Month: November 2022

Shimizu, Satoko published the artcileChemical factors underlying the more rapid β-O-4 bond cleavage of syringyl than guaiacyl lignin under alkaline delignification conditions, Formula: C16H18O4, the publication is Journal of Wood Chemistry and Technology (2017), 37(6), 451-466, database is CAplus.

This study aimed to clarify why the β-O-4 bond cleavage of syringyl lignin is more rapid than that of guaiacyl lignin under alk. pulping conditions. We examined whether or not three chem. factors, acidity of the α-hydroxy group, nucleophilicity of the generated α-alkoxide, and leaving ability of the leaving phenoxide, are different between syringyl and guaiacyl lignins and control the rate of the alk.-induced β-O-4 bond cleavage, employing dimeric non-phenolic β-O-4-type lignin model compounds (LMCs) and novel methods for estimating these three factors. The results indicated that the α-hydroxy groups of syringyl-type LMCs are relatively more acidic than those of guaiacyl-type and that syringyl nucleus is a better leaving group than guaiacyl nucleus in the β-O-4 bond cleavage. These factors result in the β-O-4 bond of syringyl lignin being more prone to the alk.-induced cleavage than that of guaiacyl lignin.

Journal of Wood Chemistry and Technology published new progress about 183303-74-4. 183303-74-4 belongs to ethers-buliding-blocks, auxiliary class Benzene,Alcohol,Ether, name is 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol, and the molecular formula is C4H5BN2O2, Formula: C16H18O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Katoh, Takahiro published the artcileSynthesis of DL-standishinal and its related compounds for the studies on structure-activity relationship of inhibitory activity against aromatase, Related Products of ethers-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2007), 15(7), 2736-2748, database is CAplus and MEDLINE.

DL-Standishinal (I), an aromatase inhibitor isolated from Thuja standishii, was synthesized in 15 steps from p-formylanisole via an acid catalyzed aldol reaction of (±)-12-hydroxy-6,7-secoabieta-8,11,13-trien-6,7-dial (II). It was found that the aldol condensation of II proceeded in excellent yield with the protonic catalyst such as d-camphorsulfonic acid in CH₂Cl₂. Moreover, structure-activity relationship of I and its related compounds, such as (±)-O-methylferruginol (III), was studied, and it was revealed that the isomers having cis-configuration on the A/B-ring generally exhibited more potent inhibitory activities against aromatase than those with trans-configuration.

Bioorganic & Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hartz, Richard A. published the artcileSynthesis, Structure-Activity Relationships, and In Vivo Evaluation of N³-Phenylpyrazinones as Novel Corticotropin-Releasing Factor-1 (CRF₁) Receptor Antagonists, Product Details of C4H12ClNO, the publication is Journal of Medicinal Chemistry (2009), 52(14), 4173-4191, database is CAplus and MEDLINE.

Evidence suggested that corticotropin-releasing factor-1 (CRF₁) receptor antagonists may offer therapeutic potential for the treatment of diseases associated with elevated levels of CRF such as anxiety and depression. A pyrazinone-based chemotype of CRF₁ receptor antagonists was discovered. Structure-activity relationship studies led to the identification of numerous potent analogs including I, a highly potent and selective CRF₁ receptor antagonist with an IC₅₀ value of 0.26 nM. The pharmacokinetic properties of I were assessed in rats and Cynomolgus monkeys. Compound I was efficacious in the defensive withdrawal test (an animal model of anxiety) in rats. The synthesis, structure-activity relationships and in vivo properties of compounds, e.g., I, within the pyrazinone chemotype were described.

Journal of Medicinal Chemistry published new progress about 1162054-86-5. 1162054-86-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic Chain, name is (S)-1-Methoxypropan-2-amine hydrochloride, and the molecular formula is C4H12ClNO, Product Details of C4H12ClNO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kim, Yun-Hi published the artcileSynthesis and characterization of poly(terphenylenevinylene) derivatives containing alkoxy substituents and (or) phenyl pendant group, Application of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, the publication is Polymer (2004), 45(8), 2525-2532, database is CAplus.

The blue electroluminescent polymers, poly(terphenylenevinylene) derivatives that have advantages of PPP and PPV, were prepared by Suzuki coupling reaction. The structure and properties of the polymers were analyzed by various spectroscopic methods. Poly(MHTPPV) and poly(TPPV) with Ph pendant group in a vinyl bridge showed blue shifted absorption spectra, large band gap and enhanced thermal stability as compared with that of poly(MHTPV). The PL spectra of the films of the polymers showed maximum peaks at 450-460 nm, which are pure blue emissions. The blue electroluminescence (λ_max=450-460 nm) was obtained with the turn on voltage of 8-10 V, when the simple light-emitting diodes of ITO/polymer/Al were fabricated. The excimer emission due to interchain interaction was reduced by the introduction of substituents into the vinyl bridge and (or) the main chain.

Polymer published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Application of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Singh, Bhagat published the artcileReduced Phenalenyl in Catalytic Dehalogenative Deuteration and Hydrodehalogenation of Aryl Halides, HPLC of Formula: 93-04-9, the publication is Journal of Organic Chemistry (2021), 86(10), 7242-7255, database is CAplus and MEDLINE.

Dehalogenative deuteration reactions are generally performed through metal-mediated processes. This report demonstrates a mild protocol for hydrodehalogenation and dehalogenative deuteration of aryl/heteroaryl halides (39 examples) using a reduced odd alternant hydrocarbon phenalenyl under transition metal-free conditions and has been employed successfully for the incorporation of deuterium in various biol. active compounds The combined approach of exptl. and theor. studies revealed a single electron transfer-based mechanism.

Journal of Organic Chemistry published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C65H82N2O18S2, HPLC of Formula: 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Puspitasari, W. C. published the artcileThe study of corrosion behaviour of intumescent fire retardant coating with structural steel substrate, Safety of 2-Methoxypropan-1-ol, the publication is International Journal of Electrochemical Science (2018), 13(10), 9916-9930, database is CAplus.

The aim of this work is to study corrosion behavior of intumescent coating and the primer on steel substrate before and after a fire test. The coated steel substrates were subjected to fire in a furnace at o 950° C for a vari able duration ranging from 30, 45, 90 and 120 min. All coated steel substrates were a lso subjected to corrosion test by immersing them in 5% NaCl solution, for 15 min and three months duration using Electrochem. Impedance Spectroscopy (EIS). The specimen’s impedance before fire test and before immersion was 4.37 × 108 cm². After 15 min exposure to NaCl, this value was reduced by 26, 53, 60 and 65% for specimens fired for 30, 45, 90 and 120 min, resp. Further reduction in the impedance by 97.6, 97.8, 97.9 and 98.9% for samples fired for 30, 45, 90 and 120 min, resp., were me asured after three months in 5% NaCl immersion.

International Journal of Electrochemical Science published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Safety of 2-Methoxypropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Nilsson, Aake published the artcileElectrolytically initiated selective aliphatic hydrogen exchange in 4-isopropylanisole, Product Details of C10H14O, the publication is Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry (1988), B42(6), 378-83, database is CAplus.

Anodic oxidation of 4-isopropylanisole in CF₃COOH-d was observed to promote the exchange of the Me H of the iso-Pr group. No aliphatic H exchange was detected when 2-isopropylanisole and 4-ethylanisole were treated in the same way. Oxidation products from constant potential electrolysis of 4-isopropylanisole and 2-isopropylanisole were identified.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Smith, Amos B. III published the artcileTotal Synthesis of (-)-Cylindrocyclophanes A and F Exploiting the Reversible Nature of the Olefin Cross Metathesis Reaction, COA of Formula: C21H37BO, the publication is Journal of the American Chemical Society (2001), 123(25), 5925-5937, database is CAplus and MEDLINE.

Efficient total syntheses of the C₂-sym. (-)-cylindrocyclophanes A (I, R = OH) and F (I, R = H) have been achieved. The initial strategy featured the use of a common advanced intermediate to assemble in stepwise fashion the required macrocycle of I (R = H), exploiting in turn a Myers reductive coupling followed by ring-closing metathesis. In a second-generation strategy, a remarkable cross olefin metathesis dimerization cascade was discovered and exploited to assemble the requisite [7,7]-paracyclophane macrocycles of both I (R = OH) and I (R = H) from dienyl monomers. The successful syntheses also featured the effective use of the Danheiser annulation to construct substrates for both the Myers reductive coupling and the metathesis dimerizations strategies. Finally, the Kowalski two-step chain homologation of esters to siloxyalkynes proved superior over the original one-step protocol.

Journal of the American Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C7H3Cl2NO, COA of Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tollefson, Michael B. published the artcile1-(2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors, COA of Formula: C4H7F3O2, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(10), 3125-3128, database is CAplus and MEDLINE.

1H-Pyrazolo[4,3-d]pyrimidines were previously disclosed as a potent second generation class of phosphodiesterase 5 (PDE5) inhibitors. This work explores the advancement of more selective and potent PDE5 inhibitors resulting from the substitution of 2-(2,2,2-trifluoroethoxy)ethyl at the 1 position in the so-called alkoxy pocket.

Bioorganic & Medicinal Chemistry Letters published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C19H21N3O, COA of Formula: C4H7F3O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lim, Su-Jin published the artcileTraceless Solid-Phase Synthesis of 7-Aminothiazolo[4,5-d]pyrimidine-Based Library via Dimroth Rearrangement, Synthetic Route of 6850-57-3, the publication is Journal of Organic Chemistry (2021), 86(18), 12517-12527, database is CAplus and MEDLINE.

In this work, a novel protocol for the synthesis of 7-aminothiazolo[4,5,-d]pyrimidine scaffold libraries on solid support was developed using a traceless linker. Dimroth rearrangement afforded the desired intermediate with a fused heterocyclic thiazolo[4,5,-d]pyrimidine core skeleton. To diversify the synthesized library, three types of building blocks were introduced to the resin-bound thiazolo[4,5,-d]pyrimidine through N-acylation, N-alkylation, and nucleophilic substitution with amines, during cleavage from the resin. The synthesized compounds were produced in seven steps, with overall yields of 11-48%. Addnl., physicochem. properties, as well as drug-likeness of the library were calculated

Journal of Organic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Synthetic Route of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem