Month: December 2022

Zeng, Bo published the artcileOn the origin of nitrogen-containing promoters in the cobalt-catalyzed methoxycarbonylation of epoxides, COA of Formula: C4H10O2, the publication is Applied Catalysis, A: General (2021), 118291, database is CAplus.

The detailed promotion mechanism of nitrogenous compounds in the cobalt-catalyzed methoxycarbonylation of epoxides has not been studied to date. Herein, we present the intrinsic correlation between nitrogenous promoters and activity and selectivity in the alkoxycarbonylation of epoxides by a comprehensive in situ IR spectroscopy and DFT studies. In situ IR spectroscopy confirmed the acid-base neutralization of the nitrogenous promoters and HCo(CO)₄, resulting in reduction of the acidity of the catalyst. With the reduced acid-derived activity for formation of ethers as byproducts, the selectivity of desired esters was increased. DFT calculations showed that a nitrogenous base could facilitate the methanolysis of cobalt-acyl species with lowered activation energy, which is considered to be the rate-determining step in the catalytic cycle. As a result, the reaction activity towards carbonylation was also improved by nitrogenous promoters. The present studies will provide new insights to the long-term confusing problems in epoxides carbonylation.

Applied Catalysis, A: General published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C5H6BNO2, COA of Formula: C4H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Fu, Yao published the artcileFirst-Principle Predictions of Absolute pK_a‘s of Organic Acids in Dimethyl Sulfoxide Solution, Name: 2-Methoxyacetamide, the publication is Journal of the American Chemical Society (2004), 126(3), 814-822, database is CAplus and MEDLINE.

MP2/6-311++G(d,p) and B3LYP/6-311++G(2df,p) methods are able to predict the gas-phase acidities of various organic acids with a precision of 2.2 and 2.3 kcal/mol. A PCM cluster-continuum solvation method was developed that could predict the solvation free energies of various neutral, cationic, and anionic organic species in DMSO with a precision of âˆ?.0 kcal/mol. Using these carefully tested methods, the authors successfully predicted the pK_a‘s of 105 organic acids in DMSO with a precision of 1.7-1.8 pK_a units. The authors also predicted the pK_a‘s of a variety of organosilanes in DMSO for the first time using the newly developed methods. This study was one of the first that employed first-principle methods for calculating pK_a‘s of unrelated compounds in organic solutions

Journal of the American Chemical Society published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Name: 2-Methoxyacetamide.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gui, Honggang published the artcileCross-metathesis approach for stereocontrolled synthesis of the C1-C15 fragment of rhizopodin, COA of Formula: C21H37BO, the publication is Synlett (2014), 25(1), 138-142, database is CAplus.

The C1-C15 fragment of rhizopodin was synthesized through either Suzuki coupling reaction of vinyl iodide and vinyl boronate or cross-metathesis of a terminal olefin and a diene adduct in the presence of Hoveyda-Grubbs II catalyst.

Synlett published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, COA of Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xia, Jiajin published the artcileDivergent Access to Polycyclic N-Heterocyclic Compounds through Büchner-Type Dearomatization Enabled Cycloisomerization of Diynamides under Gold Catalysis, HPLC of Formula: 6850-57-3, the publication is Organic Letters (2022), 24(23), 4298-4303, database is CAplus and MEDLINE.

Herein, an unprecedented gold-catalyzed oxidative Buechner-type cyclopropanation of diynamides was described to afford polycyclic N-heterocyclic products I [R¹ = mesyl, nosyl, tosyl; R² = Ph, 4-MeC₆H₄, 2-ClC₆H₄, etc.], II [R³ = Ph, 4-FC₆H₄, 4-BrC₆H₄, etc.], III [R⁴ = Ph, 3-thienyl, 2-ClC₆H₄, etc.] and IV [R⁵ = Ph, 3-ClC₆H₄, 3-BrC₆H₄, etc.; R⁶ = mesyl, tosyl]. By variation of the position of substituents on the Ph ring, a variety of compounds I, II, III, IV with challenging structural skeletons were obtained divergently.

Organic Letters published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C15H24O2, HPLC of Formula: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhuang, Xiuzheng published the artcileSelective catalysis for the reductive amination of furfural toward furfurylamine by graphene-co-shelled cobalt nanoparticles, Application In Synthesis of 6850-57-3, the publication is Green Chemistry (2022), 24(1), 271-284, database is CAplus.

Amines with functional groups are widely used in the manufacture of pharmaceuticals, agricultural chems., and polymers but most of them are still prepared through petrochem. routes. The sustainable production of amines from renewable resources, such as biomass, is thus necessary. For this reason, we developed an eco-friendly, simplified, and highly effective procedure for the preparation of a non-toxic heterogeneous catalyst based on earth-abundant metals, whose catalytic activity on the reductive amination of furfural or other derivatives (more than 24 examples) proved to be broadly available. More surprisingly, the cobalt-supported catalyst was found to be magnetically recoverable and reusable up to eight times with an excellent catalytic activity; on the other hand, the gram-scale tests catalyzed by the same catalyst exhibited the similar yield of the target products in comparison to its smaller scale, which was comparable to the com. noble-based catalysts. Further results from a series of anal. technologies involving XRD, XPS, TEM/mapping, and in situ FTIR revealed that the structural features of the catalyst are closely in relation to its catalytic mechanisms. In simple terms, the outer graphitic shell is activated by the electronic interaction as well as the induced charge redistribution, enabling the easy substitution of the -NH2 moiety toward functionalized and structurally diverse mols., even under very mild industrially viable and scalable conditions. Overall, this newly developed catalyst introduces the synthesis of amines from biomass-derived platforms with satisfactory selectivity and carbon balance, providing cost-effective and sustainable access to the wide applications of reductive amination.

Green Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H5F3O3, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wei, Ya-Nan published the artcileStructural changes for lignin from Chinese quince during the sequential fractionation of cell wall polysaccharides, SDS of cas: 134-96-3, the publication is Process Biochemistry (Oxford, United Kingdom) (2022), 167-176, database is CAplus.

The crosslinking between lignin and cell wall polysaccharides is one of recalcitrance to extract pectin and hemicellulose. In this work, water-, chelator-, Na₂CO₃-soluble pectin (WSP, CSP, NSP) and alkali-soluble hemicellulose (ASH) were sequentially removed, milled wood lignins (WMWL, CMWL, NMWL and KMWL) were isolated from Chinese quince. Quant. chem. anal. techniques (e.g., HPAEC, FT-IR, GPC, Py-GC/MS, TG and 2D NMR) were used for characterizing the lignin fractions. Results indicate that there are tight linkages between arabinose and lignin. The mol. weight and thermal stability decreased as different types of pectin (WSP, CSP and NSP) were removed. Py-GC/MS and 2D NMR data showed that the major interunit β-O-4′ aryl ether bonds of lignin (61.07%-72.53%) and the S/G ratios (0.56-2.68) were changed. It was revealed that Chinese quince pectin and hemicellulose polysaccharides have more covalent crosslinks with S-type lignin from secondary wall S2 than G-type lignin. These results will contribute to realizing the mechanisms of cell wall polysaccharides isolation and be beneficial for the potential application of Chinese quince fruits in food and other industries.

Process Biochemistry (Oxford, United Kingdom) published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C10H14O, SDS of cas: 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Wei published the artcileResearch progress of apratoxin A: a marine cyclic-depsipeptide with significant anticancer activity, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Youji Huaxue (2014), 34(3), 475-484, database is CAplus.

Apratoxin A, a marine natural cyclic-depsipeptide bearing novel and complex structure, showed significant antiproliferative activity against several cancer cell lines. A brief introduction on the research progress of this natural product including total synthesis, structure-activity relationship, pharmacol. studies, and biosynthetic pathway was summarized.

Youji Huaxue published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C10H12O5, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liu, Kai published the artcileOne-Pot Synthesis of Dimethyl Carbonate over a Binary Catalyst of an Ionic Liquid and an Alkali Carbonate under Low Pressure, Recommanded Product: 2-Methoxypropan-1-ol, the publication is ACS Omega (2021), 6(21), 13839-13846, database is CAplus and MEDLINE.

A mild and highly efficient approach has been developed for the one-pot synthesis of di-Me carbonate (DMC) from epoxide, carbon dioxide, and methanol under low initial pressure. The key to the successful transformation is the use of a bicomponent catalytic system composed of a hydroxyl-functionalized ionic liquid and an alkali carbonate. This bicomponent catalytic system demonstrated excellent reusability in four runs. Under the optimal reaction conditions, a 64% yield of DMC from propylene oxide and an 81% yield of DMC from ethylene oxide were obtained.

ACS Omega published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Recommanded Product: 2-Methoxypropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yu, Xiaochun published the artcileManganese Dioxide Catalyzed N-Alkylation of Sulfonamides and Amines with Alcohols under Air, Quality Control of 52818-63-0, the publication is Organic Letters (2011), 13(23), 6184-6187, database is CAplus and MEDLINE.

By simply running the reactions under air and solvent-free conditions using catalytic amounts of manganese dioxide, a practical and efficient N-alkylation method for a variety of sulfonamides and amines using alcs. as green alkylating reagents was developed.

Organic Letters published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C4H6O3, Quality Control of 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Beraki, Simret published the artcileA pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke, SDS of cas: 637-58-1, the publication is PLoS One (2013), 8(7), e69233, database is CAplus and MEDLINE.

With the availability and ease of small mol. production and design continuing to improve, robust, high-throughput methods for screening are increasingly necessary to find pharmacol. relevant compounds amongst the masses of potential candidates. Here, we demonstrate that a primary oxygen glucose deprivation assay in primary cortical neurons followed by secondary assays (i.e. post-treatment protocol in organotypic hippocampal slice cultures and cortical neurons) can be used as a robust screen to identify neuroprotective compounds with potential therapeutic efficacy. In our screen about 50% of the compounds in a library of pharmacol. active compounds displayed some degree of neuroprotective activity if tested in a pre-treatment toxicity assay but just a few of these compounds, including Carbenoxolone, remained active when tested in a post-treatment protocol. When further examined, Carbenoxolone also led to a significant reduction in infarction size and neuronal damage in the ischemic penumbra when administered six hours post middle cerebral artery occlusion in rats. Pharmacol. testing of Carbenoxolone-related compounds, acting by inhibition of 11-β-hydroxysteroid dehydrogenase-1 (11β-HSD1), gave rise to similarly potent in vivo neuroprotection. This indicates that the increase of intracellular glucocorticoid levels mediated by 11β-HSD1 may be involved in the mechanism that exacerbates ischemic neuronal cell death and inhibiting this enzyme could have potential therapeutic value for neuroprotective therapies in ischemic stroke and other neurodegenerative disorders associated with neuronal injury.

PLoS One published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, SDS of cas: 637-58-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem