Month: December 2022

Kurose, Ryo published the artcileMetal-Free Direct Trifluoromethylthiolation of Aromatic Compounds Using Triptycenyl Sulfide Catalyst, Synthetic Route of 93-04-9, the publication is Organic Letters (2021), 23(6), 2380-2385, database is CAplus and MEDLINE.

Herein we report an efficient synthetic method for the electrophilic trifluoromethylthiolation of aromatic compounds The key is to use triptycenyl sulfide (Trip-SMe) and TfOH to enhance the electrophilicity of SCF₃ fragment through the formation of sulfonium intermediates. This method enables direct installation of an SCF₃ group onto unactivated aromatics at room temperature, adopting a com. available saccharin-based reagent. Preliminary DFT calculation was carried out to investigate the substitution effect on the catalytic activity.

Organic Letters published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Synthetic Route of 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Prakash, Govindan published the artcileHeteroleptic binuclear copper(I) complexes bearing bis(salicylidene)hydrazone ligands: Synthesis, crystal structure and application in catalytic N-alkylation of amines, Category: ethers-buliding-blocks, the publication is Polyhedron (2015), 62-69, database is CAplus.

A new series of heteroleptic binuclear Cu(I) bis(salicylidene)hydrazone complexes (1–4) bearing triphenylphosphine coligands have been synthesized from the reactions of copper(II) precursor complex [CuCl₂(PPh₃)₂] with oxadiazole compounds A-D, resp. It has been observed that the oxadiazole compounds undergo ring cleavage with in situ reduction of Cu(II) ion, during the formation of complexes (1–4). The oxadiazoles (A-D) and the Cu(I) complexes (1–4) have been characterized by anal. and spectroscopic methods. Single crystal x-ray diffraction study of complex 2 revealed a distorted tetrahedral geometry around each Cu(I) center. Catalytic efficiency of the new complexes on the N-alkylation of amines using alcs. was studied under optimized conditions. The new complexes have also been tested for their catalytic activity towards the direct N-alkylation of 2-nitropyridine.

Polyhedron published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C13H14N2O, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Nilsson, Aake published the artcileStructural effects on selective aliphatic hydrogen exchange in alkyl-substituted aromatic compounds in deuterated trifluoroacetic acid, Category: ethers-buliding-blocks, the publication is Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry (1985), B39(1), 25-30, database is CAplus.

A qual. study was carried out concerning structural effects on selective aliphatic H exchange for a variety of alkylated aromatic compounds in CF₃CO₂D. β-H exchange in iso-Pr and cyclohexyl groups is severely hindered by the presence of an ortho substituent, whereas this is not the case for the exchange in a cyclopentyl group. In 1-isopropylnaphthalene (1-I), hindrance from the peri H inhibits aliphatic H exchange in the Me group, whereas aliphatic exchange does occur in 2-I. Also, bulky substituents [e.g., iso-Pr groups ortho to the MeO group in 2,4,6-(Me₂CH)₃C₆H₂OMe] retard the rate of H exchange in the 4-iso-Pr group strongly. Structural effects on aliphatic β-H exchange for some derivatives of indan, Tetralin, chroman, Ph₂O and biphenyl were also studied. For the indan and Tetralin derivatives, the presence of a methine H in the benzylic position was no longer necessary for aliphatic H exchange to occur. For 5-methoxy-1-methylindan, α-H exchange in position 1 was also observed along with the β-H exchange.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Popovic, Radomir published the artcileCoulometric determination of some local anesthetics, COA of Formula: C17H28ClNO3, the publication is Acta Pharmaceutica Jugoslavica (1967), 17(2), 77-80, database is CAplus.

Coulometric determination of the local anesthetics procaine-HCl, tetracaine-HCl, lignocaine-HCl, amylocaine-HCl, dibucaine-HCl, pramoxine-HCl, Panthesine-HCl, and Falicaine-HCl is proposed. After passing the solution (1%) of anesthetic through a column of Dowex 2 the effluent (5 ml.) is titrated coulometrically in the anode compartment in the presence of 10 ml. 0.01 N H2SO4 and 5 drops phenolphthalein.

Acta Pharmaceutica Jugoslavica published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, COA of Formula: C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sato, Eisuke published the artcileElectro-oxidative Trimerization of 1,2-Dimethoxybenzene: Reductive Workup Strategy and Alternating Current Electrolysis to Peel off the Precipitated Radical Cation Ion Pair, Safety of 1,2-Dimethoxybenzene, the publication is Chemistry Letters (2022), 51(6), 629-632, database is CAplus.

An oxidative trimerization of catechol and its derivatives affords triphenylene derivatives Under these electrochem. conditions, overoxidn. results in precipitation of a radical cation pair of triphenylenes with a counter anion, which prevents efficient synthesis. A reductive workup strategy, in which the precipitate is peeled from the electrodes, affords the trimer in good yield. Furthermore, a.c. (AC) electrolysis provides a convenient synthesis without any precipitation

Chemistry Letters published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Guolin published the artcileTransition-metal-free formal cross-coupling of aryl methyl sulfoxides and alcohols via nucleophilic activation of C-S bond, Recommanded Product: 2-Methoxynaphthalene, the publication is Nature Communications (2020), 11(1), 2890, database is CAplus and MEDLINE.

A transition-metal-free cross-coupling strategy utilizing aryl(heteroaryl) Me sulfoxides R¹S(O)Me (R¹ = Ph, 4-NCC₆H₄, 2-naphthyl, 3-pyridyl, 2-benzimidazolyl, etc.) and alcs. R²OH (R² = Me, i-Pr, 2-cyclohexylethyl, 1-adamantylmethyl, etc.) to afford alkyl aryl(heteroaryl) ethers R¹OR² is reported. Two drug mols. were successfully prepared using this protocol as a key step and emphasized its potential utility in medicinal chem. A DFT computational study suggests that the reaction proceeds via initial addition of the alkoxide to the sulfoxide. This adduct facilitates further intramol. addition of the alkoxide to the aromatic ring wherein charge on the aromatic system is stabilized by the nearby potassium cation. Rate-determining fragmentation then delivers Me sulfenate and the aryl or heteroaryl ether. This study establishes the feasibility of nucleophilic addition to an appended sulfoxide as a means to form a bond to aryl(heteroaryl) systems and this modality is expected to find use with many other electrophiles and nucleophiles leading to new cross-coupling processes.

Nature Communications published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Recommanded Product: 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gowrisankar, Saravanan published the artcileA convenient and practical synthesis of anisoles and deuterated anisoles by palladium-catalyzed coupling reactions of aryl bromides and chlorides, Product Details of C10H14O, the publication is Chemistry – A European Journal (2012), 18(9), 2498-2502, S2498/1-S2498/31, database is CAplus and MEDLINE.

A palladium-catalyzed coupling reaction of aryl halides with methanol is described. A variety of substituted anisoles have been prepared in moderate to good yields from activated and nonactivated (hetero)aryl substrates. Meanwhile, deuterated anisoles could be obtained via coupling of aryl halides with CD₃OD.

Chemistry – A European Journal published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Okabe, Hiroyuki published the artcileAcceptor-Controlled Transfer Dehydration of Amides to Nitriles, Safety of 2-Methoxyacetamide, the publication is Organic Letters (2019), 21(12), 4767-4770, database is CAplus and MEDLINE.

Palladium-catalyzed dehydration of primary amides to nitriles efficiently proceeds under mild, aqueous conditions via the use of dichloroacetonitrile as a water acceptor. A key to the design of this transfer dehydration catalysis is the identification of an efficient water acceptor, dichloroacetonitrile, that preferentially reacts with amides over other polar functional groups with the aid of the Pd catalyst and makes the desired scheme exergonic, thereby driving the dehydration.

Organic Letters published new progress about 16332-06-2. 16332-06-2 belongs to ethers-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Ether, name is 2-Methoxyacetamide, and the molecular formula is C3H7NO2, Safety of 2-Methoxyacetamide.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wilkes, Sally R. published the artcileHow Clinically Relevant Are Treatment Comparisons of Topical Calcineurin Inhibitor Trials for Atopic Eczema?, COA of Formula: C17H28ClNO3, the publication is Journal of Investigative Dermatology (2016), 136(10), 1944-1949, database is CAplus and MEDLINE.

We sought to explore the architecture of trials of calcineurin inhibitors for atopic eczema to document the extent to which comparisons with active treatments such as topical corticosteroids might have been included or avoided. We identified all eligible randomized controlled trials using the Global Resource for EczemA Trials (GREAT) database. Network plots were produced where the nodes represented a treatment type and the lines between the nodes represented the number of trials or participants involved in the various treatment comparisons. A total of 174 randomized controlled trials for atopic eczema treatments were identified in which pimecrolimus, tacrolimus, or topical corticosteroids were compared with another intervention or a vehicle/emollient. Of 39 trials involving pimecrolimus and 41 trials involving tacrolimus, 8 (20.5%) and 13 (31.7%), resp., made comparisons with topical corticosteroids, and 25 (64.1%) and 15 (36.6%), resp., were vehicle-controlled studies. The high rate of comparisons with vehicle controls in randomized controlled trials that assessed the efficacy of pimecrolimus or tacrolimus long after efficacy had been established is a matter of concern. Active comparators (mild topical corticosteroids for pimecrolimus and moderate to potent topical corticosteroids for tacrolimus) are best placed to determine how topical calcineurin inhibitors compare with established clin. practice.

Journal of Investigative Dermatology published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C4H5F3N2O3S, COA of Formula: C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Joshua, C. P. published the artcileOxidation of mixtures of s-diarylthiocarbamides and thiocarbamide. Formation of 3-amino-4-aryl-5-arylimino-1,2,4Δ2-thiadiazolines, Computed Properties of 14807-75-1, the publication is Indian Journal of Chemistry (1973), 11(12), 1272-5, database is CAplus.

Oxidation of an acid alc. solution of a binary mixture of s-diphenyl-, s-di-o-tolyl- or s-di-p-tolylthiocarbamide and thiocarbamide yields the related 3-amino-4-aryl-5-(arylimino)-1,2,4-Δ2-thiadiazoline (I). A mechanism of formation is described.

Indian Journal of Chemistry published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Computed Properties of 14807-75-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem