Month: December 2022

Ibrahim, Fawzia published the artcileComparative study of two different chromatographic approaches for quantitation of hydrocortisone acetate and pramoxine hydrochloride in presence of their impurities, Formula: C17H28ClNO3, the publication is Journal of Food and Drug Analysis (2018), 26(3), 1160-1170, database is CAplus and MEDLINE.

In the present study, we compare the performance of two reversed-phase liquid chromatog. approaches using different eluents either conventional hydro-organic eluent or micellar one for simultaneous estimation of hydrocortisone acetate and pramoxine hydrochloride in presence of their degradants and process-related impurities; hydrocortisone and 4-butoxyphenol, resp. For conventional reversed-phase liquid chromatog. (RPLC), separation of the studied compounds was completed on an Inertsil ODS 3-C18 column (150 mm × 4.6 mm, 5μm particle size) with a mobile phase consists of 50 mM phosphate buffer (pH 5.0): acetonitrile (50: 50, volume/volume). For micellar liquid chromatog. (MLC), an Eclipse XDB-C8 column (150 mm × 4.6 mm, 5μm particle size) was chosen for the separation with a green mobile phase consists of 0.15 M sodium dodecyl sulfate, 0.3% triethylamine and 10% n-butanol in 20 mM orthophosphoric acid (pH 5.0). Both methods were extended to analyze hydrocortisone acetate and pramoxine hydrochloride in their co-formulated cream. RPLC was superior to MLC with regard to sensitivity for the estimation of impurities. While, MLC represents an eco-friendly, less hazardous and biodegradable approach. Furthermore, the direct injection of the cream to the system without the need to laborious samples pretreatment, excessive amount of anal. time and/or use of large amount of toxic organic solvents is one of the outstanding advantages of MLC.

Journal of Food and Drug Analysis published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Formula: C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hassfeld, Jorma published the artcileSynthesis of the C1-C17 macrolactone of tedanolide, Related Products of ethers-buliding-blocks, the publication is Synthesis (2005), 1183-1199, database is CAplus.

The vinylogous Mukaiyama aldol reaction is a useful method to build up complex polyketide structures. It is successfully employed in the synthesis of the C1-C17 macrolactone of tedanolide, a highly cytotoxic marine natural product. These studies present a practical approach toward the total synthesis of tedanolide; it is pursued using the appropriate C13-C23 segment that is introduced by a pivotal aldol reaction to join both hemispheres.

Synthesis published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wild, Andreas published the artcileAnthracene- and thiophene-containing MEH-PPE-PPVs: Synthesis and study of the effect of the aromatic ring position on the photophysical and electrochemical properties, Safety of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2009), 47(9), 2243-2261, database is CAplus.

This contribution reports on the synthesis and characterization of thiophene- (P1, P2, and P3) and anthracene- (P4 and P5) containing PPE-PPV [poly(phenylene-ethynylene)-poly(phenylenevinylene)] copolymers. The thermostable, soluble and film-forming polymers were fully characterized by NMR, IR and elemental anal.; they exhibit high molar masses with polydispersity indexes below 2.5. The position of the thiophene in the polymeric backbone has insignificant influence on the spectroscopic properties of the polymers. In contrast, the anthracene-containing polymers reveal position dependent optical properties. A constant bathochromic shift of 50 nm was observed going from P4, where anthracene is surrounded by two double bonds, to P5, where anthracene is at the bridge between a triple bond and a double bond, as well as from P5 to P6 where anthracene is surrounded by two triple bonds. This correlates to the decrease of the observed anthracene band around 255 nm going from P4 through P5 to P6, amounting to the degree of contribution of the anthracene unit to the main chain conjugation. The phenomenon known as CN-PPV effect was observed in the case of P4 [Φ_f (solution) = 3%, Φ_f (solid) = 13%]. Electrochem. studies carried out under absolute inert conditions revealed lower electrochem. band gap energies, E_g^ec, than E_g^opt. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 2243-2261, 2009.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C10H16BNO2, Safety of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Beller, Matthias published the artcilePalladium-catalyzed reactions for fine chemical synthesis, Part 6. Efficient chemoenzymic synthesis of enantiomerically pure α-amino acids, Product Details of C3H7NO2, the publication is Chemistry – A European Journal (1998), 4(5), 935-941, database is CAplus.

A general two-step chemoenzymic synthesis for enantiomerically pure natural and nonnatural α-amino acids is presented. In the first step of the sequence, the ubiquitous educts aldehyde, amide and carbon monoxide react by palladium-catalyzed amidocarbonylation to afford the racemic N-acyl amino acids in excellent yields. In the second step, enzymic enantioselective hydrolysis yields the free optically pure α-amino acid and the other enantiomer as the N-acyl derivative, both in optical purities of 85-99.5% ee. The advantage of the chemoenzymic process compared to other amino acid synthesis are demonstrated by the preparation of various functionalized (-OR, -Cl, -F, -SR) α-amino acids on a 10-g scale.

Chemistry – A European Journal published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Product Details of C3H7NO2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tsuruda, Takeshi published the artcileStereoselective Synthesis of the C1-C29 Part of Amphidinol 3, Quality Control of 99438-28-5, the publication is Journal of Organic Chemistry (2015), 80(2), 859-871, database is CAplus and MEDLINE.

Stereoselective synthesis of the C1-C29 part (I) of amphidinol 3 (AM3) was achieved. The C1-C20 part was assembled from three building blocks via regioselective cross metathesis to form the C4-C5 double bond and addition of an alkenyllithium and a lithium acetylide to two Weinreb amides followed by asym. reduction to form the C9-C10 and C14-C15 bonds, resp. The C21-C29 part was synthesized via successive cross metathesis and oxa-Michael addition sequence to construct the 1,3-diol system at C25 and C27 and Brown asym. crotylation to introduce the stereogenic centers at C23 and C24. Coupling of the C1-C20 and C21-C29 parts was achieved by Julia-Kocienski olefination and regio- and stereoselective dihydroxylation of the C20-C21 double bond in the presence of the C4-C5 and C8-C9 double bonds to afford the C1-C29 part of AM3.

Journal of Organic Chemistry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C3H5BN2O2, Quality Control of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Oguzcan, Semih published the artcileEnvironmental impact assessment model for substitution of hazardous substances by using life cycle approach, Formula: C4H10O2, the publication is Environmental Pollution (Oxford, United Kingdom) (2019), 254(Part_A), 112945, database is CAplus and MEDLINE.

Regulations that are indirectly driving the substitution of hazardous chems., such as the EU REACH regulation, necessitate improvements in chem. alternatives assessment frameworks. In those frameworks, life cycle thinking lacks some important aspects such as systematic and quant. occupational safety methods and risks from intermediate chems. that are not released to the environment under normal operating conditions. Concerns of companies about regulatory drivers regarding substances of very high concern often lead to inadequate evaluation of the baseline situation; an issue also overlooked by the frameworks. Moreover, life cycle assessment is optional for assessors with limited resources, such as small and medium enterprises. However, the success of substitution should not be evaluated without life cycle concerns. An environmental impact assessment model has been suggested to overcome these shortcomings of the chem. alternatives assessment frameworks. The model was applied to a case study of primed metal sheet production, where the company was driven to substitute reprotoxic 2-methoxypropanol used in their formulations. The results show that the proposed model is promising for solving the mentioned shortcomings, informing the assessor about substances of very high concern along the life cycle, and it has the potential to be further improved with the help of supporting software and databases.

Environmental Pollution (Oxford, United Kingdom) published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Formula: C4H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sarkar, Sougata published the artcileRedox-Switchable Copper(I) Metallogel: A Metal-Organic Material for Selective and Naked-Eye Sensing of Picric Acid, Application of Formamidine disulfide dihydrochloride, the publication is ACS Applied Materials & Interfaces (2014), 6(9), 6308-6316, database is CAplus and MEDLINE.

Thiourea (TU), a com. available laboratory chem., has been discovered to introduce metallogelation when reacted with copper(II) chloride in aqueous medium. The chem. involves the reduction of Cu(II) to Cu(I) with concomitant oxidation of thiourea to dithiobisformamidinium dichloride. The gel formation is triggered through metal-ligand complexation, i.e., Cu(I)-TU coordination and extensive hydrogen bonding interactions involving thiourea, the disulfide product, water, and chloride ions. Entangled network morphol. of the gel selectively develops in water, maybe for its superior hydrogen-bonding ability, as accounted from Kamlet-Taft solvent parameters. Complete and systematic chem. analyses demonstrate the importance of both Cu(I) and chloride ions as the key ingredients in the metal-organic coordination gel framework. The gel is highly fluorescent. Again, exclusive presence of Cu(I) metal centers in the gel structure makes the gel redox-responsive and therefore it shows reversible gel-sol phase transition. However, the reversibility does not cause any morphol. change in the gel phase. The gel practically exhibits its multiresponsive nature and therefore the influences of different probable interfering parameters (pH, selective metal ions and anions, selective complexing agents, etc.) have been studied mechanistically and the results might be promising for different applications. Finally, the gel material shows a highly selective visual response to a commonly used nitroexplosive, picric acid among a set of 19 congeners and the preferred selectivity has been mechanistically interpreted with d. functional theory-based calculations

ACS Applied Materials & Interfaces published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Application of Formamidine disulfide dihydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Arora, Vinay published the artcileSolvent-Free N-Alkylation and Dehydrogenative Coupling Catalyzed by a Highly Active Pincer-Nickel Complex, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine, the publication is Organometallics (2020), 39(11), 2162-2176, database is CAplus.

The synthesis and characterization of a pincer-Ni complex (^iPr2NNN)NiCl₂(MeCN) is reported here. The authors demonstrated the utility of this pincer-Ni complex (0.02 mol % and 0.002 mol %) for the catalytic N-alkylation of amines using various alcs. Under solvent-free conditions, while the highest yield (âˆ?0%) was obtained for alkylation of 2-amino pyridine with naphthyl-1-methanol, excellent turnovers (34000 TONs) was observed for alkylation of 2-amino pyridine with 4-methoxy benzyl alc. To demonstrate the synthetic utility of these systems, high yield reactions (up to 98%) were probed for representative substrates with a higher loading of the pincer-Ni catalyst (4 mol %). DFT studies indicate that while β-hydride elimination is the RDS for alc. dehydrogenation, the N-alkylated product can be formed either via hydrogenation with a rate-determining σ-bond metathesis or by alcoholysis that has imine insertion as RDS. All the corresponding resting states were observed by HRMS(ESI) anal. The labeling experiments are also complementary to DFT studies and show evidence for the involvement of benzylic C-H bond in RDS with a k_CHH/k_CHD of âˆ?.5. This method was applied to accomplish efficient (2000 TONS) dehydrogenative coupling leading to various benzimidazoles.

Organometallics published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Renaud, J. L. published the artcileRuthenium-catalysed enantioselective hydrogenation of trisubstituted enamides derived from 2-tetralone and 3-chromanone: Influence of substitution on the amide arm and the aromatic ring, Product Details of C3H7NO2, the publication is Advanced Synthesis & Catalysis (2003), 345(1+2), 230-238, database is CAplus.

Cyclic enamides, e.g. I, were prepared in one step from tetralone and chromanone derivatives and primary amides under acidic conditions. The enantioselective hydrogenation of these enamides bearing an endocyclic trisubstituted carbon-carbon double bond was performed at room temperature in the presence of ruthenium catalysts. The nature of the amide group had little influence on the enantioselectivity of the hydrogenation when mononuclear precatalysts were used. The presence of a coordinating atom at some specific position on the tetralone and chromanone skeleton led to a dramatic decrease of the enantiomeric excesses.

Advanced Synthesis & Catalysis published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Product Details of C3H7NO2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhu, Guanxin published the artcileSelective C-C bonds formation, N-alkylation and benzo[d]imidazoles synthesis by a recyclable zinc composite, Name: (2-Methoxyphenyl)methanamine, the publication is Chinese Chemical Letters (2022), 33(1), 266-270, database is CAplus.

Earth abundant metals are much less expensive, promising, valuable metals and could be served as catalysts for the borrowing hydrogen reaction, dehydrogenation and heterocycles synthesis, instead of noble metals. The uniformly dispersed zinc composites were designed, synthesized and carefully characterized by means of XPS, EDS, TEM and XRD. The resulting zinc composite showed good catalytic activity for the N-alkylation of amines 2-R-3-R¹-4-R²-5-R³-C₆HNH₂ (R = H, Cl, Me; R¹ = H, Cl; R² = H, Cl, OMe; R³ = H, Me) with amines R⁴CH₂NH₂ (R⁴ = Ph, 2-methylphenyl, thiophen-2-yl, etc.), ketones R⁵C(O)CH₃ (R⁵ = Ph, 3-bromophenyl, naphthalen-2-yl, etc.;) with alcs. R⁶CH₂OH (R⁶ = Ph, 3,4-difluorophenyl, thiophen-2-yl, etc.) in water under base-free conditions, while unsaturated carbonyl compounds R⁵C(O)CH=CHR⁶ and R⁵C(O)(CH₂)₂R⁶ could also be synthesized by tuning the reaction conditions. Importantly, it was the first time to realize the synthesis of 2-aryl-1H-benzo[d]imidazole derivatives I (R⁷ = H, Cl, Me) by using this zinc composite under green conditions. Meanwhile, this zinc catalyst could be easily recovered and reused for at least five times.

Chinese Chemical Letters published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C11H17BN2O2, Name: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem