Month: December 2022

Bates, Roderick W. published the artcileTetrahydropyran synthesis by intramolecular conjugate addition to enones: synthesis of the clavosolide tetrahydropyran ring, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Synthesis (2010), 2935-2942, database is CAplus.

The synthesis of a tetrahydropyran intermediate for clavosolide A is reported, employing a combination of cross-metathesis and intramol. oxa-Michael addition The intramol. oxa-Michael addition to α,β-unsaturated esters requires the use of strong bases and can result in either modest yields or stereo-isomeric mixtures, and can be highly variable according to the substrate structure. In contrast, the corresponding ketones cyclize under very mild conditions to give the 2,6-cis-isomers directly. The use of appropriately substituted ketones allows efficient conversion into esters.

Synthesis published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liu, Chao published the artcileRapid construction of C4-substituted phenanthridinones through palladium-catalyzed domino N-arylation/aryl-aryl coupling process, Synthetic Route of 6850-57-3, the publication is Molecular Catalysis (2021), 111766, database is CAplus.

An excellent chemo- and regioselective palladium-catalyzed cascade intermol. N-arylation/aryl-aryl coupling process had been developed. Employing Pd(TFA)₂, PCy₃•HBF₄, K₂CO₃ and 1,4-dioxane in an oil bath at 100°C for 12 h, diverse C4-substituted phenanthridinones I [R = H, Me, OMe; R¹ = Me, Ph, 2-thienyl, etc.; R² = H, Me, OMe, F] were synthesized from o-bromobenzamides in 42-92% yield. Broad substrate scope and excellent functional group tolerance were observed The synthetic utility of this method was illustrated by the further derivatization to prepare multiple-substituted phenanthridinones II [R³ = Et, Bn, 1-adamantyl] in 30-75% yield.

Molecular Catalysis published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Synthetic Route of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ashirov, Timur published the artcileSalt-Templated Solvothermal Synthesis of Dioxane-Linked Three-Dimensional Nanoporous Organic Polymers for Carbon Dioxide and Iodine Capture, Safety of 1,2-Dimethoxybenzene, the publication is ACS Applied Nano Materials, database is CAplus.

Precise control over the textural properties of porous organic polymers, POPs, is a daunting task, yet highly important to achieve desired porosity and pore connectivity for the target applications. Accordingly, the introduction of hard templates in the solvothermal synthesis of POPs could help to control the surface area and pore size without altering their chem. structure. In this direction, here, we synthesized a dioxane linked 3D tetraphenylene-based nanoporous organic polymer (3D-tPOP) using low-cost and readily available NaCl salt as a hard template under solvothermal conditions. The presence of hard template enhanced the surface area and enabled control over the morphol., micropore/mesopore ratio as well as the pore volume with respect to the template amount Whereas micron-sized NaCl templates facilitated the surface growth of a microporous polymer network, nanosized NaCl crystallites led to formation of mesopores. The resulting 3D-tPOPs showed tunable micropore/mesopore ratios and surface areas in the range of 349 to 1058 m² g^-1 with a linear correlation to the template amount High CO₂ uptake capacity of 5.02 mmol g^-1 at 273 K, 1 bar and iodine uptake capacity of 1180 mg g^-1 were observed for 3D-tPOPs with micropore and mesopore ratios of 50.2% and 71.4%, resp.

ACS Applied Nano Materials published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Qinghe published the artcileSynthesis of diaryliodonium tetrafluoroborates, Recommanded Product: 2-Isopropylanisole, the publication is Zhongguo Yaowu Huaxue Zazhi (2000), 10(4), 288-289, database is CAplus.

Two diaryliodonium tetrafluoroborates bis(3-isopropyl-4-methoxyphenyl)iodonium tetrafluoroborate and bis(4-methoxyphenyl)iodonium tetrafluoroborate were synthesized by iodination of 2-isopropylphenyl Me ether or methoxybenzene in acetic anhydride in the presence of HNO₃ and trifluoroacetic acid at -30° and salification with NaBF₄.

Zhongguo Yaowu Huaxue Zazhi published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C8H6ClN, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hirner, Sebastian published the artcileMicrowave-assisted rearrangement of vinylaziridines to 3-pyrrolines: formal synthesis of (-)-anisomycin, Safety of (+)-B-Methoxydiisopinocampheylborane, the publication is Synlett (2005), 3099-3102, database is CAplus.

An efficient microwave-assisted rearrangement of activated vinylaziridines to 3-pyrrolines is described. The rearrangement proceeds in good to excellent yields and is mediated by NaI or LiI in MeCN at elevated temperatures The synthetic utility of this reaction is shown in an efficient formal total synthesis of the antibiotic (-)-anisomycin.

Synlett published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Safety of (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

De Rosa, Margherita published the artcileA three-step and enantioselective synthesis of (-)-(S)- or (+)-(R)-2-(furan-3-yl)-3,6-dihydro-2H-pyrans, HPLC of Formula: 99438-28-5, the publication is Tetrahedron Letters (2000), 41(10), 1593-1596, database is CAplus.

Enantiomerically enriched (3-furyl)-2-pyran derivatives, e.g. I, key-intermediates in the synthesis of the pharmacophoric pyranofuranone system of the bioactive natural products manoalide and cacospongionolide B, are easily accessible by a rapid sequence involving a chiral allylation and a ring closing metathesis reaction.

Tetrahedron Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, HPLC of Formula: 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Leonardi, G. published the artcileInteraction between pharmaceuticals and sodium poly(ethylenesulfonate), Category: ethers-buliding-blocks, the publication is Journal of Pharmaceutical Sciences (1966), 55(5), 526-8, database is CAplus.

The interaction of several drugs, mainly local anesthetics, with Na poly(ethylenesulfonate) was studied by means of membrane equilibrium dialysis measurements. Data on equilibrium constants of the association between the drugs considered, as hydrochlorides, and the polyelectrolyte are reported.

Journal of Pharmaceutical Sciences published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Knorrscheidt, Anja published the artcileAccessing chemo- and regioselective benzylic and aromatic oxidations by protein engineering of an unspecific peroxygenase, COA of Formula: C11H10O, the publication is ACS Catalysis (2021), 11(12), 7327-7338, database is CAplus and MEDLINE.

Unspecific peroxygenases (UPOs) enable oxyfunctionalizations of a broad substrate range with unparalleled activities. Tailoring these enzymes for chemo- and regioselective transformations represents a grand challenge due to the difficulties in their heterologous productions. Herein, we performed protein engineering in Saccharomyces cerevisiae using the MthUPO from Myceliophthora thermophila. More than 5300 transformants were screened. This protein engineering led to a significant reshaping of the active site as elucidated by computational modeling. The reshaping was responsible for the increased oxyfunctionalization activity, with improved k_cat/K_m values of up to 16.5-fold for the model substrate 5-nitro-1,3-benzodioxole. Moreover, variants were identified with high chemo- and regioselectivities in the oxyfunctionalization of aromatic and benzylic carbons, resp. The benzylic hydroxylation was demonstrated to perform with enantioselectivities of up to 95% ee. The proposed evolutionary protocol and rationalization of the enhanced activities and selectivities acquired by MthUPO variants represent a step forward toward the use and implementation of UPOs in biocatalytic synthetic pathways of industrial interest.

ACS Catalysis published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, COA of Formula: C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Krueger, Peter J. published the artcileAmino group stretching vibrations in primary acid amides, Computed Properties of 16332-06-2, the publication is Canadian Journal of Chemistry (1967), 45(14), 1611-18, database is CAplus.

Most primary alkyl, primary α-substituted alkyl, and primary aromatic acid amides exhibit three sharp concentration and temperature dependent absorption bands at 3518 ± 3, 3504 ± 4, and 3486 ± 8 cm.-1, in dilute (0.003M or less) CCl4 solution, just below the fundamental antisymmetric NH2 stretching vibration. These are tentatively assigned to the shifted antisymmetric NH2 stretching vibration in cyclic dimers, cyclic trimers, and cyclic tetramers resp., with increasing NH…O hydrogen bond strength. In all alkyl amides the antisymmetric NH2 band intensity exceeds the symmetric band intensity. Conjugation of the CONH2 group with π-electron systems reverses this intensity relation, except where the acidic NH2 group can form intramol. H bonds. These observations substantiate the previously published views on the nature of the vibrational mechanism of the NH2 group. No evidence is found for enolization of amides in CCl4 solution 31 references.

Canadian Journal of Chemistry published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Computed Properties of 16332-06-2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dinh, Tam Q. published the artcileAnalogs Incorporating trans-4-Hydroxy-L-proline That Reverse Multidrug Resistance Better than Hapalosin, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Journal of Organic Chemistry (1997), 62(4), 790-791, database is CAplus.

Hydroxyproline-containing hapalosin analogs I [R = H, CH₂C₆H₄OMe (PMB); R¹ = H, CONHCH₂Ph] were prepared in several steps starting from trans-4-hydroxy-L-proline. Whereas the PMB ether of hapalosin possesses substantially lower lower anti-multidrug resistance activity than hapalosin, analogs I (R = PMB, R¹ = H; R = H, R¹ = CONHCH₂Ph) reverse multidrug resistance better than hapalosin, while I (R = = R¹ = H; R = PMB, R¹ = CONHCH₂Ph) were less effective that hapalosin. These results suggest that a free hydroxyl and an aromatic group may be important in the multidrug resistance activity of hapalosin and its analogs.

Journal of Organic Chemistry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem