Month: December 2022

Xie, Yong published the artcileSynthesis, Biological Activity, and Conformational Study of N-Methylated Allatostatin Analogues Inhibiting Juvenile Hormone Biosynthesis, Recommanded Product: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, the publication is Journal of Agricultural and Food Chemistry (2015), 63(11), 2870-2876, database is CAplus and MEDLINE.

An allatostatin (AST) neuropeptide mimic (H17) is a potential insect growth regulator, which inhibits the production of juvenile hormone (JH) by the corpora allata. To determine the effect of conformation of novel AST analogs and their ability to inhibit JH biosynthesis, eight insect AST analogs were synthesized using H17 as the lead compound by N-methylation scanning, which is a common strategy for improving the biol. properties of peptides. A bioassay using JH production by corpora allata of the cockroach Diploptera punctata indicated that single N-methylation mimics (analogs 1-4) showed more activity than double N-methylation mimics (analogs 5-8). Especially, analogs 1 and 4 showed roughly equivalent activity to that of H17, with IC₅₀ values of 5.17 × 10^-8 and 6.44 × 10^-8 M, resp. Mol. modeling based on NMR data showed that the conformation of analogs 1 and 4 seems to be flexible, whereas analogs 2 and 3 showed a type IV β-turn. This flexible linear conformation was hypothesized to be a new important and indispensable structural element beneficial to the activity of AST mimics.

Journal of Agricultural and Food Chemistry published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C12H17NO2, Recommanded Product: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Xiaoying published the artcileNickel Complexes Bearing N,N,O-Tridentate Salicylaldiminato Ligand: Efficient Catalysts for Imines Formation via Dehydrogenative Coupling of Primary Alcohols with Amines, Product Details of C8H11NO, the publication is Organometallics (2021), 40(22), 3843-3853, database is CAplus.

Treatment of salicylaldiminato ligand L1H-L2H (L1H = 2,4-di-tert-butyl-6-((quinolin-8-ylimino)methyl)phenol; L2H = 2,4-di-tert-butyl-6-(((2-(diethylamino)ethyl)imino)methyl)phenol) with Ni(OAc)₂·4H₂O in refluxing EtOH afforded Ni complexes [(L1)Ni(OAc)] (1) and [(L2)Ni(OAc)] (2), resp. Reaction of L3H (L3H = (2,4-di-tert-butyl-6-(((2-(pyridin-2-yl)ethyl)imino)methyl)phenol)) with Ni(OAc)₂·4H₂O in the presence of excess triethylanmine gave the dual ligands coordinated Ni complex [(L2)₂Ni] (3). Complexes 1–3 were well characterized by high-resolution mass spectrometry, IR spectroscopy, elemental anal., and x-ray diffraction anal. All the three Ni(II) complexes exhibited efficient activity and good selectivity in the acceptorless dehydrogenative coupling of alcs. and amines to produce imines and diimines. The present protocol provides an atom-economical and sustainable route for the synthesis of various imine derivatives by employing an earth-abundant Ni salt and easily prepared salicylaldiminato ligands.

Organometallics published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H19NO2, Product Details of C8H11NO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xie, Hong-Xu published the artcileNovel tetrahydrobenzo[b](thiophen-2-yl)urea derivatives as novel α-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation, Application In Synthesis of 6850-57-3, the publication is Bioorganic Chemistry (2021), 105236, database is CAplus and MEDLINE.

α-Glucosidase inhibitors, which can inhibit the digestion of carbohydrates into glucose, are one of important groups of anti-type 2 diabetic drugs. In the present study, we report our effort on the discovery and optimization of α-glucosidase inhibitors with tetrahydrobenzo[b](thiophen-2-yl)urea core. Screening of an inhouse library revealed a moderated α-glucosidase inhibitors, 5a, and then the following structural optimization was performed to obtain more efficient derivatives Most of these derivatives showed increased inhibitory activity against α-glucosidase than the parental compound 5a (IC₅₀ of 26.71 ± 1.80 μM) and the pos. control acarbose (IC₅₀ of 258.53 ± 1.27 μM). Among them, compounds 8r (IC₅₀ = 0.59 ± 0.02 μM) and 8s (IC₅₀ = 0.65 ± 0.03 μM) were the most potent inhibitors, and showed selectivity over α-amylase. The direct binding of both compounds with α-glucosidase was confirmed by fluorescence quenching experiments Kinetics study revealed that these compounds were non-competitive inhibitors, which was consistent with the mol. docking results that compounds 8r and 8s showed high preference to bind to the allosteric site instead of the active site of α-glucosidase. In addition, compounds 8r and 8s were not toxic (IC₅₀ > 100 μM) towards LO2 and HepG2 cells. Finally, the in vivo anti-hyperglycemic activity assay results indicated that compounds 8r could significantly decrease the level of plasma glucose and improve glucose tolerance in SD rats treated with sucrose. The present study provided the (tetrahydrobenzo[b]thiophen-2-yl)urea chemotype for developing novel α-glucosidase inhibitors against type 2 diabetes.

Bioorganic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C9H6N2O2, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Cheng, Xiuyan published the artcilePeriodically nanoporous hydrogen-bonded organic frameworks for high performance photocatalysis, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is Nanoscale (2022), 14(27), 9762-9770, database is CAplus and MEDLINE.

The development of highly catalytic hydrogen-bonded organic frameworks (HOFs) is of great importance, but remains challenging. Herein, we demonstrate the fabrication of a periodically nanoporous HOF for high performance photocatalysis. Compared with the conventional microporous HOFs, the nanoporous HOF architecture has a larger number of free carboxyl groups on the surface and presents greatly improved photoelectrochem. properties. It exhibits high catalytic activity for the photo-oxidative coupling of amines under mild conditions such as air atm. and room temperature and without any co-catalysts, sacrificial reagents or photosensitizers. The relationship between the structure, properties and catalytic performance of the nanoporous HOF was studied by exptl. and theor. investigations. It shows that such a HOF structure facilitates reactant adsorption and O₂ dissociation, thus promoting the oxidative coupling reaction. This work provides a new way for improving the catalytic performance of a single HOF.

Nanoscale published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wu, Bi-Sha published the artcileMolecular mechanisms for pH-mediated amelioration of aluminum-toxicity revealed by conjoint analysis of transcriptome and metabolome in Citrus sinensis roots, Product Details of C9H10O4, the publication is Chemosphere (2022), 134335, database is CAplus and MEDLINE.

Little is known about the effects of pH-aluminum (Al) interactions on gene expression and/or metabolite profiles in plants. Eleven-week-old seedlings of Citrus sinensis were fertilized with nutrient solution at an Al level of 0 or 1 mM and a pH of 3.0 or 4.0 for 18 wk. Increased pH mitigated Al-toxicity-induced accumulation of callose, an Al-sensitive marker. In this study, we identified more differentially expressed genes and differentially abundant metabolites in pH 4.0 + 1 mM Al-treated roots (P4AR) vs pH 4.0 + 0 mM Al-treated roots (P4R) than in pH 3.0 + 1 mM Al-treated roots (P3AR) vs pH 3.0 + 0 mM Al-treated roots (P3R), suggesting that increased pH enhanced root metabolic adaptations to Al-toxicity. Further anal. indicated that increased pH-mediated mitigation of root Al-toxicity might be related to several factors, including: enhanced capacity to maintain the homeostasis of phosphate and energy and the balance between generation and scavenging of reactive oxygen species and aldehydes; and elevated accumulation of secondary metabolites such as polyphenol, proanthocyanidins and phenolamides and adaptations of cell wall and plasma membrane to Al-toxicity.

Chemosphere published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C2H2N3NaS, Product Details of C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Xia published the artcileExtending the 2D conjugated microporous polymers linked by thiazolo[5,4-d]thiazole for green light-driven selective aerobic oxidation of amines, Safety of (2-Methoxyphenyl)methanamine, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2022), 10(28), 14965-14975, database is CAplus.

Donor-π-acceptor (D-π-A) type CMPs linked by the electron-deficient thiazolo[5,4-d]thiazole (TzTz, i.e. the acceptor) were designed by extending the donor from benzene to pyrene to broaden the visible light activity. Subsequently, two-dimensional (2D) CMPs, TzTz-CMP-Be and TzTz-CMP-Py, were constructed via a solvothermal process. The more extended π-conjugation and planar pyrene bestow upon TzTz-CMP-Py with broader absorption of visible light and higher efficiency of charge transfer than TzTz-CMP-Be. Significantly, TzTz-CMP-Py outperformed TzTz-CMP-Be in the green light-driven selective aerobic oxidation of amines RCH₂NHR¹ [R = Ph, pyridin-2-yl, thiophen-2-yl, etc.; R¹ = H, t-Bu, Bn, 4-fluorobenzyl, etc.]. Remarkable photocatalytic performance was observed in converting a wealth of primary and secondary amines to corresponding imines RCH=NR¹ with mol. oxygen (O₂) over TzTz-CMP-Py. This work suggests that CMPs can be rationally designed for extensive visible light-driven selective organic transformations.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Safety of (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wei, Yanze published the artcileCdSe 1D/2D Mixed-Dimensional Heterostructures: Curvature-Complementary Self-Assembly for Enhanced Visible-Light Photocatalysis, SDS of cas: 6850-57-3, the publication is Small (2021), 17(33), 2102047, database is CAplus and MEDLINE.

Mixed-dimensional heterostructures (MDHs), which combine nanomaterials of different dimensionalities deliver on the promise to bypass intrinsic limitations of a given low-dimensional material. Here, a strategy to engineer MDHs between two low-dimensional materials by curvature-complementary self-assembly is described. CdSe nanotubes rolled from 2D nanosheets and 1D CdSe nanorods, with neg. and pos. curvatures, resp., are selected to illustrate complementary curvature self-assembly. The assembly process, optical, and photoelec. properties of the CdSe MDHs are thoroughly investigated. Several remarkable features of CdSe MDHs, including increased light absorption, efficient charge separation, and appropriate bandgap structure are confirmed. The MDHs significantly alleviate the sluggish kinetics of electron transfer in the quantum sized CdSe subunits (onset potential of 0.21 V vs RHE for MDHs; 0.4 V lower than their low-dimensional building blocks), while the spatial nano-confinement effect in the CdSe MDHs also assists the interfacial reaction kinetics to render them ideal photocatalysts for benzylamine oxidation (conversion > 99% in 4 h with a two times higher rate than simple mixtures). The results highlight opportunities for building MDHs from low-dimensional building blocks with curvature-complementary features and expand the application spectrum of low dimensional materials in artificial photosynthesis.

Small published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is Al2H32O28S3, SDS of cas: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Huan-Huan published the artcilePhotocatalytic Hydrogen Evolution Coupled with Production of Highly Value-Added Organic Chemicals by a Composite Photocatalyst CdIn₂S₄@MIL-53-SO₃Ni_1/2, Synthetic Route of 6850-57-3, the publication is Chemistry – An Asian Journal (2021), 16(11), 1499-1506, database is CAplus and MEDLINE.

Photocatalytic water splitting coupled with the production of highly value-added organic chems. is of significant importance, which represents a very promising pathway for transforming green solar energy into chem. energy. Herein, we report a composite photocatalyst CdIn₂S₄@MIL-53-SO₃Ni_1/2, which is highly efficient on prompting water splitting for the production of H₂ in the reduction half-reaction and selective oxidation of organic mols. for the production of highly value-added organic chems. in the oxidation half-reaction under visible light irradiation The superior photocatalytic properties of the composite photocatalyst CdIn₂S₄@MIL-53-SO₃Ni_1/2 should be ascribed to coating suspended ion catalyst (SIC), consisting of redox-active Ni^II ions in the anionic pores of coordination network MIL-53-SO₃^–, on the surface of photoactive CdIn₂S₄, which endows photogenerated electron-hole pairs sep. more efficiently for high rate production of H₂ and selective production of highly value-added organic products, demonstrating great potential for practical applications.

Chemistry – An Asian Journal published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C5H10Cl3O3P, Synthetic Route of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Lei published the artcileCatalyst-Free 1,2-Dibromination of Alkenes Using 1,3-Dibromo-5,5-dimethylhydantoin (DBDMH) as a Bromine Source, Recommanded Product: 2-Methoxynaphthalene, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

A direct 1,2-dibromination method of alkenes is realized using 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) as bromine source. This reaction proceeds under mild reaction conditions without the use of catalyst and external oxidant. Various sorts of alkene substrates are transformed into the corresponding 1,2-dibrominated products in good to excellent yields with broad substrate scope and exclusive diastereoselectivity. This method offers a green and practical approach to synthesize vicinal dibromide compounds

Journal of Organic Chemistry published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C38H24F4O4P2, Recommanded Product: 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Adriani, John published the artcileThe comparative potency and effectiveness of topical anesthetics in man, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Clinical Pharmacology & Therapeutics (New York, NY, United States) (1964), 49-62, database is CAplus and MEDLINE.

A technique with the use of elec. stimulation was developed. The tip of the tongue is the most sensitive area in the body to this type of stimulation. Over 40 drugs with topical activity were studied with the tip of the tongue as the test site. The most potent and effective compounds are tetracaine, cocaine, dibucaine, lidocaine, and dyclonine (I). With exception of I, these are toxic systemically if used in excess. The addition of vasoconstrictors, detergents, demulcents, cations, hyaluronidase, and other often-suggested potentiating agents does extend the period of activity.

Clinical Pharmacology & Therapeutics (New York, NY, United States) published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem