Month: December 2022

Taniya, Olga S. published the artcileAbnormal push-pull benzo[4,5]imidazo[1,2-a][1,2,3]triazolo[4,5-e]pyrimidine fluorophores in planarized intramolecular charge transfer (PLICT) state: Synthesis, photophysical studies and theoretical calculations, Quality Control of 91-16-7, the publication is Dyes and Pigments (2022), 110405, database is CAplus.

Herein, a series of novel 4-heteroaryl-substituted 2-aryl-2H-benzo[4,5]imidazo[1,2-a][1,2,3]triazolo[4,5-e]pyrimidine fluorophores possessing a planarized intramol. charge transfer (PLICT) state was designed. All these fluorophores exhibited high luminescence quantum yields (up to 60%) and large Stokes shift values of up to 7459 cm^-1. Among them, the fluorophore I was found to exhibit the most pronounced pos. solvatochromic effect and the probe II exhibited the most pronounced aggregation induced emission characteristics. This aggregation induced emission behavior was further confirmed by means of time-resolved fluorescence lifetime measurements as well as DFT-assisted geometry optimization studies. In the presence of trifluoroacetic acid (TFA) compound I exhibited a well-pronounced acidochromism via visible color change from yellow-green to orange which returned to the original yellow-green solution after the addition of triethylamine (TEA). The Stern-Volmer constant for the probe I towards TFA was 38 M^-1. Finally, for the compounds II, III, I theor. calculations in the ground and excited states in different solvents were carried out to confirm the PLICT process. Based on all above the herein reported PLICT fluorophores can be successfully applied as biol. probes and optical switches.

Dyes and Pigments published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C12H25Br, Quality Control of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tydlitat, Jiri published the artcileInfluence of Donor-Substituents on Triphenylamine Chromophores Bearing Pyridine Fragments, Quality Control of 596819-12-4, the publication is European Journal of Organic Chemistry (2019), 2019(9), 1921-1930, database is CAplus.

Efficient synthetic routes that combine different palladium-catalyzed cross-coupling reactions were developed for the preparation of a new family of push-pull derivatives in which pyridine was used as the acceptor group and different para-substituted diphenylamines as the donor groups. All compounds showed absorption in the UV/visible region and blue-green emission with high quantum yields. Significant red shifts were observed in the absorption and fluorescence emission maxima on increasing the electron-donating ability of the substituents or on incorporating a π-conjugated linker. This finding can be explained on the basis of enhanced intramol. charge transfer (ICT). Strong emission solvatochromism confirmed the formation of an intramol. charge-separated emitting state. The HOMO-LUMO energy gaps were estimated by exptl. electrochem. measurements and the results were interpreted with the aid of DFT calculations The thermal behavior of all materials also was studied by DSC.

European Journal of Organic Chemistry published new progress about 596819-12-4. 596819-12-4 belongs to ethers-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ether,Boronate Esters,Boronic acid and ester, name is 2-(5-Methoxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C3H6BrNaO3S, Quality Control of 596819-12-4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Zheng published the artcileUltrastrong Interaction and High Dispersibility of TS-1 on Polymer-Modified Carbon Nanotubes/Nickel Foam, Related Products of ethers-buliding-blocks, the publication is Industrial & Engineering Chemistry Research (2019), 58(41), 19033-19041, database is CAplus.

In this paper, monolithic TS-1 (a zeolitic material containing both silicon and titanium) was successfully synthesized on polymer-modified carbon nanotubes/nickel foam (PMTS-1). PMTS-1 had high surface areas and aggregated pores (confined pores formed in an aggregated structure), and TS-1 could be evenly dispersed on the surface, which could facilitate reactant transport and improve dispersibility of TS-1. TS-1 strongly interacted with the polymer-modified CNTs/NF and is highly dispersed because the PDDA-modification could enhance the positivity of CNTs/NF. PMTS-1 was beneficial to the adsorption of the reactant propylene and the desorption of the product propylene oxide, which reduced the side reaction of the deep oxidation of propylene oxide, pore blocking, and coke formation. Also, the adsorption capacity of PMTS-1 to H₂O₂ was enhanced, which created a microenvironment conducive to the forward reaction. After the reaction, PMTS-1 was easily separated from the reactants, which offered an economical application prospect.

Industrial & Engineering Chemistry Research published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C12H21NO7, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lin, King-Fu published the artcileOrigin of the methylene bonds in poly[2-methoxy-5-(2′-ethyl-hexyloxy)-1,4-phenylenevinylene] prepared according to Gilch’s method: novel applications, Formula: C15H24O2, the publication is Polymer International (2006), 55(8), 938-944, database is CAplus.

Impurities containing methylene bridges between 2-((2′-ethylhexyl)oxy)-5-methoxy-benzene mols. are inevitably formed during the synthesis of 1,4-bis(chloromethyl)-2-((2′-ethylhexyl)oxy)-5-methoxy-benzene, the monomer used in the preparation of poly[2-methoxy-5-(2′-ethyl-hexyloxy)-1,4-phenylenevinylene] (MEH-PPV), but they can be removed by double recrystallization of the monomer prior to polymerization When impurities containing methylene bridges participate in a Gilch polymerization, the methylene bonds formed in the main chains are prone to break at 200 °C, i.e., at least 150 °C below the major degradation temperature of defect-free MEH-PPV. Interestingly, the thermal treatment used to break the methylene bonds bonds present reduces the chain aggregation of MEH-PPV during film formation and induces its blends with poly(2,3-diphenyl-5-octyl-p-phenylene-vinylene) (DPO-PPV) to form a morphol. similar to that of block copolymers. Both significantly enhance the luminescence properties.

Polymer International published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Formula: C15H24O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Reddy, Y. Krishna published the artcileAsymmetric Total Synthesis of (+)-Fostriecin, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Organic Letters (2002), 4(6), 969-971, database is CAplus and MEDLINE.

(+)-Fostriecin (I), a potent protein phosphatase inhibitor and anticancer agent, was prepared by an efficient, multi-convergent asym. synthesis. Key transformations include a ring forming olefin metathesis leading to the α,β-unsaturated lactone II and creation of the triene moiety via Suzuki cross-coupling.

Organic Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Baciocchi, Enrico published the artcileLignin peroxidase-catalyzed oxidation of nonphenolic trimeric lignin model compounds: Fragmentation reactions in the intermediate radical cations, Application In Synthesis of 183303-74-4, the publication is Journal of Organic Chemistry (2003), 68(23), 9061-9069, database is CAplus and MEDLINE.

The H₂O₂-promoted oxidations of the two nonphenolic β-O-aryl lignin model trimers 1 and 2, catalyzed by lignin peroxidase (LiP) at pH = 3.5, have been studied. The results have been compared with those obtained in the oxidation of 1 and 2 with the genuine one-electron oxidant potassium 12-tungstocobalt(III)ate. These models present a different substitution pattern of the three aromatic rings, and by one-electron oxidation, they form radical cations with the pos. charge, which is localized in the dialkoxylated ring as also evidenced by a pulse radiolysis study. Both the oxidations with the enzymic and with the chem. systems lead to the formation of products deriving from the cleavage of C-C and C-H bonds in a β position with respect to the radical cation with the charge residing in the dialkoxylated ring (3,4-dimethoxybenzaldehyde (5) and a trimeric ketone 6 in the oxidation of 1 and a dimeric aldehyde 8 and a trimeric ketone 9 in the oxidation of 2). These products are accompanied by a dimeric aldehyde 7 in the oxidation of 1 and 4-methoxybenzaldehyde (10) in the oxidation of 2. The unexpected formation of these two products has been explained by suggesting that 1^â€? and 2^â€? can also undergo an intramol. electron transfer leading to the radical cations 1a^â€? and 2a^â€? with the charge residing in a monoalkoxylated ring. The fast cleavage of a C-C bond β to this ring, leading to 7 from 1^â€? and to 10 from 2^â€?, is the driving force of the endoergonic electron transfer. A kinetic steady-state investigation of the LiP-catalyzed oxidation of the trimer 2, the dimeric model 1-(3,4-dimethoxyphenyl)-2-phenoxy-1-ethanol (4), and 3,4-dimethoxybenzyl alc. (3) has indicated that the turnover number (k_cat) and the affinity for the enzyme decrease significantly by increasing the size of the model compound In contrast, the three substrates exhibited a very similar reactivity toward a chem. oxidant [Co^IIIW]. This suggests a size-dependent interaction of the enzyme with the substrate which may influence the efficiency of the electron transfer.

Journal of Organic Chemistry published new progress about 183303-74-4. 183303-74-4 belongs to ethers-buliding-blocks, auxiliary class Benzene,Alcohol,Ether, name is 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol, and the molecular formula is C16H18O4, Application In Synthesis of 183303-74-4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Babon, Juan C. published the artcileHydration of Aliphatic Nitriles Catalyzed by an Osmium Polyhydride: Evidence for an Alternative Mechanism, Application of 2-Methoxyacetamide, the publication is Inorganic Chemistry (2021), 60(10), 7284-7296, database is CAplus and MEDLINE.

The hexahydride OsH₆(PⁱPr₃)₂ competently catalyzes the hydration of aliphatic nitriles to amides. The main metal species under the catalytic conditions are the trihydride osmium(IV) amidate derivatives OsH₃{κ²-N,O-[HNC(O)R]}(PⁱPr₃)₂, which have been isolated and fully characterized for R = ⁱPr and ^tBu. The rate of hydration is proportional to the concentrations of the catalyst precursor, nitrile, and water. When these exptl. findings and d. functional theory calculations are combined, the mechanism of catalysis has been established. Complexes OsH₃{κ²-N,O-[HNC(O)R]}(PⁱPr₃)₂ dissociate the carbonyl group of the chelate to afford κ¹-N-amidate derivatives, which coordinate the nitrile. The subsequent attack of an external water mol. to both the C(sp) atom of the nitrile and the N atom of the amidate affords the amide and regenerates the κ¹-N-amidate catalysts. The attack is concerted and takes place through a cyclic six-membered transition state, which involves C_nitrile···O-H···N_amidate interactions. Before the attack, the free carbonyl group of the κ¹-N-amidate ligand fixes the water mol. in the vicinity of the C(sp) atom of the nitrile.

Inorganic Chemistry published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Application of 2-Methoxyacetamide.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Suleman, Zubair published the artcileNeuroprotective effects of Lippia javanica (Burm.F.) Spreng. Herbal tea infusion on Lead-induced oxidative brain damage in Wistar rats, HPLC of Formula: 134-96-3, the publication is BMC Complementary Medicine and Therapies (2022), 22(1), 4, database is CAplus and MEDLINE.

Though Lippia javanica (Burm.f.) Spreng antioxidant activity has been demonstrated, its effect in protecting the brain from lead (Pb)-induced oxidative damage is unknown. This study investigated the effect of L. javanica against Pb-induced oxidative stress, inflammation, apoptosis and acetylcholinesterase activity in rats brain. L. javanica herbal tea infusion was prepared, its phytochem. constituent was revealed by liquid chromatog.-Mass spectrometer (LC-MS) and was administered simultaneously with Pb. Four groups of male Wistar rats (n = 5/group) were used: control received distilled water; Pb-acetate group received 50 mg Pb/ Kg bodyweight (bw), treatment group received 50 mg Pb/ Kg Pb-acetate + 5 mL/kg bw L. javanica and L. javanica group received 5 mL/Kg bw of L. javanica tea infusion only. After 6 wk of treatment, oxidative status, acetylcholinesterase activity, inflammation and apoptosis was assessed in brain tissue which was also histol. examined Mean brain and heart weight was reduced (p < 0.05) while liver and spleen weights were increased (p < 0.05) in Pb exposed animals but were prevented by L. juvanica treatment. Treatment with L. javanica increased (p < 0.05) overall brain antioxidant status (glutathione and superoxide dismutase activities) and reduced lipid peroxidation (p < 0.05) compared to the Pb exposed animals. Pro-inflammatory cytokine tumor necrotic factor-alpha, pro-apoptosis Bax protein and anticholinesterase activity were reduced (p < 0.05) in Pb-L. javanica treated animals compared to the Pb exposed group. Histol. examination confirmed neuroprotective effects of L. javanica as evidenced by reduced apoptosis/necrosis and inflammation-induced vacuolization and edema in the hippocampus. The L. javanica treatment alone had no detrimental effects to the rats. LC-MS anal. revealed L. javanica to be rich in phenolics. This study demonstrated that L. javanica, rich in phenolics was effective in reducing Pb-induced brain oxidative stress, inflammation, apoptosis, acetylcholinesterase activity and neuronal damage.

BMC Complementary Medicine and Therapies published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C23H43NP2, HPLC of Formula: 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Goto, Akihiro published the artcileRh^I-catalyzed hydration of organonitriles under ambient conditions, SDS of cas: 16332-06-2, the publication is Angewandte Chemie, International Edition (2008), 47(19), 3607-3609, database is CAplus and MEDLINE.

The hydration of organonitriles catalyzed by a Rh^I(OMe) species under nearly pH-neutral and ambient conditions (25°C, 1 atm) is chemoselective and high-yielding (93 to 99%) and has a broad substrate scope, and may thus be complementary to enzymic hydration methods for the introduction of a terminal amido group (CONH₂) onto a carbon chain.

Angewandte Chemie, International Edition published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, SDS of cas: 16332-06-2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Juhl, Cathleen published the artcileDevelopment of Potent and Metabolically Stable APJ Ligands with High Therapeutic Potential, Related Products of ethers-buliding-blocks, the publication is ChemMedChem (2016), 11(21), 2378-2384, database is CAplus and MEDLINE.

The apelin ligand receptor system is an important target to develop treatment strategies for cardiovascular diseases. Although apelin exhibits strong inotropic effects, its pharmaceutical application is limited because no agonist with suitable properties is available. On the one hand, peptide ligands are too instable, and on the other hand, small-mol. agonists show only low potency. This study describes the development of apelin (APJ) receptor agonists with not only high activity but also metabolic stability. Several strategies including capping of termini, insertion of unnatural amino acids, cyclization, and lipidation were analyzed. Peptide activity was tested using a Ca²⁺-mobilization assay and the degradation of selected analogs was analyzed in rat plasma. The best results were obtained by N-terminal lipidation of a 13-mer apelin derivative This analog displayed a half-life of 29 h in rat plasma, compared with 0.025 h for the wild-type peptide. Furthermore, in vivo pharmacokinetics revealed a clearance of 0.049 L h^-1 kg^-1 and a half-life of 0.36 h. In summary, amino acid substitution and fatty acid modification resulted in a potent and 1000-fold more stable peptide that exhibits high pharmaceutical potential.

ChemMedChem published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem