Month: December 2022

D’Orsi, Rosarita published the artcileKumagawa and Soxhlet Solvent Fractionation of Lignin: The Impact on the Chemical Structure, Quality Control of 91-16-7, the publication is ACS Omega (2022), 7(29), 25253-25264, database is CAplus and MEDLINE.

We investigated the effects of solvent fractionation on the chem. structures of two com. tech. lignins. We compared the effect of Soxhlet and Kumagawa extraction The aim of this work was to compare the impact of the methods and of the solvents on lignin characteristics. Our investigation confirmed the potentialities of fractionation techniques in refining lignin properties and narrowing the mol. weight distribution. Furthermore, our study revealed that the Kumagawa process enhances the capacity of oxygenated solvents (ethanol and THF) to extract lignin that contains oxidized groups and is characterized by higher average mol. weights Furthermore, the use of THF after ethanol treatment enabled the isolation of lignin with a higher ratio between carbonyl and other oxidized groups. This result was confirmed by attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR), ¹³C NMR and two-dimensional (2D) NMR spectroscopies, gel permeation chromatog. (GPC), and anal. pyrolysis-gas chromatog.-mass spectrometry (GC-MS) anal. UV-visible (UV-vis) spectra evidenced the enrichment in the most conjugated species observed in the extracted fractions. Elemental analyses pointed at the cleavage of C-heteroatom bonds enhanced by the Kumagawa extraction

ACS Omega published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Quality Control of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lei, Zepeng published the artcileHighly stable dioxin-linked metallophthalocyanine covalent organic frameworks, Computed Properties of 91-16-7, the publication is Chinese Chemical Letters (2021), 32(12), 3799-3802, database is CAplus.

We report a series of highly stable metallophthalocyanine-based covalent organic frameworks (MPc-dx-COFs) linked by robust 1,4-dioxin bonds constructed through nucleophilic aromatic substitution (S_NAr) reaction. The chem. structures and crystallinity of the COFs largely remain unchanged even after treating with boiling water (90 °C), concentrated acids (12 mol/L HCl) or bases (12 mol/L NaOH), oxidizing (30% H₂O₂) or reducing agents (1 mol/L NaBH₄) for three days due to their stable M-Pc building blocks and resilient dioxin linkers. With metalated phthalocyanine active sites regularly arranged in the stable framework structures, MPc-dx-COFs can be directly used as efficient electrocatalysts for the oxygen reduction reaction (ORR) without pyrolysis treatment that has commonly been used in previous studies.

Chinese Chemical Letters published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Computed Properties of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liu, Bingxin published the artcileWhite light emission transparent polymer nanocomposites with novel poly(p-phenylene vinylene) derivatives and surface functionalized CdSe/ZnS NCs, Formula: C15H24O2, the publication is Dyes and Pigments (2013), 99(1), 192-200, database is CAplus.

A series of new polymers with conjugated poly(p-phenylene vinylene) units and non-conjugated poly(p-xylylene) units containing vinyl and carboxyl groups were synthesized. The monodisperse CdSe/ZnS nanocrystals with a red light emission were prepared by using the phosphine-free precursors. A novel fluorescent polymer and 5-(2-methacryloylethyloxymethyl)-8-quinolinol were dispersed in vinyl monomers containing CdSe/ZnS NCs to successfully fabricate transparent bulk nanocomposites by in situ polymerization The 5-(2-methacryloylethyloxymethyl)-8-quinolinol mols. can be coordinated to the surface of CdSe/ZnS nanocrystals to form a metalloquinolate with green light emission at about 500 nm, while the red light emission of nanocrystals remained after the polymerization process. The efficient white light emitting polymer nanocomposites with color coordinates (0.32, 0.34) can be obtained when the weight ratio of nanocrystals to 5-(2-methacryloylethyloxymethyl)-8-quinolinol is 10:1. A charge transfer from the photoexcited metalloquinolates to the nanocrystals was observed in the system.

Dyes and Pigments published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Formula: C15H24O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xiao, Juan-Ding published the artcileRelation Between Coordination and Lewis-Acid Property of MOF-Derived Mononuclear Zn(II) Catalyst Toward Epoxide Hydroxylation, Name: 2-Methoxypropan-1-ol, the publication is ChemCatChem (2021), 13(24), 5236-5242, database is CAplus.

Lewis-acid properties of the coordinatively unsaturated metal ions are highly relevant to the coordination environment; however, it remains a challenge to establish the coordination structure-activity relationship, especially in heterogeneous catalysis. Here, a typical metal-organic framework, ZIF-8, is selected as the precursor to prepare Lewis-acid based Zn-N/P-C mononuclear catalysts, with well-designed external structures but difference in the local coordination. The obtained mononuclear Zn(II) catalysts can not only inherit the advantages of MOF in coordination, but also simulate the homogeneous environment during the catalysis owing to the monodispersed metal sites in ZIF-8. Eventually, relation between coordination and Lewis-acid property toward epoxide hydroxylation has been illustrated. Results show the substituted coordination atom of P and the decrease of coordination number strongly enhance the Lewis-acidity of Zn²⁺, causing the TOF values changes from 8.7 to 80.1 h^-1 based on Zn content. The work affords an understanding and inspiration of coordination environment matters toward Lewis-acid catalysis in organic transformations.

ChemCatChem published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C13H19Br2ClN2O, Name: 2-Methoxypropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ren, Miao-miao published the artcileSupercritical extraction and characterization of corn stover lignin, COA of Formula: C4H10O2, the publication is Huaxue Gongye Yu Gongcheng (Tianjin, China) (2012), 29(5), 52-57, database is CAplus.

ScCO₂/ethanol-water was used to extract lignin from corn stover. Lignin product was obtained from the extraction by precipitation The composition of the extract and the structure of the extracted lignin product were analyzed using GC-MS, FTIR and UV. Thermogravimetric anal. was conducted to study the thermal stability of extracted lignin. The results showed that the extracted lignin appeared to show the typical lignin structures and to decompose mostly between 180°C and 500°C. The three dimension supramol. structure of lignin was greatly broken down, primarily through the cleavage of ether linkages. The internal bonds of lignin-hemicellulose were not hydrolyzed completely, which leading to the extracted lignin containing a certain amount of carbohydrate.

Huaxue Gongye Yu Gongcheng (Tianjin, China) published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, COA of Formula: C4H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Herold-Majumdar, Owik Matthias published the artcileRemoval of hard COD from acidic eucalyptus kraft pulp bleach plant effluent streams using oxidoreductases, Quality Control of 134-96-3, the publication is Biotechnology and Applied Biochemistry (2022), 69(2), 687-700, database is CAplus and MEDLINE.

The bleach plant of a pulp and paper (P&P) mill presents a major source of wastewater containing toxic organic matter characterized as COD (COD). Due to their high oxidizing power, oxidoreductases hold promise to be a key solution for the removal of dissolved organic material. Here, four oxidoreductases from different enzyme families were selected to treat bleach plant effluents. Haloperoxidase treatment of the final effluent resulted in the highest levels of decolorization (71%) and reduction of aromatic compounds (36%). Using single compound anal., 27 low mol. weight compounds were found to be persistent throughout the wastewater treatment process and, therefore, classified as hard COD. The tested enzymes efficiently removed several of the identified COD compounds Hence, this study suggests that the application of oxidoreductases will serve as an environmental-friendly solution for reducing waste from P&P production

Biotechnology and Applied Biochemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Quality Control of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Nielsen, Daniel S. published the artcileHigh Cell Permeability Does Not Predict Oral Bioavailability for Analogues of Cyclic Heptapeptide Sanguinamide A*, Category: ethers-buliding-blocks, the publication is Australian Journal of Chemistry (2020), 73(4), 344-351, database is CAplus.

The cyclic heptapeptide derivative, sanguinamide A, is a model scaffold for studying how component amino acids, heterocycles, and N-methylation influence membrane permeability and oral bioavailability. Membrane permeable sanguinamide A analogs have been reported, but there is limited data on their pharmacokinetic properties in vivo. Here we report pharmacokinetic properties for highly cell and membrane permeable sanguinamide A analogs in rats and find that there is no correlation between reported permeability in vitro and oral bioavailability in vivo. We show that N-methylation of sanguinamide A analogs gives compounds with greater flexibility, greater susceptibility to degradation by rat liver microsomes, and lower oral bioavailability in rats.

Australian Journal of Chemistry published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Fliri, Anton F. published the artcileDrug effects viewed from a signal transduction network perspective, Related Products of ethers-buliding-blocks, the publication is Journal of Medicinal Chemistry (2009), 52(24), 8038-8046, database is CAplus and MEDLINE.

Understanding how drugs affect cellular network structures and how resulting signals are translated into drug effects holds the key to the discovery of medicines. Herein we examine this cause-effect relationship by determining protein network structures associated with the generation of specific in vivo drug-effect patterns. Medicines having similar in vivo pharmacol. have been identified by a comparison of drug-effect profiles of 1320 medicines. Protein network positions reached by these medicines were ascertained by examining the coinvestigation frequency of these medicines and 1179 protein network constituents in millions of scientific investigations. Interestingly, medicine associations obtained by comparing by drug-effect profiles mirror those obtained by comparing drug-protein coinvestigation frequency profiles, demonstrating that these drug-protein reachability profiles are relevant to in vivo pharmacol. By using protein associations obtained in these investigations and independent, curated protein interaction information, drug-mediated protein network topol. models can be constructed. These protein network topol. models reveal that drugs having similar pharmacol. profiles reach similar discrete positions in cellular protein network systems and provide a network view of medicine cause-effect relationships.

Journal of Medicinal Chemistry published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Stephens, Thomas C. published the artcileSynthesis of cyclic peptide mimetics by the successive ring expansion of lactams, Name: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, the publication is Chemistry – A European Journal (2017), 23(54), 13314-13318, database is CAplus and MEDLINE.

A successive ring-expansion protocol is reported that enables the controlled insertion of natural and non-natural amino acid fragments into lactams. Amino acids can be installed into macrocycles via an operationally simple and scalable iterative procedure, without the need for high dilution This method is expected to be of broad utility, especially for the synthesis of medicinally important cyclic peptide mimetics.

Chemistry – A European Journal published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C8H15NO, Name: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Boyle, Mhairi published the artcileAmide Bond Formation via the Rearrangement of Nitrile Imines Derived from N-2-Nitrophenyl Hydrazonyl Bromides, Synthetic Route of 6850-57-3, the publication is Organic Letters (2022), 24(1), 334-338, database is CAplus and MEDLINE.

Rearrangement of highly reactive nitrile imines derived from N-2-nitrophenyl hydrazonyl bromides could be harnessed for the facile construction of amide bonds was reported. This amidation reaction was found to be widely applicable to the synthesis of primary, secondary, and tertiary amides and was used as the key step in the synthesis of the lipid-lowering agent bezafibrate. The orthogonality and functional group tolerance of this approach was exemplified by the N-acylation of unprotected amino acids.

Organic Letters published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Synthetic Route of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem