Month: December 2022

Fraga, Gabriel published the artcileRole of Catalyst Support’s Physicochemical Properties on Catalytic Transfer Hydrogenation over Palladium Catalysts, COA of Formula: C8H10O2, the publication is ChemCatChem (2021), 13(24), 5191-5202, database is CAplus.

Catalytic transfer hydrogenation (CTH) is a promising reaction for valorisation of bio-based feedstocks via hydrogenation without needing to use H₂. Unlike standard hydrogenation, CTH occurs via dehydrogenation (DHD) of a hydrogen donor (H-donor) and hydrogenation (HYD) of a substrate. Therefore, the “ideal” CTH catalyst must balance the catalysis of both reactions to maximize the hydrogen transfer between H-donor and substrate with minimal H₂ loss to gas (high atom efficiency). Addnl., the H-donor must be highly stable to prevent secondary reactions with the substrate. Herein we study the impact of the catalyst’s properties on CTH of guaiacol using bicyclohexyl, a liquid organic hydrogen carrier, as a H-donor. The reaction was promoted by palladium dispersed on three typical support materials (γ-Al₂O₃, MgO, and SiO₂). The performance of these catalysts in the conversion of bicyclohexyl and guaiacol was evaluated, allowing to estimate the H-transfer efficiency, as well as the potential for recycling the spent H-donor (bicyclohexyl). The apparent activation energies for DHD of bicyclohexyl and HYD of guaiacol revealed that slow DHD combined with fast HYD, as is the case with Pd/MgO, favors hydrogen transfer efficiency and selectivity towards hydrogenated products. In addition, an investigation of the DHD of bicyclohexyl and HYD of guaiacol independently showed that the affinity between the organic mols. and the support significantly impacts CTH. Indeed, Pd/SiO₂ was highly active for both reactions individually and almost inactive for CTH. Consequently, these findings highlight the importance of the interaction between solvent-substrate-support in designing catalysts for transfer hydrogenation.

ChemCatChem published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, COA of Formula: C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

De la Rosa, Jose M. published the artcileImpact of Biochar Amendment on Soil Properties and Organic Matter Composition in Trace Element-Contaminated Soil, Synthetic Route of 91-16-7, the publication is International Journal of Environmental Research and Public Health (2022), 19(4), 2140, database is CAplus and MEDLINE.

The application of biochar as an organic amendment in polluted soils can facilitate their recovery by reducing the availability of contaminants. In the present work, the effect of biochar application to acid soils contaminated by heavy metal spillage is studied to assess its effect on the quantity and composition of soil organic matter (SOM), with special attention given to soil humic acids (HAs). This effect is poorly known and of great importance, as HA is one of the most active components of SOM. The field experiment was carried out in 12 field plots of fluvisols, with moderate and high contamination by trace elements (called MAS and AS, resp.), that are located in the Guadiamar Green Corridor (SW Spain), which were amended with 8 Mg·ha-1 of olive pit biochar (OB) and rice husk biochar (RB). The results indicate that 22 mo after biochar application, a noticeable increase in soil water holding capacity, total organic carbon content, and soil pH were observed The amounts of oxidisable carbon (C) and extracted HAs in the soils were not altered due to biochar addition Thermogravimetric analyses of HAs showed an increase in the abundance of the most thermostable OM fraction of the MAS (375-650°C), whereas the HAs of AS were enriched in the intermediate fraction (200-375°C). Spectroscopic and chromatog. analyses indicate that the addition of biochar did not alter the composition of the organic fraction of HAs, while Cu, Fe, and as were considerably accumulated at HAs.

International Journal of Environmental Research and Public Health published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Synthetic Route of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ma, Yiming published the artcileSelective production of 2-(tert-butyl)-3-methylphenol from depolymerization of enzymatic hydrolysis lignin with MoS₂ catalyst, Product Details of C8H10O2, the publication is Catalysis Today, database is CAplus.

Low selectivity and complex product distribution are the main challenges for the utilization of lignin. Herein, the selective production of 2-(tert-butyl)-3-methylphenol (TBC), an antioxidant in the polymer industry, from depolymerization of enzymic hydrolysis lignin (EHL) on a hydrothermally synthesized MoS₂ catalyst is studied. The total aromatic monomer yield is 124.1 mg/g EHL and the selectivity of TBC is up to 40.3 wt% in methanol at 280 °C under 2 MPa H₂ for 6 h. The FT-IR anal. of products reveals that MoS₂ has a high activity for demethylation, dehydroxylation and alkylation, and the dimer conversions reveal that C-O and C-C bonds in EHL are broken with MoS₂. The guaiacol and its derivatives are identified as the intermediate for formation of TBC in EHL depolymerization according to the effect of time on product distribution and monomer conversion.

Catalysis Today published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ge, Chenyang published the artcileUnsymmetrical indazolyl-pyridinyl-triazole ligand-promoted highly active iridium complexes supported on hydrotalcite and its catalytic application in water, Formula: C13H14N2O, the publication is Green Chemistry (2018), 20(8), 1805-1812, database is CAplus.

Herein, an indazolyl-pyridinyl-triazole ligand was synthesized and its Ir complex supported on hydrotalcite was characterized via x-ray power diffraction (XRD), XPS, energy dispersive X-ray (EDX) spectroscopy and TEM. This new heterogeneous catalyst bearing the unsym. indazolyl-pyridinyl-triazole ligand exhibits high catalytic activity in H₂O. Both functionalized amines and imines were obtained from the challenging selective reaction of benzylamines with arylamines through transfer hydrogenation and dehydrogenation under clean conditions. In particular, this catalyst system showed good recovery performance in H₂O. Mechanistic studies showed that this transformation occurs via amine dehydrogenation, hydrolysis and condensation processes. The direct capture of the reaction intermediate provides sufficient proof for this process.

Green Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Formula: C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Macsari, Istvan published the artcilePhenyl isoxazole voltage-gated sodium channel blockers: Structure and activity relationship, Recommanded Product: 2-(2,2,2-Trifluoroethoxy)ethanol, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(13), 3871-3876, database is CAplus and MEDLINE.

Blocking of certain sodium channels is considered to be an attractive mechanism to treat chronic pain conditions. Ph isoxazole carbamate (I) was identified as a potent and selective Na_V1.7 blocker. Structural analogs of I, both carbamates, ureas and amides, were proven to be useful in establishing the structure-activity relation and improving ADME related properties. Amide II showed a good overall in vitro profile, that translated well to rat in vivo PK.

Bioorganic & Medicinal Chemistry Letters published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C4H7F3O2, Recommanded Product: 2-(2,2,2-Trifluoroethoxy)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Arbulu, Maria published the artcileCharacterisation of the flavour profile from Graciano Vitis vinifera wine variety by a novel dual stir bar sorptive extraction methodology coupled to thermal desorption and gas chromatography-mass spectrometry, COA of Formula: C4H10O2, the publication is Analytica Chimica Acta (2013), 41-48, database is CAplus and MEDLINE.

A new anal. technique was developed for the study of the organoleptic compounds (flavor profile) of the Graciano Vitis vinifera wine variety. The cv. Graciano is a singular variety of red grapes with its origins in La Rioja and Navarra (northern Spain). This variety transfers an intense red color, aroma and high acidity to musts and provides greater longevity and, consequently, a better capacity for aging wine. A new dual-stir bar sorptive extraction approach coupled with thermal desorption (TD) and GC-MS has been used to extract the volatile and semivolatile compounds In this extraction step, the optimal values for the exptl. variables were obtained through the Response Surface Methodol. (RSM). Full scan chromatogram data were evaluated with two deconvolution software tools, and the results were compared. The volatile and semivolatile components were identified with an MS match ≥80%. As a result, the flavor metabolome of the Graciano Vitis vinifera wine variety was obtained, and 205 metabolites were identified using different databases. These metabolites were grouped into esters, acids, alcs., nitrogen compounds, furans, lactones, ketones, aldehydes, phenols, terpenes, norisoprenoids, sulfur compounds, acetals and pyrans. The majority of the metabolites observed had already been reported in the literature; however, this work also identified new, previously unreported metabolites in red wines, which may be characteristic of the Graciano variety.

Analytica Chimica Acta published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, COA of Formula: C4H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhao, Guangkuan published the artcileA Broad Substrate Scope of Aza-Friedel-Crafts Alkylation for the Synthesis of Quaternary α-Amino Esters, COA of Formula: C11H10O, the publication is Organic Letters (2020), 22(15), 5822-5827, database is CAplus and MEDLINE.

A versatile synthetic protocol of aza-Friedel-Crafts alkylation has been developed for the synthesis of quaternary α-amino esters. This operationally simple alkylation proceeds under ambient conditions with high efficiency, regioselectivity, and an exceptionally broad scope of arene nucleophiles. A key feature of this alkylation is the role associated with the silver(I) salt counteranions liberated during the reaction. Taking advantage of a phase-transfer counteranion/Bronsted acid pair mechanism, we also report a catalytic enantioselective example of the reaction.

Organic Letters published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C12H17NS2, COA of Formula: C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ziegler, E. published the artcileSyntheses of heterocyclics. XLI. Cyclic dichloromalonyl compounds, Formula: C2H8Cl2N4S2, the publication is Monatshefte fuer Chemie (1962), 1376-82, database is CAplus.

cf. ibid. 1062-4; CA 57, 9850b. The method of Baeyer and Bloem (Ber. Deut. Chem. Ges. 15, 2150 (1882)) for chlorination of 4-hydroxycarbostyril (I) was examined in various solvents. Thus, 60 g. I was heated to boiling in a mixture of 220 ml. dioxane, 100 ml. concentrated HCl, and 40 ml. H₂O. After heating was stopped, 200 ml. 30% H₂O₂ was quickly added. After 15 min. the oil which separated gradually crystallized to give 91% 3,3-dichloro-2,4-dioxo-1,2,3,4-tetrahydroquinoline (II), m. 175° (C₆H₆). Yields in other solvents were: H₂O-AcOH, 70%; EtOH, 58%. The following substituted 2,4-dioxo-1,2,3,4-tetrahydroquinolines were prepared in the same way (yield, m.p.): 3,3-dichloro-6,8-dimethyl, quant., 215° (C₆H₆); 1-methyl-3-benzyl-3-chloro (III), 97%, 136.0-6.5° (MeOH). 5,5-Dichlorobarbituric acid, m. 211-15° (dilute HCl), was prepared similarly in 80% yield from barbituric acid, while 5 g. 1-phenyl-3-methyl-2-pyrazolin-5-one was converted in 96% yield to its 4,4-dichloro derivative (IV), m. 61° (dilute alc.). A suspension of 40 g. I in 100 ml. dioxane was heated to 50°, stirred, and 55 ml. SO₂Cl₂ added slowly. Solution began and the mixture was boiled for a short time, cooled, and treated with 300 ml. ice-H₂O to give 96% II. The following 2,4-dioxo-1,2,3,4-tetrahydroquinoline derivatives were prepared from the corresponding 4-hydroxycarbostyrils (yield, m.p.): 3,3-dichloro-6-fluoro, quant., 119° (EtOH); 3,3-dichloro-1-phenyl (V), quant., 200° (PhCl); 3,3-dichloro-1-benzyl (VI), quant., 122° (EtOH); 3-benzyl-3-chloro, 96%, 186° (AcOH). 5-Chlorobarbituric acid, m. 280-90° (decomposition) (H₂O), was similarly prepared in 79% yield. I (4 g.) in 25 ml. dioxane and 15 ml. H₂O was treated with Cl at 80° for 10-15 min., cooled, and 30 ml. H₂O added to give 96% 3,3,6-trichloro-2,4-dioxo-1,2,3,4-tetrahydroquinoline, m. 230-2° (EtOH). II (3 g.) was dissolved in 30 ml. EtOH and 10 ml. AcOH by boiling and 3 g. Zn dust added in small portions. Decolorization began in a few min., after which 150 ml. H₂O was added to precipitate 96.5% 3-chloro-4-hydroxycarbostyril (VII), which sintered at 270° and m. 275-80° (decomposition) (EtOH). Also prepared (name, starting compound, yield, m.p.) were: 1-phenyl-3-methyl-4-chloro-2-pyrazolin-5-one, IV, 94%, 153°; 1-phenyl-3-chloro-4-hydroxycarbostyril, V, quant., 264° (EtOH); 1-benzyl-3-chloro-4-hydroxycarbostyril, VI, quant., 253-4° (BuOH); 1-methyl-3-benzyl-4-hydroxycarbostyril, III, 86%, 213°. VII also was prepared in 94% yield by treating 0.2 g. II with 10 ml. 5% I in dioxane and 0.5 ml. concentrated HCl. CS(NH₂)₂ (3 g.) was partly dissolved in 40 ml. absolute EtOH and 1 ml. alc. HCl by heating at 50°, then the solution of II was added in small portions. Cooling caused precipitation of 2.5 g. diamidino disulfide dihydrochloride, m. 170° (decomposition).

Monatshefte fuer Chemie published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C22H18O2, Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Rahmatpour, Ali published the artcileCross-linked poly(N-vinylpyrrolidone)-titanium tetrachloride complex: A novel stable solid TiCl₄ equivalent as a recyclable polymeric Lewis acid catalyst for regioselective ring-opening alcoholysis of epoxides, Formula: C4H10O2, the publication is Applied Organometallic Chemistry (2021), 35(11), e6385, database is CAplus.

Crosslinked poly(N-vinylpyrrolidone) resin beads were prepared as macromol. ligand precursors by suspension copolymerization of N-vinyl-2-pyrrolidone and N,N’-methylenebisacrylamide (MBA) as a crosslinking agent in water. Subsequently, the resulting polymer carrier precursor was readily combined with titanium tetrachloride to form a stable polymeric coordination complex (PNVP/TiCl₄), and this novel stable TiCl₄ equivalent evaluated as a heterogeneous and reusable solid Lewis acid catalyst for the regio-and stereoselective nucleophilic ring opening of various epoxides with various alcs. to prepare β-alkoxy alcs. in excellent yields without generating any waste. The MBA-crosslinked PNVP and resultant catalyst were characterized by Fourier transform IR spectroscopy (FT-IR), field-emission scanning electron microscope (FE-SEM), energy dispersive X-ray (EDX), inductively coupled plasma (ICP), and thermogravimetric anal. (TGA) techniques. Moreover, the catalyst is very stable, easily separated, and reused at least five times without significant loss of activity. In terms of scope, yields, the amount of catalyst used, and reaction time, the PNVP-TiCl₄ complex catalyst is an improvement over previously reported heterogeneous catalysts for ring opening of epoxides methods. Further, the exptl. outcome revealed that using the copolymer beads as carriers with a high percentage of crosslinking and the high mesh size leads had an adverse effect on the reaction rate.

Applied Organometallic Chemistry published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Formula: C4H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Osorio-Gonzalez, Carlos S. published the artcileInhibitor degradation by Rhodosporidium toruloides NRRL 1588 using undetoxified wood hydrolysate as a culture media, Product Details of C9H10O4, the publication is Biomass and Bioenergy (2022), 106419, database is CAplus.

Lignocellulosic biomass has been identified as a renewable and sustainable feedstock to produce liquid hydrolyzates as a suitable substrate to produce a variety of compounds through biochem. processes. Nevertheless, the main challenge to using this substrate is the hydrolysis needed to release fermentable sugars. This pretreatment leads to the production of microbial toxic compounds such as furans, phenols and organic acids. In this work, an oleaginous yeast, R. toruloides NRRL 1588, was used to study its ability to degrade inhibitors in C5 and C6 wood hydrolyzates obtained from forestry residues. The study showed that R. toruloides NRRL 1588 can grow, accumulate lipids, and degrade up to 8.01 mgL-1 h-1 of furfural, 5.63 mgL-1 h-1 of 5-hydroxy Me furfural, 1.70 mgL-1 h-1 of levulinic acid, 1.15 mgL-1 h-1 of syringaldehyde, 0.67 mgL-1 h-1 of vanillin, and 1.03 mgL-1 h-1 of vanillic acid. This work confirms the robustness of R. toruloides NRRL 1588 when grows in wood hydrolyzates containing inhibitory compounds

Biomass and Bioenergy published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Product Details of C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem