Month: December 2022

Nakib, Rifka published the artcileRetama sphaerocarpa, Atractylis serratuloides and Eruca sativa honeys from Algeria: Pollen dominance and volatile profiling (HS-SPME/GC-MS), Application In Synthesis of 91-16-7, the publication is Microchemical Journal (2022), 107088, database is CAplus.

The volatile fraction of three monofloral honey types produced in arid and semiarid areas of Algeria was studied to establish a link between their chem. composition and their botanical origin. Palynol. anal. was performed to confirm the main botanical origin. Volatile extraction using HS-SPME coupled to GC-MS revealed exclusive components for each type: 1,6,10-dodecatrien-3-ol,3,7,11-trimethyl-, (E); 1,6-octadien-3-ol,3,7- dimethyl; phenol, 2-methoxy and 2-naphtalene methanol, decahydro-α,α,4a- trimethyl-8-methylene-, [2R-(2α,4aα,8a,8aβ)] for Atractylis honey, lilac aldehyde and lilac aldehyde D for Retama honey, and di-Me trisulfide for Eruca. The PCA anal. made it possible to correlate some volatile compounds with the most important pollen types, and to evaluate the authenticity related to the geog. and botanical origin of the honey.

Microchemical Journal published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Guan, Qingqing published the artcileBiodiesel from transesterification at low temperature by AlCl₃ catalysis in ethanol and carbon dioxide as cosolvent: Process, mechanism and application, Quality Control of 16332-06-2, the publication is Applied Energy (2016), 380-386, database is CAplus.

Finding a more efficient method for the transesterification of triglycerides to biodiesel fuel (BD) is important in today’s world. In this study, transesterification of trilaurin was carried out in a solution containing 4 wt% of the Lewis acid AlCl₃ dissolved in a cosolvent of ethanol and 5 MPa CO₂. A conversion rate of over 90% was achieved within 1 h at the low temperature of 180°C. The process indicates a co-catalytic effect of the Lewis acid and CO₂. We postulate several key steps for the mechanism. First, the CO₂-ethanol mixture enhances the hydrogen bonding, increasing the concentration of C₂H₅O^·. Second AlCl₃ attacks the oxygen of C-O-C to weaken the bonds to form carbonyl carbon OR1, which is then easily attacked by C₂H₅O^· to give the transesterified product (C₂H₄COOR1). Third, AlCl₃ is finally replaced by H to form glycerin (GL) and intermediates, such as unmethyl esterified compounds (uME). AlCl₃ was used as a flocculant and catalyst for converting waste cooking oil (WCO) to BD. The process achieved 97% free fatty acid (FFA) conversion at 120 °C in 90 min, making it one of the most efficient systems available for WCO recovery. AlCl₃ was also successfully applied to microalgae, signaling the potential for a process that combines harvesting, lipid extraction, and transesterification, leading to fully integrated, microalgae-based BD production

Applied Energy published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Quality Control of 16332-06-2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhu, Zhengrong published the artcileDesign and Application of a DNA-Encoded Macrocyclic Peptide Library, HPLC of Formula: 77128-73-5, the publication is ACS Chemical Biology (2018), 13(1), 53-59, database is CAplus and MEDLINE.

A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × 10¹² members composed of 4-20 natural and non-natural amino acids. Affinity-based selection was performed against two therapeutic targets, VHL and RSV N protein. On the basis of selection data, some peptides were selected for resynthesis without a DNA tag, and their activity was confirmed.

ACS Chemical Biology published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C3H7BrO2S, HPLC of Formula: 77128-73-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ibrahim, A. Mohammed published the artcileAntimicrobial new Schiff base polyesters: design, thermal, and structural characterizations, Recommanded Product: 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Polymer Bulletin (Heidelberg, Germany) (2022), 79(2), 1119-1132, database is CAplus.

In this work, a series of isovanillin-or syringaldehyde-based new Schiff base monomers were synthesized and polymerized using terephthaloyl chloride by solution condensation polymerization technique. Both the monomers and polymers were characterized by FT-IR, ¹H-NMR, and ¹³C-NMR. The thermal and mol. weight properties were determined by thermogravimetric anal. (TGA) and Gel permeation chromatog. (GPC). The antimicrobial activities of the polyesters were evaluated based on min. inhibition concentration against bacteria such as Escherichia coli, Vibrio parahaemolyticus, and staphylococcus aureus as well as fungi such as Candida albicans and Aspergillus niger. The results of inhibition zones showed that new Schiff base polyesters had good antimicrobial activity.

Polymer Bulletin (Heidelberg, Germany) published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Recommanded Product: 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sahiba, Nusrat published the artcileA facile biodegradable chitosan-SO₃H catalyzed acridine-1,8-dione synthesis with molecular docking, molecular dynamics simulation and density functional theory against human topoisomerase II beta and Staphylococcus aureus tyrosyl-tRNA synthetase, SDS of cas: 134-96-3, the publication is Journal of Molecular Structure (2022), 133676, database is CAplus.

An efficient and ecobenign pseudo one-pot multicomponent synthesis of I [R = Me, Et, Ph, etc,] was investigated using biodegradable and heterogeneous catalyst, chitosan-SO₃H under ambient reaction conditions. The highly proficient reaction of dimedone, aldehydes, and ammonium acetate in aqueous ethanol using chitosan-SO₃H catalyst at room temperature showed high yields in short reaction time. The bioactivity of mols. was further studied through mol. docking and mol. dynamics simulations, protein-ligand interaction energy calculations and DFT studies. Among all, acridinedione compounds I [R = 4-methoxyphenyl], I [R = 4-cyanophenyl], I [R = 4-hydroxyphenyl] and I [R = 4-(benzyloxy)phenyl] (- 10.8 kcal/mol), I [R = 3-nitrophenyl], I [R = 4-nitrophenyl], I [R = 3,4-dimethoxyphenyl]were the most potent against Human Topoisomerase II beta (3QX3) and Staphylococcus aureus (S. aureus) tyrosyl-tRNA synthetase (1JIJ), resp. and displayed good binding affinity and interaction pattern. Easy availability of substrate and catalyst, use of biodegradable and recyclable polymeric solid acid catalyst, avoid the use of toxic and metallic reagents, operational simplicity, no need of column chromatog., easy workup, clean reaction profile, high yields (70-95%) and purity in short time period (3-12 min) with wide substrate scope (32 derivatives including 10 novel) and broad spectrum of bioactivity are notable advantages of the present protocol.

Journal of Molecular Structure published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, SDS of cas: 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Moutaoukil, Zakaria published the artcileN-Alkylation of organonitrogen compounds catalyzed by methylene-linked bis-NHC half-sandwich ruthenium complexes, Formula: C13H14N2O, the publication is Organic & Biomolecular Chemistry (2022), 20(4), 831-839, database is CAplus and MEDLINE.

An efficient ruthenium-catalyzed N-alkylation of amines, amides and sulfonamides was developed employing novel pentamethylcyclopentadienylruthenium(II) complexes bearing the methylene linked bis(NHC) ligand bis(3-methylimidazol-2-ylidene)methane. The acetonitrile complex I was proved to be particularly effective with a broad range of substrates with low catalyst loading (0.1-2.5 mol%) and high functional group tolerance under mild conditions. A total of 52 N-alkylated organonitrogen compounds including biol. relevant scaffolds were synthesized from (hetero)aromatic and aliphatic amines, amides and sulfonamides using alcs. or diols as alkylating agents in up to 99% isolated yield, even on gram-scale reactions. In the case of sulfonamides, it was the first example of N-alkylation employing a transition-metal complex bearing NHC ligands.

Organic & Biomolecular Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Formula: C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Posada, Laura published the artcileFirst total synthesis of versicotide D and analogs, Recommanded Product: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, the publication is Tetrahedron Letters (2019), 60(48), 151281, database is CAplus.

The first total synthesis of cyclotetrapeptide versicotide D has been achieved in 21% overall yield using solid phase peptide synthesis and solution cyclization. In addition, in the search for candidates of antimalarial new drugs, one cyclic tetrapeptide analog which differs in the sequence, and four cyclic pentapeptide containing N-Me amino acids, were prepared The obtained compounds were evaluated against P. falciparum 3D7. Versicotide D showed low micromolar antiplasmodial activity.

Tetrahedron Letters published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Recommanded Product: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wei, Peter E. published the artcileNew vulcanizing agents for ethylene-propylene elastomers. III, Formula: C2H8Cl2N4S2, the publication is Rubber Chemistry and Technology (1966), 39(4), 1094-104, database is CAplus.

Perchloro-3a,4,7,7a-tetrahydro-4,7-methanonindene and perchloro-1,1′ -bis (2,2′ – cyclopentene) vulcanized ethylene-propylene rubber (I) when used in combination with S and Fe2O3. Vulcanization of I by octachlorocyclopentene (II)-S-Fe2O3 was enhanced by the presence of dithiodiformamidine-2HCl, phenylenediamine-HCl, diaminotoluene-2HCl, diaminophenol-2HCl, dichlorodimethylhydantoin, and trichloroisocyanuric acid. A vulcanization mechanism was given for the II-S-Fe2O3 system which proposes the formation of SF4, which abstracts H. Synergistic effects were observed with I vulcanization with II and tert-Bu2O2. The tensile strength of the polymers was most affected by the synergism.

Rubber Chemistry and Technology published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C8H15NO, Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chandrashekhar, Vishwas G. published the artcileSilica-supported Fe/Fe-O nanoparticles for the catalytic hydrogenation of nitriles to amines in the presence of aluminium additives, Computed Properties of 6850-57-3, the publication is Nature Catalysis (2022), 5(1), 20-29, database is CAplus.

The hydrogenation of nitriles to amines represents an important and frequently used industrial process due to the broad applicability of the resulting products in chem. and life sciences. Despite the existing portfolio of catalysts reported for the hydrogenation of nitriles, the development of iron-based heterogeneous catalysts for this process is still a challenge. Here, we show that the impregnation and pyrolysis of iron(II) acetate on com. silica produces a reusable Fe/Fe-O@SiO₂ catalyst with a well-defined structure comprising the fayalite phase at the Si-Fe interface and α-Fe nanoparticles, covered by an ultrathin amorphous iron(III) oxide layer, growing from the silica matrix. These Fe/Fe-O core-shell nanoparticles, in the presence of catalytic amounts of aluminum additives, promote the hydrogenation of all kinds of nitriles, including structurally challenging and functionally diverse aromatic, heterocyclic, aliphatic and fatty nitriles, to produce primary amines under scalable and industrially viable conditions.

Nature Catalysis published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Computed Properties of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Schmidt, A. C. published the artcileCrystal polymorphism of local anesthetic drugs. Part I: Pramocaine base in comparison with pramocaine hydrochloride, Application In Synthesis of 637-58-1, the publication is Journal of Thermal Analysis and Calorimetry (2003), 73(2), 397-408, database is CAplus.

Crystal polymorphs of pramocaine hydrochloride (PRCNC) and pramocaine (PRCN) free base were produced and characterized by means of thermomicroscopy, differential scanning calorimetry (DSC), FTIR- and FT-Raman-spectroscopy as well as x-ray-powder diffractometry. The relative thermodn. stabilities of all forms were determined and are represented in semi-schematic energy/temperature diagrams. PRCN, which is a viscous liquid at room temperature and insoluble in water, was found to exist in two different crystal forms with the m.ps. 23.5° (mod. I°) and 12.5° (mod. II). The water-soluble PRCNC crystallizes in three different crystal modifications. Mod. II° is the thermodynamically stable form at room temperature and is present in com. products. This form is obtained by crystallization from solvents and transforms on heating at about 95° into the high temperature form mod. I which melts at 171.0°. Both compounds show conformational polymorphism with forms of low kinetic stability.

Journal of Thermal Analysis and Calorimetry published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Application In Synthesis of 637-58-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem