Month: December 2022

Rizzo, P. V. published the artcileIdentification of aroma-active compounds in Cheddar cheese imparted by wood smoke, Related Products of ethers-buliding-blocks, the publication is Journal of Dairy Science (2022), 105(7), 5622-5640, database is CAplus and MEDLINE.

Cheddar cheese is the most popular cheese in the United States, and the demand for specialty categories of cheese, such as smoked cheese, are rising. The objective of this study was to characterize the flavor differences among Cheddar cheeses smoked with hickory, cherry, or apple woods, and to identify important aroma-active compounds contributing to these differences. First, the aroma-active compound profiles of hickory, cherry, and apple wood smokes were analyzed by solid-phase microextraction (SPME) gas chromatog.-olfactometry (GCO) and gas chromatog.-mass spectrometry (GC-MS). Subsequently, com. Cheddar cheeses smoked with hickory, cherry, or apple woods, as well as an unsmoked control, were evaluated by a trained sensory panel and by SPME GCO and GC-MS to identify aroma-active compounds Selected compounds were quantified with external standard curves. Seventy-eight aroma-active compounds were identified in wood smokes. Compounds included phenolics, carbonyls, and furans. The trained panel identified distinct sensory attributes and intensities among the 3 cheeses exposed to different wood smokes (P < 0.05). Hickory smoked cheeses had the highest intensities of flavors associated with characteristic “smokiness” including smoke aroma, overall smoke flavor intensity, and meaty, smoky flavor. Cherry wood smoked cheeses were distinguished by the presence of a fruity flavor. Apple wood smoked cheeses were characterized by the presence of a waxy, green flavor. Ninety-nine aroma-active compounds were identified in smoked cheeses. Phenol, guaiacol, 4-methylguaiacol, and syringol were identified as the most important compounds contributing to characteristic “smokiness.” Benzyl alc. contributed to the fruity flavor in cherry wood smoked cheeses, and 2-methyl-2-butenal and 2-ethylfuran were responsible for the waxy, green flavor identified in apple wood smoked cheeses. These smoke flavor compounds, in addition to diacetyl and acetoin, were deemed important to the flavor of cheeses in this study. from this study identified volatile aroma-active compounds contributing to differences in sensory perception among Cheddar cheeses smoked with different wood sources.

Journal of Dairy Science published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Topolovcan, Nikola published the artcileChemoselective and Regioselective Synthesis of Spiroisoindolinone Indenes via an Intercepted Meyer-Schuster Rearrangement/Intramolecular Friedel-Crafts Alkylation Relay, SDS of cas: 91-16-7, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

A Bronsted acid-catalyzed reaction between isoindolinone-derived propargylic alcs. I [R = H, 2-Me, 3-Cl, 4-Me, etc.; R ₁ = Me, iso-Pr, benzyl, etc.] and external aromatic nucleophiles [such as 1,3,5-trimethoxybenzene, 1-naphthol, 1H-indole, etc.] for the construction of spiroisoindolinone indenes II [R ₂ = H, 7-Me, 6-Cl, 5-Me, etc.], e.g., III is described. The reaction proceeds rapidly with a broad range of substrates to generate spiroindenes II, e.g., III chemoselectively and regioselectively in moderate to high yields. Key to the success of this transformation is an intercepted Meyer-Schuster rearrangement/intramol. Friedel-Crafts alkylation relay that offers a modular approach in the synthesis of target compds II, e.g., III.

Journal of Organic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H17Br, SDS of cas: 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Delbeke, F. T. published the artcileDetection of some local anesthetics in horse urine and plasma by gas-liquid chromatography, COA of Formula: C17H28ClNO3, the publication is Journal of Chromatography (1981), 206(3), 594-9, database is CAplus and MEDLINE.

A gas-liquid chromatog. (GLC) method using a N specific detector is described for the screening of several local anesthetics in horse plasma and urine. The glass columns used were: 5% OV-101, 3% OV-7, and 3% OV-25 on Chromosorb W (80-100 mesh). Blank plasma or urine samples were spiked with the local anesthetics, echothiophate iodide was added followed by NH₄⁺/NH₃ buffer (pH 9.4) and the mixture extracted with cyclohexane. The residue from the organic layer was used for GLC anal. Detection limits and percentage recoveries for the 11 anesthetics studied are given for urine and plasma.

Journal of Chromatography published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, COA of Formula: C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Shengping published the artcileCyclization of linear tetrapeptides containing N-methylated amino acids by using 1-propanephosphonic acid anhydride, SDS of cas: 77128-73-5, the publication is European Journal of Organic Chemistry (2017), 2017(1), 149-158, database is CAplus.

The cyclization of the linear tetrapeptides sequence H-NMePhe-Xaa¹-NMePhe-Xaa²-OH (for which Xaa¹ = Xaa² = Ile, Val, or Leu; Xaa¹ = Val; Xaa² = Ile or Leu) by using 1-propanephosphonic acid anhydride was explored. An unanticipated finding is the cyclization towards cyclotetrapeptide conformers (kinetic products) that were highly prone to hydrolysis and that slowly interconvert into the more stable trans,cis,trans,cis (tctc) conformers (thermodn. products).

European Journal of Organic Chemistry published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C6H12F3NO5S, SDS of cas: 77128-73-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Blanco-Brieva, Gema published the artcileSelective hydrogenation of hydrogen peroxide in the epoxidation effluent of the HPPO process, SDS of cas: 1589-47-5, the publication is Catalysis Communications (2012), 83-87, database is CAplus.

This work describes selective H₂O₂ hydrogenation in the exit stream of the epoxidation reactor employed in the Hydrogen Peroxide-Propylene Oxide (HPPO) process. Pd/Al₂O₃ and Pt/Al₂O₃ catalysts were employed for this purpose. The effect of the reaction temperature, catalyst amount and hydrogen partial pressure on catalyst performance were investigated. It was found that the Pt catalyst is much more active than its Pd counterpart. Under optimized reaction conditions, the hydrogen peroxide present in the exit stream can be completely hydrogenated with the Pt catalyst with a reaction time of no longer than 20 min and an almost negligible amount of byproducts derived from propylene oxide.

Catalysis Communications published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, SDS of cas: 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Blanco-Brieva, Gema published the artcileSelective decomposition of hydrogen peroxide in the epoxidation effluent of the HPPO process, Recommanded Product: 2-Methoxypropan-1-ol, the publication is Catalysis Today (2012), 187(1), 168-172, database is CAplus.

This work describes the selective H₂O₂ decomposition in the exit stream of the epoxidation reactor employed in the Hydrogen Peroxide-Propylene Oxide (HPPO) process. Pd/Al₂O₃ and Pt/Al₂O₃ catalysts were tested. The effects of the reaction temperature and the pH of the solution on catalyst performance were investigated. It was found that the Pt catalyst is much more active than its Pd counterpart. An increase in the temperature and the pH of the solution resulted in an increase in the H₂O₂ decomposition rate; however, a parallel increase of byproducts from PO was also observed Working with a Pt/Al₂O₃ catalyst under optimized reaction conditions (333 K, pH = 7), hydrogen peroxide can be completely decomposed at reaction times of 120 min with no byproducts produced from propylene oxide.

Catalysis Today published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Recommanded Product: 2-Methoxypropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ma, Xuerui published the artcileTartramide Ligands for Copper-Catalyzed N-Arylation at Room Temperature, HPLC of Formula: 6850-57-3, the publication is Advanced Synthesis & Catalysis (2022), 364(12), 2023-2031, database is CAplus.

Readily accessible tartramide ligands R¹NHC(O)CH(OH)CH(OH) C(O)NHR (R = Ph, Bn, cyclohexyl, etc.)have been demonstrated to promote copper-catalyzed N-arylation under mild conditions. In addition, the coupling protocol employs cheap and readily available pre-catalyst, ligand, and base (NaOH), and overcomes many current limitations often associated with Ullmann coupling: it can be run with low catalyst loadings, does not require the use of excess amine, operates at room temperature, is fully homogeneous, and displays improved tolerance to air and moisture. Detailed kinetic studies using reaction progress kinetic anal. (RPKA) methods have provided insight into the factors influencing the reaction rate in terms of impact of ligand structure, reactant/catalyst dependence and catalyst (in)stability. These kinetic insights have been used in a quality-by-design approach for further optimization of the reaction protocol. The reaction scope was extended to 22 examples, showing broad applicability for a wide range of substituted aryl iodides ArI (Ar = 3,5-dimethylphenyl, 4-chlorophenyl, 3-cyanophenyl, etc.) with both primary and secondary amines R¹NHR² (R¹ = H); R² = -(CH₂)₂O(CH₂)₂-, -(CH₂)₂N(CH₃)(CH₂)₂-, -(CH₂)₅-, etc.

Advanced Synthesis & Catalysis published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, HPLC of Formula: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zampella, Angela published the artcileStereoselective synthesis of (2R,3R,4R)-3-hydroxy-2,4,6-trimethylheptanoic acid and determination of the absolute stereochemistry of the natural product from callipeltin A, Quality Control of 99438-28-5, the publication is Tetrahedron: Asymmetry (2002), 13(12), 1237-1239, database is CAplus.

A revised stereostructure of 3-hydroxy-2,4,6-trimethylheptanoic acid, the β-hydroxy acid that acylates the N-terminus of callipeltin A, is proposed on the basis of anal. of J-coupling in the ¹H NMR spectrum of the acetonide derivative obtained from the acid hydrolyzate of callipeltin A. The proposed structure was definitively confirmed by enantioselective synthesis.

Tetrahedron: Asymmetry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C7H13NO2, Quality Control of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Megemont, C. published the artcileComparative activities of some local anesthetics in modifying the effect of acetylcholine in presence of the isolated ventricle of Helix pomatia and the denervated dorsal muscle of Hirudo medicinalis, Application of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales (1960), 64-6, database is CAplus.

In low concentrations all of 11 diverse local anesthetics augmented the neg. chronotropic and inotropic effects of acetylcholine on the isolated snail ventricle, and all but 2 antagonized the effect of acetylcholine on the denervated leech muscle.

Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Application of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sulimov, A. V. published the artcileKinetics of propylene epoxidation with hydrogen peroxide catalyzed by extruded titanium silicalite in methanol, Category: ethers-buliding-blocks, the publication is Kinetics and Catalysis (2016), 57(4), 466-473, database is CAplus.

The kinetics of propylene oxidation into propylene oxide in the presence of extruded titanium silicalite was studied. Based on the exptl. data, a kinetic model of the process was designed and the activation energies of the target and side reactions, the rate constants, and the adsorption equilibrium constants were determined The adequacy of the proposed kinetic model was verified on a continuously-operated test bench laboratory unit.

Kinetics and Catalysis published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C7H7BrN2O2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem