Month: December 2022

Chen, Shengxin published the artcileEpoxide ring-opening reaction promoted by ionic liquid reactivity: interplay of experimental and theoretical studies, Recommanded Product: 2-Methoxypropan-1-ol, the publication is Catalysis Science & Technology (2019), 9(20), 5567-5571, database is CAplus.

Ionic liquids (ILs) have been widely introduced recently into the epoxide ring-opening reaction as catalysts or solvent without considering the chem. stability of ILs in propylene oxide (PO). Through a combination of electrospray-ionization quadrupole time-of-flight mass spectrometry (ESI-QTOF-MS) investigations and quantum-chem. calculations, we demonstrate that AC- (acetate) and MC-(Me carbonate) based ILs exhibit modified activity for ring opening of PO compared with the reaction between ILs and epoxide compounds The chem. unstable ILs and the solvent effect can also dominate the catalytic performance of the coupling reaction of PO with methanol. Based on these findings, we further design the reaction process for highly efficient synthesis of propylene glycol Me ether, in which the yield of the main product increased more than 40% under the same ILs catalysts. The results explained how the chem. instability and substrate affected the PO coupling reaction and further controlled it.

Catalysis Science & Technology published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Recommanded Product: 2-Methoxypropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hickey, Jennifer L. published the artcilePassive Membrane Permeability of Macrocycles Can Be Controlled by Exocyclic Amide Bonds, Product Details of C25H23NO4, the publication is Journal of Medicinal Chemistry (2016), 59(11), 5368-5376, database is CAplus and MEDLINE.

We have developed a strategy for synthesizing passively permeable peptidomimetic macrocycles. The cyclization chem. centers on using aziridine aldehydes in a multicomponent reaction with peptides and isocyanides. The linker region in the resulting product contains an exocyclic amide positioned α to the peptide backbone, an arrangement that is not found among natural amino acids. This amide provides structural rigidity within the cyclic peptidomimetic and promotes the creation of a stabilizing intramol. hydrogen bonding network. This exocyclic control element also contributes to the increased membrane permeability exhibited by multicomponent-derived macrocycles with respect to their homodetic counterparts. The exocyclic control element is employed along with a strategic placement of N-Me and D-amino acids to produce passively permeable peptides, which contain multiple polar residues. This strategy should be applicable in the pursuit of synthesizing therapeutically relevant macrocycles.

Journal of Medicinal Chemistry published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Product Details of C25H23NO4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Rahmatpour, Ali published the artcileMBA-cross-linked poly(N-vinyl-2-pyrrolidone)/ferric chloride macromolecular coordination complex as a novel and recyclable Lewis acid catalyst: Synthesis, characterization, and performance toward for regioselective ring-opening alcoholysis of epoxides, Recommanded Product: 2-Methoxypropan-1-ol, the publication is Reactive & Functional Polymers (2021), 105032, database is CAplus.

A novel macromol.-metal coordination complex, MBA-cross-linked PNVP/FeCl₃ material was fabricated by immobilization of water intolerant ferric chloride onto the porous cross-linked poly(N-vinyl-2-pyrrolidone) carrier beads as a macromol. ligand or carrier which was prepared by suspension free-radical copolymerization of N-vinyl-2-pyrrolidone (NVP) and N,N’-methylene bis-acrylamide (MBA) as a crosslinking agent in water. The obtained PNVP/FeCl₃ was characterized by UV/vis and FT-IR spectroscopies, TGA, FE-SEM, EDX, and ICP techniques. This heterogenized version of ferric chloride is a convenient and safe alternative to highly water intolerant ferric chloride. The catalytic performance of (PNVP/FeCl₃) as an efficient and recyclable polymeric Lewis acid catalyst was appropriately probed in the regio-and stereoselective nucleophilic ring opening of various epoxides with various alcs. in excellent yields with TOF up to 182.48 h^-1 without generating any waste. The activity data indicate that this heterogeneous catalyst is very active and could be easily recovered, and reused at least six times without appreciable loss of activity indicating its stability under exptl. conditions.

Reactive & Functional Polymers published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Recommanded Product: 2-Methoxypropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Jacob, Nicolas published the artcileCobalt-Catalyzed Enantioselective C-H Arylation of Indoles, Recommanded Product: 2-Methoxynaphthalene, the publication is Journal of the American Chemical Society (2022), 144(2), 798-806, database is CAplus and MEDLINE.

Herein, the unprecedented earth-abundant 3D-metal-catalyzed atroposelective direct arylation was reported, furnishing rare atropoisomeric C2-arylated indoles. Kinetic studies and DFT computation revealed an uncommon mechanism for this asym. transformation, with the oxidative addition being the rate- and enantio-determining step. Excellent stereoselectivities were reached (up to 96% ee), while using an unusual N-heterocyclic carbene-ligand bearing essential remote substituent. Attractive dispersion interactions along with pos. C-H—π interactions exerted by the ligand were identified as key factors to guarante the excellent enantioselection.

Journal of the American Chemical Society published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Recommanded Product: 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Martinez-Asencio, Ana published the artcilePalladium(II) acetate as catalyst for the N-alkylation of aromatic amines, sulfonamides, and related nitrogenated compounds with alcohols by a hydrogen autotransfer process, Formula: C13H14N2O, the publication is Synthesis (2011), 3730-3740, database is CAplus.

Palladium(II) acetate is a versatile, inexpensive, and simple catalyst for the selective N-monoalkylation of amino derivatives with poor nucleophilic character, such as aromatic and heteroaromatic amines as well as carboxamides, sulfonamides, and phosphazenes, using, in all cases, primary alcs. as the initial source of the electrophile, through a hydrogen autotransfer process. The regioselectivity of the benzothiazol-2-amine alkylation is contrary to that found using halogenated electrophiles.

Synthesis published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Formula: C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Cano, Rafael published the artcileImpregnated palladium on magnetite as catalyst for multicomponent reductive amination reactions and other related reducing processes, HPLC of Formula: 52818-63-0, the publication is Tetrahedron (2011), 67(42), 8079-8085, database is CAplus.

The impregnated palladium oxide on magnetite catalyst is a versatile system for different reduction processes using inexpensive polymethylhydrosiloxane, including multicomponent reductive amination reactions, and aldehyde, imine, sulfinimide and sulfoxide reductions This catalyst avoids the use of any type of expensive organic ligand, showing excellent yields under mild reaction conditions. The catalyst is easily removed from the reaction medium, just by using a magnet. The catalytic system is very selective permitting the discrimination between ketones and aldehydes in the reductive amination process.

Tetrahedron published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, HPLC of Formula: 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mei, Xinyi published the artcileSynthesis of new fluorine-containing room temperature ionic liquids and their physical and electrochemical properties, HPLC of Formula: 2358-54-5, the publication is Journal of Fluorine Chemistry (2018), 26-37, database is CAplus.

An improved synthesis of fluorine-containing room temperature ionic liquids (FRTILs) is described. Twelve FRTILs are synthesized, in which the fluorinated cations based on N-Me pyrrolidinium (MPy), 1-Me imidazolium (MIm) and diethylsulfide (DES) are associated with anions, such as dicyanamide (DCA) or bis(trifluoromethane sulfonyl)imide (TFSI). The mol. structures of these FRTILs were confirmed by FT-IR, ¹H-NMR, ¹³C-NMR and elemental anal. The FRTILs have been investigated for their potential as electrolyte solvents, especially for lithium-sulfur (Li-S) batteries. Thermal behaviors were also studied by thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC) showing excellent thermal stability, exceeding 150°C, for all FRTILs. Some of their physicochem. properties were determined, including d., flammability, viscosity, and miscibility with polar and nonpolar solvents. Due to the high viscosity of FRTILs, two low viscosity ILs (co-solvent thinners), [MImEt] [DCA] and [MImEt] [TFSI], have been synthesized and used to dilute the FRTILs. The resulting ternary electrolyte systems, LiTFSI in 1:1wt.% FRTILs/thinner, were characterized by their ionic conductivity and electrochem. stability.

Journal of Fluorine Chemistry published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C4H7F3O2, HPLC of Formula: 2358-54-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Shi, Jiale published the artcileBoron carbonitride photocatalysts for direct decarboxylation: the construction of C(sp³)-N or C(sp³)-C(sp²) bonds with visible light, Safety of 2-Methoxynaphthalene, the publication is Green Chemistry (2021), 23(11), 3945-3949, database is CAplus.

A metal-free protocol was established for the decarboxylative N-H or C(sp₂₎-H functionalization of acids via metal-free boron carbon nitride (BCN) photocatalysis, delivering the desired products under ambient conditions. This methodol.was applicable to the late-stage modification of pharmaceutical mols. and gram-scale experiments as well as in the recovery and reuse of the photocatalysts without the loss of reactivity. The developed photochem. reaction system fulfills the requirements of green and sustainable chem.

Green Chemistry published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C7H4BrClO2, Safety of 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xiao, Yang published the artcileConjugated copolymers of 2-methoxy-5-2′-ethyl-hexyloxy-1,4-phenylenevinylene and 2,5-dicyano-1,4-phenylenevinylene as materials for polymer light-emitting diodes, HPLC of Formula: 146370-51-6, the publication is Synthetic Metals (1999), 106(3), 165-170, database is CAplus.

A series of electroluminescent polymers was prepared, which incorporates segments of 2,5-dicyano-1,4-phenylenevinylene (DCN-PV) into the backbone of poly(2-methoxy-5-(2′-ethyl-hexyloxy)-p-phenylene vinylene) (MEH-PPV). The copolymers have optical properties similar to those of MEH-PPV. The oxidation potential of the copolymers is slightly larger than that of MEH-PPV. The copolymers exhibit pre-reduction processes, beginning at about -0.9 V (vs. SCE), before the main reduction processes. The pre-reduction feature promotes electron injection, consequently, it improves electroluminescence (EL) performance. The improved EL performance of the copolymers in comparison with MEH-PPV was demonstrated by a single-layer copolymer as emitter layer in a light-emitting diode (PLED) test device.

Synthetic Metals published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C14H31NO2, HPLC of Formula: 146370-51-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Dao published the artcileEffect of the Dihedral Angle of Biaryl-Bridged Bis(N-Heterocylic Carbene) Ligands on Enantioselectivity in Pd-Catalyzed Asymmetric Aryl-Aryl Cross-Coupling, COA of Formula: C11H10O, the publication is Organometallics (2022), 41(6), 811-819, database is CAplus.

New biaryl-bridged bis(N-heterocylic carbene) Pd complexes were synthesized and applied in asym. Suzuki cross-coupling of aryl halide and aryl boronic acid. X-ray crystallog. studies of square-planar Pd complexes of four of these bis(NHC) ligands revealed that the dihedral angle of the bridging biaryl moiety depends on its identity and lies 79.65-92.69°. A linear correlation between the dihedral angle in these Pd complexes and cross-coupling enantioselectivity is 1st reported. Also, larger C_carbene-Pd-C_carbene bite angles lead to increased enantioselectivity in a 1st fast and then slow growing tendency.

Organometallics published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C10H7NO3, COA of Formula: C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem