Month: December 2022

Xie, Chen published the artcileSelf-Assembled Semiconducting Polymer Nanoparticles for Ultrasensitive Near-Infrared Afterglow Imaging of Metastatic Tumors, Quality Control of 146370-51-6, the publication is Advanced Materials (Weinheim, Germany) (2018), 30(21), n/a, database is CAplus and MEDLINE.

Detection of metastatic tumor tissues is crucial for cancer therapy; however, fluorescence agents that allow to do share the disadvantage of low signal-to-background ratio due to tissue autofluorescence. The development of amphiphilic poly(p-phenylenevinylene) derivatives that can self-assemble into the nanoagent (SPPVN) in biol. solutions and emit near-IR afterglow luminescence after cessation of light irradiation for ultrasensitive imaging of metastatic tumors in living mice is herein reported. As compared with the counterpart nanoparticle (PPVP) prepared from the hydrophobic PPV derivate, SPPVN has smaller size, higher energy transfer efficiency, and brighter afterglow luminescence. Moreover, due to the higher PEG d. of SPPVN relative to PPVP poly(ethylene glycol), SPPVN has a better accumulation in tumor. Such a high sensitivity and ideal biodistribution allow SPPVN to rapidly detect xenograft tumors with the size as small as 1 mm³ and tiny peritoneal metastatic tumors that are almost invisible to naked eye, which is not possible for PPVP. Moreover, the oxygen-sensitive afterglow makes SPPVN potentially useful for in vivo imaging of oxygen levels. By virtue of enzymic biodegradability and ideal in vivo clearance, these organic agents can serve as a platform for the construction of advanced afterglow imaging tools.

Advanced Materials (Weinheim, Germany) published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C12H23N3S, Quality Control of 146370-51-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hu, Boqin published the artcileEthanol extracts of Rhaponticum uniflorum (L.) DC flowers attenuate doxorubicin-induced cardiotoxicity via alleviating apoptosis and regulating mitochondrial dynamics in H9c2 cells, COA of Formula: C9H10O4, the publication is Journal of Ethnopharmacology (2022), 114936, database is CAplus and MEDLINE.

Loulu flowers (LLF) is the inflorescence of Rhaponticum uniflorum (L.) DC. (R. uniflorum), a member of the Compositae family. This plant possesses heat-clearing properties, detoxification effects, and is therefore frequently used for the treatment of cardiovascular diseases. Aim of this study: This study aimed to investigate the cardioprotective effects of ethanol extracts of LLF against doxorubicin (DOX)-induced cardiotoxicity and explore the associated mechanisms. Ethanol extracts of LLF were prepared and analyzed by LC-ESI-MS/MS. DOX-treated H9c2 cells and DOX-treated zebrafish models were used to explore the cardioprotective effect of ethanol extracts on myocardial function. The effects of LLF on DOX-induced cytotoxicity in H9c2 cells were investigated by MTT assay. Reactive Oxygen Species (ROS) levels, mitochondrial membrane potential (MMP), and nuclear translocation of NF-κB p65 were examined using fluorescent probes. The expression level of Bax, Bcl-2, PARP, caspase-3, cleaved-caspase3, caspase9, IκBα, p-IκBα, IKK, p-IKK, p65, p-p65, OPA1, Mfn1, MFF and Fis 1 and GAPDH was determined by western blotting. Twenty-five compounds were detected in ethanol extracts of LLF, include Nicotinamide, Coumarin, Parthenolide, and Ligustilide. Pre-treatment with LLF attenuated the DOX-induced decrease in viability and ROS production in H9c2 cells. Moreover, LLF treatment maintained the mitochondrial membrane integrity and suppressed apoptosis by upregulating expression level of Bcl-2 and downregulating the expression level of Bax, cleaved-caspase-3, cleaved-caspase-9 and cleaved-PARP. In addition, LLF significantly inhibited the DOX-induced activation of NF-κB signaling. Cells treated with DOX showed aberrant expression of mitochondrial dynamics related proteins, and these effects were alleviated by LLF pre-treatment. In conclusion, these results show that LLF can alleviate DOX-induced cardiotoxicity by blocking NF-κB signaling and re-balancing mitochondrial dynamics. Ethanol extracts of LLF is a potential treatment option to against DOX-induced cardiotoxicity.

Journal of Ethnopharmacology published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, COA of Formula: C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xu, Yueting published the artcileHydrogen bonding-catalyzed alcoholysis of propylene oxide at room temperature, Category: ethers-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(70), 8734-8737, database is CAplus and MEDLINE.

Alcoholysis of propylene oxide (PO) was achieved over azolate ionic liquids (IL, e.g., 1-hydroxyethyl-3-Me imidazolium imidazolate) at room temperature to access glycol ethers R¹OCH₂CHOHR² [R¹ = Me, Et, iPr, etc.; R² = Me, Et] in high yields with excellent selectivity (e.g., >99%). Mechanism investigation indicated that cooperation of hydrogen-bonding of the anion with methanol and that of the cation with PO catalized the reaction. This catalytic protocol was simple, green, highly efficient and might had promising applications in the production of glycol ethers.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C25H23NO4, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wu, Lizhi published the artcileIn-depth understanding of acid catalysis of solvolysis of propene oxide over titanosilicates and titanosilicate/H₂O₂ systems, Recommanded Product: 2-Methoxypropan-1-ol, the publication is Journal of Catalysis (2016), 248-259, database is CAplus.

A comprehensive investigation was carried out to understand the acidic nature of titanosilicates and titanosilicate/H₂O₂ catalytic systems. According to a typical probe reaction, the ring opening of propylene oxide (PO) with CH₃OH and H₂O based on the side reaction in the hydrogen peroxide-propylene oxide (HPPO) process, as well as on the characterization of the IR spectrum, four types of acid sites were confirmed and their alcoholysis ability decreased in the order Ti-OOH > Si-OH groups generated by defect sites ≫ tetrahedral Ti⁴⁺ centers ≈ Ti-OH. The Bronsted acid sites (BAS) of the Si-OH groups generated by defect sites and the Ti-OOH species should be mainly responsible for the ring opening of epoxides. Meanwhile, the alcoholysis products ratio of 1-methoxy-2-propanol (PPM) to 2-methoxy-1-propanol (SPM) was demonstrated to be correlated with the specific acid sites for the first time: BAS tend to generate SPM, while Lewis acid sites (LAS) of tetrahedral Ti⁴⁺ centers tend to form PPM. It is found that the reaction activation energy of alcoholysis is higher than that of hydrolysis, since hydrolysis could proceed directly without acid sites. Fine ion exchange and proper additives were adopted to suppress corresponding specific acid sites, which could obviously enhance the PO selectivity in propylene epoxidation

Journal of Catalysis published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C7H8BFO2, Recommanded Product: 2-Methoxypropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Shengbiao published the artcilePoly-(p-phenylene vinylenes) with pendent 2,4-difluorophenyl and fluorenyl moieties: Synthesis, characterization, and device performance, Application In Synthesis of 146370-51-6, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2009), 47(10), 2500-2508, database is CAplus.

To improve efficiency, processability, and stability, three novel poly(p-phenylenevinylenes) (PPVs) derivatives (P_a, P_b, and P_c) with pendent 2,4-difluorophenyl and fluorenyl moieties were synthesized via Gilch reaction. Their structures were characterized by ¹H NMR, ¹³C NMR, and ELEM. ANAL. Compared with those of PPV and MEH-PPV, the absolute quantum efficiencies of these polymers showed remarkable improvement (measured at 38.7, 37.2, and 20.3%, resp.), which can be attributed to the presence of twisted multiaryl segments and fluorine atoms. TGA revealed that the inflection temperatures of their thermal decomposition curves were above 400°. Double-layered electroluminescent devices with these polymers as light-emitting layers [ITO/PEDOT:PSS/Polymer/Ba/Al] showed peak emissions at 493/515, 503, and 600 nm and maximum luminance of 2700, 450, and 4700 cd/m² for P_a, P_b, and P_c, resp., with onset voltages of ∼4 V. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 2500-2508, 2009.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Application In Synthesis of 146370-51-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Shuxiang published the artcileSynthesis, characterization and properties of a novel fluorinated methacrylate polymer, Product Details of C4H7F3O2, the publication is Journal of Fluorine Chemistry (2011), 132(11), 915-919, database is CAplus.

A fluorinated monomer of 2-(2,2,2-trifluoroethoxy)ethyl methacrylate (FEMA) was prepared by a “one pot” process and then a novel fluorinated methacrylate polymer, poly[2-(2,2,2-trifluoroethoxy)ethyl methacrylate] (PFEMA), was successfully synthesized via miniemulsion polymerization using cetyltrimethyl ammonium bromide (CTAB) as emulsifier, hexadecane (HD) as co-stabilizer and 2,2′-azobisisobutyronitrile (AIBN) as initiator. The chem. structure of PFEMA was characterized by FT-IR, ¹H NMR and ¹⁹F NMR. GPC results show that the number average mol. weight (M_n) of PFEMA was as high as 8.5 × 10⁵ g/mol and the polydispersity index (PDI) was only 1.3. SEM and DLS characterizations showed that the morphol. of PFEMA latex was uniform spheres with the diameter of about 110-125 nm. It was also found that PFEMA has high thermo-stability (T_d > 200 °C), low glass transition temperature (T_g = 13.0 °C), and nice hydrophobicity (θ_water = 99.9°). Comparison studies on PFEMA and poly(2,2,2-trifluoroethyl methacrylate) show that an introduced functional group (-CH₂CH₂O-) has a significant effect on lowering T_g and improving hydrolysis resistance without impairing surface properties.

Journal of Fluorine Chemistry published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C9H22OSi, Product Details of C4H7F3O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Guo-Ning published the artcileDiscovery and optimization of 2-((1H-indol-3-yl)thio)-N-benzyl-acetamides as novel SARS-CoV-2 RdRp inhibitors, Application In Synthesis of 6850-57-3, the publication is European Journal of Medicinal Chemistry (2021), 113622, database is CAplus and MEDLINE.

The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global pandemic coronavirus disease (COVID-19), but no specific antiviral drug has been proven effective for controlling this pandemic to date. In this study, several 2-((indol-3-yl)thio)-N-benzyl-acetamides were identified as SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitors. After a two-round optimization, a new series of 2-((indol-3-yl)thio)-N-benzyl-acetamides was designed, synthesized, and evaluated for SARS-CoV-2 RdRp inhibitory effect. Compounds 6b2, 6b5, 6c9, 6d2, and 6d5 were identified as potent inhibitors with IC₅₀ values of 3.35 ± 0.21μM, 4.55 ± 0.2μM, 1.65 ± 0.05μM, 3.76 ± 0.79μM, and 1.11 ± 0.05μM, resp.; the IC₅₀ of remdesivir (control) was measured as 1.19 ± 0.36μM. All of the compounds inhibited RNA synthesis by SARS-CoV-2 RdRp. The most potent compound 6d5, which showed a stronger inhibitory activity against the human coronavirus HCoV-OC43 than remdesivir, is a promising candidate for further investigation.

European Journal of Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C5H10N2OS, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yin, Xueqiang published the artcileCarbocyclic sinefungin, Computed Properties of 99438-28-5, the publication is Tetrahedron Letters (2007), 48(28), 4809-4811, database is CAplus and MEDLINE.

(3AS,4S,6R,6aR)-Tetrahydro-2,2-dimethyl-6-vinyl-3aH-cyclopenta[d][1,3]-dioxol-4-ol, itself available from ribose, provided a convenient entry point for an 18-step preparation of carbocyclic sinefungin. This procedure is adaptable to a number of carbocyclic sinefungin analogs with diversity of heterocyclic base and in the amino acid bearing side chain.

Tetrahedron Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C4H4OS, Computed Properties of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Jiangli published the artcileIn-Depth Identification of Phenolics Fractionated from Eucalyptus Kraft Lignin, Quality Control of 134-96-3, the publication is Advanced Sustainable Systems (2022), 6(5), 2100406, database is CAplus.

Kraft lignin, the principal byproduct of the pulping industry, is an abundant yet highly underutilized aromatic resource. It is useful due to the vast scales involved as a source of fuels, chems., and functional materials when suitable postprocessing is applied. It is deemed to be a renewable alternative to fossil sources. Because of the extreme complexity of kraft lignin, in-depth composition anal. and chem. structural identification are crucial for the development of effective valorization strategies. This work embarks on the characterization and identification of lignin-derived phenolic compounds in representative hardwood (Eucalyptus) kraft lignin after selective fractionation using a single solvent. Advanced 2D heteronuclear single quantum coherence (HSQC) NMR, ³¹P NMR, and mass spectrometry in combination with synthetic authentic compounds are used for the structural identification of the low-mol.-weight fraction of kraft lignin. A total of 20 phenolic compounds, including several novel monomers (catechols), dimers (diarylethanes, diarylethenes, etc.), and trimers with tri-Ph structures are systematically identified in the Eucalyptus kraft lignin. In addition, polysulfide is detected in the low-mol.-weight fraction, indicating that the oxidative polymerization of S^2-/HS^– occurrs during the kraft pulping process. An improved understanding of kraft lignin, especially the low-Mw fraction, is expected to provide essential information for the selective fractionation and valorization of lignin.

Advanced Sustainable Systems published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H22OSi, Quality Control of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Guo, Jianan published the artcileN-Propargylamine-hydroxypyridinone hybrids as multitarget agents for the treatment of Alzheimer disease, Category: ethers-buliding-blocks, the publication is Bioorganic Chemistry (2021), 105013, database is CAplus and MEDLINE.

AD is a progressive brain disorder. Because of the lack of remarkable single-target drugs against neurodegenerative disorders, the multitarget-directed ligand strategy has received attention as a promising therapeutic approach. Herein, we rationally designed twenty-nine hybrids of N-propargylamine-hydroxypyridinone. The designed hybrids possessed excellent iron-chelating activity (pFe3+ = 17.09-22.02) and potent monoamine oxidase B inhibitory effects. Various biol. evaluations of the optimal compound 6b were performed step by step, including inhibition screening of monoamine oxidase (hMAO-B IC50 = 0.083 ± 0.001 μM, hMAO-A IC50 = 6.11 ± 0.08 μM; SI = 73.5), prediction of blood-brain barrier permeability and mouse behavioral research. All of these favorable results proved that the N-propargylamine-hydroxypyridinone scaffold is a promising structure for the discovery of multitargeted ligands for AD therapy.

Bioorganic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem