Author: Jessica.F

Yoon, Hyunjee; Shin, Seoyoon; Park, Sooyeol; Shin, Moo Whan published the artcile< Low-viscosity quaternary ammonium-based ionic liquid electrolytes for lithium air batteries>, Category: ethers-buliding-blocks, the main research area is ammonium ionic liquid electrolyte lithium air battery viscosity.

Ionic liquids (ILs) have attracted significant attention as candidates for Li-air battery electrolyte solvents owing to their novel properties, such as non-volatility and low reactivity with lithium metal anodes. However, the main drawback of IL-based electrolytes is their high viscosity, which results in poor battery capacity and conductivity In this study, we synthesized low-viscosity ILs with reduced mol. weights using the side-chain shortening method. In particular, the IL: tri-Me ethoxymethyl ammonium bis(fluoromethylsulfonyl)imide (N111(1O2) FSI), has a lower viscosity (111.4 cP) than that of the electrochem. stable reference material, diethylmethyl (2-methoxyethyl) ammonium bis(fluoromethylsulfonyl)imide (DEME FSI; viscosity of 131.1cP). The use of the optimal IL, N111(1O2) FSI, resulted in an initial capacity 3.75 times higher than that obtained using DEME FSI in the cell test. The chem. stability of N111(1O2) FSI with lithium metal was confirmed by microstructure anal. of the lithium surface. The physicochem. properties, such as viscosity, ionic conductivity, m.p., and electrochem. properties, were thoroughly characterized.

Journal of Molecular Liquids published new progress about Electric current-potential relationship. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Tao; Luan, Yu-Xin; Lam, Nelson Y. S.; Li, Jiang-Fei; Li, Yue; Ye, Mengchun; Yu, Jin-Quan published the artcile< A directive Ni catalyst overrides conventional site selectivity in pyridine C-H alkenylation>, Category: ethers-buliding-blocks, the main research area is alkenylated pyridine preparation; alkyne pyridine alkenylation heterocyclic carbene ligated nickel aluminum catalyst.

Herein, application of bifunctional N-heterocyclic carbene-ligated Ni-Al catalyst in C3-H alkenylation of pyridines was described. This method overrode the intrinsic C2 and/or C4 selectivity, and provided a series of C3-alkenylated pyridines such as I in 43-99% yields and up to 98:2 C3 selectivity. This method not only allowed a variety of pyridine and heteroarene substrates to be used as the limiting reagent, but was also effective for the late-stage C3 alkenylation of diverse complex pyridine motifs in bioactive mols.

Nature Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xue, Yu; Vughs, Dennis; Hater, Wolfgang; Huiting, Hans; Vanoppen, Marjolein; Cornelissen, Emile; Verliefde, Arne; Brunner, Andrea M. published the artcile< Liquid chromatography-high-resolution mass spectrometry-based target and nontarget screening methods to characterize film-forming amine-treated steam-water systems>, Product Details of C17H37NO2, the main research area is liquid chromatog high resolution mass spectrometry target nontarget screening; screening film forming amine treated steam water systems.

Film-forming amine products (FFAP) are frequently used as corrosion inhibitors in steam-water systems. To have a better understanding of their behavior in the treated system, a liquid chromatog. coupled to the high-resolution mass spectrometry (LC-HRMS) method was developed. This method enabled the concurrent targeted quant. anal. of the film-forming amine oleyl propylenediamine (OLDA) and the nontarget screening (NTS)-based anal. of potential degradation products of FFAP or other organic matter in the system. The method was applied to samples collected from an FFAP-treated industrial steam-water system. OLDA was detected at a concentration of 0.027 mg/L after the FFAP dosing in the low-pressure steam drum. A feature (a combination of mass-to-charge ratio and retention time associated with a signal intensity) prioritization workflow was designed and applied to the NTS results to focus on the potential thermal degradation products of FFAP that could affect the studied steam-water system. Six features were prioritized from a total of 4596 detected features. Structural elucidation of these features was attempted based on mass spectrometry fragmentation data. One of the prioritized features was successfully identified as 2,2′-(tridecylimino)diethanol, presumably a degradation product of the FFAP emulsifier. Because of the chem. structure of the mol., 2,2′-(tridecylimino)diethanol was considered as noncorrosive to the system. Overall, the developed LC-HRMS method facilitated the efficient anal. of OLDA with a limit of quantification of 0.002 mg/L and a comprehensive monitoring of organic matter across the steam-water system, including potential degradation products of the dosed FFAP.

Industrial & Engineering Chemistry Research published new progress about Boiler waters. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Product Details of C17H37NO2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reddy, Reddy Rajasekhar; Gudup, Satish Sonbarao; Ghorai, Prasanta published the artcile< Organocatalytic, Enantioselective Synthesis of Cyclohexadienone Containing Hindered Spirocyclic Ethers through an Oxidative Dearomatization/Oxa-Michael Addition Sequence>, Electric Literature of 52244-70-9, the main research area is cyclohexadienone enantioselective preparation spirocyclic ether oxidative dearomatization oxa Michael; asymmetric synthesis; chromans; organocatalysis; oxa-Michael addition; tetrahydrofurans.

An unprecedented enantioselective oxa-Michael reaction of α-tertiary alcs. using cinchona-alkaloid-based chiral bifunctional squaramide catalysts is reported. An oxidative dearomatization of phenol followed by an enantioselective oxa-Michael addition sequence provided a broad array of chiral sterically hindered tetrahydrofurans and tetrahydropyrans attached to a cyclohexadienone moiety in spiro fashion. In general, good yields and excellent enantioselectivities (up to 99 %) were observed The chiral oxo-cycles obtained have easily been transformed into chromans without disturbing the enantioselectivity.

Angewandte Chemie, International Edition published new progress about Dearomatization (oxidative). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Electric Literature of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lu, Biao; Cao, Hu; Cao, Jingsong; Huang, Song; Hu, Qiyue; Liu, Dong; Shen, Ru; Shen, Xiaodong; Tao, Weikang; Wan, Hong; Wang, Dan; Yan, Yinfa; Yang, Liuqing; Zhang, Jiayin; Zhang, Lei; Zhang, Lianshan; Zhang, Minsheng published the artcile< Discovery of EBI-907: A highly potent and orally active B-RafV600E inhibitor for the treatment of melanoma and associated cancers>, Product Details of C8H9BrO2, the main research area is pyrazolo isoquinoline derivative preparation oral BRaf inhibitor cancer structure; B-Raf(V600E); Cancer; Kinase; Pyrazolo[3,4-c]isoquinoline; Scaffold hopping.

A novel series of pyrazolo[3,4-c]isoquinoline derivatives was discovered as B-RafV600E inhibitors through scaffold hopping based on a literature lead PLX4720. Further SAR exploration and optimization led to the discovery of potent B-RafV600E inhibitors with good oral bioavailability in rats and dogs. One of the compounds EBI-907 (13g) demonstrated excellent in vivo efficacy in B-RafV600E dependent Colo-205 tumor xenograft models in mouse and is under preclin. studies for the treatment of melanoma and B-RafV600E associated cancers.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, Product Details of C8H9BrO2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhen, Long; Fan, Hui; Wang, Xiaoji; Jiang, Liqin published the artcile< Synthesis of Thiocarbamoyl Fluorides and Isothiocyanates Using CF3SiMe3 and Elemental Sulfur or AgSCF3 and KBr with Amines>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is thiocarbamoyl fluoride isothiocyanate preparation amine sulfur trifluoromethyl trimethylsilane.

Reactions of thiocarbonyl fluoride derived from cheap, readily available, and widely used CF3SiMe3, elemental sulfur, and KF with secondary amines and primary amines at room temperature in THF provided a wide variety of thiocarbamoyl fluorides and isothiocyanates in moderate to excellent yields, resp. The two reactions show broad substrate scope and good functional group tolerance. Moreover, AgSCF3 reacts with secondary/primary amines under KBr at room temperature, affording quant. thiocarbamoyl fluorides/isothiocyanates, which feature late-stage application.

Organic Letters published new progress about Fluorides Role: SPN (Synthetic Preparation), PREP (Preparation) (thiocarbamoyl). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Feng, Shao-Ping; Huang, Kun published the artcile< Enhanced separation of Pd(II) and Pt(IV) from hydrochloric acid aqueous solution using 2-((2-methoxyethyl)thio)-1H-benzimidazole>, Synthetic Route of 6482-24-2, the main research area is palladium platinum separation extraction methoxyethyl thiobenzimidazole.

Separation of palladium (Pd) and platinum (Pt) by solvent extraction is difficult because of their extremely similar physicochem. properties. Development of new extractants with a high extraction efficiency and excellent separation selectivity is the primary focus for enhancing the separation of Pd and Pt by solvent extraction In this study, a new extractant, 2-((2-methoxyethyl)thio)-1H-benzimidazole (MOBI), which contains N, S, and O atoms, was synthesized and used to sep. Pd(II) and Pt(IV) from a hydrochloric acid aqueous solution The exptl. results revealed that Pd(II) and Pt(IV) were effectively separated under the optimal conditions: MOBI concentration of 0.005 mol·L-1, HCl concentration of 0.2 mol·L-1, organic/aqueous (O/A) phase ratio of 1.0, and contact time of 15 min. The separation coefficient between Pd(II) and Pt(IV) was 1246.40, which indicates that MOBI has a higher selectivity for Pd(II) than Pt(IV). In addition, the mechanism of coordination between Pd(II) and MOBI was demonstrated through the slope method, Fourier transform IR spectroscopy (FTIR), hydrogen-1 NMR spectroscopy (1H NMR), and carbon-13 NMR spectroscopy (13C NMR). The results revealed that MOBI could coordinate with Pd(II) via the N atom in the benzimidazole ring of MOBI mols. to form [Pd(MOBI)2Cl2](O).

Rare Metals (Beijing, China) published new progress about Extraction (stripping). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Synthetic Route of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shinohara, Koichi; Tsurugi, Hayato; Mashima, Kazushi published the artcile< N-Methylation of Aniline Derivatives with CO2 and Phenylsilane Catalyzed by Lanthanum Hydridotriarylborate Complexes bearing a Nitrogen Tridentate Ligand>, Product Details of C8H11NO, the main research area is methyl aniline preparation; aniline methylation phenylsilane lanthanum hydridotriarylborate complex nitrogen tridentate ligand; lanthanum hydridotriarylborate complex nitrogen tridentate ligand preparation.

A lanthanum amide complex, La(L)[N(SiHMe2)2](thf) (L = N,N””-bis(pentafluorophenyl)diethylenetriamine dianion), upon activation with B(3,4,5-F2C6H2)3, showed excellent catalytic activity for N-methylation of N-alkylaniline derivatives with CO2 in the presence of PhSiH3. A catalytically active lanthanum hydridotriarylborate complex, [La(L)(thf)2][HB(3,4,5-F3C6H2)3], was generated via hydride abstraction from the Si-H moiety by moderate Lewis acid B(3,4,5-F2C6H2)3 in THF. DFT studies of the CO2 hydrosilylation step clarified the following multiple noncovalent interactions as key factors for locating the HB(3,4,5-F2C6H2)3 anion and B(3,4,5-F3C6H2)3 near the lanthanum center in the transition states of CO2 reduction and Si-O bond formation: (1) π-π interaction between the electron-deficient C6F5 ring on ligand L and the 3,4,5-F3C6H2 ring of the HB(3,4,5-F3C6H2)3 anion and (2) C-H···F hydrogen bonds between the ortho-C-H bond of B(3,4,5-F3C6H2)3 and the fluorine atoms of L.

ACS Catalysis published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xin, Zhili; Himmelbauer, Martin K.; Jones, J. Howard; Enyedy, Istvan; Gilfillan, Rab; Hesson, Thomas; King, Kristopher; Marcotte, Douglas J.; Murugan, Paramasivam; Santoro, Joseph C.; Gonzalez-Lopez de Turiso, Felix published the artcile< Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors>, Computed Properties of 6482-24-2, the main research area is preparation CNS penetrant apoptosis signal regulating kinase inhibitor.

Apoptosis signal-regulating kinase 1 (ASK1) is a key mediator in the apoptotic and inflammatory cellular stress response. To investigate the therapeutic value of modulating this pathway in neurol. disease, we have completed medicinal chem. studies to identify novel CNS-penetrant ASK1 inhibitors starting from peripherally restricted compounds reported in the literature. This effort led to the discovery of 21, a novel ASK1 inhibitor with good potency (cell IC50 = 138 nM), low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat Kp,uu = 0.38).

ACS Medicinal Chemistry Letters published new progress about Apoptosis. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Computed Properties of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bhatthula, Bharath Kumar Goud; Kanchani, Janardhan Reddy; Arava, Veera Reddy; Subha, M. C. S. published the artcile< Total synthesis of carbazole alkaloids>, Reference of 190788-60-4, the main research area is carbazole alkaloid total synthesis Suzuki Miyaura cross coupling; Cadogan reductive cyclization total synthesis carbazole alkaloid.

A Suzuki-Miyaura cross coupling, followed by triphenylphosphine mediated Cadogan reductive cyclization sequence provided efficient access to a series of carbazole alkaloids. In the present work, this approach was applied to the total synthesis of mukonine, clauszoline K, koenoline, murrayanine, murrayafoline A, mukoeic acid, glycoborine, glycozolicine, mukolidine, mukoline, glycozoline, 3-methoxy-9H-carbazole-1-carboxylic acid Me ester, (3-methoxy-9H-carbazol-1-yl)-methanol, 3-methoxy-9H-carbazole-1-carbaldehyde, 3-methoxy-9H-carbazole-1-carboxylic acid, 2-methyl-9H-carbazole and nonsteroidal anti-inflammatory drug (NSAID) carprofen and its derivatives

Tetrahedron published new progress about Cadogan reaction. 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Reference of 190788-60-4.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem