Month: December 2022

Joshua, C. P. published the artcileOxidation of mixtures of thiocarbamides. II. Oxidation of mixtures of 1-alkyl-3-arylthiocarbamides and thiocarbamide. Formation of 3-amino-5-alkylimino-4-aryl-1,2,4-Δ2-thiadiazolines, Formula: C2H8Cl2N4S2, the publication is Indian Journal of Chemistry (1974), 12(9), 962-5, database is CAplus.

Oxidation of mixtures of 1-alkyl-3-arylthiocarbamides and thiocarbamide yielded 3-amino-5-alkylimino-4-aryl-1,2,4-Δ2-thiadiazolines. The role of 1-amidino-3-alkyl-1-arylthiocarbamide-HCl as intermediates in the oxidation was established by their isolation under mild conditions. The 1-amidino-3-alkyl-1-arylthiocarbamide salts and 3-amino-5-alkylimino-4-aryl-1-2,4-Δ2-thiadiazolines are interconvertible by oxidation-reduction Interactions between bis(N-alkyl-N’-aryl)dithioformamidine dihydrochlorides and dithioformamidine dihydrochloride also lead to 1-amidino-3-alkyl-1-arylthiocarbamide salts.

Indian Journal of Chemistry published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Formula: C2H8Cl2N4S2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sunagawa, Genshun published the artcileSynthesis of organic bases. VI. Synthesis of thonzylamine, HPLC of Formula: 52818-63-0, the publication is Takamine Kenkyusho Nenpo (1952), 36-9, database is CAplus.

cf. C.A. 48, 8777d. Thonzylamine (I) was prepared by the following 3 routes: (a) Heating anisaldehyde, 2-aminopyridine (Ia), and HCO₂H gave 2-(p-methoxybenzylamino)pyridine (II), m. 108-9°, which, converted to the Na salt and treated with Me₂NCH₂CH₂Cl (III), gave 96% I, b₃ 191-3°. (b) 2-Formylaminopyridine and anisaldehyde in ethylene glycol gave 73.1% II which with III gave I, (lower yield than method a). (c) Ia and III in the presence of NaNH₂ yielded 29.4% N,N-Dimethyl-N’-(2-pyrimidyl)ethylenediamine, b₃ 90-5°, which was converted to the N’-formyl compound, b₆ 121-5° (96.4% yield), and finally heated with anisaldehyde in glycol to give I.

Takamine Kenkyusho Nenpo published new progress about 52818-63-0. 52818-63-0 belongs to ethers-buliding-blocks, auxiliary class Pyridine,Amine,Benzene,Ether, name is N-(4-Methoxybenzyl)pyridin-2-amine, and the molecular formula is C3H6O2, HPLC of Formula: 52818-63-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kurasaki, Haruaki published the artcileIsostearyl mixed anhydrides for the preparation of N-methylated peptides using C-terminally unprotected N-methylamino acids, Synthetic Route of 77128-73-5, the publication is Organic Letters (2020), 22(20), 8039-8043, database is CAplus and MEDLINE.

Sustainable and efficient manufacturing methods for N-methylated peptides remain underexplored despite growing interest in therapeutic N-methylated peptides within the pharmaceutical industry. A methodol. for the coupling of C-terminally unprotected N-methylamino acids mediated by an isostearic acid halide (ISTAX) and silylating reagent has been developed. This approach allows for the coupling of a wide variety of amino acids and peptides in high yields under mild conditions without the need for a C-terminal deprotection step in the process of C-terminal elongation. These advantages make this a useful synthetic method for the production of peptide therapeutics and diagnostics containing N-methylamino acids.

Organic Letters published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C25H23NO4, Synthetic Route of 77128-73-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yoshimura, Hiroyuki published the artcileA Novel Type of Retinoic Acid Receptor Antagonist: Synthesis and Structure-Activity Relationships of Heterocyclic Ring-Containing Benzoic Acid Derivatives, Application In Synthesis of 2944-47-0, the publication is Journal of Medicinal Chemistry (1995), 38(16), 3163-73, database is CAplus and MEDLINE.

A new series of heterocyclic ring-containing benzoic acids was prepared, and the binding affinity and antagonism of its members against all-trans-retinoic acid were evaluated by in vitro assay systems using human promyelocytic leukemia (HL-60) cells. Structure-activity relationships indicated that both an N-substituted pyrrole or pyrazole (1-position) and a hydrophobic region, with these linked by a ring system, were indispensable for effective antagonism. Among the compounds evaluated, optimal antagonism was exhibited by 4-[4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra[1,2-b]pyrrol-3-yl]benzoic acid, 4-[7,8,9,10-tetrahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)-4-thiaanthra[1,2-b]pyrrol-3-yl]benzoic acid, and 4-[4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)anthra[2,1-d]pyrazol-3-yl]benzoic acid, all of which possess a 3-pyridylmethyl group at the five-membered ring nitrogen atom.

Journal of Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C2H10Cl2N2, Application In Synthesis of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Brei, V. V. published the artcileDehydrogenation of alcohols over copper catalyst: correlation between the activation energy of reaction and chemical shift δ (R17OH), Computed Properties of 1589-47-5, the publication is Ukrainskii Khimicheskii Zhurnal (Russian Edition) (2017), 83(8), 117-122, database is CAplus.

The dehydrogenation of primary and secondary alcs. over Cu/ZnO-ZrO2-Al2O3 catalyst were studied using a desorption mass-spectrometry technique. The correlation between activation energy of reaction and chem. shift δ (R17OH) of studied alcs. was found. It is shown that ability of alcs. to dehydrogenation decreases with increase of their nucleofility. The mechanism of alc. dehydrogenation on metal copper clasters was proposed.

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about 1589-47-5. 1589-47-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-Methoxypropan-1-ol, and the molecular formula is C4H10O2, Computed Properties of 1589-47-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bombicz, Petra published the artcileSynthesis, vibrational spectra and X-ray structures of copper(I) thiourea complexes, Safety of Formamidine disulfide dihydrochloride, the publication is Inorganica Chimica Acta (2004), 357(2), 513-525, database is CAplus.

Complex formation of thiourea with Cu takes place as an intermediate step in the preparation of Cu sulfide thin films by spray pyrolysis starting from aqueous solutions of Cu(II) chloride and thiourea. The stoichiometry of the complex and that of the resulting thin film primarily depends on the mol. ratio of the starting materials. For comparison, the structures of all Cu(I) thiourea complexes found in the Cambridge Structural Database are classified. Syntheses, structural (single crystal XRD also at low temperature 193 K) and spectroscopic studies (FTIR and Raman) of six Cu-thiourea complexes are now reported. The Cu to thiourea stoichiometric ratio is 1:3 in four of these complexes, but their structures are basically different as dimerization or polymer formation takes place depending on whether the H₂O of crystallization is present or absent. The structure of bis(μ-thiourea)tetrakis(thiourea)dicopper(I) dichloride dihydrate, [Cu₂(tu)₆]Cl₂·2H₂O (1) was determined at room and also at low temperature Bis(μ-thiourea)tetrakis(thiourea)dicopper(I) dibromide dihydrate, [Cu₂(tu)₆]Br₂·2H₂O (2) is isomorphous with 1, and the anhydrous compounds chlorotris(thiourea)copper(I), [Cu(tu)₃]Cl (3) and bromotris(thiourea)copper(I), [Cu(tu)₃]Br (4) are isomorphous. In the 3rd isomorphous pair of complexes the Cu to thiourea stoichiometric ratio is 1:1, viz. chloro(thiourea)copper(I) hemihydrate, [Cu(tu)]Cl·0.5H₂O (5) and bromo(thiourea)copper(I) hemihydrate, [Cu(tu)]Br·0.5H₂O (6). During the preparation of chloro(thiourea)copper(I) hemihydrate (5) a reaction byproduct α,α^‘-dithiobisformamidinium dichloride, [SC(NH₂)₂]₂Cl₂ (7) was identified and structurally characterized which made it possible to suggest a reaction path leading to complex formation.

Inorganica Chimica Acta published new progress about 14807-75-1. 14807-75-1 belongs to ethers-buliding-blocks, auxiliary class Salt,Thiourea,Amine,Aliphatic hydrocarbon chain, name is Formamidine disulfide dihydrochloride, and the molecular formula is C2H8Cl2N4S2, Safety of Formamidine disulfide dihydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yeomans, Larisa published the artcilePhosphorylation of enkephalins: NMR and CD studies in aqueous and membrane-mimicking environments, Recommanded Product: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, the publication is Chemical Biology & Drug Design (2011), 78(5), 749-756, database is CAplus and MEDLINE.

Phosphorylation of L-serine-containing enkephalin analogs has been explored as an alternative to glycosylation in an effort to increase blood-brain barrier permeability and CNS bioavailability of peptide pharmacophores. Two enkephalin-based peptides were modified for these studies, a set related to DTLES, a mixed μ/δ-agonist, and one related to DAMGO, a highly selective μ-agonist. Each unglycosylated peptide was compared to its phosphate, its mono-benzylphosphate ester, and its β-D-glucoside. Binding was characterized in membrane preparations from Chinese hamster ovary cells expressing human μ, δ and κ-opiate receptors. Antinociception was measured in mice using the 55 °C tail-flick assay. To estimate bioavailability, the antinociceptive effect of each opioid agonist was evaluated after intracerebroventricular (i.c.v.) or i.v. administration (i.v.) of the peptides. CD methods and high-field NMR were used in the presence and absence of sodium dodecylsulfate to understand how the presence of a membrane might influence the peptide conformations.

Chemical Biology & Drug Design published new progress about 77128-73-5. 77128-73-5 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid, and the molecular formula is C7H6BF3O2S, Recommanded Product: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

De Flaviis, Riccardo published the artcileCould environmental effect overcome genetic A chemometric study on wheat volatiles fingerprint, Application In Synthesis of 91-16-7, the publication is Food Chemistry (2022), 131236, database is CAplus and MEDLINE.

A deeper knowledge of the causes of volatile organic compounds (VOCs) variance in wheat is crucial for quality improvement and control of its derivatives The VOCs profile of common and durum wheat kernels grown in different fields sited at different altitudes over two years was analyzed and 149 compounds were identified by gas chromatog.-mass spectrometry. Principal component anal. evidenced that the year of cultivation was the highest source of VOCs variance. The effects of wheat origin, as described by the cultivation site, its elevation, and species were further investigated by PLS-DA, that permitted to correctly classify wheat of different origin on the basis of its VOCs profile. The importance of the different effects was investigated by multidimensional test and resulted: year of cultivation > field of cultivation > species > altitude. Findings suggest that environmental conditions are more important than species in the determination of the VOCs variance of wheat.

Food Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

De Flaviis, Riccardo published the artcileQuantitatively unravelling the effect of altitude of cultivation on the volatiles fingerprint of wheat by a chemometric approach, Recommanded Product: 1,2-Dimethoxybenzene, the publication is Food Chemistry (2022), 131296, database is CAplus and MEDLINE.

The cultivation of crops at high elevations in response to climate changes leads to modifications in the volatile organic compounds (VOCs) profile. The VOCs profile of common and durum wheat grown in different fields sited at three different elevations over two years was analyzed. Partial least square anal. (PLS2) evidenced the effect of altitude on VOCs variance that was hidden among others (cultivation year, species, farm) not correlated with it. PLS1 anal. was further carried out using VOCs as explanatory variables and altitude as dependent variable to find the linear combination of VOCs able to continuously predict the altitude of samples. Selected VOCs, related to biotic, abiotic and oxidative stress conditions, could describe the changes in VOCs profile of wheat induced by altitude increase. Furthermore, common and durum wheat showed different responses to stress at high altitude. These results could be considerably useful for wheat product classification and authentication.

Food Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Park, Jaeyong published the artcileTotal chemocatalytic cascade conversion of lignocellulosic biomass into biochemicals, Product Details of C9H10O4, the publication is Applied Catalysis, B: Environmental (2022), 121280, database is CAplus.

Because of its complexity, selective conversion of lignocellulosic biomass into platform chems. presents significant challenges. Herein, we converted birch wood into high-yield lignin-derived phenolic monomers and dimers and holocellulose-derived polyols and monocarboxylic acids via a two-step cascade reaction using 0.1 wt% Pd on N-doped carbon (Pd_0.1/CN_x) and passivated alumina-coated Ni on activated carbon (Ni₂ @Al₂O₃/AC) catalysts. The catalytic fractionation of birch sawdust using Pd_0.1/CN_x produced 11.1 wt% monomers, 5.6% dimers, and 63.4 wt% pulp-rich solid (PRS) based on feed weight The subsequent conversion of PRS over passivated Ni₂ @Al₂O₃/AC produced 21.6 wt% C₂-C₆ polyols and 7.9 wt% monocarboxylic acids. After the whole biomass conversion reaction, the Pd_0.1/CN_x and Ni₂ @Al₂O₃/AC catalysts were separated using their different magnetic responses and reused three times without activity loss. The structure-performance relationships of the Pd_0.1/CN_x catalysts synthesized using different methods and effect of passivation on the performance of the Ni₂ @Al₂O₃/AC catalyst were analyzed.

Applied Catalysis, B: Environmental published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Product Details of C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem