Month: December 2022

Van Tamelen, E. E. published the artcileBiogenetic-type total synthesis of (±)-triptonide and (±)-triptolide, Product Details of C10H14O, the publication is Journal of the American Chemical Society (1982), 104(6), 1785-6, database is CAplus.

A biogenetic-type total synthesis of the naturally occurring anticancer agents triptolide (I; R = H, R¹ = OH) and triptonide (I; RR¹ = O) was carried out via cyclization of aromatic β-oxo ester II.

Journal of the American Chemical Society published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C7H13BrSi, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chadha, Vijay K. published the artcileInhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism, Product Details of C3H7NO2, the publication is Journal of Medicinal Chemistry (1983), 26(6), 916-22, database is CAplus and MEDLINE.

Sulfoxides and amides were tested as inhibitors of liver alc. dehydrogenase  [9031-72-5] and of EtOH [64-17-5] metabolism in rats. With both series of compounds, increasing the hydrophobicity resulted in better inhibition, and introduction of polar groups reduced inhibition. Of the cyclic sulfoxides, tetramethylene sulfoxide (I) [1600-44-8] was the best inhibitor as compared to the tri- [13153-11-2] and pentamethylene analogs [4988-34-5] and other compounds, and it may be a transition-state analog. The most promising compounds, I and isovaleramide  [541-46-8], were essentially uncompetitive inhibitors of purified horse and rat liver alc. dehydrogenases with respect to EtOH as substrate. These compounds also were uncompetitive inhibitors in vivo, which is advantageous since the inhibition is not overcome at higher concentrations of EtOH, as it is with competitive inhibitors, such as pyrazole. The uncompetitive inhibition constants for I and isovaleramide for rat liver alc. dehydrogenase were 200 and 20 μM, resp. in vitro, whereas in vivo the values were 340 and 180 μmol/kg, resp. The differences in the values may be due to metabolism or distribution of the compounds Further studies will be required to determine if isovaleramide or I is suitable for therapeutic purposes.

Journal of Medicinal Chemistry published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Product Details of C3H7NO2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hickey, Deirdre M. B. published the artcileSynthesis of thyroid hormone analogs. Part 3. Iodonium salt approaches to SK & F L-94901, Application of 2-Isopropylanisole, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1988), 3103-11, database is CAplus.

The key step in the synthesis of the title compound L–I, a novel, selective, and potent thyromimetic, is the formation of the hindered diaryl ether moiety. This paper describes an investigation into the formation of the required diaryl ether by copper-catalyzed reaction both of sym. iodonium salts, e.g. R₂I⁺ O₂CCF₃, and mixed iodonium salts II (R¹ = H, R² = OMe; R¹ = R² = H, OMe) with protected dibromotyrosine 4,3,5-HO(Br)₂C₆H₂CH₂CH(NHCOCF₃)CO₂Me. The importance of the counterion of the iodonium salt is discussed. This work is extended to a large-scale synthesis of SK & F L-94901 (I).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Application of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ryu, Jung-Yi published the artcileMobility characteristics of novel oligomer structuralized by biphenyl conjugated with electron donating units, Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2009), 15(4), 504-509, database is CAplus.

Oligomers containing biphenyl backbone were prepared by using Wittig reaction and their optical properties were characterized. The drift mobility of oligomers was measured by using TOF method. The drift mobility showed elec. field-dependent character and coincidence with Poole-Frankel relation.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Starace, Anne K. published the artcilePredicting Catalytic Pyrolysis Aromatic Selectivity from Pyrolysis Vapor Composition Using Mass Spectra Coupled with Statistical Analysis, Recommanded Product: 1,2-Dimethoxybenzene, the publication is ACS Sustainable Chemistry & Engineering (2022), 10(1), 234-244, database is CAplus.

The behavior of fast pyrolysis (FP) and catalytic FP (CFP) of 20 renewable feedstocks was studied in a microscale reactor with mol. beam mass spectral anal. of products generated. A partial least-squares (PLS) model was constructed based on the FP vapor spectra that predicts the aromatic selectivity when upgrading over a ZSM-5 catalyst. Addnl., principal component anal. of both FP and CFP spectra was performed for comprehensive spectral anal. This work highlighted the value of vapor-phase mass spectral screening to predict the subsequent feedstock performance and demonstrated that the quantity of coke deposited on the catalyst is not a reliable measure of catalyst deactivation when the feedstock type is varied.

ACS Sustainable Chemistry & Engineering published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C14H14, Recommanded Product: 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Shin, Sang Baek published the artcileThe effects of impregnation of precious metals on the catalytic activity of titanium silicate (TS-1) in epoxidation of propene using hydrogen peroxide, SDS of cas: 1589-47-5, the publication is Journal of Molecular Catalysis A: Chemical (2016), 478-488, database is CAplus.

Propene oxide is an important chem. intermediate and titanium silicalite (TS-1) has been widely investigated as a promising catalyst for the direct epoxidation of propene with ex-situ or in-situ produced hydrogen peroxide as an oxidant. In order to clarify the effects of the kind of precious metal and treatment process in the catalyst preparation on the propene epoxidation and the hydrogen peroxide decomposition, TS-1 was impregnated with gold and palladium via drying, calcination and reduction and the experiments to check its catalytic performance were conducted in a gas aspirating autoclave reactor in the absence of mass transfer limitations. The presence of precious metals vigorously catalyzed the side reactions and hydrogen peroxide decomposition Some of the precious metal containing TS-1 catalysts showed high initial rates but there was no catalyst with a propene oxide yield after 5 h reaction time comparable to TS-1 alone because of the enhancement of side reactions by precious metals. The significant decline in the selectivity to propene oxide over the dried precious metal containing TS-1 catalysts was attributed to the leaching of precious metals into the reaction medium. Palladium containing TS-1 showed exceptionally high decomposition of hydrogen peroxide. Reduction and calcination increased the decomposition by forming metallic gold and palladium. Homogeneous dispersion of gold nanoparticles was achieved by a sol immobilization method which led to a decrease of propene oxide selectivity and an increase of hydrogen peroxide decomposition

Journal of Molecular Catalysis A: Chemical published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C11H24O3, SDS of cas: 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mukherjee, Sumit published the artcileApplication of Tandem Ring-Closing Enyne Metathesis: Formal Total Synthesis of (-)-Cochleamycin A, Application of (+)-B-Methoxydiisopinocampheylborane, the publication is Organic Letters (2009), 11(13), 2916-2919, database is CAplus and MEDLINE.

A tandem ring-closing metathesis of a silaketal-based dienyne substrate proceeded efficiently to provide a bicyclic siloxane, which upon removal of the silicon tether afforded an (E,Z)-1,3-dienediol. Further manipulation of this key functional motif rendered synthesis of the entire C1-C19 linear skeleton of (-)-cochleamycin A (I) , a late-stage intermediate employed in the previous total synthesis of (+)-cochleamycin A by Roush and co-workers.

Organic Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Application of (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hall, Sara M. published the artcileDiscovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain, Product Details of C25H23NO4, the publication is ACS Chemical Neuroscience (2016), 7(12), 1746-1752, database is CAplus and MEDLINE.

Dynorphin A (Dyn A) is a unique endogenous ligand that possesses well-known neuroinhibitory effects via opioid receptors with a preference for the kappa receptor but also neuroexcitatory effects, which cause hyperalgesia. We have shown that the neuroexcitatory effects are mediated through bradykinin (BK) receptors and that intrathecal (i.th.) administration of our lead ligand 1, [des-Arg⁷]-Dyn A-(4-11), which shows good binding affinity (IC₅₀ = 150 nM) at the BK receptors, blocks Dyn A-induced hyperalgesia in naïve animals and reverses thermal and tactile hypersensitivities in a dose-dependent manner in nerve-injured animals. However, 1 has a serious drawback as a potential drug candidate for the treatment of neuropathic pain because of its susceptibility to enzymic degradation In an effort to increase its stability, we modified ligand 1 using non-natural amino acids and found that analogs substituted at or near the N-terminus with a D-isomer retain binding at the receptor and provide a large increase in stability. In particular when Leu⁵ was modified, with either the D-isomer or N-methylation, there was a large increase in stability (t_1/2 = 0.7-160 h in rat plasma) observed From these studies, we have developed a very stable Dyn A analog 16, [D-Leu⁵,des-Arg⁷]-Dyn A-(4-11), that binds to BK receptors (IC₅₀ = 130 nM) in the same range as ligand 1 and shows good antihyperalgesic effects in both naïve rats and L₅/L₆ spinal nerve ligation rats.

ACS Chemical Neuroscience published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Product Details of C25H23NO4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Caldarelli, Marina published the artcileUse of acridinium-based photocatalyst in the Giese-type coupling of arylboronic acids with electron poor olefins, Application In Synthesis of 93-04-9, the publication is Tetrahedron Letters (2022), 153978, database is CAplus.

The development of a visible light-mediated Giese-type reaction using arylboronic acids as aryl radical source was described. The synthetic protocol capitalizes on the employment of environmentally benign metal-free catalyst to forge Csp²-Csp³ bonds. Applications of the methodol. to the synthesis of aminoesters and the anti-inflammatory drug nabumetone, either in batch or in flow, was also reported.

Tetrahedron Letters published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Application In Synthesis of 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hammarlund, E. R. published the artcileMethods of preparing isotonic solutions by means of graphs or tables on the basis of experimentally found iso-osmotic values, Recommanded Product: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Pharmaceutica Acta Helvetiae (1960), 593-607, database is CAplus.

Four graphical and three tabular methods for preparing isotonic aqueous solutions are described. New exptl. data is presented for 353 compounds to be used for the recommended and most practical of the methods studied for isotonicity adjustment. All the methods described may be used in practical pharmacy. The graphical methods are more accurate but consume more space than the tabular methods.

Pharmaceutica Acta Helvetiae published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Recommanded Product: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem