Month: December 2022

Martinez, Ricardo published the artcileSelective N-monoalkylation of aromatic amines with benzylic alcohols by a hydrogen autotransfer process catalyzed by unmodified magnetite, Product Details of C13H14N2O, the publication is Organic & Biomolecular Chemistry (2009), 7(10), 2176-2181, database is CAplus and MEDLINE.

Magnetite is an effective catalyst for the selective N-alkylation of (hetero)aromatic amines using benzylic alcs. as electrophiles. The process could be repeated up to eight times without losing effectiveness. The catalyst recycling is very easy, using a simple magnet. The catalyst is selective, and could discriminate between aromatic and aliphatic amines, as well as between benzylic and aliphatic alcs., as the reactions only take place with aromatic amines and benzylic alcs.

Organic & Biomolecular Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Product Details of C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Cano, Rafael published the artcileImpregnated Ruthenium on Magnetite as a Recyclable Catalyst for the N-Alkylation of Amines, Sulfonamides, Sulfinamides, and Nitroarenes Using Alcohols as Electrophiles by a Hydrogen Autotransfer Process, Product Details of C13H14N2O, the publication is Journal of Organic Chemistry (2011), 76(14), 5547-5557, database is CAplus and MEDLINE.

Various impregnated metallic salts on magnetite have been prepared, including cobalt, nickel, copper, ruthenium, and palladium salts, as well as a bimetallic palladium-copper derivative Impregnated ruthenium catalyst is a versatile, inexpensive, and simple system for the selective N-monoalkylation of amino derivatives with poor nucleophilic character, such as aromatic and heteroaromatic amines, sulfonamides, sulfinamides, and nitroarenes, using in all cases alcs. as the initial source of the electrophile, through a hydrogen autotransfer process. In the case of sulfinamides, this is the first time that these amino compounds have been alkylated following this strategy, allowing the use of chiral sulfinamides and secondary alcs. to give the alkylated compound with a diastereomeric ratio of 92:8. In these cases, after alkylation, a simple acid deprotection gave the expected primary amines in good yields. The ruthenium catalyst is quite sensitive, and small modifications of the reaction medium can change the final product. The alkylation of amines using potassium hydroxide renders the N-monoalkylated amines, and the same protocol using sodium hydroxide yields the related imines. The catalyst can be easily removed by a simple magnet and can be reused up to ten times, showing the same activity.

Journal of Organic Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Product Details of C13H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dominguez-Rodriguez, Gloria published the artcileComposition of Nonextractable Polyphenols from Sweet Cherry Pomace Determined by DART-Orbitrap-HRMS and Their In Vitro and In Vivo Potential Antioxidant, Antiaging, and Neuroprotective Activities, Related Products of ethers-buliding-blocks, the publication is Journal of Agricultural and Food Chemistry (2022), 70(26), 7993-8009, database is CAplus and MEDLINE.

Sweet cherry pomace is an important source of phenolic compounds with beneficial health properties. As after the extraction of phenolic compounds, a phenolic fraction called nonextractable polyphenols (NEPs) remains usually retained in the extraction residue, alk. and acid hydrolyzes and enzymic-assisted extraction (EAE) were carried out in this work to recover NEPs from the residue of conventional extraction from sweet cherry pomace. In vitro and in vivo evaluation of the antioxidant, antihypertensive, antiaging, and neuroprotective capacities employing Caenorhabditis elegans was achieved for the first time. Extractable phenolic compounds and NEPs were separated and identified by families by high-performance thin-layer chromatog. (HPTLC) with UV/Vis detection. A total of 39 phenolic compounds were tentatively identified in all extracts by direct anal. in real-time high-resolution mass spectrometry (DART-Orbitrap-HRMS). EAE extracts presented the highest in vitro and in vivo antioxidant capacity as well as the highest in vivo antiaging and neuroprotective capacities. These results showed that NEPs with interesting biol. properties are retained in the extraction residue, being usually underestimated and discarded.

Journal of Agricultural and Food Chemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Cobo-Golpe, M. published the artcilePortable dehumidifiers condensed water: A novel matrix for the screening of semi-volatile compounds in indoor air, Name: 2-Methoxynaphthalene, the publication is Chemosphere (2020), 126346, database is CAplus and MEDLINE.

The comprehensive identification of organic species existing in indoor environments is a key issue to understand their impact in human health. This study proposes the anal. of condensed water samples, collected with portable dehumidifiers, to characterize semi-volatile compounds in the gas phase of confined areas. Water samples are concentrated by solid-phase extraction (SPE). The obtained extracts are analyzed by gas chromatog. (GC) time-of-flight mass spectrometry (TOF-MS), following a non-target screening data mining approach. In first term, spectra of deconvoluted compounds are compared with those in NIST low resolution library; thereafter, tentative identifications are verified using an inhouse database of accurate electron ionization (EI) MS spectra. Chromatog. (retention index) and spectral data are combined for unambiguous species identification. The potential of condensed water samples to reflect changes in the composition of indoor atmospheres, the match between data obtained using different dehumidifiers, and the relative concentration efficiency of condensed water compared to that attained by active sampling of moderate air volumes are discussed. A total of 141 semi-volatile compounds were identified (98 confirmed against authentic standards) in a set of 21 samples obtained from different homes and working places. This list contains more than 40 fragrances (including several potential allergens), solvents and intermediates in the production of polymeric materials, plasticizers and flame retardants.

Chemosphere published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Name: 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Grujic-Vasic, J. published the artcileThin-layer chromatographic separation and colorimetric determination of some local anesthetics and tropane alkaloids, HPLC of Formula: 637-58-1, the publication is Glasnik Hemicara i Tehnologa Bosne i Hercegovine (1970), 41-6, database is CAplus.

Tropane alkaloids and local anesthetics can be separated by thin-layer chromatog. on cellulose powder D impregnated with a borate/phosphate buffer at pH 6.6, using n-butanol saturated with H2O. Quant. determination is carried out by the method of Decker, et al. (1965).

Glasnik Hemicara i Tehnologa Bosne i Hercegovine published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, HPLC of Formula: 637-58-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Balamurugan, Gunasekaran published the artcileNickel(II)-N^ΛN^ΛO Pincer Type Complex-Catalyzed N-alkylation of Amines with Alcohols via the Hydrogen Autotransfer Reaction, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine, the publication is Journal of Organic Chemistry (2020), 85(11), 7125-7135, database is CAplus and MEDLINE.

A highly sustainable catalytic protocol for the coupling of alcs. and amines for selective monoalkylated amines using Ni(II)-N^ΛN^ΛO pincer type complexes through the borrowing hydrogen methodol. is described. An array of Ni(II) catalysts (1-3; acylhydrazone Ph group substituted with p-H, OMe, Cl, resp.) was synthesized and characterized by various spectral and anal. methods. Furthermore, the distorted square planar geometry of the complexes (1 and 2) was substantiated with single crystal X-ray diffraction study. The inexpensive nickel-based catalytic methodol. displays a broad substrate scope for the N-alkylation of aromatic and heteroaromatic amines using a diverse range of primary alcs. with excellent yields up to 97%. The present approach is environmentally benign, which liberates water as the sole byproduct. A short synthesis of drug intermediates such as mepyramine and chloropyramine illustrates the utility of the present protocol.

Journal of Organic Chemistry published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Recommanded Product: N-(4-Methoxybenzyl)pyridin-2-amine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Subaramanian, Murugan published the artcileConvenient and Reusable Manganese-Based Nanocatalyst for Amination of Alcohols, SDS of cas: 52818-63-0, the publication is ChemCatChem (2021), 13(20), 4334-4341, database is CAplus.

Herein, a reusable heterogeneous N-doped graphene-based manganese nanocatalyst (Mn@NrGO) for selective N-alkylation of amines with alcs. to gave (arylmethyl)anilines Ar¹NHCHR¹R² [Ar₁ = Ph, 2-pyridyl, 1-naphthyl, etc.; R¹ = H, Ph, 4-MeC₆H₄, 2-MeC₆H₄, 4-ClC₆H₄, 4-MeOC₆H₄; R² = Ph, 4-ClC₆H₄, 2-furyl, etc.] was described. Mechanistic studies illustrate that the catalytic reaction followed a domino dehydrogenation-condensation-hydrogenation sequence of alcs. and amines with the formation of water as the sole byproduct. The scope of the reaction was extended to the synthesis of pharmaceutically important N-alkylated amine intermediates. The heterogeneous nature of the catalyst made it easy to sep. for long-term performance, and the recycling study revealed that the catalyst was robust and retained its activity after several recycling experiments

ChemCatChem published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C4H6O3, SDS of cas: 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bhar, Shanta S. published the artcileAnnulation strategy for the biomimetic synthesis of cis-fused diterpenoids, Safety of 2-Isopropylanisole, the publication is Tetrahedron Letters (2006), 47(44), 7805-7807, database is CAplus.

Concise and efficient formal syntheses of the A/B cis-fused ring C-aromatic tricyclic diterpenes, xanthoperol, and cis-A/B-coleon V are reported, via the application of domino reactions followed by a novel annulation method, in which the highly substituted target mols. are assembled from an acyclic precursor, namely the easily accessible monoterpene, citral.

Tetrahedron Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Safety of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lu, Hai-Hua published the artcileSynthesis and Biological Evaluation of Paleo-Soraphens, Application In Synthesis of 99438-28-5, the publication is Angewandte Chemie, International Edition (2013), 52(51), 13549-13552, database is CAplus and MEDLINE.

Possible natural product precursors of soraphen A [(1R,2S,5S,10S,11R,12E,14S,15S,16S,17S,18R)-1,17-dihydroxy-10,11,18-trimethoxy-2,14,16-trimethyl-5-phenyl-4,19-dioxabicyclo[13.3.1]nonadec-12-en-3-one] (I) were prepared The synthesis of the target compounds was achieved by a multistep process. The title compounds thus formed included a precursor for soraphen A (II) and a precursor for soraphen B (III). The title compounds were evaluated against Pythium debaryanum, Mucor hiemalis, Botrytis cinerea (fungal pathogens, antifungal agents) and against animal cell line L-929 (mouse connective tissue fibroblast cell line), animal cell line KB-3-1, human cervical carcinoma cell line (anticancer agents, antitumor agents). The compounds were evaluated as deoxyribonucleate topoisomerase I inhibitors.

Angewandte Chemie, International Edition published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Application In Synthesis of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Senthilkumar, P. published the artcileAntibacterial activity of 26-member [2 + 2] macrocycles: a structure-reactivity study, Safety of 1,2-Dimethoxybenzene, the publication is World Journal of Pharmaceutical Research (2022), 11(1), 1103-1113, database is CAplus.

26 Member [2 + 2] macrocyclic Schiff base compounds were investigated for their antibacterial activity against Gram pos. and Gram neg. bacteria. The recorded data of zone of inhibition showed significant broad activity when compared with standard The structure reactivity correlation of the compounds has been studied. The antibacterial searching suggests that all the synthesized macrocyclic compounds showed moderate to very good activity against the tested organisms. Among the compounds, -COOH substituted compound showed the most promising antibacterial activity. The inhibition zone diameters of these compounds have been correlated with Hammett substituent constants, F and R parameters. From the results of statistical anal., the effects of substituent on the antibacterial activity of compounds have been studied.

World Journal of Pharmaceutical Research published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C17H18N2O6, Safety of 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem