Month: December 2022

Thao, Nguyen Phuong published the artcileCytotoxic metabolites from the leaves of the mangrove Rhizophora apiculata, Category: ethers-buliding-blocks, the publication is Phytochemistry Letters (2022), 51-55, database is CAplus.

One new 8,4-oxyneolignan (1) and one new 7,8-dihydrobenzofuranone (2), together with twenty-one known compounds (3-23) were isolated from the methanol extract of Rhizophora apiculata leaves. The structures of new compounds, as well as their absolute configuration, were determined by a combination of spectroscopic methods and quantum chem. calculations of NMR and ECD data. All isolated compounds were evaluated for their cytotoxicity, and only 2,6-dimethoxy-1,4-benzoquinone (8) exhibited inhibitory effects against SK-LU-1, HepG2, and MCF7 cells with IC50 values in the range of 8.33-14.82 μM.

Phytochemistry Letters published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C16H12O, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wu, Ke published the artcileNi-catalyzed reductive decyanation of nitriles with ethanol as the reductant, COA of Formula: C11H10O, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(18), 2273-2276, database is CAplus and MEDLINE.

A nickel-catalyzed reductive decyanation of aromatic nitriles has been developed, in which the readily available and abundant ethanol was applied as the hydride donor. Various functional groups on the aromatic rings, such as alkoxyl, amino, imino and amide, were compatible in this catalytic protocol. Heteroaryl, benzylic and alkenyl nitriles were also tolerated. Mechanistic investigation indicated that ethanol provided hydride efficiently via β-hydride elimination in this reductive decyanation.

Chemical Communications (Cambridge, United Kingdom) published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C8H15ClN2, COA of Formula: C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yuan, Shuqing published the artcileChromium-Catalyzed Reductive Cleavage of Unactivated Aromatic and Benzylic C-O Bonds, Related Products of ethers-buliding-blocks, the publication is Synthesis (2021), 53(18), 3343-3350, database is CAplus.

Reductive cleavage of aromatic and benzylic C-O bonds by chromium catalysis was reported. This deoxygenative reaction was promoted by low-cost CrCl₂ precatalyst combined with poly(Me hydrogen siloxane) as the mild reducing agent, providing a strategy in forming reduced motifs by cleavage of unactivated C-O bonds. A range of functional groups such as bromide, chloride, fluoride, hydroxyl, amino and alkoxycarbonyl was retained in the reduction

Synthesis published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C12H20O6, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mantel, Mette L. H. published the artcilePd-catalyzed C-N bond formation with heteroaromatic tosylates, SDS of cas: 16332-06-2, the publication is Chemistry – A European Journal (2010), 16(18), 5437-5442, S5437/1-S5437/52, database is CAplus and MEDLINE.

A protocol for the palladium(0)-catalyzed amidation of heteroaromatic tosylates was successfully developed. The methodol. proved to be effective for a variety of heteroaryl tosylates including the pyridine, pyrimidine, quinoline and quinoxaline ring systems. Successful carbon-nitrogen bond formation with these heteroaryl tosylates could be performed with a wide range of primary amides, oxazolidinones, lactams, anilines and indoles, including one cyclic urea. Moreover, this C-N bond forming reaction provided products with high structural diversity. The coupling reaction was also amenable to scale up applications.

Chemistry – A European Journal published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, SDS of cas: 16332-06-2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chou, Hsuan-Liang published the artcileChain composition dependence of optoelectronic properties for MEH-PV/DPO-PV copolymers, Computed Properties of 146370-51-6, the publication is Guoli Taiwan Daxue Gongcheng Xuekan (2003), 111-119, database is CAplus.

The copolymerization of 5-methoxy-2-((2′-ethyl-hexyl)-oxy)-p-phenylenevinylene (MEH-PV) and 2,3-diphenyl-5-octyl-1,4-phenylenevinylene (DPO-PV) via the Gilch route tended to form an alternative copolymer. As a result, the emission color of electroluminescence (EL) of MEH-PPV could be adjusted from orange-red to blue-green by copolymerization, however, the turn-on voltage of the prepared light-emitting diode device was increased and the EL efficiency was decreased with the content of DPO-PV in copolymer.

Guoli Taiwan Daxue Gongcheng Xuekan published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Computed Properties of 146370-51-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liu, Chao published the artcileLignin-first biorefinery of corn stalk via zirconium(IV) chloride/sodium hydroxide-catalyzed aerobic oxidation to produce phenolic carbonyls, Category: ethers-buliding-blocks, the publication is Bioresource Technology (2022), 127183, database is CAplus and MEDLINE.

Lignin-first biorefinery of corn stalk via ZrCl₄/NaOH-catalyzed aerobic oxidation for phenolic carbonyls production was reported. Under the co-catalysis of ZrCl₄ and NaOH, lignin in corn stalk was oxidized into phenolic aldehydes (p-hydroxybenzaldehyde, vanillin, and syringaldehyde), ketones (p-hydroxyacetophenone, acetovanillone, and acetosyringone), acids (p-hydroxybenzoic acid and vanillic acid), and other derivatives Reaction conditions, including time, temperature, ZrCl₄ dosage, NaOH dosage, MeCN/H₂O ratio, and initial O₂ pressure were comprehensively screened, and the optimal lignin-derived monomer yields of 13.2 weight% was obtained. Among these aromatic compounds, phenolic aldehydes were the main products, and the overall selectivity of phenolic carbonyls was as high as 93%. Cellulose-rich residues after lignin-first oxidation were further characterized by thermogravimetry and anal. pyrolysis with corn stalk as the control, proving the good fragmentation and dissolution of lignin streams. In general, ZrCl₄/NaOH-catalyzed lignin-first oxidation provided a novel approach for lignin valorization, and achieved the highest reported phenolic carbonyls selectivity.

Bioresource Technology published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chang, Meng-Yang published the artcileGram-Scale Synthesis of Substituted Triarylmethanes, Quality Control of 91-16-7, the publication is Synthesis, database is CAplus.

A high-yield, open-vessel route for the facile-operational, gram-scale synthesis of functionalized triarylmethanes (TRAMs) was described via silica-coated magnetic nanoparticles of modified polyphosphoric acid (NiFe₂O₄@SiO₂-PPA)-mediated intermol. Friedel-Crafts reaction of substituted aryl aldehydes with 2 equiv of oxygenated arenes under environmentally friendly reaction conditions. Among the overall reaction process, only water was generated as the byproduct. Various reaction conditions were investigated for efficient transformation.

Synthesis published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Quality Control of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Amandi, Rodrigo published the artcileFriedel-Crafts Alkylation of Anisole in Supercritical Carbon Dioxide: A Comparative Study of Catalysts, Recommanded Product: 2-Isopropylanisole, the publication is Organic Process Research & Development (2005), 9(4), 451-456, database is CAplus.

The Friedel-Crafts alkylation of anisole with n-propanol was carried out over five different Bronsted solid acid catalysts using supercritical carbon dioxide as the reaction medium. The reaction temperature and pressure were evaluated in terms of selectivity for the monoalkylated products, conversion of the starting material, and the products’ isomeric ratio. Desulfonation of the catalysts was observed when the temperature was increased above 150 °C for the organic supported catalysts investigated Amberlyst 15 and Purolite CT-175, and above 200 to 250 °C for the inorganic supported catalysts Nafion SAC-13 and Deloxan ASP I/7. A decrease in the catalytic performance of organic supported catalysts was observed with increasing pressure. This decrease was related to the phase behavior of the reaction.

Organic Process Research & Development published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liu, Chuanzhi published the artcileDiscovery and Mechanistic Studies of a General Air-Promoted Metal-Catalyzed Aerobic N-Alkylation Reaction of Amides and Amines with Alcohols, Product Details of C13H14N2O, the publication is Journal of Organic Chemistry (2011), 76(14), 5759-5773, database is CAplus and MEDLINE.

The thermodynamically unfavorable anaerobic dehydrogenative alc. activation to aldehydes and hydridometal species is the bottleneck in metal-catalyzed N-alkylations due to a general and unnoticed catalyst deactivation by amines/amides. Thus, different from the anaerobic dehydrogenation process in borrowing hydrogen or hydrogen autotransfer reactions that require noble metal complexes or addition of capricious ligands for catalyst activation, the water-producing, exothermic, metal-catalyzed aerobic alc. oxidation is thermodynamically more favorable and the most effective and advantageous aldehyde generation protocol. This leads to a general and advantageous air-promoted metal-catalyzed aerobic N-alkylation methodol. that effectively uses many simpler, less expensive, more available, and ligand-free metal catalysts that were inactive under typical anaerobic borrowing hydrogen conditions, avoiding the use of preformed metal complexes and activating ligands and the exclusive requirement of inert atm. protection. This aerobic method is quite general in substrate scope and tolerates various amides, amines, and alcs., revealing its potentially broad utilities and interests in academy and industry. In contrast to the commonly accepted borrowing hydrogen mechanism, based on a thorough mechanistic study and supported by the related literature background, a new mechanism analogous to the relay race game that has never been proposed in metal-catalyzed N-alkylation reactions is presented.

Journal of Organic Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Product Details of C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Huang, Chenghong published the artcileSilver-Mediated Trifluoromethoxylation of Aryl Stannanes and Arylboronic Acids, Recommanded Product: (3-(Methoxycarbonyl)-5-methylphenyl)boronic acid, the publication is Journal of the American Chemical Society (2011), 133(34), 13308-13310, database is CAplus and MEDLINE.

A silver-mediated cross-coupling of trifluoromethoxide with aryl stannanes and arylboronic acids to give aryl trifluoromethyl ethers, e.g., I, is reported. This is the first report of a transition-metal-mediated C_aryl-OCF₃ bond formation.

Journal of the American Chemical Society published new progress about 929626-18-6. 929626-18-6 belongs to ethers-buliding-blocks, auxiliary class Boronic acid and ester,Benzene,Ester,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (3-(Methoxycarbonyl)-5-methylphenyl)boronic acid, and the molecular formula is C9H11BO4, Recommanded Product: (3-(Methoxycarbonyl)-5-methylphenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem