Month: February 2023

Tuerxun, Feilure et al. published their research in ACS Applied Materials & Interfaces in 2020 | CAS: 112-49-2

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Application of 112-49-2

Determining Factor on the Polarization Behavior of Magnesium Deposition for Magnesium Battery Anode was written by Tuerxun, Feilure;Yamamoto, Kentaro;Hattori, Masashi;Mandai, Toshihiko;Nakanishi, Koji;Choudhary, Ashu;Tateyama, Yoshitaka;Sodeyama, Keitaro;Nakao, Aiko;Uchiyama, Tomoki;Matsui, Masaki;Tsuruta, Kazuki;Tamenori, Yusuke;Kanamura, Kiyoshi;Uchimoto, Yoshiharu. And the article was included in ACS Applied Materials & Interfaces in 2020.Application of 112-49-2 This article mentions the following:

To clarify the origin of the polarization of magnesium deposition/dissolution reactions, electrochem. measurement, operando soft X-ray absorption spectroscopy (operando SXAS), Raman, and d. functional theory (DFT) techniques are combined to three different electrolytes: magnesium bis(trifluoromethanesulfonyl)amide (Mg(TFSA)2)/triglyme, magnesium borohydride (Mg(BH4)2)/tetrahydrofuran (THF), and Mg(TFSA)2/2-methyltetrahydrofuran (2-MeTHF). Cyclic voltammetry revealed that magnesium deposition/dissolution reactions occur in Mg(TFSA)2/triglyme and Mg(BH4)2/THF, while the reactions do not occur in Mg(TFSA)2/2-MeTHF. Raman spectroscopy shows that the [TFSA]– in the Mg(TFSA)2/triglyme electrolyte largely does not coordinate to the magnesium ions, while all of the [TFSA]– in Mg(TFSA)2/2-MeTHF and [BH4]– in Mg(BH4)2/THF coordinate to the magnesium ions. In operando SXAS measurements, the intermediate, such as the Mg+ ion, was not observed at potentials above the magnesium deposition potential, and the local structure distortion around the magnesium ions increases in all of the electrolytes at the magnesium electrode|electrolyte interface during the cathodic polarization. The DFT calculation and XPS results indicate that the [TFSA]–, strongly bound to the magnesium ion in the Mg(TFSA)2/2-MeTHF electrolyte, undergoes reduction decomposition easily, instead of deposition of magnesium metal, which makes the electrolyte inactive electrochem. In the Mg(BH4)2/THF electrolyte, because the [BH4]– coordinated to the magnesium ions is stable even under the potential of the magnesium deposition, the magnesium deposition is not inhibited by the decomposition of [BH4]–. Conversely, because [TFSA]– is weakly bound to the magnesium ion in Mg(TFSA)2/triglyme, the reduction decomposition occurs relatively slowly, which allows the magnesium deposition in the electrolyte. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Application of 112-49-2).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Application of 112-49-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

McDonald, Russell W. et al. published their research in Anti-Cancer Drug Design in 2001 | CAS: 3929-47-3

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Category: ethers-buliding-blocks

Synthesis and anticancer activity of nordihydroguaiaretic acid (NDGA) and analogues was written by McDonald, Russell W.;Bunjobpon, Wilawan;Liu, Tong;Fessler, Sue;Pardo, Olivier E.;Freer, Isabel K. A.;Glaser, Mark;Seckl, Michael J.;Robins, David J.. And the article was included in Anti-Cancer Drug Design in 2001.Category: ethers-buliding-blocks This article mentions the following:

Nordihydroguaiaretic acid (NDGA) is a constituent of the creosote bush Larrea divaricata and is well known to be a selective inhibitor of lipoxygenases. NDGA can also inhibit the platelet derived growth factor receptor and the protein kinase C intracellular signalling family, which both play an important role in proliferation and survival of cancers. Moreover, NDGA induces apoptosis in tumor xenografts. Although it is likely to have several targets of action, NDGA is well tolerated in animals. These encouraging results have prompted interest in the compound for clin. study. However, high concentrations of NDGA are required for efficacy and more potent analogs are required. We have synthesized five analogs of NDGA with different lengths of carbon bridge between the two catechol moieties in order to establish the spacing required for optimum anticancer effect and to compare their activities with NDGA. In order to ascertain if the catechol moieties are essential for anticancer activity, we prepared five analogs of NDGA containing only one hydroxyl group on each aromatic ring. NDGA, its racemic form, and catechol derivatives with five or six carbon atom bridges and the phenol analogs with bridges of three to six carbon atoms all showed similar activity, with IC50 values of âˆ?-5 μM against the H-69 small cell lung cancer cell line. Analogs with shorter or longer bridges were much less active. The most potent analog was the biscatechol with a four-carbon bridge I which was >10 times more active than NDGA and therefore represents a new lead compound in this area. Surprisingly, the tetra-Me ether of this compound was slightly more active than NDGA, but the trihydroxy analog was less active than NDGA. In summary, simplification of the structure of NDGA by removal of the Me groups has produced a new lead compound I, which is >10 times more potent than NDGA as a proliferative inhibitor of H-69 small cell lung cancer cells. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Category: ethers-buliding-blocks).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem