Month: October 2022

Gao, Xinpei; Wu, Fanglin; Mariani, Alessandro; Passerini, Stefano published the artcile< Concentrated Ionic-Liquid-Based Electrolytes for High-Voltage Lithium Batteries with Improved Performance at Room Temperature>, Reference of 6482-24-2, the main research area is concentration ionic liquid electrolyte lithium battery room temperature viscosity; Li-rich cathode; asymmetric anions; ether-functionalized cations; high concentrated electrolytes; ionic liquids.

Ionic liquids (ILs) have been widely explored as alternative electrolytes to combat the safety issues associated with conventional organic electrolytes. However, hindered by their relatively high viscosity, the electrochem. performances of IL-based cells are generally assessed at medium-to-high temperature and limited cycling rate. A suitable combination of alkoxy-functionalized cations with asym. imide anions can effectively lower the lattice energy and improve the fluidity of the IL material. The Li/Li1.2Ni0.2Mn0.6O2 cell employing N-N-diethyl-N-methyl-N-(2-methoxyethyl)ammonium (fluorosulfonyl)(trifluoromethanesulfonyl)imide (DEMEFTFSI)-based electrolyte delivered an initial capacity of 153 mAh g-1 within the voltage range of 2.5-4.6 V, with a capacity retention of 65.5 % after 500 cycles and stable coulombic efficiencies exceeding 99.5 %. Moreover, preliminary battery tests demonstrated that the drawbacks in terms of rate capability could be improved by using Li-concentrated IL-based electrolytes. The improved room-temperature rate performance of these electrolytes was likely owing to the formation of Li+-containing aggregate species, changing the concentration-dependent Li-ion transport mechanism.

ChemSusChem published new progress about Activation energy. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Reference of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pelter, Andrew; Ward, Robert S.; Rao, Ramohan R. published the artcile< An approach to the biomimetic synthesis of aryltetralin lignans>, Application of C11H16O2, the main research area is cyclization quinone methide ketal; Lewis acid cyclization catalyst; aryltetralin; tetralin aryl.

The BF3 catalyzed cyclization of 3-(arylpropyl)quinone-methide ketals I (R, R1, R2 = H, OMe) affords a mild biomimetic route to aryltetralins II. I were prepared from the corresponding 4-arylbutanoic acids in 5 steps.

Tetrahedron published new progress about Cyclization. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lu, Yuting; Shen, Xiaoyue; Hang, Taijun; Song, Min published the artcile< Identification and characterization of process-related substances and degradation products in apremilast: Process optimization and degradation pathway elucidation>, Product Details of C12H19NO4S, the main research area is apremilast degradation product analysis LC MS process optimization; Apremilast; LC–MS; Process optimization; Related substances.

This study aims at investigating the separation, identification and characterization of related substances in apremilast by LC-MS hyphenated techniques, as well as the synthesis optimization and the degradation pathways elucidation. Forced degradation studies were conducted under the ICH prescribed stress conditions. The chromatog. separation was achieved on XBridge C18 column (4.6 mm × 150 mm, 3.5 μm) using a mobile phase consisting of water adjusted to pH 3.0 with formic acid as solvent A and acetonitrile as solvent B in linear gradient elution program. Twelve related substances were detected all together in apremilast and its stress samples. Their structures were identified mainly through pos. ESI high-resolution TOF-MS anal. of the parent ions’ accurate masses and elemental compositions, and the corresponding MS/MS spectra elucidation. There were three process-related substances and nine degradation products, seven of them were first reported. Two degradation products and one process-related substance were further verified by semi-preparation and NMR determination Their origins and formation mechanisms were also discussed, based on which effective approaches for the synthesis optimization were conducted. Therefore, the related substances investigation are valuable for apremilast manufacturing process optimization and quality control.

Journal of Pharmaceutical and Biomedical Analysis published new progress about Chromatography. 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, Product Details of C12H19NO4S.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yu, Jianjin; Li, Chao-Jun; Zeng, Huiying published the artcile< Dearomatization-Rearomatization Strategy for ortho-Selective Alkylation of Phenols with Primary Alcohols>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is palladium catalyzed ortho selective alkylation phenol alc dearomatization rearomatization; aromaticity; cross-coupling; palladium; reaction mechanisms; synthetic methods.

Phenols are common precursors and core structures of a variety of industrial chems. ranging from pharmaceuticals to polymers. However, the synthesis of site-specifically substituted phenols is challenging, and thus the development of new methods for this purpose would be highly desirable. Reported here is a protocol for palladium-catalyzed ortho-selective alkylation reactions of phenols with primary alcs. by a dearomatization-rearomatization strategy, with water as the sole byproduct. Various substituted phenols and primary alcs. were compatible with the standard reaction conditions. The detailed mechanism of this transformation was also investigated.

Angewandte Chemie, International Edition published new progress about Alkylation. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ma’arif, Burhan; Fitri, Hilwa; Saidah, Nisfatul Lailatus; Najib, Luqman Alfani; Yuwafi, Achmad Hamdan; Atmaja, Ria Ramadhani Dwi; Inayatillah, Fidia Rizkiah; Dianti, Meilina Ratna; Laswati, Hening; Agil, Mangestuti published the artcile< Prediction of compounds with antiosteoporosis activity in Chrysophyllum cainito L. leaves through in silico approach>, Name: 2,2′-(Tridecylazanediyl)diethanol, the main research area is Chrysophyllum antiosteoporosis leaf phytoestrogen; Chrysophyllum cainito L.; antiosteoporosis; in silico; phytoestrogen.

The aims of this study were to analyze the metabolite profiling results of various extract of Chyrsophyllum cainito L. leaves, which contain phytoestrogen, through in silico study against 3OLS protein, an X-ray protein of ERβ, so it can predict the types of the phytoestrogen contents which have antiosteoporosis property. In silico anal. was carried out for the compounds from the metabolite profiling data of C. cainito leaves from our previous study. The structure compounds from metabolite profiling results of various extract of C. cainito leaves were prepared with Avogadro 1.0.1 software, mol. docking was done using PyRx 0.8 software, and Biovia Discovery Studio Visualizer 2016 software was used to visualize the structure of compounds against 3OLS protein. The physicochem. characteristics of the compounds were analyzed using the SwissADME web tool. It was known that there were total 11 compounds in C. cainito leaves that predicted as phytoestrogens which have ERβ agonist properties against 3OLS protein. The ERβ agonist was a compound that has parameters similar to 17β-estradiol in its interaction with 3OLS protein, which has a pharmacophore distance of 10.862 Å, and binding to amino acids His 475 and Glu 305 or Arg 346 at receptor-ligand docking simulation. C. cainito leaves contain 11 compounds that are predicted to be phytoestrogens with ERβ agonist properties, which is responsible for antiosteoporosis activity.

Journal of Basic and Clinical Physiology and Pharmacology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Name: 2,2′-(Tridecylazanediyl)diethanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Jing; Shi, Qiang; Han, Ying; Chen, Chuan-Feng published the artcile< Complexation of 2,6-helic[6]arene and its derivatives with 1,1'-dimethyl-4,4'-bipyridinium salts and protonated 4,4'-bipyridinium salts: an acid-base controllable complexation>, Name: 1-Bromo-2-methoxyethane, the main research area is helicarene preparation inclusion compound formation constant crystal mol structure; 4,4′-bipyridinium salts; complexation; helic[6]arene; hydrogen bond; macrocycles; macrocyclic arene.

2,6-Helic[6]arene and its derivatives I [R = H, Me, (CH2)3, (CH2)2OCH3, (CH2)2OH] were synthesized, and their complexation with 1,1′-dimethyl-4,4′-bipyridinium and protonated 4,4′-bipyridinium salts were investigated in detail. It was found that the helic[6]arene and its derivatives could all form 1:1 complexes with both 1,1′-dimethyl-4,4′-bipyridinium salts and protonated 4,4′-bipyridinium salts II (R1 = H, Me; X = PF6, tetrakis[3,5-bis(trifluoromethyl)phenyl]boranuide) in solution and in the solid state. Especially, the helic[6]arene and its derivatives I [R = (CH2)2OCH3, (CH2)2OH] exhibited stronger complexation with the guests than the other helic[6]arene derivatives for the addnl. multiple hydrogen bonding interactions between the hosts and the guests, which were evidenced by 1H NMR titrations, X-ray crystal structures and DFT calculations Moreover, it was also found that the association constants (Ka) of the complexes could be significantly enhanced with larger counteranions of the guests and in less polar solvents. Furthermore, the switchable complexation between the helic[6]arene and protonated 4,4′-bipyridinium salt could be efficiently controlled by acids and bases.

Beilstein Journal of Organic Chemistry published new progress about Acid-base titration. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Name: 1-Bromo-2-methoxyethane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Henley-Smith, Peter; Whiting, Donald A.; Wood, Andrew F. published the artcile< Methods for the construction of linear 1,7-diarylheptanoids; synthesis of di-O-methylcentrolobol and precursors (synthetic and biosynthetic) to the meta,meta-bridged biphenyls myricanol and myricanone>, Application In Synthesis of 52244-70-9, the main research area is heptanoid diaryl; arylheptanoid; centrolobol analog; myricanol open chain analog; myricanone open chain analog; Grignard reaction phenylpropanal arylhaloalkane; propanal phenyl Grignard reaction; oxazine salt Grignard reaction; dithiane lithiation diarylheptanoid.

Grignard couplings of arylhaloalkanes with arylpropanals or oxazonium salts and the reactions of arylhaloalkanes with lithiated dithianes were used to prepare 1,7-diarylheptanoids, including synthetic and biosynthetic precursors of meta,meta-bridged biphenyls and related macrocyclic ethers. Thus, 4-(2-benzyloxy-3,4-dimethoxy)-1-bromobutane was treated with Mg and the product was treated with 4-PhCH2OC6H4(CH2)2CHO to give the desired alc. I (X = H, OH; R = R3 = OCH2Ph, R1 = R2 = OMe). Similarly, 4-MeOC6H4(CH2)4Br was treated with Mg and the Grignard reagent produced was treated with the oxazine salt II to give the desired ketone I (X = O, R = R1 = H, R2 = R3 = OMe). 4-(2,3,4-Trimethoxyphenyl)-1-iodobutane reacted with lithiated 2-[2-(p-methoxyphenyl)ethyl]-1,3-dithiane to give after oxidation the desired ketone I (X = O, R = R1 = R2 = R3 = OMe).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Alcohols Role: USES (Uses). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application In Synthesis of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Yi-Ning; Liu, Ye; Yang, Han-Han; Zhang, Wen-Fu; Lu, Xiao-Bing published the artcile< Intramolecular Partners in Asymmetric Catalysis Copolymerization: Highly Enantioselective and Controllable at Enhanced Temperatures and Low Loadings>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is asym catalyst polymerization enantioselective controllable alternating chiral; Asymmetric Ring-Opening Copolymerization; Bifuctional Bimetallic Catalyst; High Molecular Weight Polyester; Intramolecular Synergistic Catalysis; Low Loadings.

Asym. copolymerization of meso-epoxide and anhydride is a powerful strategy for preparing various isotactic polyesters with two contiguous stereogenic centers. However, the previous binary systems suffered from slow rates at low loadings, poor enantioselectivities and transesterification reactions at enhanced temperatures Herein, we report novel dinuclear aluminum complexes with multiple chiralities and ammonium salts anchored on ligand frameworks. These bifunctional catalysts exhibit high activities and enantioselectivities for epoxides/anhydrides copolymerizations at harsh conditions via intramolecularly synergistic catalysis, affording polyesters with unprecedented mol. weights and narrow distributions. Notably, no transesterification reactions were observed, significantly different from the binary catalyst/cocatalyst pairs. This study represents a rare example regarding temperature-independent asym. induction for preparing chiral polymers from achiral monomers.

Angewandte Chemie, International Edition published new progress about Chirality. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ma, Jiaoli; Li, Jing; Guo, Penghu; Liao, Xincheng; Cheng, Huicheng published the artcile< Synthesis and antitumor activity of novel indole derivatives containing α-aminophosphonate moieties>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is aminophosphonate moiety indole derivative antitumor activity.

A series of novel indole derivatives containing α-aminophosphonate moieties were synthesized as antitumor agents. The in vitro cytotoxic activity of the compounds was evaluated against human hepatoma cells (HepG2) and human gastric cancer cells (MGC-803) by MTT assay, revealing that most of target compounds exhibited moderate to high antitumor activities. Among them, compound C5 (IC50 = 34.2 μM) demonstrated superior inhibitory activities against HepG2 compared with 5-fluorouracil (IC50 = 78.7 μM). It is noteworthy that compound B7 (IC50 = 35.7 μM) displayed higher inhibitory activities against MGC-803 than that of 5-fluorouracil (IC50 = 82.0 μM).

Arabian Journal of Chemistry published new progress about Antiproliferative agents. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Ning; Chi, Zhuomin; Wang, Xinchao; Gao, Zezhong; Li, Shangda; Li, Gang published the artcile< Formal C-H/C-I Metathesis: Site-Selective C-H Iodination of Anilines Using Aryl Iodides>, Application In Synthesis of 10541-78-3, the main research area is iodinated aniline preparation regioselective; aniline iodination palladium catalyst.

Protocols for the meta- and ortho-C-H iodination of aniline derivatives via formal C(sp2)-H/C(sp2)-I metathesis using 2-nitrophenyl iodides as mild iodinating reagents were reported herein. These protocols led to the production of a range of valuable iodinated aniline derivatives These results demonstrated the potential of developing novel site-selective C-H activation reactions with electron-rich compounds, since mild reagents can often been utilized in functional group metathesis reactions.

Organic Letters published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application In Synthesis of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem