Month: December 2022

Wang, Hualin published the artcileSynthesis and optical properties of an alternating copolymer composed of MEHPV and 1,3,4-oxadiazole, Quality Control of 146370-51-6, the publication is Journal of Southeast University (English Edition) (2008), 24(2), 238-242, database is CAplus.

A poly (p-phenylenevinylene) (PPV) alternating copolymer, poly [(2, 5-diphenylene-1, 3, 4-oxadiazole) 44′ – vinylene-alt-2-methoxy-5-(2-ethylhexyloxy)-1, 4-phenylenevinylene] (oxa-MEHPV), is synthesized by Heck coupling reaction and characterized with UV-vis, Fourier transform IR (FT-IR), ¹H-NMR and photoluminescence (PL) spectroscopy. oxa-MEHPV possesses an outstanding thermal stability and shows excellent solubility in common organic solvents such as dichloromethane, chloroform, toluene, and tetrahydrofuran(THF). The introduction of the electron-deficient 1, 3, 4-oxadiazole units into the MEH-PPV backbone also increases the electron affinities of the conjugated segment, which leads to the blue-shift of the maximum absorption wavelength and makes the polymer have a high optical band-gap energy, good electron-transporting stability and high PL quantum yield.

Journal of Southeast University (English Edition) published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C4H3Cl2N3, Quality Control of 146370-51-6.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lu, Shu-Ning published the artcileMetal-free Synthesis of 5-Trifluoromethyl-1,2,4-triazoles via elemental sulfur promoted oxidative cyclization of trifluoroacetimidohydrazides with benzylic and aliphatic amines, Related Products of ethers-buliding-blocks, the publication is Molecular Catalysis (2022), 112336, database is CAplus.

An elemental sulfur-mediated oxidative cyclization of readily available trifluoroacetimidohydrazides and aliphatic amines has been achieved, which provided a direct avenue to structurally diverse 5-trifluoromethyl-1,2,4-triazoles. In this transformation, sulfur acts as a traceless oxidizing agent. A myriad of benzyl amines and tertiary aliphatic amines were tolerated in this protocol. The reaction can be scaled up easily and also been applied to build GlyT1 inhibitor as an example of bio-active mol.

Molecular Catalysis published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Jintong published the artcileNickel-Catalyzed Enantioselective Arylative Activation of Aromatic C-O Bond, COA of Formula: C11H10O, the publication is Journal of the American Chemical Society (2021), 143(44), 18380-18387, database is CAplus and MEDLINE.

The pioneering nickel-catalyzed cross-coupling of C-O electrophiles was unlocked by Wenkert in the 1970s; however, the transition-metal-catalyzed asym. activation of aromatic C-O bonds has never been reported. Herein the first enantioselective activation of an aromatic C-O bond is demonstrated via the catalytic arylative ring-opening cross-coupling of diarylfurans. This transformation is facilitated via nickel catalysis in the presence of chiral N-heterocyclic carbene ligands, and chiral 2-aryl-2′-hydroxy-1,1′-binaphthyl (ArOBIN) skeletons are delivered axially in high yields with high ee. Moreover, this versatile skeleton can be transformed into various synthetic useful intermediates, chiral catalysts, and ligands by using the CH- and OH-based modifiable sites. This chem. features mild conditions and good atom economy.

Journal of the American Chemical Society published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C9H6FNO, COA of Formula: C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liu, Zhuqing published the artcilePhIO-Mediated Oxidative C=C Bond Cleavage and Reassembly toward Highly Functionalized Oxazolones, Category: ethers-buliding-blocks, the publication is Organic Letters (2022), 24(6), 1323-1328, database is CAplus and MEDLINE.

An efficient PhIO-mediated oxidative C = C bond cleavage and reassembly of enaminone toward oxazolone I [R¹ = Ph, 3-MeC₆H₄, 4-MeC₆H₄, etc.; R² = Me, Et; R³ = Bn, 2-MeOC₆H₄, CH₂CH₂Ph, etc.] with high regioselectivity was reported. DFT calculations revealed that the reaction proceeded through oxygen atom transfer, C = C bond cleavage, alkylthio migration, and reassembly cascade. This strategy was highlighted by high atom and step economy with formation of five bonds in one pot and generation of high-valued oxazolone skeleton under mild conditions.

Organic Letters published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhu, Runqing published the artcilepara-selective hydroxylation of alkyl aryl ethers, Quality Control of 2944-47-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(97), 13190-13193, database is CAplus and MEDLINE.

Para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(II) catalyst, hypervalent iodine(III) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile and efficient method for preparing clin. drugs monobenzone and pramocaine on a gram scale.

Chemical Communications (Cambridge, United Kingdom) published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C15H20O6, Quality Control of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Wenxuan published the artcileEnantioselective Friedel-Crafts Reaction of 2-Alkynyphenols with Aromatic Ethers by Chiral Bronsted Acid Catalysis, Category: ethers-buliding-blocks, the publication is Journal of Organic Chemistry (2022), 87(14), 9100-9111, database is CAplus and MEDLINE.

Herein, authors report chiral strong Bronsted acid-catalyzed enantioselective Friedel-Crafts reaction of 2-alkynyphenols with aromatic ethers. The reaction affords the corresponding axially chiral styrenes in up to 91% yield and 97% ee.

Journal of Organic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C15H24S, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Bao published the artcileVapor Liquid Equilibrium for the Binary of 1-Methoxy-2-propanol + 1,2-Propanediol and 2-Methoxy-1-propanol + 1,2-Propanediol at 101.3 kPa and 50.0 kPa, Quality Control of 1589-47-5, the publication is Journal of Chemical & Engineering Data (2020), 65(11), 5110-5117, database is CAplus.

The isobaric vapor-liquid equilibrium (VLE) data of 1-methoxy-2-propanol (PM) + 1,2-propanediol (PG) and 2-methoxy-1-propanol (MP) + 1,2-propanediol (PG) was measured in this work by a modified Rose-Williams still under pressures of 101.3 kPa and 50.0 kPa. The Wisniak test and the Van Ness test were applied to confirm the thermodn. consistency of the VLE data. The exptl. isobaric VLE data were correlated by the nonrandom two-liquid and universal quasichem. models. The experiment results showed that these two models perfectly correlate the measured VLE data.

Journal of Chemical & Engineering Data published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Quality Control of 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Danov, S. M. published the artcileMathematical modeling of the vapor-liquid equilibrium in the system of products of propylene oxide synthesis in methanol medium, COA of Formula: C4H10O2, the publication is Vestnik MITKHT (2012), 7(1), 36-41, database is CAplus.

Comparison of literature and calculated data on vapor-liquid equilibrium for systems formed by products of propylene oxide synthesis was carried out. On the basis of NRTL and UNIQUAC models the literature data on vapor-liquid equilibrium for the investigated systems were optimized. The model parameters and their deviations were estimated The corresponding phase diagrams were calculated and plotted.

Vestnik MITKHT published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, COA of Formula: C4H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Thavornsin, Nopparat published the artcileDirect synthesis of poly(p-phenyleneethynylene)s from calcium carbide, Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, the publication is Polymer Chemistry (2014), 5(1), 48-52, database is CAplus.

An efficient method for the preparation of poly(p-phenyleneethynylene)s (PPEs) from direct coupling reactions between aryl diiodides and the inexpensive chem. feedstock calcium carbide was developed. A variety of PPEs can be prepared in high yields (71-93%) with the d.p. between 36 and 128, offering fluorescence quantum efficiencies in the range of 0.34-0.71.

Polymer Chemistry published new progress about 146370-51-6. 146370-51-6 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 1-((2-Ethylhexyl)oxy)-4-methoxybenzene, and the molecular formula is C18H12ClNO, Recommanded Product: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Narita, Koichi published the artcileSynthesis and evaluation of trypanocidal activity of derivatives of naturally occurring 2,5-diphenyloxazoles, Synthetic Route of 6850-57-3, the publication is Bioorganic & Medicinal Chemistry (2021), 116253, database is CAplus and MEDLINE.

African trypanosomiasis is a zoonotic protozoan disease affecting the nervous system. Various natural products reportedly exhibit trypanocidal activity. Naturally occurring 2,5-diphenyloxazoles present in Oxytropis lanata, and their derivatives, were synthesized. The trypanocidal activities of the synthesized compounds were evaluated against Trypanosoma brucei brucei, T. b. gambiense, T. b. rhodesiense, T. congolense, and T. evansi. Natural product 1 exhibited trypanocidal activity against all the species/subspecies of trypanosomes, exhibiting half-maximal inhibitory concentrations (IC50) of 1.1-13.5μM. Modification of the oxazole core improved the trypanocidal activity. The 1,3,4-oxadiazole (7) and 2,4-diphenyloxazole (9) analogs exhibited potency superior to that of 1. However, these compounds exhibited cytotoxicity in Madin-Darby bovine kidney cells. The O-methylated analog of 1 (12) was non-cytotoxic and exhibited selective trypanocidal activity against T. congolense (IC50 = 0.78μM). Structure-activity relationship studies of the 2,5-diphenyloxazole analogs revealed aspects of the mol. structure critical for maintaining selective trypanocidal activity against T. congolense.

Bioorganic & Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Synthetic Route of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem