Month: December 2022

Bano, Kulsum published the artcileFacile Synthesis of Benzimidazole and Benzothiazole Compounds Mediated by a Zinc Precatalyst Supported by an Iminopyrrole-Morpholine Ligand, Application In Synthesis of 6850-57-3, the publication is European Journal of Inorganic Chemistry (2022), 2022(10), e202200023, database is CAplus.

Three zinc complexes, with the general formula {κ2-C₄H₃NH[2-CH=NCH₂CH₂N(CH₂CH₂)₂O]ZnX₂} [X = Cl, Br, I], supported by a neutral iminopyrrole-morpholine ligand, were synthesized by the reaction between {C₄H₃NH-2-[CH=NCH₂CH₂N (CH₂CH₂)₂O]} and anhydrous zinc dihalides (ZnCl₂, ZnBr₂, ZnI₂) at ambient temperature in dry methanol. The zinc complexes were fully characterized using multinuclear NMR spectroscopic techniques and the mol. structures of complexes in their solid states were determined by single-crystal X-ray diffraction anal. The zinc diiodo complex proved to be a competent precatalyst in the formation of a wide range of benzimidazole and benzothiazole compounds, via aerobic oxidative condensation of several benzylamines with o-phenylenediamine, N-phenyl-o-phenylene-diamine, and o-mercaptoaniline. The benzimidazole and benzothiazole derivatives were successfully characterized using ¹H and ¹³C{1H} NMR spectroscopy.

European Journal of Inorganic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Golovnev, N. N. published the artcileSynthesis and properties of compounds of formamidindium disulfide with d-element tetrahalide anions, COA of Formula: C2H8Cl2N4S2, the publication is Russian Journal of Inorganic Chemistry (2013), 58(6), 701-705, database is CAplus.

Products of reactions of salts of d elements with formamidine disulfide dihydrochloride (FDSH₂Cl₂) in concentrated HCl and HBr solutions were synthesized and characterized. The following compounds were obtained: FDSH₂[CuCl₄]·H₂O, FDSH₂[CoCl₄], FDSH₂[ZnCl₄], FDSH₂[HgCl₄], and FDSH₂[HgBr₄]. The identity of these compounds was confirmed by x-ray diffraction; their compositions were derived from the results of chem. anal. and thermal anal. The IR and Raman scattering spectra of the compounds indicate the presence therein of FDSH cation. FDSH transforms into formamidindium trisulfide cation (NH₂)₂C-S-S-S-C(NH₂) upon storage in air in HCl solution

Russian Journal of Inorganic Chemistry published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, COA of Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tomioka, Hideo published the artcileButtressing effect in carbene chemistry. Effect of 3-alkyl groups on the reactions of 2-alkoxydiphenylcarbenes, Related Products of ethers-buliding-blocks, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1991), 471-7, database is CAplus.

Irradiation of 3,2-R(MeO)C₆H₃CPh:N₂ (I; R = H) in Et₂O at 10° gave 3-phenyldihydrofuran (II; R = H) and a small amount of 3,2-R(MeO)C₆H₃CHPhR¹ [III; R¹ = H, R = EtOCHMe (IV)]; IV was the major product when the irradiation was carried out in an Et₂O matrix at -196°. With I (R = alkyl) the reaction patterns were dramatically changed. Only II (R = alkyl) were formed in Et₂O at +10 or -196°. This was due to the buttressing effect of R, which prevents the 2-MeO group from lying in the plane of the Ph ring in the precursor mols. and assists the MeO group in rotating around the C-O bond toward the carbene center after elimination of N. The effect of buttressing on the generation of carbene in MeOH is also discussed.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C8H7ClO3, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Pengfei published the artcileSynthesis of the Potent Immunostimulatory Adjuvant QS-21A, Formula: C21H37BO, the publication is Journal of the American Chemical Society (2005), 127(10), 3256-3257, database is CAplus and MEDLINE.

QS-21A is one of the most promising new adjuvants for immune response potentiation and dose-sparing in vaccine therapy, given its exceedingly high level of potency and its favorable toxicity profile. Melanoma, breast cancer, small cell lung cancer, prostate cancer, HIV-1, and malaria are among the numerous maladies targeted in more than 80 recent and ongoing clin. trials involving QS-21A as a critical component for immune response augmentation in microgram doses. Herein is reported the first synthesis and structure verification of QS-21A_api, applying novel glycosylation methodologies in the convergent modular construction of this rare and potent natural product immunostimulant (no biol. data).

Journal of the American Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C15H21BO3, Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Son, Jung Beom published the artcileEnantioselective total synthesis of (-)-clavosolide A and B, Category: ethers-buliding-blocks, the publication is Bulletin of the Korean Chemical Society (2010), 31(3), 653-663, database is CAplus.

Enantioselective total synthesis of proposed and revised structure of (-)-clavosolide A and B by a convergent approach, where syn-selective aldol, hydroxy-directed cyclopropanation, Mitsunobu inversion, Schmidt-type glycosylation, and macrolactonization reactions were utilized as key reactions. The relative and absolute stereochem. of the natural products were confirmed unambiguously by comparing the optical rotation values and ¹H and ¹³C NMR spectra of them.

Bulletin of the Korean Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C9H5ClO2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Meringdal, Jonas W. published the artcileModular Synthesis of Halogenated Xanthones by a Divergent Coupling Strategy, Application In Synthesis of 91-16-7, the publication is Journal of Organic Chemistry (2022), 87(14), 9375-9383, database is CAplus and MEDLINE.

A versatile strategy to halogenated xanthones I (R¹ = H, R² = Br; R¹ = Br, R² = H; R³ = H, Cl) that relied on a modular coupling of vanillin derivatives with a dibromoquinone has been developed. Depending on the reaction conditions, either the 6- or the 7-bromo heterocycles can be obtained in a divergent manner. These heterocycles were readily further elaborated by sequential Sonogashira couplings, and the sequence might be successfully applied to substructures of the antibiotic lysolipin.

Journal of Organic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tennie, Iris K. published the artcilePolymeric ¹⁹F MRI Contrast Agents Prepared by Ring-Opening Metathesis Polymerization/Dihydroxylation, Product Details of C4H7F3O2, the publication is Macromolecules (Washington, DC, United States) (2020), 53(23), 10386-10396, database is CAplus.

The capability of ring-opening metathesis polymerization (ROMP) to efficiently incorporate bulky monomers and conserve olefin bonds during polymerization was exploited to design water-soluble fluoropolymers, which were evaluated as potential quant. ¹⁹F magnetic resonance imaging (MRI) contrast agents. The fluoromonomeric units comprised 3, 6, 9, or 18 magnetically equivalent fluorine atoms. Aqueous solubility was achieved through dihydroxylation of the partially unsaturated polymeric backbone and by tetraethylene glycol (TEG)-based linker incorporation, ammonium quaternization, or copolymerization

Macromolecules (Washington, DC, United States) published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C20H12N2O2, Product Details of C4H7F3O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kubczak, Malgorzata published the artcileHippophae rhamnoides L. leaf and twig extracts as rich sources of nutrients and bioactive compounds with antioxidant activity, Quality Control of 134-96-3, the publication is Scientific Reports (2022), 12(1), 1095, database is CAplus and MEDLINE.

Plants have served for centuries as sources of compounds useful for human health such as antioxidant, anti-diabetic and antitumor agents. They are also rich in nutrients that improve the human diet. Growing demands for these compounds make it important to seek new sources for them. Hippophae rhamnoides L. is known as a plant with health-promoting properties. In this study we investigated the chem. composition and biol. properties of bioactive components of ethanol extracts from leaves and twigs of H. rhamnoides L. Chem. components such as the total content of phenolic compounds, vitamins and amino acids and the antioxidant activities of these compounds in cellular and cell-free systems were assessed. The results suggest that the studied extracts are rich in bioactive compounds with potent antioxidant properties. Cytotoxicity and hemotoxicity assays showed that the extracts had low toxicity on human cells over the range of concentrations tested. Interaction with human serum albumin was investigated and conformational changes were observed Our results indicate that leaf and twig extracts of H. rhamnoides L. should be considered as a non-toxic source of bioactive compounds which may be of interest to the food, pharmaceutical and cosmetic industries.

Scientific Reports published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Quality Control of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bridoux, Alexandre published the artcileDesign, synthesis, and biological evaluation of bifunctional thyrointegrin inhibitors: new anti-angiogenesis analogs, Computed Properties of 2944-47-0, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2011), 26(6), 871-882, database is CAplus and MEDLINE.

Context: Inhibition of pathol. angiogenesis. Objective: Obtaining new transactivator, bifunctional, thyroid antagonist, non-toxic anti-angiogenic compounds Materials and methods: In silico drug design, synthesis in bulk and biol. evaluation in chick chorioallantoic membrane (CAM) model. Results: Significant inhibition (range 65-73%) at 0.25-2.0 μg/mL doses. Discussion and conclusion: The synthesis of compounds (9), (10), and (11) incorporating long-chain moieties guanidine, urea, Me amine and, Pr amine substitutions, resp., into the core mol. framework of tetrac (tetraiodothyroacetic acid) were undertaken. The evaluation of the anti-angiogenic bioactivity of these compounds in the CAM model revealed no loss of activity in comparison with tetrac and XT199, which showed nearly 86% inhibition at dose levels of 1 and 0.5 μg/mL, resp., and validated the concept.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Computed Properties of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yadav, Naveen published the artcileRapid Access to Arylated and Allylated Cyclopropanes via Bronsted Acid-Catalyzed Dehydrative Coupling of Cyclopropylcarbinols, HPLC of Formula: 91-16-7, the publication is Journal of Organic Chemistry (2022), 87(10), 6886-6901, database is CAplus and MEDLINE.

A regioselective protocol for the synthesis of cyclopropyl derivatives that relies on Brookhart acid-catalyzed dehydrative coupling over substituted cyclopropylcarbinols without rearrangement is reported herein. The reactions proceed promptly at 25° with only 2.0 mol % catalyst loading and produce the cyclopropyl derivatives in excellent yields. This method is well tolerated with a vast range of cyclopropylcarbinols including aliphatic cyclopropylcarbinols, where no elimination product was obtained, demonstrating the protocol’s utility. Further, the Hammett correlation suggested the formation of a cyclopropylcarbinyl cation followed by a coupling reaction. An extremely effective gram-scale reaction has also been demonstrated with a high turnover number

Journal of Organic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C3H9ClOS, HPLC of Formula: 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem