Category: 10365-98-7

The author of 《Access to Multifunctionalized Benzofurans by Aryl Nickelation of Alkynes: Efficient Synthesis of Anti-Arrhythmic Drug Amiodarone》 were Iqbal, Naeem; Iqbal, Naila; Maiti, Debabrata; Cho, Eun Jin. And the article was published in Angewandte Chemie, International Edition in 2019. Reference of 3-Methoxyphenylboronic acid The author mentioned the following in the article:

An unconventional nickel-catalyzed reaction was developed for the synthesis of multifunctionalized benzofurans from alkyne-tethered phenolic esters. The transformation involves the generation of a nucleophilic vinyl NiII species by the regioselective syn-aryl nickelation of an alkyne, which then undergoes an intramol. cyclization with phenol ester to yield highly functionalized 1,1-disubstituted alkenes with 3-benzofuranyl and (hetero)aryl substituents. The methodol. can be used for the late-stage benzofuran incorporation of various drug mols. and natural products, such as 2-propylvaleric acid, gemfibrozil, biotin, and lithocholic acid. Furthermore, this arylative cyclization method was successfully applied for the efficient synthesis of the anti-arrhythmic drug amiodarone. In the part of experimental materials, we found many familiar compounds, such as 3-Methoxyphenylboronic acid(cas: 10365-98-7Reference of 3-Methoxyphenylboronic acid)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Reference of 3-Methoxyphenylboronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Photoinduced Single-Electron Transfer as an Enabling Principle in the Radical Borylation of Alkenes with NHC-Borane》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Xia, Peng-Ju; Song, Dan; Ye, Zhi-Peng; Hu, Yuan-Zhuo; Xiao, Jun-An; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua. HPLC of Formula: 10365-98-7 The article mentions the following:

A photoinduced SET process enables the direct B-H bond activation of NHC-boranes. Photochem. radical borylation of α-trifluoromethylstyrenes ArC(CF3):CH2 with NHC-borane H3B-IMe catalyzed by [Ir(ppy)2(dfbpy)][PF6] afforded difluoromethylene-substituted borylethylarenes CF2:CArCH2BH2-IMe (Ar = substituted Ph, 2-naphthyl, 3-thienyl; IMe = 1,3-dimethyl-2-imidazolylidene). In contrast to common hydrogen atom transfer (HAT) strategies, this photoinduced reaction simply takes advantage of the beneficial redox potentials of NHC-boranes, thus obviating the need for extra radical initiators. The resulting NHC-boryl radical was used for the borylation of a wide range of α-trifluoromethylalkenes and alkenes with diverse electronic and structural features, providing facile access to highly functionalized borylated mols. Labeling and photoquenching experiments provide insight into the mechanism of this photoinduced SET pathway.3-Methoxyphenylboronic acid(cas: 10365-98-7HPLC of Formula: 10365-98-7) was used in this study.

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.HPLC of Formula: 10365-98-7

Referemce:
Ether – Wikipedia,
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Yue, Wen-Jun; Day, Craig S.; Martin, Ruben published their research in Journal of the American Chemical Society in 2021. The article was titled 《Site-Selective Defluorinative sp3 C-H Alkylation of Secondary Amides》.Computed Properties of C7H9BO3 The article contains the following contents:

A site-selective defluorinative sp3 C-H alkylation of secondary amides that rapidly and reliably incorporates gem-difluoroalkene motifs into previously unfunctionalized sp3 sites was disclosed. This protocol was distinguished by its mild conditions, wide scope and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites. In the experimental materials used by the author, we found 3-Methoxyphenylboronic acid(cas: 10365-98-7Computed Properties of C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Computed Properties of C7H9BO3

Referemce:
Ether – Wikipedia,
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The author of 《Radiosynthesis of a carbon-11-labeled AMPAR allosteric modulator as a new PET radioligand candidate for imaging of Alzheimer’s disease》 were Miao, Caihong; Dong, Fugui; Jia, Limeng; Li, Wei; Wang, Min; Zheng, Qi-Huang; Xu, Zhidong. And the article was published in Bioorganic & Medicinal Chemistry Letters in 2019. SDS of cas: 10365-98-7 The author mentioned the following in the article:

Methoxyphenoxybenzothiadiazinedione I (R = 11CH3) was prepared as an allosteric PET ligand for the α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid receptor (AMPAR) for potential use as an imaging agent for Alzheimer’s disease. I (R = Me) and I (R = H) were prepared in eight and nine steps and 3% and 1% yields, resp. Methylation of I (R = H) with 11CH3OTf yielded I as the minor product in 10-15% radiochem. yield (based on [11C]CO2), with N4-methylation as the major reaction. The radiochem. purity was >99%, and the molar activity at end of bombardment (EOB) was 370-740 GBq/μmol with a total synthesis time of 35-40 min from EOB. The lipophilicity of I (R = 11CH3) and its N4-methylated isomer were determined and compared to the calculated lipophilicities for I (R = 11CH3) and its N4- and N2-methylated isomers. In the experiment, the researchers used 3-Methoxyphenylboronic acid(cas: 10365-98-7SDS of cas: 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.SDS of cas: 10365-98-7

Referemce:
Ether – Wikipedia,
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《Serendipitous discovery of aryl boronic acids as β-lactamase inhibitors》 was published in Bioorganic & Medicinal Chemistry Letters in 2020. These research results belong to Yang, Shu-Wei; Pan, Jianping; Root, Yuriko; Scapin, Giovanna; Xiao, Li; Su, Jing. Quality Control of 3-Methoxyphenylboronic acid The article mentions the following:

High throughput screening for β-lactamase inhibitors afforded biphenyl hits such as 1. Hit confirmation and X-ray soaking experiments with Pseudomonas Aeruginosa AmpC enzyme led to the identification of an aryl boronic acid-serine complex 4, which was formed from Ph boronic acid 8 (an impurity in compound 1) and ethylene glycol (the cryoprotectant in the soaking experiment). In the experiment, the researchers used many compounds, for example, 3-Methoxyphenylboronic acid(cas: 10365-98-7Quality Control of 3-Methoxyphenylboronic acid)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Quality Control of 3-Methoxyphenylboronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Bismuth-Catalyzed Oxidative Coupling of Arylboronic Acids with Triflate and Nonaflate Salts》 was published in Journal of the American Chemical Society in 2020. These research results belong to Planas, Oriol; Peciukenas, Vytautas; Cornella, Josep. Reference of 3-Methoxyphenylboronic acid The article mentions the following:

Herein, a Bi-catalyzed cross-coupling of arylboronic acids with perfluoroalkyl sulfonate salts based on a Bi(III)/Bi(V) redox cycle is presented. An electron-deficient sulfone ligand proved to be key for the successful implementation of this protocol, which allows the unusual construction of C(sp2)-O bonds using com. available NaOTf and KONf as coupling partners. Preliminary mechanistic studies as well as theor. investigations reveal the intermediacy of a highly electrophilic Bi(V) species, which rapidly eliminates Ph triflate. In the experimental materials used by the author, we found 3-Methoxyphenylboronic acid(cas: 10365-98-7Reference of 3-Methoxyphenylboronic acid)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Reference of 3-Methoxyphenylboronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Enantioselective Dicarbofunctionalization of Unactivated Alkenes by Palladium-Catalyzed Tandem Heck/Suzuki Coupling Reaction》 were Zhang, Zhan-Ming; Xu, Bing; Wu, Lizuo; Wu, Yuanqi; Qian, Yanyan; Zhou, Lujia; Liu, Yu; Zhang, Junliang. And the article was published in Angewandte Chemie, International Edition in 2019. Recommanded Product: 3-Methoxyphenylboronic acid The author mentioned the following in the article:

A highly enantioselective dicarbofunctionalization of unactivated alkenes was implemented by a Pd-catalyzed asym. tandem Heck/Suzuki coupling reaction. This reaction represents the first example of a highly enantioselective intramol. cyclization/cross-coupling of olefin-tethered aryl halides with alkyl-, alkenyl- or arylboronic acids, and provides rapid access to a number of chiral compounds, such as dihydrobenzofurans, indolines, chromanes, and indans bearing a quaternary stereocenter, in good yields with excellent enantioselectivities. The practicality of this reaction was validated in the modification of biol. complex mols. such as peptides, piperitol, CB2 receptor agonists, etc. Moreover, the synthesis of two enantiomers can be easily realized by simple change in the order of the steps in the coupling sequence. In the experiment, the researchers used 3-Methoxyphenylboronic acid(cas: 10365-98-7Recommanded Product: 3-Methoxyphenylboronic acid)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Recommanded Product: 3-Methoxyphenylboronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Quality Control of 3-Methoxyphenylboronic acidIn 2021 ,《Nickel(II)-Catalyzed Addition of Aryl and Heteroaryl Boroxines to the Sulfinylamine Reagent TrNSO: The Catalytic Synthesis of Sulfinamides, Sulfonimidamides and Primary Sulfonamides》 was published in Journal of the American Chemical Society. The article was written by Lo, Pui Kin Tony; Willis, Michael C.. The article contains the following contents:

A redox-neutral Ni(II)-catalyzed addition of (hetero)aryl boroxines to N-sulfinyltritylamine (TrNSO) was developed to afford sulfonimidamides I [R = 2-MeC6H4, 4-FC6H4, 2-furyl, etc.; R1 = (CH2)2CN, pyrrolidin-1-yl, piperidin-1-yl, etc.] and primary sulfonamides II [R2 = 2-thienyl, 4-FC6H4, 4-MeOC6H4, etc.]. The reactions used a catalyst generated from the combination of com., air-stable NiCl2·(glyme) and a com. available bipyridine ligand. These transformations were all achieved using one-pot procedures. For larger-scale reactions, the catalyst loading could be reduced to 1 mol %. In addition to this study using 3-Methoxyphenylboronic acid, there are many other studies that have used 3-Methoxyphenylboronic acid(cas: 10365-98-7Quality Control of 3-Methoxyphenylboronic acid) was used in this study.

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Quality Control of 3-Methoxyphenylboronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Goetzke, F. Wieland; Mortimore, Mike; Fletcher, Stephen P.. Reference of 3-Methoxyphenylboronic acid. The article was titled 《Enantio- and Diastereoselective Suzuki-Miyaura Coupling with Racemic Bicycles》. The information in the text is summarized as follows:

A rhodium-catalyzed enantio- and diastereoselective Suzuki-Miyaura cross-coupling between racemic fused bicyclic allylic chlorides, e.g., I and boronic acids RB(OH)2 (R = naphth-2-yl, thiophen-3-yl, 2H-1,3-benzodioxol-5-yl, etc.) has been described. The highly stereoselective transformation allows for the coupling of aryl, heteroaryl, and alkenyl boronic acids and gives access to functionalized bicyclic cyclopentenes, e.g., II which can be converted into other five-membered-ring scaffolds with up to five contiguous stereocenters. Preliminary mechanistic studies suggest that these reactions occur with overall retention of the relative stereochem. and are enantioconvergent for pseudo-sym. allylic chloride starting materials. In addition, a bicyclic allylic chloride starting material without pseudo-symmetry undergoes a highly enantioselective regiodivergent reaction. After reading the article, we found that the author used 3-Methoxyphenylboronic acid(cas: 10365-98-7Reference of 3-Methoxyphenylboronic acid)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Reference of 3-Methoxyphenylboronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Computed Properties of C7H9BO3In 2019 ,《Installation of Minimal Tetrazines through Silver-Mediated Liebeskind-Srogl Coupling with Arylboronic Acids》 was published in Journal of the American Chemical Society. The article was written by Lambert, William D.; Fang, Yinzhi; Mahapatra, Subham; Huang, Zhen; am Ende, Christopher W.; Fox, Joseph M.. The article contains the following contents:

Described is a general method for the installation of a minimal 6-methyltetrazin-3-yl group via the 1st example of a Ag-mediated Liebeskind-Srogl cross-coupling. The attachment of bioorthogonal tetrazines on complex mols. typically relies on linkers that can neg. impact the physiochem. properties of conjugates. Cross-coupling with arylboronic acids and a new reagent, 3-((p-biphenyl-4-ylmethyl)thio)-6-methyltetrazine (b-Tz), proceeds under mild, PdCl2(dppf)-catalyzed conditions to introduce minimal, linker-free tetrazine functionality. Safety considerations guided the authors’ design of b-Tz which can be prepared on decagram scale without handling hydrazine and without forming volatile, high-N tetrazine byproducts. Replacing conventional Cu(I) salts used in Liebeskind-Srogl cross-coupling with a Ag2O mediator resulted in higher yields across a broad library of aryl and heteroaryl boronic acids and provides improved access to a fluorogenic tetrazine-BODIPY conjugate. A covalent probe for MAGL incorporating 6-methyltetrazinyl functionality was synthesized in high yield and labeled endogenous MAGL in live cells. This new Ag-mediated cross-coupling method using b-Tz is anticipated to find addnl. applications for directly introducing the tetrazine subunit to complex substrates. The results came from multiple reactions, including the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7Computed Properties of C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Computed Properties of C7H9BO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem