Month: December 2022

Wang, Xiao-Dan published the artcileSynthesis and configurations of YF-0200R A and B, HPLC of Formula: 99438-28-5, the publication is Tetrahedron (2016), 72(23), 3177-3184, database is CAplus.

Two natural unsaturated fatty acids, YF-0200R A (I, R¹ = H) and B (I, R¹ = OH), with aspargyl protease inhibition activity were synthesized for the first time. The stereogenic centers were installed by using Brown asym. allylation or chiral building blocks derived from D-glucose, resp. The conjugate diene unit was introduced via an HWE reaction. The geometry of the C-C double bonds was clearly shown to be (E) by ¹H NMR in C₆D₆. The spectroscopic data for the synthetic samples were in excellent consistency with those reported for the corresponding natural ones. The optical rotations were also compatible with those for the natural ones. The absolute configurations for natural YF-0200R A and B thus could be reliably assigned as (8S) and (8S,10S), resp.

Tetrahedron published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C9H17NO, HPLC of Formula: 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tang, Shouchu published the artcileApplication of a Domino Friedel-Crafts Acylation/Alkylation Reaction to the Formal Syntheses of (±)-Taiwaniaquinol B and (±)-Dichroanone, Recommanded Product: 2-Isopropylanisole, the publication is Organic Letters (2008), 10(9), 1855-1858, database is CAplus and MEDLINE.

An efficient acid-promoted domino Friedel-Crafts (FC) acylation/alkylation reaction has been developed for the construction of the core 6,5,6-ABC tricyclic skeleton (e.g. I) of taiwaniaquinoids. The formal total syntheses of diterpenoids (±)-taiwaniaquinol B and (±)-dichroanone based on this strategy have been achieved.

Organic Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C38H74Cl2N2O4, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chen, Jiao published the artcileComparative analysis of volatile components in nine species of marine diatoms, Computed Properties of 1589-47-5, the publication is Shengwuxue Zazhi (2014), 31(2), 35-40, database is CAplus.

The volatile components in nine species of marine diatom staying in stationary phase were concentrated by head space solid-phase micro-extraction and gas chromatog.-mass spectrometry. Integral components of peak area for different diatoms were analyzed by the SIMCA-P software. The results showed that in all of the volatile components the content and types of aldehydes occupied a great advantage in all components. Nonanal, 2,4-octadienal, 2-hexenal, 2-nonenal and 2,4-heptadienal were the main components in marine diatom. The content of some alkanes such as tetradecane, pentadecane 1-pentadecene, hexadecane was only less than that of aldehydes. 3,5-octene-3-one and 1-octene-3-ol were the most common short-chain ketones and alcs. The sulfur-containing compounds, di-Me sulfide was also detected in all diatom. The volatile components like 8-heptadecene, 1-penten-3-one, 1-hexyl-3-ol and 2,6-di-Me phenol had great differences which determined the unique flavor of 9 marine diatom.

Shengwuxue Zazhi published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Computed Properties of 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Chenglu published the artcileTotal synthesis of 3-carbonyl-10-demethyl-12-methoxyabietane, Safety of 2-Isopropylanisole, the publication is Liaoning Shifan Daxue Xuebao, Ziran Kexueban (2011), 34(1), 71-73, database is CAplus.

Total synthesis of 3-carbonyl-10-demethyl-12-methoxyabietane was explored according to the strategy of AC->ABC. The 3-carbonyl-10-demethyl-12-methoxyabietane was synthesized from 2-isopropyl-1-methoxybenzene by bromination in the presence of the catalyst ammonium phosphomolybdate, the addition of ethylene oxide and further bromination. All intermediates and target product were confirmed by IR, ¹H NMR and MS. In conclusion, a simple high yield synthetic route has been developed and the target mol. was successfully synthesized.

Liaoning Shifan Daxue Xuebao, Ziran Kexueban published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C16H12O, Safety of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Mengna published the artcileDevelopment of Multifunctional and Orally Active Cyclic Peptide Agonists of Opioid/Neuropeptide FF Receptors that Produce Potent, Long-Lasting, and Peripherally Restricted Antinociception with Diminished Side Effects, Application In Synthesis of 77128-73-5, the publication is Journal of Medicinal Chemistry (2021), 64(18), 13394-13409, database is CAplus and MEDLINE.

We previously reported that a multifunctional opioid/neuropeptide FF receptor agonist, DN-9, achieved peripherally restricted analgesia with reduced side effects. To develop stable and orally bioavailable analogs of DN-9, eight lactam-bridged cyclic analogs of DN-9 between positions 2 and 5 were designed, synthesized, and biol. evaluated. In vitro cAMP assays revealed that these analogs, except 7, were multifunctional ligands that activated opioid and neuropeptide FF receptors. Analog 1 exhibited improved potency for κ-opioid and NPFF₂ receptors. All analogs exhibited potent, long-lasting, and peripherally restricted antinociception in the tail-flick test without tolerance development after s.c. administration and produced oral analgesia. Oral administration of the optimized compound analog 1 exhibited powerful, peripherally restricted antinociceptive effects in mouse models of acute, inflammatory, and neuropathic pain. Remarkably, orally administered analog 1 had no significant side effects, such as tolerance, dependence, constipation, or respiratory depression, at effective analgesic doses.

Journal of Medicinal Chemistry published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C7H5Br2F, Application In Synthesis of 77128-73-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Hang published the artcileStructure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the G_q Protein, SDS of cas: 77128-73-5, the publication is ChemMedChem (2017), 12(11), 830-834, database is CAplus and MEDLINE.

Extracellular signals perceived by G protein-coupled receptors are transmitted via G proteins, and subsequent intracellular signaling cascades result in a plethora of physiol. responses. The natural product cyclic depsipeptides YM-254890 and FR900359 are the only known compounds that specifically inhibit signaling mediated by the G_q subfamily. In this study we exploit a newly developed synthetic strategy for this compound class in the design, synthesis, and pharmacol. evaluation of eight new analogs of YM-254890. These structure-activity relationship studies led to the discovery of three new analogs, YM-13, YM-14, and YM-18, which displayed potent and selective G_q inhibitory activity. This provides pertinent information for the understanding of the G_q inhibitory mechanism by this class of compounds and importantly provides a pathway for the development of labeled YM-254890 analogs.

ChemMedChem published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C37H30ClIrOP2, SDS of cas: 77128-73-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zheng, Xuexue published the artcileCharacterization of key aroma compounds and relationship between aroma compounds and sensory attributes in different aroma types of Fu brick tea, Formula: C8H10O2, the publication is Food Chemistry: X (2022), 100248, database is CAplus and MEDLINE.

Aroma is one of the most important sensory properties of tea. Floral-fungal aroma type, ripe-fungal aroma type and fresh-fungal aroma type were the main aroma types of Fu brick tea by QDA. A total of 112 volatile compounds were identified and quantified in tea samples by HS-SPME/GC-MS anal. Ten voaltiles in floral-fungal aroma type, eleven voaltiles in ripe-fungal aroma type, and eighteen voaltiles in fresh-fungal aroma type were identified as key aroma compounds for the aroma characteristics formation in three aroma types of Fu brick tea. In addition, PLS anal. revealed that 3,4-dehydro-β-ionone, dihydro-β-ionone, (+)-carotol and linalool oxide II were the key contributors to the ′floral and fruity′ attribute, α-terpineol contributed to woody and stale attributes, and thirteen aroma compounds related to green attribute. Taken together, these findings will provide new insights into the formation mechanism of different aroma characteristics in Fu brick tea.

Food Chemistry: X published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C7H16ClNO2, Formula: C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yang, Yue-Qin published the artcileNitrogen-doped carbon anchored ruthenium nanoparticles for biofuel upgrade, Safety of 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Fuel (2022), 123100, database is CAplus.

The development of efficient catalysts is of great significance for the hydrodeoxygenation (HDO) of renewable biomass into value-added biofuel and chems. to mitigate the environmental and energy menace. Herein, we report a sustainable strategy to fabricate ruthenium nanoparticles (NPs) anchored on defective nitrogen-doped carbon (Ru@NC) via a facile pyrolysis of a mixture of ruthenium trichloride and urea with carbon support. The highly distributed Ru NPs, constituted by N-enriched graphene shells, have been established as an excellent catalyst for the selective HDO of lignin- and furan- derivatives toward biofuel upgrade. Impressively, Ru@NC exhibits enhanced catalytic performance to com. Ru/C, which could be attributed to the presence of the ensemble effects resulting from defective graphene sheet coverage on the Ru surface. Notably, the prepared catalyst was not affected after five successive reaction cycles, demonstrating superior stability and reproducibility. We envision that this work may pave the way for the development of highly efficient novel metal catalysts for heterogeneous catalytic HDO reactions in sustainable energy conversion.

Fuel published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C13H10O3, Safety of 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhao, Yun-Peng published the artcileSequential Extraction and Thermal Dissolution of Baiyinhua Lignite in Isometric CS₂/Acetone and Toluene/Methanol Binary Solvents, Formula: C4H10O2, the publication is Energy & Fuels (2016), 30(1), 47-53, database is CAplus.

Baiyinhua lignite (BL) was sequentially extracted and thermally dissolved in isometric CS₂/acetone and toluene/methanol binary solvents to obtain an extract in isometric CS₂/acetone (E_ICA) and a soluble portion (SP) in isometric toluene/methanol (SP_ITM). The yields of E_ICA and SP_ITM are notably higher than the total extract yield from sequential extraction with CS₂ and acetone (or acetone and CS₂) and the total SP yield from sequential thermal dissolution in toluene and methanol (or methanol and toluene), indicating that there exists an obvious synergic effect between CS₂ and acetone during the extraction and between toluene and methanol during the thermal dissolution E_ICA and SP_ITM mainly consist of hydrocarbons and oxygen-containing organic species, resp. Little difference in Fourier transform IR spectroscopy spectra of BL and its extraction residue was observed, while the intensities of absorbances assigned to the phenolic OH, C=O, and C-O/C-O-C groups of the thermal dissolution residue are obviously lower than those of BL and its extraction residue. XPS anal. shows that C-O/C-O-C groups in BL remarkably decreased after thermal dissolution, corresponding to the abundant phenols dissolved in SP_ITM. The difference in weight loss between BL and its extraction residue is close to the yield of E_ICA, while the difference in weight loss between extraction and thermal dissolution residues is significantly lower than the yield of SP_ITM.

Energy & Fuels published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C8H16O2, Formula: C4H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lin, Min published the artcileGreen and efficient epoxidation of propylene with hydrogen peroxide (HPPO process) catalyzed by hollow TS-1 zeolite: A 1.0 kt/a pilot-scale study, Safety of 2-Methoxypropan-1-ol, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2016), 370-375, database is CAplus.

The propylene epoxidation catalyzed by hollow TS-1 zeolite with 30 wt% H₂O₂ solution as oxidant at 1.0 kt/a pilot plant has been examined Rising reaction temperature is in favor of increasing TOF of H₂O₂ but reduces the selectivity of PO, due to the promotion of major and side reactions at the same time. Enhancing the CH₃OH amount and the WHSV of H₂O₂ is preferential to improving the TOF of H₂O₂ and the selectivity of PO, but increase capital and energy consumption as well. Taking all into consideration, the optimized epoxidation has been confirmed: T is 40-50 °C; molar ratio of CH₃OH/H₂O₂ is 5-15, and the WHSV of H₂O₂ is more than 1.2 h^-1. When the epoxidation of propylene carried out over 6000 h, the TOF of H₂O₂ is 30.9-32.2 mmol g^-1 h^-1 and the PO selectivity is 96-99%, resp. The final PO product from this plant is at 99.97% purity, which has been used as an intermediate to synthesize kinds of chems.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Safety of 2-Methoxypropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem