Month: December 2022

Ge, Aimin published the artcileUnraveling the Unstable Nature of Tetraglyme-Based Electrolytes toward Superoxide and the Inhibitory Effect of Lithium Ions by Using In Situ Vibrational Spectroscopies, Application In Synthesis of 143-24-8, the main research area is tetraglyme electrolyte superoxide lithium oxide battery.

The stability of solvents is critical for the efficiency and cyclability of rechargeable aprotic lithium-oxygen (Li-O2) batteries. Here, we report a combined spectroscopic study on the stability of tetraglyme (G4), which is one of the most commonly used solvents in Li-O2 batteries, against superoxide (O2-) during oxygen reduction reaction (ORR). Based on sum-frequency generation spectroscopy characterization, we found that ORR induces significantly irreversible structural changes in G4 mols. on the electrode surface in an O2-saturated Li+-free solution In the Li+-containing solution, however, reversibility for the structural change in G4 mols. is primarily improved. Furthermore, IR reflectance absorption spectroscopy and surface-enhanced Raman spectroscopy measurements confirmed that G4 is extremely unstable during ORR in the Li+-free G4 solution In addition, several decomposition products have been identified during ORR. On the other hand, the decomposition of G4 during ORR is significantly suppressed when Li+ is included in the solution These results indicate that O2- plays a crucial role in the cathodic decomposition of the G4 solvent during ORR. The decomposition mechanism and the inhibitory effect of Li+ are discussed based on spectroscopic observations.

Journal of Physical Chemistry C published new progress about Battery cathodes. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Application In Synthesis of 143-24-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Celik Kucuk, Asuman published the artcileEffects of LiBOB on salt solubility and BiF3 electrode electrochemical properties in fluoride shuttle batteries, Quality Control of 143-24-8, the main research area is bismuth fluoride lithium bisoxalatoborate salt electrode electrochem shuttle battery.

In this study, lithium bis(oxalato)borate (LiBOB) was used for the first time in a fluoride shuttle battery (FSB) to overcome the solubility problem of fluorine-based salts typically present in organic solvents. For this purpose, tetraglyme (G4) electrolytes containing CsF salt and LiBOB with three different concentrations (LiBOB0.06/CsF/G4, LiBOB0.25/CsF/G4, and LiBOB0.5/CsF/G4) were prepared The effects of LiBOB on the electrochem. compatibility of the bismuth fluoride pos. electrode were examined by cyclic voltammetry, charge-discharge tests, and a.c. impedance measurements. The related discharge and charge reactions were confirmed by X-ray diffractometry, whereas 19F NMR and Raman spectroscopies were used to detect potential interactions in the various LiBOB/CsF/G4 systems. At the lowest and highest LiBOB concentrations (i.e., in LiBOB0.06/CsF/G4 and LiBOB0.5/CsF/G4, resp.), the electrolyte decomposition was dominant, whereas the intermediate concentration in LiBOB0.25/CsF/G4 was found to be the optimum condition and played a critical role in CsF solubility, allowing a successful fluoride shuttle-based redox reaction.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Battery cathodes. 143-24-8 belongs to class ethers-buliding-blocks, name is 2,5,8,11,14-Pentaoxapentadecane, and the molecular formula is C10H22O5, Quality Control of 143-24-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jin, Xiang-xiang published the artcileA chalcone-syringaldehyde hybrid inhibits triple-negative breast cancer cell proliferation and migration by inhibiting CKAP2-mediated FAK and STAT3 phosphorylation, Computed Properties of 134-96-3, the publication is Phytomedicine (2022), 154087, database is CAplus and MEDLINE.

Although triple-neg. breast cancer (TNBC) accounts for only 15% of breast cancer cases, it is associated with a high relapse rate and poor outcome after standard treatment. Currently, the effective drugs and treatment strategies for TNBC remain limited, and thus, developing effective treatments for TNBC is pressing. Several studies have demonstrated that both chalcone and syringaldehyde have anticancer effect, but their potential anti-TNBC bioactivity are still unknown. The present study aimed to synthesize a chalcone-syringaldehyde hybrid (CSH1) and explore its potential anti-TNBC effects and the underlying mol. mechanism. Cell cytotoxicity was determined by 3-(4,5-dimethythiazol)-2,5-diphenyltetrazolium bromide (MTT). The activity of cell proliferation was measured by colony formation assay and 5-ethynyl-2′-deoxyuridine (EdU) staining assay. Cell cycle distribution and cell apoptosis were determined by fluorescence-activated cell sorter (FACS). The situation of DNA damage was observed using fluorescence microscopy. The ability of cell-matrix adhesion, migration and invasion was detected using cell adhesion assay and transwell assay. Transcriptome sequencing was performed to find out the changed genes. Levels of various signaling proteins were assessed by western blotting. CSH1 treatment triggered DNA damage and inhibited DNA replication, cell cycle arrest, and cell apoptosis via suppressing signal transducer and activator of transcription 3 (STAT3) phosphorylation. Whole genome RNA-seq anal. suggested that 4% of changed genes were correlated to DNA damage and repair, and nearly 18% of changed genes were functionally related to cell adhesion and migration. Exptl. evidence indicated that CSH1 treatment significantly affected the distribution of focal adhesion kinase (FAK) and its phosphorylation, resulting in cell-matrix-adhesion reduction and migration inhibition of TNBC cells. Further mechanistic studies indicated that CSH1 inhibited TNBC cell proliferation, adhesion, and migration by inhibiting cytoskeleton-associated protein 2 (CKAP2)-mediated FAK and STAT3 phosphorylation signaling. These results suggest that CKAP2-mediated FAK and STAT3 phosphorylation signaling is a valuable target for TNBC treatment, and these findings also reveal the potential of CSH1 as a prospective TNBC drug.

Phytomedicine published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Computed Properties of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yue, Zheng published the artcileSynthesis and physical properties of new fluoroether sulfones, Safety of 2-(2,2,2-Trifluoroethoxy)ethanol, the publication is Journal of Fluorine Chemistry (2018), 118-123, database is CAplus.

Eight new strategically designed fluoroether sulfone solvents have been synthesized through different synthetic pathways for potential applications in lithium-sulfur battery electrolytes. The structures of these compounds have been confirmed by ¹H-NMR, ¹³C-NMR and elemental anal. Several 1,2-dimethoxyethane (DME)-based electrolyte formulations have been prepared with these solvents to derive an electrolyte with good ionic conductivity (>5 mS cm^-1 at 25 °C). The viscosity of these new additives has also been determined as it is directly related to the ionic conductivity Three of these solvents that contain a trifluoromethyl group displayed acceptable ionic conductivity

Journal of Fluorine Chemistry published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C10H10CoF6P, Safety of 2-(2,2,2-Trifluoroethoxy)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Panova, Maria V. published the artcileSupramolecular stereoelectronic effect in hemiketals, Quality Control of 1589-47-5, the publication is Mendeleev Communications (2017), 27(6), 595-598, database is CAplus.

Hemiketals are important targets for crystal prediction and mol. modeling. The supramol. stereoelectronic effect (SSE) recently found in carboxylic acid associates occurs in hemiketals: the presence and nature of an H-bond acceptor affect the conformational preference of hemiketals. To provide a structural basis for the multitude of biol. roles played by hemiketal-containing structures, it is important to accurately model their spatial and dynamic properties, so the SSE in hemiketals should be explicitly implemented in future force fields.

Mendeleev Communications published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Quality Control of 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Thakur, Khalid A. M. published the artcileProton MAS NMR analysis of phenyl silane functionalized silica nanoparticles, Synthetic Route of 1589-47-5, the publication is ACS Symposium Series (2011), 495-508, database is CAplus.

High temperature magic-angle-spinning (MAS) ¹H NMR was used to identify organic components on the surface of functionalized silica nanoparticles. The high temperature data acquisition, by preferential narrowing of resonances, enabled differentiation between species that were adsorbed or weakly bound vs. those that were covalently bound to the surface. MAS NMR of a sample as a slurry with appropriate solvent provided information similar to that obtained at higher temperatures With increasing temperature, gradual separation and up-field shift of silanol proton and water resonances at different rates was observed, possibly a result of diminished hydrogen bonding at increasingly higher temperatures

ACS Symposium Series published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C6H12O2, Synthetic Route of 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Galebach, Peter H. published the artcileProduction of Alcohols from Cellulose by Supercritical Methanol Depolymerization and Hydrodeoxygenation, Application of 2-Methoxypropan-1-ol, the publication is ACS Sustainable Chemistry & Engineering (2018), 6(3), 4330-4344, database is CAplus.

The reaction pathway and products of cellulose supercritical methanol depolymerization and hydrodeoxygenation (SCM-DHDO) were investigated. Monoalcs., diols, alc. ethers, and Me esters were produced from cellulose at 300 °C with a CuMgAl mixed metal-oxide catalyst. Time-course experiments show that cellulose is rapidly solubilized and depolymerized within 1 h with C₂-C₄ diols being intermediates. Experiments with glucose-¹³C₆ show that methanol is incorporated in all liquid products accounting for approx. 30-40% of the carbon in these products. Experiments with model compounds (dihydroxyacetone, isosorbide, and 5-hydroxymethylfurfural) indicate that the reaction pathway for cellulose occurs primarily through retro-aldol condensation of solubilized cellulose followed by recondensation with methanol. Methanol produces H₂, CO, and CO₂ through reformation with 30% of the generated H₂ being incorporated into the liquid products. Anal. of the liquid products with Fourier transform ion cyclotron resonance MS (FT-ICR MS) measured C₇-C₁₂ partially oxygenated species with 2-6 double bond equivalence which could not be detected via gas chromatog. (GC). We conclude that the reaction pathway occurs through rapid solubilization and depolymerization of cellulose followed by retro-aldol condensation to C₂-C₄ oxygenates. Retro-aldol condensation products undergo hydrodeoxygenation and extensive carbon-carbon coupling to produce C₂-C₇ alcs. or other oxygenates.

ACS Sustainable Chemistry & Engineering published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Application of 2-Methoxypropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Anokhina, Viktoriya S. published the artcileEnhancing the ligand efficiency of anti-HIV compounds targeting frameshift-stimulating RNA, Category: ethers-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2019), 27(13), 2972-2977, database is CAplus and MEDLINE.

Ribosomal frameshifting, a process whereby a translating ribosome is diverted from one reading frame to another on a contiguous mRNA, is an important regulatory mechanism in biol. and an opportunity for therapeutic intervention in several human diseases. In HIV, ribosomal frameshifting controls the ratio of Gag and Gag-Pol, two polyproteins critical to the HIV life cycle. We have previously reported compounds able to selectively bind an RNA stemloop within the Gag-Pol mRNA; these compounds alter the production of Gag-Pol in a manner consistent with increased frameshifting. Importantly, they also display antiretroviral activity in human T-cells. Here, we describe new compounds with significantly reduced mol. weight, but with substantially maintained affinity and anti-HIV activity. These results suggest that development of more “ligand efficient” enhancers of ribosomal frameshifting is an achievable goal.

Bioorganic & Medicinal Chemistry published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Danielski, Renan published the artcileA non-conventional approach for obtaining phenolic antioxidants from red guava (Psidium guajava L.) by-products, Related Products of ethers-buliding-blocks, the publication is Journal of Food Processing and Preservation (2022), 46(6), e16502, database is CAplus.

The recovery of phenolic antioxidants from agro-industrial byproducts using non-conventional techniques is a powerful tool to explore the bioactive potential of natural sources. Therefore, it is imperative to analyze the most suitable method to investigate a plant material’s phenolic composition This study used ultra-turrax (UTE), ultrasonic bath (BUAE), and pressurized liquid (PLE) for soluble phenolic extraction from guava’s pulp and processing waste. UTE at 25°C for 1 h yielded the highest concentration of total phenolics and flavonoids from guava pulp, while PLE for 30 min at 60°C/10 MPa presented the best performance for flavonoids and condensed tannins recovery from guava waste. PLE produced extracts with 39 phenolics and high antioxidant capacity. Besides, scopoletin, resveratrol, and naringin are being reported for the first time in this fruit. These results suggest possible alternatives for the recovery of bioactive compound, which may be used to develop nutraceuticals and/or functional foods. Practical applications : Upon guava processing, 30% of fruit’s total volume is lost in the form of byproducts (seeds, peels, and pulp leftovers). Evidence points out that this fraction, along with guava’s pulp, is rich in phenolics with antioxidant properties. An extraction procedure should be conducted to recover these compounds However, conventional techniques are laborious, time-consuming, and they generally use a large amount of toxic organic solvent. Ultra-turrax-UTE, ultrasonic bath-BUAE, and pressurized liquid-PLE are non-conventional approaches that make possible the reduction of solvents and the recovery of selected phenolics not possible with conventional techniques. These extracts could be further applied to lipid-rich foods as a natural antioxidant system and/or as an ingredient in the development of nutraceuticals and functional foods.

Journal of Food Processing and Preservation published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Nambu, Noritoshi published the artcilePhysical and electrochemical properties of fluorinated dialkyl ethers, COA of Formula: C4H7F3O2, the publication is Electrochemistry (Tokyo, Japan) (2016), 84(10), 776-778, database is CAplus.

Dialkyl ethers show high relative permittivities and low viscosities as compared to the corresponding linear carbonates. We have synthesized 1-(2-fluoroethoxy)-2-(2,2,2-trifluoroethoxy)ethane (FETFEE). The relative permittivity and viscosity of FETFEE were higher than those of 1,2-diethoxyethane (DEE, ethylene glycol di-Et ether). The conductivity of 1 mol dm^-3 LiPF₆ solution in FETFEE was higher than that in 1-ethoxy-2-(2,2,2-trifluoroethoxy)ethane (ETFEE). The use of FETFEE as a co-solvent improved the discharge capacity of a Li ‘ LiCoO₂ coin cell.

Electrochemistry (Tokyo, Japan) published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C4H7F3O2, COA of Formula: C4H7F3O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem