Month: December 2022

Wu, Shujuan published the artcileHydrazone-linked 2D porphyrinic covalent organic framework photocatalysis for visible light-driven aerobic oxidation of amines to imines, Category: ethers-buliding-blocks, the publication is Journal of Colloid and Interface Science (2022), 446-454, database is CAplus and MEDLINE.

A hydrazone-linked 2D (two-dimensional) porphyrinic COF, Por-DETH-COF, was assembled from 5,10,15,20-tetrakis(4-benzaldehyde)porphyrin (p-Por-CHO) and 2,5-diethoxyterephthalohydrazide (DETH) and its photocatalytic activity was duly appraised with the aerobic oxidation of amines. Thereby, the red light-driven selective oxidation of benzyl amines to imines RCH=NR¹ [R = Ph, 4-FC₆H₄, 2-thienyl, etc.; R¹ = t-Bu, Bn, 4-MeC₆H₄CH₂, etc.]was obtained in very high conversions and selectivities with ambient air as the oxidant. Importantly, the photocatalytic system exhibited remarkable compatibility of functional groups and extensive scope of benzyl amines. Notably, the Por-DETH-COF photocatalyst displayed outstanding recyclability after five successive cycles. This work suggests that 2D COFs could contribute a unique juncture for selective organic transformations by photocatalysis.

Journal of Colloid and Interface Science published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C11H16BNO3, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Hongchao published the artcileNovel soluble N-phenyl-carbazole-containing PPVs for light-emitting devices: Synthesis, electrochemical, optical, and electroluminescent properties, Application In Synthesis of 146370-51-6, the publication is Macromolecular Chemistry and Physics (2004), 205(2), 247-255, database is CAplus.

Novel PPV derivatives (PCA8-PV and PCA8-MEHPV) containing N-phenyl-carbazole units on the backbone were successfully synthesized by the Wittig polycondensation of 3,6-bisformyl-N-(4-octyloxy-phenyl)carbazole with the corresponding tri-Bu phosphonium salts in good yields. The newly formed and dominant trans vinylene double bonds were confirmed by FT-IR and NMR spectroscopy. The polymers (with M̅_w of 6289 for PCA8-PV and 7387 for PCA8-MEHPV) were soluble in common organic solvents and displayed high thermal stability (T_gs are 110.7°C for PCA8-PV and 92.2°C for PCA8-MEHPV, resp.) because of the incorporation of the N-phenyl-carbazole units. Cyclic voltammetry investigations (onsets: 0.8 V for PCA8-PV and 0.7 V for PCA8-MEHPV) suggested that the polymers possess enhanced hole injection/transport properties, which can be also attributed to the N-phenyl-carbazole units on the backbone. Both the single-layer and the double-layer light-emitting diodes (LEDs) that used the polymers as the active layer emitted a greenish-blue or bluish-green light (the maximum emissions located 494 nm for PCA8-PV and 507 nm for PCA8-MEHPV, resp.). Compared with those of the single-layer devices, the emission efficiencies of the double-layer devices, in which an electron-transporting layer (Alq₃) was added, were enhanced by a factor of 10, implying that the better hole-electron balance is achieved because of the incorporation of the electron-transporting layer.

Macromolecular Chemistry and Physics published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C15H24O2, Application In Synthesis of 146370-51-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Zhibin published the artcileSelective electrochemical oxidation of aromatic hydrocarbons and preparation of mono/multi-carbonyl compounds, Quality Control of 6850-57-3, the publication is Science China: Chemistry (2021), 64(12), 2134-2141, database is CAplus.

A selective electrochem. oxidation was developed under mild condition. Various mono-carbonyl and multi-carbonyl compounds can be prepared from different aromatic hydrocarbons with moderate to excellent yield and selectivity by virtue of this electrochem. oxidation The produced carbonyl compounds can be further transformed into α-ketoamides, homoallylic alcs. and oximes in a one-pot reaction. In particular, a series of α-ketoamides were prepared in a one-pot continuous electrolysis. Mechanistic studies showed that 2,2,2-trifluoroethan-1-ol (TFE) can interact with catalyst species and generate the corresponding hydrogen-bonding complex to enhance the electrochem. oxidation performance.

Science China: Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Quality Control of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wu, Wei published the artcileSynthesis and light-emitting performance of MEH-PPV-type monomer 2,5-bis(4-bromo-2,5-dimethoxyphenylvinylene)-1-methoxy-4-(2-ethylhexyloxy)benzene, Synthetic Route of 146370-51-6, the publication is Hecheng Huaxue (2010), 18(2), 222-225, database is CAplus.

A method for the preparation of a green light-emitting monomer [i.e., bis[(4-bromo-2,5-dimethoxyphenyl)vinylene]-1-methoxy-4-[(2-ethylhexyl)oxy]benzene, 1,4-bis[2-(4-bromo-2,5-dimethoxyphenyl)ethenyl]-2-[(2-ethylhexyl)oxy]-5-methoxybenzene] was designed and the synthesis of the target compound was achieved (44.7% yield) by a Wittig-Horner reaction of 2,5-dimethoxy-4-bromobenzaldehyde with P,P‘-[[2-[(2-ethylhexyl)oxy]-5-methoxy-1,4-phenylene]bis(methylene)]bis[phosphonic acid] P,P,P‘,P‘-tetraethyl ester and the product thus obtained was confirmed by ¹H-NMR, ¹³C-NMR, elemental anal. The light-emitting performance of that compound was also determined by UV-Vis and fluorescence anal. and the results showed that λ_max of UV-Vis and fluorescence (FL) were 410 nm and 479 nm, 497 nm, resp. The title compound is a MEH-PPV-type monomer used for light-emitting diodes.

Hecheng Huaxue published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C8H10BNO3, Synthetic Route of 146370-51-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mi, Si published the artcileGeographical discrimination and authentication of Chinese garlic based on multi-element, volatile and metabolomics profiling combined with chemometrics, Application In Synthesis of 91-16-7, the publication is Food Control (2021), 108328, database is CAplus.

This study aims to discriminate the garlics collected from four different geog. locations of China. The multi-element (12 samples), volatile (12 samples) and metabolome (24 samples) composition of the garlics were analyzed and compared. A total of 34 chem. elements, 68 volatiles and 854 metabolites were detected in the garlic samples. Significant differences were observed in the chem. element, volatile and metabolomics profiles of the four groups of garlic. Multivariate statistics indicate that 10 chem. elements, 6 volatiles and 225 metabolites could be used as candidate markers for the separation of garlics obtained from Langfang, Jining, Kaifeng and Dali of China. The current work provides a chem. fingerprint of the selected Chinese garlics. Our results demonstrate that chem. profiling in combination with chemometrics has the potential to be used as feasible approaches for the authentication of the geog. origin of garlic.

Food Control published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

He, Ben published the artcileortho-Terphenylene Viologens with Through-Space Conjugation for Enhanced Photocatalytic Oxidative Coupling and Hydrogen Evolution, Application In Synthesis of 6850-57-3, the publication is Journal of the American Chemical Society (2022), 144(10), 4422-4430, database is CAplus and MEDLINE.

A series of novel ortho-terphenylene viologen derivatives (o-TPV²⁺) with through-space conjugation (TSC) via the combination of ortho-terphenylene skeletons with viologen structure is reported. Their optoelectronic properties can be adjusted by N-arylation or N-alkylation reactions. Compared with other viologen derivatives, o-TPV²⁺ not only exhibits strong photoluminescence, but also retards the charge recombination process and stabilizes diradicals state without forming a quinoid structure due to the special TSC effect. Based on their special redox characteristics, o-TPV²⁺ were applied to the photocatalytic oxidative coupling of benzylamine with 96% yield. In addition, pTA-o-TPV²⁺ (tethered with p-toluic acid) modified g-C₃N₄ was used for visible-light-driven hydrogen production for the first time, exceeding 15 times the rate over unmodified g-C₃N₄.

Journal of the American Chemical Society published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liu, Chun published the artcileLow pressure one-pot synthesis of dimethyl carbonate catalyzed by an alkali carbonate, Safety of 2-Methoxypropan-1-ol, the publication is Cuihua Xuebao (2015), 36(7), 1136-1141, database is CAplus.

A mild and efficient protocol for the alkali carbonate-catalyzed one-pot synthesis of di-Me carbonate (DMC) from epoxide, CO₂ and methanol was developed. The reaction conditions for the one-pot synthesis of DMC were investigated. Under the optimized conditions of initial pressure 0.5 MPa, 120 degree and catalyst loading of 7.5 mol%, 63.5% yield of DMC was achieved using ethylene oxide as the starting material. A mechanism for the catalysis by the alkali carbonate was proposed.

Cuihua Xuebao published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Safety of 2-Methoxypropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Shan published the artcileDesign, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities, Category: ethers-buliding-blocks, the publication is European Journal of Medicinal Chemistry (2021), 113573, database is CAplus and MEDLINE.

A series of 2,4-diamino pyrimidine (DAPY) derivatives I (R¹ = 2-ClC₆H₄, 4-MeOC₆H₄, 4-BrC₆H₄, etc.), II (R² = 4-H₂NC₆H₄, 4-MeOC₆H₄, 2-O₂NC₆H₄, etc.) were designed, synthesized, and evaluated as inhibitors of focal adhesion kinase (FAK) with antitumor and anti-angiogenesis activities. Most compounds effectively suppressed the enzymic activities of FAK, and the IC₅₀s of I (R¹ = 2-ClC₆H₄) and II (R² = 2-MeOC₆H₄) were 2.75 and 1.87 nM, resp. They exhibited strong antiproliferative effects against seven human cancer cells, with IC₅₀ values against two FAK-overexpressing pancreatic cancer cells (PANC-1 and BxPC-3) of 0.98μM, 0.55μM, and 0.11μM, 0.15μM, resp. Moreover, the above two compounds obviously suppressed the colony formation, migration, and invasion of PANC-1 cells in a dose-dependent manner. Meanwhile, these two compounds could induce the apoptosis of PANC-1 cells and arrest the cell cycle in G2/M phase according to the flow cytometry assay. Western blot revealed that these compounds effectively inhibited the FAK/PI3K/Akt signal pathway and significantly decreased the expression of cyclin D1 and Bcl-2. In addition, the above compounds potently inhibited the antiproliferative of HUVECs and obviously altered the cell morphol and also significantly inhibited the migration, tube formation of HUVECs and severely impaired the angiogenesis in the zebrafish model. Overall, these results revealed the potential of these compounds as promising candidates for further preclin. studies.

European Journal of Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C10H9NO4S, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hou, Zhong-Wei published the artcileCatalyst- and Oxidizing Reagent-Free Electrochemical Benzylic C(sp³)-H Oxidation of Phenol Derivatives, COA of Formula: C9H10O4, the publication is Journal of Organic Chemistry (2022), 87(12), 7806-7817, database is CAplus and MEDLINE.

A site-selective electrochem. approach for the benzylic C(sp³)-H oxidation reaction of phenol derivatives along with hydrogen evolution was developed. The protocol proceeded in an easily available undivided cell at room temperature under catalyst- and oxidizing reagent-free conditions. The corresponding aryl aldehydes and ketones were obtained in satisfactory yields, and the gram-scale synthesis is easy to be carried out.

Journal of Organic Chemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, COA of Formula: C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chen, Jia published the artcileUtilization of Diaphragma juglandis extract as a natural antioxidant for improving the oxidative stability of soybean oil during deep frying, Category: ethers-buliding-blocks, the publication is Food Chemistry: X (2022), 100359, database is CAplus and MEDLINE.

Lipid oxidation significantly shortens the life of frying oils, and this challenge can be addressed by using antioxidants. This work aimed to investigate the effect of Diaphragma juglandis extract (DJE) on the oxidative stability of soybean oil during deep frying. Tert-butylhydroquinone (TBHQ) and tea polyphenol (TP) were applied as pos. controls. A total of 31 polyphenols were determined in DJE, and catechin, quercitrin, taxifolin, quercetin 3-β-d-glucoside, epicatechin, gallic acid, and 3,4-dihydroxybenzoic acid were the main components. The antioxidants effectively delayed the degradation of triglycerides and inhibited the increase in the contents of p-anisidine, oxidized triglyceride monomers, triglyceride dimers, and triglyceride oligomers, with DJE exhibiting better performance. Moreover, DJE showed better inhibitory effect on the formation of (E)-2-alkenals, (E,E)-2,4-alkadienals, 4-oxo-alkanals, primary alcs., and secondary alcs. detected by ¹H NMR than TBHQ and TP. Therefore, DJE has great potential as an excellent antioxidant in large-scale industrial applications.

Food Chemistry: X published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem