium H37Rv strain in preliminary anal. using the BACTEC MGIT method. A secondary antimycobacterial assay using the Lowenstein-Jensen MIC method indicates that I [R = bromo, trifluoromethyl, hydroxy] groups substituted analogs was showed strong efficacy in the range of 3.12-6.25 μg/mL. Active compounds were also tested for their cytotoxic activity against Human cervical (HeLa) cells at their MICs. The synthesized analogs were analyzed by IR, 1H NMR, 13 C NMR, MS, and elemental anal. for their structure determination

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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4-(Piperazin-1-yl)phenol(SMILESS: OC1=CC=C(N2CCNCC2)C=C1,cas:56621-48-8) is researched.Synthetic Route of C35H27N2O2Ir. The article 《Synthesis and antioxidant activity of some 1-aryl/aralkyl piperazine derivatives with xanthine moiety at N4》 in relation to this compound, is published in Biotechnology & Biotechnological Equipment. Let’s take a look at the latest research on this compound (cas:56621-48-8).

Six new aryl/aralkyl substituted piperazine derivatives, containing methylxanthine moiety I (R = Bn, 4-FC6H4, 4-HOC6H4, etc.) were synthesized. All compounds were in vitro screened for their activity as antioxidants using DPPH (2,2′-Diphenyl-1-picrylhydrazyl), ABTS (2,2′-azinobis-(3-ethylbenzothiazine-6-sulfonic acid)) and FRAP (ferric reducing/antioxidant power) methods. The antioxidant activity of the studied compounds against lipid peroxidation was also measured. The highest antioxidant activity was demonstrated by compound I (R = 4-HOC6H4). It is obvious that the presence of a hydroxyl group in the structure is essential for the antioxidant properties and should be taken into consideration in further design of structures with potential antioxidant properties.

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Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem