Month: December 2022

Timofeeva, Maria N. published the artcileSynthetic and natural materials with the brucite-like layers as high active catalyst for synthesis of 1-methoxy-2-propanol from methanol and propylene oxide, Quality Control of 1589-47-5, the publication is Journal of Molecular Catalysis A: Chemical (2016), 22-30, database is CAplus.

The aim of this study was to investigate the correlation between the basic and catalytic properties of brucite and Mg,Al-layered double hydroxides (Mg,Al-LDHs) in the reaction of propylene oxide with methanol. The basic properties of the solids were investigated by FT-IR spectroscopy using CDCl₃ as probe mol. and Hammett acidity titration with n-butylamine and benzoic acid. Both the increase in the activation temperature and the decrease in Al content favored the increase in the basicity of Mg,Al-LDH. The nature of “Mⁿ⁺-O^2- Lewis acid-ba se” pairs was a key factor to control the catalytic behavior of the solids. The length of the M-O bond, the basicity of the oxygen ion and the strength of the metal ion on the surface affected the catalytic activity of the solids and their isomer selectivity in the reaction between methanol and propylene oxide to form 1-methoxy-2-propanol. It was demonstrated that brucite(150) can be applied as catalyst for at least four successive cycles without loss of activity.

Journal of Molecular Catalysis A: Chemical published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H6O3, Quality Control of 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chen, C. Y. published the artcileA New Benzenoid from Liriodendron chinense, Formula: C9H10O4, the publication is Chemistry of Natural Compounds (2022), 58(3), 387-389, database is CAplus.

A new benzenoid, liriodenchic acid (1), along with nine known compounds that include two aporphine alkaloids, liriodenine (2) and (-)-anonaine (3); two lignans, (+)-syringaresinol (4) and (+)-yangambin (5); and five benzenoids, p-hydroxybenzoic acid (6), vanillic acid (7), vanillin (8), syringic acid (9), and syringaldehyde (10), were isolated from the leaves of Liriodendron chinense (Magnoliaceae). These compounds were characterized and identified by phys. and spectral evidences.

Chemistry of Natural Compounds published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Formula: C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Budeev, Anton published the artcileUgi reaction-derived 1H-pyrrol-2(5H)-ones proved as valid precursors to a new class of heterocyclic α-diazocarbonyl compounds, Synthetic Route of 6850-57-3, the publication is Tetrahedron Letters (2022), 153598, database is CAplus.

1H-Pyrrol-2(5H)-ones synthesized via a modified literature procedure from primary amines, 3-substituted propiolic acids, isocyanides and glyoxal underwent a facile Regitz diazo transfer to give novel heterocyclic α-diazocarbonyl compounds – polysubstituted diazo pyrrol-2-ones I [R¹ = Me, n-Pr, Ph, etc.; R² = n-Bu, Bn, 3-FC₆H₄CH₂, etc.; R³ = t-Bu, cyclohexyl] .

Tetrahedron Letters published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Synthetic Route of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kasama, Kengo published the artcileChemo- and regioselective cross-dehydrogenative coupling reaction of 3-hydroxycarbazoles with arenols catalyzed by a mesoporous silica-supported oxovanadium, Category: ethers-buliding-blocks, the publication is RSC Advances (2021), 11(56), 35342-35350, database is CAplus and MEDLINE.

Cross-dehydrogenative coupling between 3-hydroxycarbazoles I(R = H; R¹ = H, Br, Me; RR¹ = -CH:CH-CH:CH-; R² = H, Me, Ph, benzyl, acetyl, tolyl) and 2-naphthols II (R³ = 6-MeO, 7-Br, 3-Me, etc.) has been achieved by using a mesoporous silica-supported oxovanadium catalyst.

RSC Advances published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Reddy, P. Srinivasa published the artcileReductive amination of carbonyl compounds using NaBH₄ in a Bronsted acidic ionic liquid, COA of Formula: C13H14N2O, the publication is Tetrahedron Letters (2007), 48(50), 8807-8810, database is CAplus.

Reductive amination of carbonyl compounds using sodium borohydride is conducted in the Bronsted acidic ionic liquid, 1-methylimidazolium tetrafluoroborate ([HMIm][BF₄]). The ionic liquid plays the dual role of solvent as well as catalyst for efficient conversion of aldehydes and ketones to amines in excellent yields without the formation of side products.

Tetrahedron Letters published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, COA of Formula: C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Seong, Chaehyeon published the artcileTotal Synthesis of 1-Oxomiltirone and Arucadiol, COA of Formula: C10H14O, the publication is Synlett (2020), 31(19), 1953-1956, database is CAplus.

A practical and efficient approach for the total synthesis of arucadiol (I) and 1-oxomiltirone (II) is reported. The key step, which involves an intramol. [4+2] cycloaddition catalyzed by gold(III) bromide or copper(II) triflate, leads to the formation of 6-6-6-fused aromatic abietane core.

Synlett published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C6H10F3NO, COA of Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Shahar, Or David published the artcileA high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Nucleic Acids Research (2014), 42(9), 5689-5701, database is CAplus and MEDLINE.

DNA double-strand breaks (DSBs) are the most severe type of DNA damage. DSBs are repaired by non-homologous end-joining or homol. directed repair (HDR). Identifying novel small mols. that affect HDR is of great importance both for research use and therapy. Mols. that elevate HDR may improve gene targeting, whereas inhibiting mols. can be used for chemotherapy, since some of the cancers are more sensitive to repair impairment. Here, the authors performed a high-throughput chem. screen for FDA approved drugs, which affect HDR in cancer cells. The authors found that HDR frequencies are increased by retinoic acid and Idoxuridine and reduced by the antihypertensive drug Spironolactone. The authors further revealed that Spironolactone impairs Rad51 foci formation, sensitizes cancer cells to DNA damaging agents, to Poly (ADP-ribose) polymerase (PARP) inhibitors and crosslinking agents and inhibits tumor growth in xenografts, in mice. This study suggests Spironolactone as a new candidate for chemotherapy.

Nucleic Acids Research published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C18H12ClNO, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Schneider, Anselm F. L. published the artcileDiscovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors, Application In Synthesis of 77128-73-5, the publication is RSC Chemical Biology (2021), 2(6), 1661-1668, database is CAplus and MEDLINE.

Mouse double minute 2 homolog (MDM2, Hdm2) is an important neg. regulator of the tumor suppressor p53. Using a mRNA based display technique to screen a library of >10¹² in vitro-translated cyclic peptides, we have identified a macrocyclic ligand that shows picomolar potency on MDM2. X-Ray crystallog. reveals a novel binding mode utilizing a unique pharmacophore to occupy the Phe/Trp/Leu pockets on MDM2. Conjugation of a cyclic cell-penetrating peptide (cCPP) to the initially non cell-permeable ligand enables cellular uptake and a pharmacodynamic response in SJSA-1 cells. The demonstrated enhanced intracellular availability of cyclic peptides that are identified by a display technol. exemplifies a process for the application of intracellular tools for drug discovery projects.

RSC Chemical Biology published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Application In Synthesis of 77128-73-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yamaguchi, Akitake published the artcileConformationally stable peptide macrocycles assembled using the Petasis borono-Mannich reaction, SDS of cas: 77128-73-5, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(71), 10567-10570, database is CAplus and MEDLINE.

Macrocyclization of linear peptide precursors using the Petasis borono-Mannich reaction affords a diverse range of macrocycles with an endocyclic amine. Anal. of the corresponding macrocyclic structures underscores that the hydrogen bond between an endocyclic amine and the adjacent amide NH is a powerful control element for conformationally homogeneous peptide macrocycles.

Chemical Communications (Cambridge, United Kingdom) published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C9H11BO4, SDS of cas: 77128-73-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Varga, Janos M. published the artcileMechanism of allergic cross-reactions. I. Multispecific binding of ligands to a mouse monoclonal anti-DNP IgE antibody, Quality Control of 637-58-1, the publication is Molecular Immunology (1991), 28(6), 641-54, database is CAplus and MEDLINE.

A recently developed solid-phase binding assay was used to investigate the specificity of ligand binding to a mouse monoclonal anti-dinitrophenyl IgE (I). All DNP-amino acids, that were tested inhibited the binding of the radio-labeled I to DNP covalently attached to polystyrene microplates; however, the concentration for 50% inhibition varied within four orders of magnitude, DNP-L-serine being the most and DNP-L-proline the least potent inhibitor. In addition to DNP analogs, a large number of drugs and other compounds were tested for their ability to compete with DNP for the binding site of I. At the concentration used for screening, 59% of compounds had no significant inhibition; 19% inhibited the binding of I more than 50%. Several families of compounds (tetracyclines, polymyxins, phenothiazines, salicylates, and quinones) that were effective competitors were found. Within these families, changes in the functional groups attached to the family stem had major effects on the affinity of ligand binding. The occurrence frequencies of interactions of ligands with I is in good agreement with the semi-empirical model for multispecific antibody-ligand interactions.

Molecular Immunology published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C7H13ClNNaO5S, Quality Control of 637-58-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem