Month: December 2022

Sun, Jian published the artcileNi-Cu/γ-Al₂O₃ catalyzed N-alkylation of amines with alcohols, Safety of N-(4-Methoxybenzyl)pyridin-2-amine, the publication is Catalysis Communications (2012), 30-33, database is CAplus.

A γ-Al₂O₃-supported Ni and Cu bimetallic nanoparticles catalyst (45 weight % Ni, Ni/Cu mass ratio = 4.5/1.0) is prepared by electroless plating method for the N-alkylation of amines with alcs. under base and Lewis acidic cocatalyst conditions. The catalyst afforded fast conversions, high selectivity for amines and alcs. with various structures under an argon atm. in o-xylene. Furthermore, the catalyst still has a stable catalytic activity after being regenerated for two consecutive cycles.

Catalysis Communications published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C6H3F2NO3, Safety of N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Xiaoping published the artcileAn efficient turn-on fluorescence chemosensor system for Zn(II) ions detection and imaging in mitochondria, Synthetic Route of 134-96-3, the publication is Journal of Photochemistry and Photobiology, B: Biology (2022), 112485, database is CAplus and MEDLINE.

Mitochondria-targetable fluorescent chemosensors, Rhodamine-B and rhodamine 6G bearing syringaldehyde based receptors were designed and synthesized for efficient chemosensing of Zinc(II) ions. The probes showed the very selective naked eye color change to pink from colorless upon addition of Zinc(II) ions, further these probes showing turn-on fluorescence enhancement with Zn(II) ions by opening of rhodamine spirolactam. The probes are very sensitive towards Zn(II) ions among other ions. These probes RBS and R6S will be applicable to detect zinc ions upto the low level concentration 0.18 and 0.19 nano molar resp. The affinity of these sensors RBS and R6S for Zinc (II) ions was found to be in the range of 1.12 x 104 M-1 and 7.28 x 104 M-1 resp. 1H-nmr titrations of the probes with Zn(II) ions clearly indicating the spiroring opening of the spirolactam. DFT calculations supporting that the perceived photophys. changes of the probes on appendage of the zinc ions. Probes RBS and R6S are useable for selective staining mitochondria. Both of the probes are applicable to reveal labile Zn(II) in live Hela and MCF-7 cells via fluorescence imaging. RBS and R6S are also finding application on quantification of Zinc(II) ions inside mitochondria via fluorescence imaging.

Journal of Photochemistry and Photobiology, B: Biology published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C16H12O, Synthetic Route of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Nicolaou, K. C. published the artcileTotal Synthesis and Biological Evaluation of Monorhizopodin and 16-epi-Monorhizopodin, Safety of (+)-B-Methoxydiisopinocampheylborane, the publication is Angewandte Chemie, International Edition (2011), 50(5), 1139-1144, S1139/1-S1139/94, database is CAplus and MEDLINE.

A highly convergent total synthesis of monorhizopodin (I) and 16-epi-monorhizopodin was developed, rendering the monomeric homologs of the powerful antitumor agent rhizopodin available for biol. investigations. Preliminary studies showed these compounds to be endowed with actin-binding properties but devoid of any associated cytotoxicity, thus posing interesting questions regarding the role of the dimeric nature of rhizopodin in its mode of action. Further studies directed toward the elucidation of the mechanism of action and the differences of rhizopodin and its monomeric homologs, monorhizopodin and 16-epi-monorhizopodin, as well as the total synthesis of the former are in progress.

Angewandte Chemie, International Edition published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Safety of (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yao, Chuansheng published the artcileHDAC1/MAO-B dual inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is Bioorganic Chemistry (2022), 105724, database is CAplus and MEDLINE.

A series of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids inhibitors combining the typical pharmacophores of hydroxamic acid/o-aminobenzamide and propargylamine I [R = H, 2-Cl, 3-F, etc.] and II [R¹ = H, 2-CH₃, 4-F, etc.] were designed and synthesized as HDAC1/MAO-B dual inhibitors for the treatment of Alzheimer’s disease. Most of the hybrids displayed moderate to good MAO-B inhibitory activities. Among them, Hybrid I [R = 3-Cl] exhibited the most potent activity against MAO-B and HDAC1 (MAO-B, IC₅₀ = 99.0 nM; HDAC1, IC₅₀ = 21.4 nM) and excellent MAO selectively (MAO-A, IC₅₀ = 9923.0 nM; SI = 100.2). Moreover, compound I [R = 3-Cl] significantly reversed Aβ1-42-induced PC12 cell damage and decreased the production of intracellular ROS, exhibiting favorable antioxidant activity. More importantly, hybrid If instantly penetrated the BBB and accumulated in brain tissue as well as markedly ameliorated cognitive dysfunction in a Morris water maze ICR mice model. In summary, HDAC1/MAO-B dual inhibitor I [R = 3-Cl] was a promising potential agent for the therapy of Alzheimer’s disease.

Bioorganic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C9H5FO2, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yu, Xiaochun published the artcilePalladium-Catalyzed N-Alkylation of Amides and Amines with Alcohols Employing the Aerobic Relay Race Methodology, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine, the publication is Chinese Journal of Chemistry (2012), 30(10), 2322-2332, database is CAplus.

Possibly because homogeneous palladium catalysts are not typically borrowing hydrogen catalysts and ligands are thus ineffective in catalyst activation under conventional anaerobic conditions, they had not been used in the N-alkylation reactions of amines/amides with alcs. in the past. By employing the aerobic relay race method with Pd-catalyzed aerobic alc. oxidation being a more effective protocol for alc. activation, ligand-free homogeneous palladium are successfully used as active catalysts in the dehydration N-alkylation reactions, giving high yields and selectivities of the alkylated amides and amines. Mechanistic studies implied that the reaction most probably proceeds by a novel relay race mechanism that was recently discovered and proposed.

Chinese Journal of Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C9H6BrNO, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zeng, Renping published the artcilePreparation and application of microporous carbons as excellent adsorbents for reversible iodine capture and efficient removal of dye, Category: ethers-buliding-blocks, the publication is Diamond and Related Materials (2021), 108718, database is CAplus.

Because of the application of treating hazardous wastes such as organic dyes and radioactive iodine, the porous carbon with high adsorption capacity has been a research hotspot. In this work, by the pyrolysis method with KOH activation, the hypercrosslinked polynaphthalenes were used as carbonaceous precursors to prepare porous carbons, which showed high sp. surface areas between 943.8 and 2754.5 m² g^-1 with high micropore ratios. Notably, the microporous carbonaceous materials showed an excellent iodine capture capacity of 739 wt% and a high adsorption capacity of malachite green with 1194.8 mg g^-1. These porous carbons provided potential applications in environmental remediation as promising adsorbent materials for adsorption of radioactive iodine, and removal of organic pollutants from aqueous solutions

Diamond and Related Materials published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C16H12O, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wu, Zhuo published the artcilePd-catalyzed cross-electrophile Coupling/C-H alkylation reaction enabled by a mediator generated via C(sp³)-H activation, SDS of cas: 93-04-9, the publication is Chemical Science (2021), 12(24), 8531-8536, database is CAplus and MEDLINE.

Pd-catalyzed cascade cross-electrophile coupling and C-H alkylation reaction of 2-iodo-alkoxylarenes with alkyl chlorides were reported. Methoxy and benzyloxy groups, which were ubiquitous functional groups and common protecting groups, were utilized as crucial mediators via primary or secondary C(sp³)-H activation. The reaction provided an innovative and convenient access for the synthesis of alkylated phenol derivatives, which were widely found in bioactive compounds and organic functional materials.

Chemical Science published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C8H15ClN2, SDS of cas: 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhou, Jun published the artcileEtherification of Fluoroarenes with Alkoxyboronic Acid Pinacol Esters via C-F Bond Cleavage, Synthetic Route of 91-16-7, the publication is Organic Letters (2022), 24(28), 5084-5089, database is CAplus and MEDLINE.

Potassium-base-mediated defluoroetherification of aryl and heteroaryl fluorides with alkoxyboronic acid pinacol esters under transition-metal-free conditions is reported. This protocol efficiently and safely provides a wide variety of aryl ethers in high yields without using metal catalysts, specific ligands, and harsh conditions to selectively forge C_sp2-O bonds via the C_sp2-F cleavage. This method can be applied to the late-stage etherification of structurally complex C_sp2-fluorides and bioactive alcs., such as β-estradiol, calciferol, and tocopherol.

Organic Letters published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C11H22N2O4, Synthetic Route of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Ruikun published the artcileForming mechanism of coke microparticles from polymerization of aqueous organics during hydrothermal carbonization process of biomass, Formula: C9H10O4, the publication is Carbon (2022), 50-60, database is CAplus.

Corn stalk was selected as a typical biomass, and the growth mechanism of coke microparticles was studied. The coke microparticles that formed from through the polymerization of aqueous organics during the hydrothermal carbonization (HTC) showed a considerable effect on the mass yield and physicochem. properties of the hydrochar. Results indicated that the average particle size of the coke microparticles rapidly increased to 6.25μm within the initial 2 h of HTC. The lower C/O at. ratio of the surface layer of the coke microparticles than that of the core, suggested that the core had a higher carbonization degree than the shell. On the basis of various measurements, the coke microparticles were inferred to have formed through the two stages of micronuclei formation and growth. Dissolved organics, including furfurals, furans, and phenols polymerized each other into aromatized macromols., and then formed solid-phase micronuclei. Subsequently, the oxygen containing groups of the micronuclei formed bonded with aqueous organic mols., as a result, the micronuclei grew up into coke microparticles. Meanwhile, the carbonization degree of the coke microparticles was enhanced due to continuous intra- and inter-mol. dehydration and decarboxylation reactions occurred between hydroxyl and carboxyl groups.

Carbon published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C14H31NO2, Formula: C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Huang, Long published the artcileBioinspired desaturation of alcohols enabled by photoredox proton-coupled electron transfer and cobalt dual catalysis, Name: 2-Methoxynaphthalene, the publication is Nature Communications (2022), 13(1), 809, database is CAplus and MEDLINE.

In the biosynthesis of sterols an enzyme-catalyzed demethylation is achieved via a stepwise oxidative transformation of alcs. e.g., 1-(4-methoxyphenyl)cyclodecan-1-ol to olefins e.g., 4-(OCH₃)C₆H₄C(O)(CH₂)₇CH=CH₂. The overall demethylation proceeds through two sequential monooxygenation reactions and a subsequent dehydroformylative saturation To mimic the desaturation processes observed in nature, photoredox proton-coupled electron transfer (PCET) and cobaloxime chem. were successfully integrated for the acceptorless dehydrogenation of alcs. The state-of-the-art remote and precise desaturation of ketones RC(O)(CH₂)₃CH=CH₂ [R = 4-(tert-butoxy)phenyl, phenanthren-9-yl, 1-benzothiophen-2-yl, etc.] proceeds efficiently through the activation of cyclic alcs. I using bond-dissociation free energy (BDFE) as thermodn. driving force. The resulting transient alkoxyl radical allows C-C bond scission to generate the carbon-centered radical remote to the carbonyl moiety. The key intermediate is subsequently combined with cobaloxime photochem. to furnish the alkene. Moreover, the mild protocol can be extended to desaturation of linear alcs. as well as aromatic hydrocarbons. Application to bioactive mols. and natural product derivatives is also presented.

Nature Communications published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Name: 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem