Category: 10541-78-3

Wang, Tao; Hoffmann, Marvin; Dreuw, Andreas; Hasagic, Edina; Hu, Chao; Stein, Philipp M.; Witzel, Sina; Shi, Hongwei; Yang, Yangyang; Rudolph, Matthias; Stuck, Fabian; Rominger, Frank; Kerscher, Marion; Comba, Peter; Hashmi, A. Stephen K. published the artcile< A Metal-Free Direct Arene C-H Amination>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is aryl amine preparation chemoselective; arene hydroxylamine amination.

Here, a metal-free arene e.g., mesitylene C-H amination using hydroxylamine derivatives 4-(CH3)C6H5S(O)2ON(R)R1 (R = H, Me; R1 = Me, Boc, Bn, etc.) under benign conditions was reported. A charge transfer interaction between the aminating reagents and the arene substrates enables the chemoselective amination of the arene, even in the presence of various functional groups. Oxygen was crucial for an effective conversion and its accelerating role for the electron transfer step was proven exptl. In addition, this was rationalized by a theor. study which indicated the involvement of a dioxygen-bridged complex with a “”Sandwich-like”” arrangement of the aromatic starting materials and the aminating agents at the dioxygen mol.

Advanced Synthesis & Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shang, Yaping; Jonnada, Krishna; Yedage, Subhash Laxman; Tu, Hua; Zhang, Xiaofeng; Lou, Xin; Huang, Shijun; Su, Weiping published the artcile< Rhodium(III)-catalyzed indole synthesis at room temperature using the transient oxidizing directing group strategy>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is alkyl indole preparation; internal alkyne aniline transient oxidizing directing group rhodium catalyst.

Rh-catalyzed reactions of N-alkyl anilines with internal alkynes at room temperature have been developed using an in situ generated N-nitroso group as a transient oxidizing directing group. Due to mild reaction conditions, this method enabled synthesis of a broad range of N-alkyl indoles, including even two indole-based medicinal compds I (R1 = Me, allyl, C6H5, etc.; R2 = 5-Me, 6-CH2OMe, 5-NO2, etc.) and II (R1 = Me, Et, i-Pr, etc.; R2 = H, 5-Me, 5-CO2Me, etc.; R3 = n-Bu, C6H5, 4-MeC6H5, etc.; R4 = Me, COMe, 3-FC6H5, etc.). This work disclosed the feasibility of the transient oxidizing directing group strategy in C-H functionalization reactions, which possesses the potential to enhance overall step-economy and impart new reactivity patterns to substrates.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkynes, internal Role: RCT (Reactant), RACT (Reactant or Reagent). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Huang, Shuang; Hong, Xi; Cui, He-Zhen; Zhan, Bing; Li, Zhi-Ming; Hou, Xiu-Feng published the artcile< Bimetallic Bis-NHC-Ir(III) Complex Bearing 2-Arylbenzo[d]oxazolyl Ligand: Synthesis, Catalysis, and Bimetallic Effects>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is potential energy surface iridacycle complex catalyzed methylation aniline DFT; bimetallic biscarbene iridium complex containing arylbenzooxazolyl ligand preparation catalyst; crystal structure bimetallic biscarbene iridium complex containing arylbenzooxazolyl ligand; mol structure bimetallic biscarbene iridium complex containing arylbenzooxazolyl ligand; isotope effect iridium carbene complex catalyzed methylation aniline.

Herein, an unprecedented bimetallic bis-NHC Cp*Ir complex 1 bearing 2-arylbenzo[d]oxazolyl and NHC ligands is reported. A significantly increase in activity was observed for N-methylation of amines and reduction of aldehydes with MeOH catalyzed by 1 compared to the monometallic analogs (2-11). Under the optimal conditions, it showed to be highly effective in N-methylation of nitroarenes with MeOH as both C1 and H2 source. Substrates, including aromatic amines, ketones and nitro compounds with various functional groups, can be well tolerated. Mechanistic studies and DFT calculation highlights the significance of bimetallic centers cooperativity.

Organometallics published new progress about Anilines Role: SPN (Synthetic Preparation), PREP (Preparation) (N-Me). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sakai, Norio; Sasaki, Kazuki; Suzuki, Hiroki; Ogiwara, Yohei published the artcile< One-pot synthesis of α-halo β-amino acid derivatives via the difunctional coupling of ethyl α-diazoacetate with silyl halides and N,O-acetals or aromatic tertiary amines>, HPLC of Formula: 10541-78-3, the main research area is halo beta amino acid ester synthesis solvent effect; ethyl diazoacetate difunctionalization silyl halide acetal aromatic tertiary amine; three component coupling reaction iminium intermediate.

The difunctionalization of Et α-diazoacetate (EDA) using silyl halides as a nucleophile and N,O-acetals as an electrophile under metal-free conditions is described. This process undergoes a novel three-component coupling (3-CC) reaction using EDA, which leads to a one-pot preparation of α-halo β-amino acid esters. Also, this protocol could be adapted to accept an electrophile composed of aromatic tertiary amines. In both 3-CC reactions, the key reaction intermediate is an iminium intermediate that can be easily and effectively generated either from N, O-acetals or from aromatic tertiary amines.

Synthesis published new progress about Multicomponent reaction. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, HPLC of Formula: 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Shaochun; Ibrahim, Jessica Juweriah; Yang, Yong published the artcile< A pincer ligand enabled ruthenium catalyzed highly selective N-monomethylation of nitroarenes with methanol as the C1 source>, Electric Literature of 10541-78-3, the main research area is aryl amine preparation; nitroarene alc selective monomethylation tandem.

A straightforward and highly selective N-monomethylation of nitro compounds RNO2 (R = 4-methylphenyl, quinolin-6-yl, 9-oxo-9H-fluoren-1-yl, etc.) with methanol as the C1 source was developed by employing [RuCl2(p-cymene)2]2 as the catalyst and an NNN pincer (amine-pyridine-imine, API) as the ligand. This protocol was found to be highly selective and effective in the N-monomethylation of a broad spectrum of nitroarenes including pharmaceutically relevant nitro compounds with good tolerance of a set of functional groups. The mechanistic studies revealed that the reaction proceeded via a borrowing-hydrogen pathway in a one-pot cascade manner and methanol serves as both a hydrogen source and a methylation agent.

Organic Chemistry Frontiers published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Electric Literature of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Yuan; Lu, Fo-Yun; Li, Rui-Xue; Guan, Zhi; He, Yan-Hong published the artcile< Visible-light-mediated Synthesis of Bromo-containing Azaspirotrienediones from N-phenylpropynamides>, Product Details of C8H11NO, the main research area is bromo azaspirotrienedione preparation photochem green chem; phenylpropynamide tandem radical addition ipsocyclization oxidation photocatalyst.

A visible-light-mediated reaction of N-phenylpropynamides 2-R1-3-R2C6H3N(R3)C(=O)CCR4 (R1 = H, Me, OMe; R2 = H, Me, CF3, Cl, F, Br; R1R2 = -CH=CHCH=CH-; R3 = Me, Et, i-Pr, Bn; R4 = Ph, 3-MeOC6H4, 4-MeOC6H4, 4-MeC6H4, 4-CF3C6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4) and 1-(3,4-dihydro-1(2H)-quinolinyl)-3-phenyl-2-propyn-1-one with di-Et 2,2-dibromomalonate for the synthesis of bromo-substituted azaspirotrienediones I and II has been developed. This method allows the formation of C-Br, C-C and C=O bonds in one pot via a cascade radical addition/ipso-cyclization/oxidation process. A possible radical mechanism involving single electron transfer and energy transfer processes is proposed based on control experiments, cyclic voltammetry determination and Stern-Volmer quenching experiments

Asian Journal of Organic Chemistry published new progress about Bond formation (C-Br, C-C, C=O). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jiang, Lei; Zhang, Xiaoyan; Wang, Yinran; Guo, Fang; Hou, Zhaomin published the artcile< N-Monomethylation of Amines with Methanol by Syndiotactic Poly(aminostyrene)-supported Palladium Nanoparticle Catalyst>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is methyl amine preparation green chem; primary amine methanol monomethylation syndiotactic polyaminostyrene support palladium nanocatalyst.

Palladium nanocatalyst supported on dimethylamino-functionalized syndiotactic polystyrene (Pd@sPSNMe2) showed high activity and selectivity for the N-monomethylation of various primary amines RNH2 (R = Ph, cyclohexyl, 3-(morpholin-4-yl)propyl, 2-(1H-indol-3-yl)ethyl, etc.) using methanol as methylation reagent under air to prepare monomethylated amines RNH(CH3), 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole and N-methyl-1H-benzo[d]imidazole. The excellent catalytic performance could be associated with the ultrafine palladium nanoparticles and high amine-adsorbing capacity of the catalyst. The Pd@sPS-NMe2 catalyst was highly robust, and could be easily recovered by filtration and reused more than ten times without decrease in activity and selectivity.

Asian Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ma, Jiaoli; Li, Jing; Guo, Penghu; Liao, Xincheng; Cheng, Huicheng published the artcile< Synthesis and antitumor activity of novel indole derivatives containing α-aminophosphonate moieties>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is aminophosphonate moiety indole derivative antitumor activity.

A series of novel indole derivatives containing α-aminophosphonate moieties were synthesized as antitumor agents. The in vitro cytotoxic activity of the compounds was evaluated against human hepatoma cells (HepG2) and human gastric cancer cells (MGC-803) by MTT assay, revealing that most of target compounds exhibited moderate to high antitumor activities. Among them, compound C5 (IC50 = 34.2 μM) demonstrated superior inhibitory activities against HepG2 compared with 5-fluorouracil (IC50 = 78.7 μM). It is noteworthy that compound B7 (IC50 = 35.7 μM) displayed higher inhibitory activities against MGC-803 than that of 5-fluorouracil (IC50 = 82.0 μM).

Arabian Journal of Chemistry published new progress about Antiproliferative agents. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Ning; Chi, Zhuomin; Wang, Xinchao; Gao, Zezhong; Li, Shangda; Li, Gang published the artcile< Formal C-H/C-I Metathesis: Site-Selective C-H Iodination of Anilines Using Aryl Iodides>, Application In Synthesis of 10541-78-3, the main research area is iodinated aniline preparation regioselective; aniline iodination palladium catalyst.

Protocols for the meta- and ortho-C-H iodination of aniline derivatives via formal C(sp2)-H/C(sp2)-I metathesis using 2-nitrophenyl iodides as mild iodinating reagents were reported herein. These protocols led to the production of a range of valuable iodinated aniline derivatives These results demonstrated the potential of developing novel site-selective C-H activation reactions with electron-rich compounds, since mild reagents can often been utilized in functional group metathesis reactions.

Organic Letters published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application In Synthesis of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhao, Xin; Yang, Fang; Zou, Shao-Yu; Zhou, Qian-Qian; Chen, Zi-Sheng; Ji, Kegong published the artcile< Cu-Catalyzed Intermolecular γ-Site C-H Amination of Cyclohexenone Derivatives: The Benefit of Bifunctional Ligands>, Formula: C8H11NO, the main research area is aniline cyclohexenone copper catalyst regioselective amination green chem; amino alc preparation antibacterial antioxidant; cyclohexadienyl oxy silyl ether aniline copper regioselective diastereoselective amination; aminocyclohexenone preparation green chem.

Utilizing 1,10-phenanthroline-type bifunctional ligands, an efficient Cu-catalyzed intermol. site-selective remote C-H amination using cyclohexenone derivatives and anilines was realized. The amide group installed on the bifunctional ligand played a key role in stabilizing the N-centered radical generated in-situ to realize C-N-directed formation. Meanwhile, a useful catalytic system for site-selective intermol. remote γ-C-H amination to p-aminophenols and γ-aminated enones was established. This economical and practical approach using oxygen as the terminal oxidant was mild and environmentally friendly.

ACS Catalysis published new progress about Amination catalysts (stereoselective, regioselective). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Formula: C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem