Month: December 2022

Saha, Argha published the artcilePhotoinduced Regioselective Olefination of Arenes at Proximal and Distal Sites, Name: 1,2-Dimethoxybenzene, the publication is Journal of the American Chemical Society (2022), 144(4), 1929-1940, database is CAplus and MEDLINE.

Herein, a photoredox catalytic system constituting a merger of palladium/organo-photocatalyst that forges oxidative olefination in an explicit regioselective fashion with diverse arenes and heteroarenes has been established. Visible light plays a significant role in executing ‘regio-resolved’ Fujiwara-Moritani reaction without the requirement of silver salts and thermal energy. The catalytic system is also amenable toward proximal and distal olefination aided by resp. directing groups, which entails the versatility of the protocol in engaging the entire spectrum of C(sp²)-H olefination. Furthermore, streamlining the synthesis of natural products/chiral mols./drugs and diversification through late-stage functionalizations underscore the importance of this sustainable protocol. The photoinduced attainment of this regioselective transformation is mechanistically established through control reactions and kinetic studies.

Journal of the American Chemical Society published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Howitz, William J. published the artcileMacrocyclic Peptides Derived from Familial Alzheimer’s Disease Mutants Show Charge-Dependent Oligomeric Assembly and Toxicity, Synthetic Route of 77128-73-5, the publication is ACS Chemical Neuroscience (2022), 13(6), 714-720, database is CAplus and MEDLINE.

This work probes the role of charge in the oligomeric assembly, toxicity, and membrane destabilization of a series of peptides derived from Aβ and the E22Q and E22K familial mutants. In the mutant Aβ peptides, an acidic residue (E) is replaced with either a neutral or basic residue (Q or K), thus altering the net charge of the peptide. Acetylation at peripheral positions permits modulation of charge of the peptides and allows investigation of the role of charge in their oligomeric assembly, cytotoxicity, and membrane disruption. Peptides with the same net charge generally behave similarly even if the amino acid residue at position 22 differs. As the net charge of the peptide decreases, so does the extent of assembly, cytotoxicity, and membrane destabilization, which were determined using sodium dodecyl sulfate-polyacrylamide gel electrophoresis, lactate dehydrogenase (LDH)-release assays with SH-SY5Y cells, and dye leakage assays using liposomes. These findings suggest that the charge of the amino acid side chain, rather than its size or hydrophobicity, accounts for the differences in the oligomeric assembly and toxicity of the E22 familial mutants of Aβ.

ACS Chemical Neuroscience published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Synthetic Route of 77128-73-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Xinhong published the artcileSynthesis and thermal analysis of thioperoxydicarbonimidic diamide ([(H₂N)C(NH)]₂S₂) dihydrochloride (formamidine disulfide dihydrochloride), Product Details of C2H8Cl2N4S2, the publication is Yingyong Huagong (2006), 35(8), 580-582, 590, database is CAplus.

Formamidine disulfide dihydrochloride was prepared using hydrochloric acid and thiourea, hydrogen peroxide as oxidant in a reactor. The optimized reaction conditions were determined and the product was characterized by IR, UV. Combustion heat of product was 3181.75 kJ/mol. Thermal anal. results indicated formamidine disulfide dihydrochloride exhibited complex behaviors from the curves of TG-DTA-DTG, firstly including two first order decomposition reactions and its apparent activation energy was 155.71 kJ/mol (36.12 kJ/mol).

Yingyong Huagong published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C6H5F4NO3S, Product Details of C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tavlarakis, Panagiotis published the artcileSimultaneous determination of pramoxine HCl and benzalkonium chloride in wound care solutions by HPLC, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Analytical Methods (2010), 2(6), 722-727, database is CAplus.

A simple gradient reversed-phase high performance liquid chromatog. (HPLC) method was developed for the simultaneous determination of total benzalkonium chloride (BAC) and pramoxine HCl in wound care solutions Laboratory formulations were diluted 1:10 with water and injected into a HPLC system equipped with a Phenomenex, Luna CN column (100 Å, 5μm, 250 mm × 4.6 mm) in order for BAC and pramoxine to sep. from other excipients and be detected by a UV detector (λ = 262 nm). The mobile phase was 0.075 mM sodium acetate trihydrate buffer (pH = 5.0) using multi-ramp gradient elution with acetonitrile. Quantitation was achieved by direct comparison of the peaks of BAC and pramoxine HCl of the sample to a reference standard of known concentrations A stress study with acid, base, peroxide, heat, and light indicated no interference from drug product or excipients. The mean recovery results for both pramoxine and benzalkonium chloride at 100% level were 100.5 ± 0.3%, 100.5 ± 0.1% resp. (mean ± SD, n = 6). In this report, the full exptl. results from developing and validating this method are presented.

Analytical Methods published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C9H10O3S, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Barcelo, Gerard published the artcilePentaalkylguanidines as etherification and esterification catalysts, Formula: C10H14O, the publication is Tetrahedron (1990), 46(6), 1839-48, database is CAplus.

Several pentaalkylguanidines were prepared and found to be superior catalysts for the preparation of aryl and aralkyl ethers from carbonates and for the methylation of phenols with Me₂CO₃. They also act as effective catalysts for esterification of acids with alkyl chloroformates but not for the acetylation of tertiary alcs. with Ac₂O.

Tetrahedron published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mertens, R. Tyler published the artcileStable Au(I) catalysts for oxidant-free C-H functionalization with iodoarenes, Formula: C8H10O2, the publication is Journal of Catalysis (2022), 109-114, database is CAplus and MEDLINE.

Herein, the development of novel tricoordinate Au(I) catalysts supported by N,N-bidentate ligands and ligated by phosphine or arsine ligands for C-H functionalization without external oxidants to form biaryls with no homocoupling was reported. The unsym. character of the Au(I) catalyst was critical to facilitating this necessary orthogonal transformation. This study unveils yet another potential of Au(I) catalysis in biaryl synthesis.

Journal of Catalysis published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Elacqua, Elizabeth published the artcilePoly(arylenevinylene)s through Ring-Opening Metathesis Polymerization of an Unsymmetrical Donor-Acceptor Cyclophane, Computed Properties of 146370-51-6, the publication is Angewandte Chemie, International Edition (2019), 58(28), 9527-9532, database is CAplus and MEDLINE.

Reported are well-defined donor-acceptor alternating copolymers prepared using ring-opening metathesis polymerization (ROMP). Unsym. cyclophanedienes comprising electron-donating (4-methoxy-1-(2-ethylhexyl)oxy)benzene (MEH) and electron-accepting benzothiadiazole (BT) rings were synthesized from the corresponding [3.3]dithiaparacyclophanes. ROMP of the strained unsym. and “electronically-ambiguous” cyclophanedienes proceeded in a controlled manner in the presence of either Hoveyda-Grubbs II or Grubbs II initiator in wake of both steric and electronic encumbrance. The resulting polymers, comprising alternating BT and MEH-PPV units, are achieved in mol. weights exceeding 20k with D values ranging from 1.1-1.4. The living nature of the polymerization is verified through the formation of rod-coil and rod-rod block copolymers. Our strategy to develop previously unrealized polymers from functional building blocks featuring a locked-in D-A unit is significant in a field striving to achieve well-defined and sequence-specific materials.

Angewandte Chemie, International Edition published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Computed Properties of 146370-51-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Deolka, Shubham published the artcilePhotoinduced Trifluoromethylation of Arenes and Heteroarenes Catalyzed by High-Valent Nickel Complexes, SDS of cas: 93-04-9, the publication is Angewandte Chemie, International Edition (2021), 60(46), 24620-24629, database is CAplus and MEDLINE.

Authors describe a series of air-stable Ni^III complexes supported by a simple, robust naphthyridine-based ligand. Access to the high-valent oxidation state is enabled by the CF₃ ligands on the nickel, while the naphthyridine exhibits either a monodentate or bidentate coordination mode that depends on the oxidation state and sterics, and enables facile aerobic oxidation of NiII to NiIII. These Ni^III complexes act as efficient catalysts for photoinduced C(sp²)-H bond trifluoromethylation reactions of (hetero)arenes using versatile synthetic protocols. This blue LED light-mediated catalytic protocol proceeds via a radical pathway and demonstrates potential in the late-stage functionalization of drug analogs.

Angewandte Chemie, International Edition published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, SDS of cas: 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ashok Kumar, Sangeetha published the artcileStable and color tunable MEH-PPV/PMMA polymer blends for light-emitting applications, Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, the publication is Chemical Physics Letters (2021), 138462, database is CAplus.

Light Emitting Polymers (LEPs) have gained attention in optoelectronics. However, stability and regulation of emission color remain a challenge. This study aims to overcome the challenge by formulating a Polymer Blend (PB) which consists of a LEP – poly [2-methoxy,5-(2-ethylhexyloxy)1,4-phynylenevinylene (MEH-PPV) and a non-conjugated polymer – poly(Me methacrylate) (PMMA). A simple approach of in situ polymerization of the non-conjugated polymer in the MEH-PPV solution leads to alteration of size of the MEH-PPV polymer chain and modified the emission color from red-orange to bluish-green. The barrier properties of PMMA improve the stability of PB in an ambient environment with unnoticeable luminescence loss. This type of PB shall find application in Organic Light-Emitting Devices.

Chemical Physics Letters published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Fangzheng published the artcileEfficient Stereoselective Synthesis of a Key Chiral Aldehyde Intermediate in the Synthesis of Picolinamide Fungicides, Formula: C21H37BO, the publication is Organic Process Research & Development (2019), 23(10), 2253-2260, database is CAplus.

A highly stereoselective and efficient synthesis of (4S,5S,6S)-6-(benzyloxy)-5-phenoxy-4-propoxyheptanal, a key intermediate for syntheses of picolinamide fungicides, is described in this report. The synthesis features a scalable allylpropyl ether preparation, an efficient synthesis of the C1-C3 anti,syn-(S,S,S) stereotriad via a highly diastereoselective allylboration, and Cu-catalyzed phenylation of a sterically hindered secondary alc. with BiPh₃(OAc)₂ followed by highly regioselective hydroformylation with the formation of a linear aldehyde. Excellent overall route efficiency was achieved (six steps and 39% yield) starting from readily available and inexpensive (S)-Et lactate.

Organic Process Research & Development published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem