Author: Jessica.F

Song, Tangqiumei; Morales-Collazo, Oscar; Brennecke, Joan F. published the artcile< Solubility and Diffusivity of Oxygen in Ionic Liquids>, Reference of 6482-24-2, the main research area is oxygen solubility diffusivity ionic liquid gravimetry.

The solubility of O2 was measured gravimetrically in 16 ionic liquids (ILs) containing piperidinium, pyrrolidinium, ammonium, tetrahydrothiophenium, methyltriazabicyclodecene, or guanidinium cations paired with bis(trifluoromethanesulfonyl)imide, bis(perfluoroethylsulfonyl)imide, or perfluoropropanoyl(trifluoromethylsulfonyl)imide anions. The temperature dependence of the solubility was determined for eight of the ILs. Henry’ law constants were determined from the solubility data as well as standard enthalpies and entropies of absorption for systems with temperature-dependent data. Knowledge of these thermodn. properties is essential in guiding the structural design of ionic liquids for different applications involving O2. The O2 solubility did not follow any obvious trend with regard to IL structure or molar volume; instead, the dipole-quadrupole interactions are the primary driving forces for O2 dissolution in ionic liquids, as demonstrated by neg. standard enthalpies of absorption for all of the ILs. In addition, diffusion coefficients of O2 in the ILs as a function of temperature (293, 313, and 333 K) and applied O2 pressure (1, 3, and 5 MPa) were obtained by fitting the time-dependent absorption data to a widely used mass diffusion model. The diffusion coefficients of O2 in ionic liquids at 293 K and 1 MPa roughly correlate inversely with the pure IL viscosity, likely due to the relatively low and similar O2 solubilities under these conditions. As expected, O2 diffusivities increase with increasing temperature However, they also increase with increasing pressure, likely due to decreasing solution viscosity with increasing gas solubility

Journal of Chemical & Engineering Data published new progress about Absorption. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Reference of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lamola, Jairus L.; Moshapo, Paseka T.; Holzapfel, Cedric W.; Christopher Maumela, Munaka published the artcile< Palladium-catalyzed borylation of aryl bromides and chlorides using phosphatrioxa-adamantane ligands>, Electric Literature of 190788-60-4, the main research area is palladium catalyst borylation aryl bromide chloride phosphatrioxa adamantane; aryl boronate ester preparation.

Catalysts based on the combination of Pd(OAc)2 and the electron-deficient phosphatrioxa-adamantane ligands are described for borylation of aryl bromides and chlorides. Catalytic evaluation of a small library of phosphatrioxa-adamantane ligands provided some insights on the preferred ligand steric profile for borylation reactions. The corresponding aryl boronate esters were accessed under mild conditions (25-70°) and isolated in high yields (up to 96%).

Tetrahedron Letters published new progress about Adamantanes Role: CAT (Catalyst Use), USES (Uses) (phosphatrioxa-). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Electric Literature of 190788-60-4.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Elhag, Amro S.; Chen, Yunshen; Noguera, Jose; Reddy, Prathima P.; Hirasaki, George J.; Nguyen, Quoc P.; Johnston, Keith P. published the artcile< Switchable amine surfactants for CO2 foams in high temperature enhanced oil recovery>, Electric Literature of 18312-57-7, the main research area is carbon dioxide foam switchable amine surfactant oil recovery.

This paper describes about the switchable amine surfactants for carbon dioxide foams in high temperature enhanced oil recovery.

Preprints – American Chemical Society, Division of Energy & Fuels published new progress about Brines. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Electric Literature of 18312-57-7.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Jing; Li, Yang; Zhang, Fuyuan; Hu, Chenchen; Chen, Yiyun published the artcile< Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp3)-H Functionalization under Mild Reaction Conditions>, Electric Literature of 52244-70-9, the main research area is visible light redox reaction carbon hydrogen bond functionalization; C−H functionalization; alkoxyl radicals; allylic compounds; photochemistry; reaction mechanisms.

Reported herein is the first visible-light-induced formation of alkoxyl radicals from N-(alkoxy)phthalimides, and the Hantzsch ester as the reductant is crucial for the reaction. The selective hydrogen atom abstraction by the alkoxyl radical enables C(sp3)-H allylation and alkenylation reactions under mild reaction conditions at room temperature Broad substrate variations, including a structurally complex steroid, undergo the C(sp3)-H functionalization reaction effectively with high regioselectivity and chemoselectivity. The synthesis of the target compounds was achieved using 2-[(phenylsulfonyl)methyl]-2-propenoic acid Et ester as a starting material in a reaction with 2-[2-[(4-methylphenyl)methoxy]ethoxy]-1H-isoindole-1,3(2H)-dione [i.e., cyclic N-(alkoxy)imide, phthalimide] derivatives Under optimized conditions tris[2-(2-pyridinyl-κN)phenyl-κC]iridium(1+) um(1+) hexafluorophosphate(1-) [i.e., fac-Ir(ppy)3] was used as a catalyst. The title compounds thus formed included 2-[[(2E)-3-phenyl-2-propen-1-yl]oxy]ethanol derivatives, γ-(2-hydroxyethoxy)-α-(methlyene)benzenebutanoic acid esters,.

Angewandte Chemie, International Edition published new progress about Aliphatic alcohols, radicals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Electric Literature of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jiang, Lei; Zhang, Xiaoyan; Wang, Yinran; Guo, Fang; Hou, Zhaomin published the artcile< N-Monomethylation of Amines with Methanol by Syndiotactic Poly(aminostyrene)-supported Palladium Nanoparticle Catalyst>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is methyl amine preparation green chem; primary amine methanol monomethylation syndiotactic polyaminostyrene support palladium nanocatalyst.

Palladium nanocatalyst supported on dimethylamino-functionalized syndiotactic polystyrene (Pd@sPSNMe2) showed high activity and selectivity for the N-monomethylation of various primary amines RNH2 (R = Ph, cyclohexyl, 3-(morpholin-4-yl)propyl, 2-(1H-indol-3-yl)ethyl, etc.) using methanol as methylation reagent under air to prepare monomethylated amines RNH(CH3), 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole and N-methyl-1H-benzo[d]imidazole. The excellent catalytic performance could be associated with the ultrafine palladium nanoparticles and high amine-adsorbing capacity of the catalyst. The Pd@sPS-NMe2 catalyst was highly robust, and could be easily recovered by filtration and reused more than ten times without decrease in activity and selectivity.

Asian Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gao, Xinpei; Wu, Fanglin; Mariani, Alessandro; Passerini, Stefano published the artcile< Concentrated Ionic-Liquid-Based Electrolytes for High-Voltage Lithium Batteries with Improved Performance at Room Temperature>, Reference of 6482-24-2, the main research area is concentration ionic liquid electrolyte lithium battery room temperature viscosity; Li-rich cathode; asymmetric anions; ether-functionalized cations; high concentrated electrolytes; ionic liquids.

Ionic liquids (ILs) have been widely explored as alternative electrolytes to combat the safety issues associated with conventional organic electrolytes. However, hindered by their relatively high viscosity, the electrochem. performances of IL-based cells are generally assessed at medium-to-high temperature and limited cycling rate. A suitable combination of alkoxy-functionalized cations with asym. imide anions can effectively lower the lattice energy and improve the fluidity of the IL material. The Li/Li1.2Ni0.2Mn0.6O2 cell employing N-N-diethyl-N-methyl-N-(2-methoxyethyl)ammonium (fluorosulfonyl)(trifluoromethanesulfonyl)imide (DEMEFTFSI)-based electrolyte delivered an initial capacity of 153 mAh g-1 within the voltage range of 2.5-4.6 V, with a capacity retention of 65.5 % after 500 cycles and stable coulombic efficiencies exceeding 99.5 %. Moreover, preliminary battery tests demonstrated that the drawbacks in terms of rate capability could be improved by using Li-concentrated IL-based electrolytes. The improved room-temperature rate performance of these electrolytes was likely owing to the formation of Li+-containing aggregate species, changing the concentration-dependent Li-ion transport mechanism.

ChemSusChem published new progress about Activation energy. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Reference of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pelter, Andrew; Ward, Robert S.; Rao, Ramohan R. published the artcile< An approach to the biomimetic synthesis of aryltetralin lignans>, Application of C11H16O2, the main research area is cyclization quinone methide ketal; Lewis acid cyclization catalyst; aryltetralin; tetralin aryl.

The BF3 catalyzed cyclization of 3-(arylpropyl)quinone-methide ketals I (R, R1, R2 = H, OMe) affords a mild biomimetic route to aryltetralins II. I were prepared from the corresponding 4-arylbutanoic acids in 5 steps.

Tetrahedron published new progress about Cyclization. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Application of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lu, Yuting; Shen, Xiaoyue; Hang, Taijun; Song, Min published the artcile< Identification and characterization of process-related substances and degradation products in apremilast: Process optimization and degradation pathway elucidation>, Product Details of C12H19NO4S, the main research area is apremilast degradation product analysis LC MS process optimization; Apremilast; LC–MS; Process optimization; Related substances.

This study aims at investigating the separation, identification and characterization of related substances in apremilast by LC-MS hyphenated techniques, as well as the synthesis optimization and the degradation pathways elucidation. Forced degradation studies were conducted under the ICH prescribed stress conditions. The chromatog. separation was achieved on XBridge C18 column (4.6 mm × 150 mm, 3.5 μm) using a mobile phase consisting of water adjusted to pH 3.0 with formic acid as solvent A and acetonitrile as solvent B in linear gradient elution program. Twelve related substances were detected all together in apremilast and its stress samples. Their structures were identified mainly through pos. ESI high-resolution TOF-MS anal. of the parent ions’ accurate masses and elemental compositions, and the corresponding MS/MS spectra elucidation. There were three process-related substances and nine degradation products, seven of them were first reported. Two degradation products and one process-related substance were further verified by semi-preparation and NMR determination Their origins and formation mechanisms were also discussed, based on which effective approaches for the synthesis optimization were conducted. Therefore, the related substances investigation are valuable for apremilast manufacturing process optimization and quality control.

Journal of Pharmaceutical and Biomedical Analysis published new progress about Chromatography. 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, Product Details of C12H19NO4S.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yu, Jianjin; Li, Chao-Jun; Zeng, Huiying published the artcile< Dearomatization-Rearomatization Strategy for ortho-Selective Alkylation of Phenols with Primary Alcohols>, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol, the main research area is palladium catalyzed ortho selective alkylation phenol alc dearomatization rearomatization; aromaticity; cross-coupling; palladium; reaction mechanisms; synthetic methods.

Phenols are common precursors and core structures of a variety of industrial chems. ranging from pharmaceuticals to polymers. However, the synthesis of site-specifically substituted phenols is challenging, and thus the development of new methods for this purpose would be highly desirable. Reported here is a protocol for palladium-catalyzed ortho-selective alkylation reactions of phenols with primary alcs. by a dearomatization-rearomatization strategy, with water as the sole byproduct. Various substituted phenols and primary alcs. were compatible with the standard reaction conditions. The detailed mechanism of this transformation was also investigated.

Angewandte Chemie, International Edition published new progress about Alkylation. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Recommanded Product: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ma’arif, Burhan; Fitri, Hilwa; Saidah, Nisfatul Lailatus; Najib, Luqman Alfani; Yuwafi, Achmad Hamdan; Atmaja, Ria Ramadhani Dwi; Inayatillah, Fidia Rizkiah; Dianti, Meilina Ratna; Laswati, Hening; Agil, Mangestuti published the artcile< Prediction of compounds with antiosteoporosis activity in Chrysophyllum cainito L. leaves through in silico approach>, Name: 2,2′-(Tridecylazanediyl)diethanol, the main research area is Chrysophyllum antiosteoporosis leaf phytoestrogen; Chrysophyllum cainito L.; antiosteoporosis; in silico; phytoestrogen.

The aims of this study were to analyze the metabolite profiling results of various extract of Chyrsophyllum cainito L. leaves, which contain phytoestrogen, through in silico study against 3OLS protein, an X-ray protein of ERβ, so it can predict the types of the phytoestrogen contents which have antiosteoporosis property. In silico anal. was carried out for the compounds from the metabolite profiling data of C. cainito leaves from our previous study. The structure compounds from metabolite profiling results of various extract of C. cainito leaves were prepared with Avogadro 1.0.1 software, mol. docking was done using PyRx 0.8 software, and Biovia Discovery Studio Visualizer 2016 software was used to visualize the structure of compounds against 3OLS protein. The physicochem. characteristics of the compounds were analyzed using the SwissADME web tool. It was known that there were total 11 compounds in C. cainito leaves that predicted as phytoestrogens which have ERβ agonist properties against 3OLS protein. The ERβ agonist was a compound that has parameters similar to 17β-estradiol in its interaction with 3OLS protein, which has a pharmacophore distance of 10.862 Å, and binding to amino acids His 475 and Glu 305 or Arg 346 at receptor-ligand docking simulation. C. cainito leaves contain 11 compounds that are predicted to be phytoestrogens with ERβ agonist properties, which is responsible for antiosteoporosis activity.

Journal of Basic and Clinical Physiology and Pharmacology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Name: 2,2′-(Tridecylazanediyl)diethanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem