Month: December 2022

Guo, Ying published the artcileA ligand-free, powerful, and practical method for methoxylation of unactivated aryl bromides by use of the CuCl/HCOOMe/MeONa/MeOH system, Category: ethers-buliding-blocks, the publication is Research on Chemical Intermediates (2015), 41(11), 8651-8664, database is CAplus.

A ligand-free, powerful, and practical method for mono and polymethoxylation of unactivated aryl bromides has been developed; CuCl was used as catalyst, HCOOMe as cocatalyst, and methanolic MeONa as both nucleophile and solvent. This eco-friendly procedure is characterized by operational simplicity, inexpensive substrates (unactivated mono to polybromoarenes), full conversion, and direct recovery of pure MeOH.

Research on Chemical Intermediates published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xu, Wenshuai published the artcileOne-pot synthesis of dimethyl carbonate over basic zeolite catalysts, Application In Synthesis of 1589-47-5, the publication is Modern Research in Catalysis (2013), 2(2A), 22-27, database is CAplus.

One-pot synthesis of di-Me carbonate (DMC) from methanol, propylene oxide (PO) and carbon dioxide has been investigated using the basic zeolites as catalysts. Among the zeolites studied, Beta showed the best catalytic performance for DMC production That the desilication of zeolite structure resulted in a hierarchical porosity of Beta, leading to more amount of KOH can be loaded on the surface of zeolite and therefore enhancing the base strength of the catalyst was proposed to be the reason for improved catalytic performance.

Modern Research in Catalysis published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C17H14F3N3O2S, Application In Synthesis of 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Jia, Zhichao published the artcileHighly Selective Hydrodeoxygenation of Lignin to Naphthenes over Three-Dimensional Flower-like Ni₂P Derived from Hydrotalcite, Category: ethers-buliding-blocks, the publication is ACS Catalysis (2022), 12(2), 1338-1356, database is CAplus.

A strategy for low-temperature synthesis of hydrotalcite-based nickel phosphide catalysts (Ni₂P-Al₂O₃) with flower-like porous structures was proposed. The in situ reduction of red phosphorus at 500°C enables Ni₂P catalysts with small particle size and abundant active and acidic sites, which facilitate the activation of substrates and H₂. In the hydrodeoxygenation of guaiacol, a 100% conversion and 94.5% yield of cyclohexane were obtained over the Ni₂P-Al₂O₃ catalyst under 5 MPa H₂ at 250°C for 3 h. Other lignin-derived phenolic compounds could also afford the corresponding alkanes with yields higher than 85%. Moreover, Ni₂P-Al₂O₃ exhibited high hydrodeoxygenation activity in the deconstruction of more complex wood structures, including lignin oil and real lignin. Among the two different types of Ni sites of Ni(1) and Ni(2) in Ni₂P, d. functional theory (DFT) calculations showed that the Ni(2) site, highly exposed on the Ni₂P-Al₂O₃ surface, possesses a stronger ability to break C-OH bonds during the hydrodeoxygenation of guaiacol in comparison with the Ni(1) site.

ACS Catalysis published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Diao, Xinyong published the artcileFabricating high temperature stable Mo-Co₉S₈/Al₂O₃ catalyst for selective hydrodeoxygenation of lignin to arenes, Quality Control of 91-16-7, the publication is Applied Catalysis, B: Environmental (2022), 121067, database is CAplus.

Achieving high-temperature stability/duration without compromising the activity remains an arduous task in catalyst design, particularly for MoS₂ materials. Herein, a robust catalyst with Mo doped Co₉S₈ nanoparticles anchored on Al₂O₃ matrix is fabricated, which could selectively convert lignin to arenes with high hydrodeoxygenation activity, selectivity and particularly excellent stability. In the hydrodeoxygenation of di-Ph ether, this catalyst afforded 99.8% conversion and 91.0% yield of benzene at 265°C for at least 10 reaction runs. The resultant Mo-Co₉S₈ structure with chem. connection by covalent bonds of Mo-S-Co type on the Co₉S₈ surface demonstrates strong ability in the adsorption and activation of oxygen-containing substrates, which enables the effective C-O cleavage while avoids undesirable hydrogenation of benzene ring. The superior stability and water-resistance at elevated temperature was attributed to the anchoring effect of Al₂O₃ matrix and “protection” of surface-rich Co₉S₈ species to the active Mo-Co₉S₈ center. This strategy provides new sights for the rational design of efficient and stable sulfide catalysts toward the applications in demanding high-temperature reactions.

Applied Catalysis, B: Environmental published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Quality Control of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bartling, Christian R. O. published the artcileTargeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation, SDS of cas: 77128-73-5, the publication is Journal of the American Chemical Society (2021), 143(2), 891-901, database is CAplus and MEDLINE.

There is an urgent need for novel therapeutic approaches to treat Alzheimer’s disease (AD) with the ability to both alleviate the clin. symptoms and halt the progression of the disease. AD is characterized by the accumulation of amyloid-β (Aβ) peptides which are generated through the sequential proteolytic cleavage of the amyloid precursor protein (APP). Previous studies reported that Mint2, a neuronal adaptor protein binding both APP and the γ-secretase complex, affects APP processing and formation of pathogenic Aβ. However, there have been contradicting results concerning whether Mint2 has a facilitative or suppressive effect on Aβ generation. Herein, we deciphered the APP-Mint2 protein-protein interaction (PPI) via extensive probing of both backbone H-bond and side-chain interactions. We also developed a proteolytically stable, high-affinity peptide targeting the APP-Mint2 interaction. We found that both an APP binding-deficient Mint2 variant and a cell-permeable PPI inhibitor significantly reduced Aβ₄₂ levels in a neuronal in vitro model of AD. Together, these findings demonstrate a facilitative role of Mint2 in Aβ formation, and the combination of genetic and pharmacol. approaches suggests that targeting Mint2 is a promising therapeutic strategy to reduce pathogenic Aβ levels.

Journal of the American Chemical Society published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, SDS of cas: 77128-73-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

De Joarder, Dripta published the artcileEnantioselective synthesis of a potential 1,5-syn-polyol C1-C24 subunit of (-)-caylobolide A, Safety of (+)-B-Methoxydiisopinocampheylborane, the publication is Tetrahedron Letters (2013), 54(43), 5826-5829, database is CAplus.

The synthesis of a protected possible 1,5-syn-polyol C(1)-C(24) subunit, I (TES = Et₃Si), resident in (-)-caylobolide A was accomplished. The key reaction sequence was a repetitive protocol for the construction of the syn-1,5-diol segment by Ru-catalyzed cross-metathesis and B-mediated allylation reactions.

Tetrahedron Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Safety of (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Jin, Youngeup published the artcileSynthesis and electroluminescent properties of copolymers based on PPV with fluoro groups in vinylene units, Application In Synthesis of 146370-51-6, the publication is Polymer (2007), 48(6), 1541-1549, database is CAplus.

Electroluminescent copolymers with fluoro groups on vinylene units, poly(2-ethylhexyloxy-5-methoxy-p-phenylenevinylene-co-2-dimethyloctylsilyl-p-phenylenedifluorovinylene) (MEH-PPV-co-DMOS-PPDFV) and poly(2-dimethyloctylsilyl-p-phenylenevinylene-co-2-dimethyloctylsilyl-p-phenylenedifluorovinylene) (DMOS-PPV-co-DMOS-PPDFV), were synthesized by the Gilch polymerization route. The fluoro groups were introduced on vinylene units to increase the electron affinity of the copolymers. In both copolymers, the band gap increased with higher ratio of DMOS-PPDFV. As compared to the photoluminescence (PL) spectra in solution, the PL spectra in solid state and EL spectra of both copolymers showed red shift and broad peaks caused by aggregation. The LEDs fabricated using MEH-PPV-co-DMOS-PPDFVs emit light with maximum at around 538-577 nm. By adjusting the feed ratio of DMOS-PPDFV in the copolymer, the emission colors were tuned from orange yellow to green. The DMOS-PPV-co-DMOS-PPDFV showed maximum electroluminescence (EL) peaks at about 514-543 nm. The DMOS-PPV-co-DMOS-PPDFV with 1:9 feed ratio showed the highest luminescence efficiency of 1.31 lm/W.

Polymer published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Application In Synthesis of 146370-51-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hu, Shaojing published the artcileDiastereo- and Enantioselective Synthesis of syn-α-Vinylchlorohydrins and cis-Vinylepoxides, Formula: C21H37BO, the publication is Journal of Organic Chemistry (1996), 61(21), 7513-7520, database is CAplus and MEDLINE.

A new method to generate chiral syn-vinylchlorohydrins and cis-vinyloxiranes is reported. Reaction of (α-haloallyl)lithiums with methoxy-9-BBN or Ipc₂BOMe followed by treatment with BF₃·OEt₂ leads to (Z)-(γ-haloallyl)boranes which react with aldehydes to yield cis-vinylepoxides (de ≥ 90%) upon oxidative workup. Alternatively, addition of ethanolamine to the allylboration product yields syn-α-halohydrins (de ≥ 90%) that are also easily cyclized to cis-vinylepoxides. Extension of this protocol using [(Z)-γ-chloroallyl]BIpc₂ leads to chiral syn-α-chlorohydrins and cis-vinylepoxides in high de (≥90%) and ee (90-99%). Enantioselectivity of reactions of chiral (Z)-(γ-chloroallyl)boranes with aldehydes are more sensitive to reaction conditions than enantioselectivity of reactions of other α- or γ-substituted allylboranes. The effects of proportion of BF₃·OEt₂ and the relative efficacies of LiNR₂ bases on diastereo- and enantioselectivity of the chloroallylation are reported.

Journal of Organic Chemistry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hu, Shaojing published the artcileDiastereoselective chloroallylboration of α-chiral aldehydes, Category: ethers-buliding-blocks, the publication is Journal of Organic Chemistry (1998), 63(24), 8843-8849, database is CAplus.

Double asym. reaction of chiral (Z)-(γ-chloroallyl)diisopinocampheylboranes, d-I and l-I, with α-chiral aldehydes (S)-MeCH₂CHMeCHO, N-Boc-L-valinal (II), (R)-2,3-O-isopropylidnene-D-glyceraldehyde, and (R)- and (S)-Me₃CSiMe₂OCH₂CHMeCHO provide a new practical method for the generation of 2,3-syn-3,4-anti and 2,3-syn-3,4-syn chiral vinylchlorohydrins and vinyl epoxides. Both enantiomers d-I and l-I exhibited excellent diastereoselectivity (≥90 de) for matched cases. The mismatched cases yielded moderate to good diastereoselectivity. Thus, l-I was generated in situ from allyl chloride and l-B-methoxydiisopinocampheylborane by treatment with Li dicyclohexylamide and F₃B.OEt₂ in Et₂O/THF and reacted with II at -95° for four hours to give 60% of 99:1 mixture of vinyl chlorohydrins III and IV. Similar reaction of II with d-I gave 61% of a 15:85 mixture of III and IV. Cyclization of III in MeOH containing K₂CO₃ gave 98% vinyloxirane V.

Journal of Organic Chemistry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Deepa, P. published the artcilePolyurethane-oligo(phenylenevinylene) random copolymers: π-conjugated pores, vesicles, and nanospheres via solvent-induced self-organization, Name: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2008), 46(17), 5897-5915, database is CAplus.

We report a new series of polyurethane-oligo(phenylenevinylene) (OPV) random copolymers and their self-assembled nanomaterials such as pores, vesicles, and luminescent spheres. The polymers were synthesized through melt transurethane process by reacting a hydroxyl-functionalized OPV with diurethane monomer and diol under solvent-free and nonisocyanate conditions. The amount of OPV was varied up to 50 mol % in the feed to incorporate various amounts of π-conjugated segments in the polyurethane backbone. The π-conjugated segmented polymers were subjected to solvent induced self-organization in THF or THF+water to produce variety of morphologies ranging from pores (500 nm to 1 μm) to spheres (100 nm to 2 μm). Upon shining 370-nm light, the dark solid nanospheres of the copolymers transformed into blue luminescent nanoballs under fluorescence microscope. The mechanistic aspects of the self-organization process were studied using solution FTIR and photophys. techniques such as absorption and emission to trace the factors which control the morphol. FTIR studies revealed that the hydrogen bonding plays a significant role in the copolymers with lower amount of OPV units. Time resolved fluorescent decay measurements of copolymers revealed that mol. aggregation via π-conjugated segments play a major role in the samples with higher OPV content in the random block polymers.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Name: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem