Month: December 2022

Li, Yonglong published the artcileTunable Photocatalytic Two-Electron Shuttle between Paired Redox Sites on Halide Perovskite Nanocrystals, Category: ethers-buliding-blocks, the publication is ACS Catalysis (2022), 12(10), 5903-5910, database is CAplus.

Perovskite semiconductors as advanced solar energy-converting materials are promising catalysts for photoredox organic synthesis. Despite the high concentration of charge carriers generated on the perovskite surface, efficient utilization of these nonequilibrium and shambolic energetic carriers to trigger a chem. reaction remains a hot and challenging subject. Here, we report a photon-mediated electron shuttle between paired redox sites on perovskite nanocrystals for the reformation of highly stable carbon-halogen bonds, where both surface electrons and holes are utilized simultaneously. The photo-redox cascade can be effortlessly tailored by precise control of the surface-reducing/-oxidizing reaction rates, which unlocks the transformation for a wide range of (het)arenes. This work demonstrates colloidal perovskite photocatalysts for the direct installation of more than 10 different synthetically important functional groups onto arenes and heteroarenes.

ACS Catalysis published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lu, Qixing published the artcileC-H heteroarylation of aromatics via catalyst free S_N2′ coupling cycloaromatization, HPLC of Formula: 93-04-9, the publication is Green Chemistry (2022), 24(11), 4399-4404, database is CAplus.

The construction of a carbon-carbon bond is the most fundamental aspect of synthetic chem. In this study, authors developed a catalyst-free S_N2′ reaction of β-OTf-substituted enamides with aromatics to obtain aryl-substituted aza-1,4-dicarbonyl compounds that can be in situ transformed into aryl-imidazole, aryl-thiazole, and aryl-oxazole in one-pot operation, thus achieving C-H heteroarylation of aromatics This simple, efficient, clean and scalable strategy, which provides difficult-to-realize biaryl products, is compatible with various aromatics having varying complexities. This method can be used for the late-stage modification of various com. pharmaceuticals or functional materials and offers an orthogonal approach for constructing biaryl compounds

Green Chemistry published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, HPLC of Formula: 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Proctor, Angela published the artcileDevelopment of a Peptidase-Resistant Substrate for Single-Cell Measurement of Protein Kinase B Activation, Recommanded Product: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, the publication is Analytical Chemistry (Washington, DC, United States) (2012), 84(16), 7195-7202, database is CAplus and MEDLINE.

An iterative design strategy using three criteria was utilized to develop a peptidase-resistant substrate peptide for protein kinase B. Libraries of peptides possessing non-native amino acids were screened for time to 50% phosphorylation, degradation half-life within a lysate, and appearance of a dominant fragment. The lead peptide possessed a half-life of 92 ± 7 and 16 ± 2 min in HeLa and LNCaP cytosolic lysates, resp., representing a 4.6- and 2.7-fold lifetime improvement over that of the starting peptide. The redesigned peptide possessed a 4.5-fold improvement in phosphorylation efficiency compared to the starting peptide. The same peptide fragments were formed when the lead peptide was incubated in a lysate or loaded into single cells although the fragments formed in significantly different ratios suggesting that distinct peptidases metabolized the peptide in the two preparations The rate of peptide degradation and phosphorylation was on average 0.1 ± 0.2 zmol pg^-1 s^-1 and 0.04 ± 0.08 zmol pg^-1 s^-1, resp., for single LNCaP cells loaded with 4 ± 8 μM of peptide. Peptidase-resistant kinase substrates should find widespread utility in both lysate-based and single-cell assays of kinase activity.

Analytical Chemistry (Washington, DC, United States) published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Recommanded Product: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Proctor, Angela published the artcileMetabolism of peptide reporters in cell lysates and single cells, Application of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, the publication is Analyst (Cambridge, United Kingdom) (2012), 137(13), 3028-3038, database is CAplus and MEDLINE.

The stability of an Abl kinase substrate peptide in a cytosolic lysate and in single cells was characterized. In the cytosolic lysate, the starting peptide was metabolized at an average initial rate of 1.7 ± 0.3 zmol pg^-1 s^-1 with a t_1/2 of 1.3 min. Five different fragments formed over time; however, a dominant cleavage site was identified. Multiple rational design cycles were utilized to develop a lead peptide with a phenylalanine and alanine replaced by an (N-methyl)phenylalanine and isoleucine, resp., to attain cytosolic peptidase resistance while maintaining Abl substrate efficacy. This lead peptide possessed a 15-fold greater lifetime in the cytosolic lysate while attaining a 7-fold improvement in k_cat as an Abl kinase substrate compared to the starting peptide. However, when loaded into single cells, the starting peptide and lead peptide possessed nearly identical degradation rates and an altered pattern of fragmentation relative to that in cell lysates. Preferential accumulation of a fragment with cleavage at an Ala-Ala bond in single cells suggested that dissimilar peptidases act on the peptides in the lysate vs. single cells. A design strategy for peptide stabilization, analogous to that demonstrated for the lysate, should be effective for stabilization in single cells.

Analyst (Cambridge, United Kingdom) published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Application of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xiao, Juan-Ding published the artcileModulating acid-base properties of ZIF-8 by thermal-induced structure evolution, Formula: C4H10O2, the publication is Journal of Catalysis (2022), 165-173, database is CAplus.

Development of strategies to tune up acid-base property of MOF-based materials at the at. level has been recognized as one of the fascinating research topics in MOF chem. Traditional methodologies focus on the fine adjustment of the elaborately chosen metal nodes and organic linkers, as well as the post-synthetic modification of MOF pores and skeletons, which are diversified while complicated. Here, the acid-base property of ZIF-8-T has been tuned simply by changing the calcination temperature (T). The catalysts show negligible Lewis acidity when T lower than 540°C; whereas an gradually increased Lewis acidity appears with calcination T higher than this value. It is found that ZIF-8-610 catalyst calcined at 610°C offers a superior catalytic activity, 200.1 h-1 in the hydroxylation of epoxide. The high-performance catalyst exhibit both acid and base sites, which show synergistical effect in the catalytic reaction. The work provides us a deeper understanding on the “structure-acid-base property” relation in MOFs and MOF-derived catalysts.

Journal of Catalysis published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C8H13NO3, Formula: C4H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kim, Yong-Jae published the artcileSynthetic Studies of Complex Immunostimulants from Quillaja saponaria: Synthesis of the Potent Clinical Immunoadjuvant QS-21A_api, Synthetic Route of 99438-28-5, the publication is Journal of the American Chemical Society (2006), 128(36), 11906-11915, database is CAplus and MEDLINE.

QS-21 is one of the most promising new adjuvants for immune response potentiation and dose-sparing in vaccine therapy given its exceedingly high level of potency and its favorable toxicity profile. Melanoma, breast cancer, small cell lung cancer, prostate cancer, HIV-1, and malaria are among the numerous maladies targeted in more than 80 recent and ongoing vaccine therapy clin. trials involving QS-21 as a critical adjuvant component for immune response augmentation. QS-21 is a natural product immunostimulatory adjuvant, eliciting both T-cell- and antibody-mediated immune responses with microgram doses. Herein is reported the synthesis of QS-21A_api in a highly modular strategy, applying novel glycosylation methodologies to a convergent construction of the potent saponin immunostimulant. The chem. synthesis of QS-21 offers unique opportunities to probe its mode of biol. action through the preparation of otherwise unattainable nonnatural saponin analogs.

Journal of the American Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Synthetic Route of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Xiaochen published the artcileEpoxide hydrolysis and alcoholysis reactions over crystalline Mo-V-O oxide, Product Details of C4H10O2, the publication is RSC Advances (2016), 6(75), 70842-70847, database is CAplus.

Crystalline Mo-V-O oxides have been used as a catalyst for the hydrolysis and alcoholysis of propylene oxide to diols such as 1,2-cyclohexanediol, 1-phenylethane-1,2-diol, 3-chloro-1,2-propanediol, etc. and ethers such as 1-(tert-butoxy)propan-2-ol, 1-(cyclohexyloxy)propan-2-ol, 1-(benzyloxy)propan-2-ol, etc. resp. Relationships between the active crystal facet, the acidity of Mo-V-O catalysts and the activity have been established. The results indicate that the a-b plane is the active facet for the hydrolysis reaction.

RSC Advances published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C9H7NO2, Product Details of C4H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liang, Jing published the artcileNano WO₃-Catalyzed One-Pot Process for Mild Oxidative Depolymerization of Lignin and its Model Compounds, HPLC of Formula: 183303-74-4, the publication is ChemCatChem (2021), 13(17), 3836-3845, database is CAplus.

Despite challenges related to the robust and irregular structure of lignin, the valorization of this aromatic biopolymer has aroused great interest. However, the current methods exhibit problems such as harsh reaction conditions, complicated operation, and difficult recovery of catalyst. Herein we present a one-pot process for the mild oxidative depolymerization of lignin and lignin model compounds catalyzed by nano WO₃, along with tert-Bu hydrogen peroxide (TBHP) as the oxidant and NaOH as the additive, which exhibits advantages of both homogeneous and heterogeneous catalysis. Under the optimized condition, it yielded 80.4 wt % of liquid oil from organosolv lignin with 7.6 wt % of vanillic acid as the main monomer product, accounting for 91.6 wt % monomeric selectivity. Mechanism studies on the model substrate suggest that the reaction proceeds via an oxidation of C_α-OH to C=O followed by C-O bond cleavage to afford phenol and ketone products which may undergo further oxidation to produce aromatic carboxylic acids. We have developed an operationally simple procedure for mild fragmentation of lignin and lignin model compounds with excellent yields, which provides the potential to expand the existing lignin usage from energy source to value-added commodity chems.

ChemCatChem published new progress about 183303-74-4. 183303-74-4 belongs to ethers-buliding-blocks, auxiliary class Benzene,Alcohol,Ether, name is 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol, and the molecular formula is C16H18O4, HPLC of Formula: 183303-74-4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mu, Jianlou published the artcilePhenolics from sea buckthorn (Hippophae rhamnoides L.) modulate starch digestibility through physicochemical modifications brought about by starch – Phenolic molecular interactions, Category: ethers-buliding-blocks, the publication is LWT–Food Science and Technology (2022), 113682, database is CAplus.

The phenolics from sea buckthorn (SP) exert various physiol. functions. This study examined the interactions of SP on the digestive and physicochem. properties of rice (RS) and wheat starch (WS), as well as the stability of starch-phenolics during digestion. The predominant phenolics from SP were syringic acid (22.14%), gallic acid (15.23%), and catechin (11.45%). The addition of SP manipulated the rheol. of starch pastes and affected the rearrangement and multi-scale structures of starch gels. Fourier transform IR spectroscopy and X-ray diffraction revealed that SP interacted with starch mainly through non-covalent hydrogen bonds, leading to a loose starch gel structure. The content of rapidly digestible starch of RS and WS decreased by 5.66% and 7.75%; the predicted glycemic index of RS (91.65) and WS (89.34) decreased to 81.81 and 80.84, resp., when the addition level of SP reached 15%, due to the inhibition activity of SP against digestive enzymes, as well as the mol. reorganisation of starch. After the in vitro digestion, the bioaccessibility of SP in starch gels increased by a magnitude of 2.58-fold (RS) and 2.98-fold (WS). These results provide evidence of using SP as functional formulations in controlling gel-like foods structure behaviors and modulating the glycemic response of starchy foods.

LWT–Food Science and Technology published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Luo, Huihui published the artcileCobalt Nanoparticles-Catalyzed Widely Applicable Successive C-C Bond Cleavage in Alcohols to Access Esters, Name: 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol, the publication is Angewandte Chemie, International Edition (2020), 59(43), 19268-19274, database is CAplus and MEDLINE.

Selective cleavage and functionalization of C-C bonds have important applications in organic synthesis and biomass use. However, functionalization of C-C bonds by controlled cleavage remains difficult and challenging because they are inert. Herein, the authors describe an unprecedented efficient protocol for the breaking of successive C-C bonds in alcs. to form esters with one or multiple carbon atoms less using heterogeneous cobalt nanoparticles as catalyst with dioxygen as the oxidant. A wide range of alcs. including inactive long-chain alkyl aryl alcs. undergo smoothly successive cleavage of adjacent -(C-C)_n– bonds to afford the corresponding esters. The catalyst was used for seven times without any decrease in activity. Characterization and control experiments disclose that cobalt nanoparticles are responsible for the successive cleavage of C-C bonds to achieve excellent catalytic activity, while the presence of Co-N_x has just the opposite effect. Preliminary mechanistic studies reveal that a tandem sequence reaction is involved in this process.

Angewandte Chemie, International Edition published new progress about 183303-74-4. 183303-74-4 belongs to ethers-buliding-blocks, auxiliary class Benzene,Alcohol,Ether, name is 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol, and the molecular formula is C16H18O4, Name: 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem