Category: 111-90-0

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Reference of 111-90-0.

Badhwar, Reena;Mangla, Bharti;Neupane, Yub Raj;Khanna, Kushagra;Popli, Harvinder research published 《 Quercetin loaded silver nanoparticles in hydrogel matrices for diabetic wound healing》, the research content is summarized as follows. Quercetin (QCT) is an effective antioxidant, antifibrotic and wound healing agent. Silver nanoparticles (AgNPs) are an effective antimicrobial, antifungal and wound healing agent and considered as gold standard for wound treatment especially diabetic and burn wounds. The present study aimed to investigate QCT loaded AgNPs in hydrogel matrixes (QCT-AgNPs hydrogel) as synergistic treatment paradigms for diabetic wound. Quality by Design approach was employed for the optimization of hydrogel preparation using carbopol-934 and aloevera. The developed QCT-AgNPs hydrogel was characterized for hydrodynamic diameter, %entrapment efficiency (%EE), surface morphol., texture anal., in-vitro drug release, skin irritation study, ex-vivo permeation study (confocal study), and antimicrobial efficacy. The optimized formulation showed hydrodynamic diameter of ∼44.1 nm with smooth spherical surface morphol. and ∼92.09% of QCT was entrapped in QCT-AgNPs hydrogel matrixes. The antimicrobial study revealed superior therapeutic efficacy of QCT-AgNPs hydrogel in comparison to marketed (MRKT) gel on S. aureus and E. coli. Moreover, in-vivo results demonstrated that QCT-AgNPs hydrogel significantly (p < 0.001) reduced the wound gap and increased % re-epithelialization compared with diabetic control after 18 d of post treatment in excisional diabetic wound model. In conclusion, this study opens up an avenue for the treatment of diabetic wound.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Reference of 111-90-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Recommanded Product: Diethylene Glycol Monoethyl Ether.

Cardona, Maria I.;Dominguez, Gina P.;Echeverry, Sandra M.;Valderrama, Ivonne H.;Bernkop-Schnurch, Andreas;Aragon, Marcela research published 《 Enhanced oral bioavailability of rutin by a self-emulsifying drug delivery system of an extract of calyces from Physalis peruviana》, the research content is summarized as follows. The aim of this study was to develop and optimize a self-emulsifying drug delivery system (SEDDS) containing an extract of calyces from Physalis peruviana with high mucus permeating properties to increase the bioavailability and the hypoglycemic activity of the active metabolites of the extract The oil, surfactant, and co-solvent were selected based on solubility studies. The formulation was optimized using Box-Behnken statistical exptl. design (BBD). Optimized conditions were Labrafac as oil 10% (weight/weight), Solutol HS 15 as surfactant 45% (weight/weight), propylene glycol as co-solvent 32% (weight/weight) and PDMSHEPMS 13% (weight/weight). The extract was loaded into SEDDS to 45% (weight/weight). The optimized SEDDS exhibited a mean droplet size of 19.5 nm, PDI of 0.20, and neg. zeta potential. Furthermore, SEDDS permeating properties were investigated in porcine intestinal mucus using the Transwell method. Extract-loaded SEDDS showed a 2.6-fold increase in mucus permeation compared to the unformulated extract A pharmacokinetic study showed a nearly 6-fold increase in rutin oral bioavailability in comparison with the unformulated extract Moreover, the hypoglycemic activity of the extract-loaded SEDDS was higher than that of the unformulated extract These results indicate that incorporating an extract of calyces from P. peruviana into SEDDS is a promising strategy to improve the oral bioavailability of the active flavonoids in the extract and the hypoglycemic activity.

Recommanded Product: Diethylene Glycol Monoethyl Ether, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Quality Control of 111-90-0.

Castro, Simone R.;Ribeiro, Ligia N. M.;Breitkreitz, Marcia C.;Guilherme, Viviane A.;Rodrigues da Silva, Gustavo H.;Mitsutake, Hery;Alcantara, Ana C. S.;Yokaichiya, Fabiano;Franco, Margareth K. K. D.;Clemens, Daniel;Kent, Ben;Lancellotti, Marcelo;de Araujo, Daniele R.;de Paula, Eneida research published 《 A pre-formulation study of tetracaine loaded in optimized nanostructured lipid carriers》, the research content is summarized as follows. Tetracaine (TTC) is a local anesthetic broadly used for topical and spinal blockade, despite its systemic toxicity. Encapsulation in nanostructured lipid carriers (NLC) may prolong TTC delivery at the site of injection, reducing such toxicity. This work reports the development of NLC loading 4% TTC. Structural properties and encapsulation efficiency (%EE > 63%) guided the selection of three pre-formulations of different lipid composition, through a 23 factorial design of experiments (DOE). DLS and TEM analyses revealed average sizes (193-220 nm), polydispersity (< 0.2), ζ potential |- 21.8 to – 30.1 mV| and spherical shape of the nanoparticles, while FTIR-ATR, NTA, DSC, XRD and SANS provided details on their structure and physicochem. stability over time. Interestingly, one optimized pre-formulation (CP-TRANS/TTC) showed phase-separation after 4 mo, as predicted by Raman imaging that detected lack of miscibility between its solid (cetyl palmitate) and liquid (Transcutol) lipids. SANS analyses identified lamellar arrangements inside such nanoparticles, the thickness of the lamellae been decreased by TTC. As a result of this combined approach (DOE and biophys. techniques) two optimized pre-formulations were rationally selected, both with great potential as drug delivery systems, extending the release of the anesthetic (> 48 h) and reducing TTC cytotoxicity against Balb/c 3T3 cells.

Quality Control of 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Recommanded Product: Diethylene Glycol Monoethyl Ether.

Bagheri, Hamidreza;Karimi, Nima;Dan, Sasan;Notej, Behrouz;Ghader, Sattar research published 《 Ionic liquid excess molar volume prediction: A conceptual comparison》, the research content is summarized as follows. In this study, the prediction of excess molar volume of ionic liquid + solvent binary system is described using modified two-parameter and three-parameter cubic equation of state (CEoS). The studied binary systems are consisted of 41 ionic liquids, 40 solvents and 5293 data point in the wide temperature range (278.15-353.15 K), ionic liquid mole fraction (0.0036-0.9920) and atm. pressure i.e. P = 1 bar. At the first step, the volume-translated parameter (c) was obtained based on three linear, distance function and exponential-type temperature-dependent cases and using exptl. pure d. After that, and due to easy-to-use of c-parameter, various formula was presented based on pure component thermodn. features for all three cases (IL and solvent, sep.). Finally, to investigate the accuracy of presented c-parameter formula, the excess molar volume of 119 various binary systems was molded using volume-translated PR (VTPR) EoS and volume-translated SRK (VTSRK) EoS without using any binary interaction parameter and the obtained results was compared with the original three-parameter CEoS, Patel-Teja (PT) EoS. The obtained results indicated that the performed two-parameter CEoS modification leads to increase the accuracy of the conventional PR EoS and SRK EoS in comparision to original two-parameter CEoS version and also, PT EoS. The average absolute percent deviation of the VTSRK EoS (c-parameter based on distance function) and the VTPR EoS (c-parameter based on exponential-type temperature-dependent volume-translated) were fewer values through all studied cases and it was 2.0443 and 2.8927, resp.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Recommanded Product: Diethylene Glycol Monoethyl Ether

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Product Details of C6H14O3.

Bayati, Mohamed;Vu, Danh C.;Vo, Phuc H.;Rogers, Elizabeth;Park, Jihyun;Ho, Thi L.;Davis, Alexandra N.;Gulseven, Zehra;Carlo, Gustavo;Palermo, Francisco;McElroy, Jane A.;Nagel, Susan C.;Lin, Chung-Ho research published 《 Health risk assessment of volatile organic compounds at daycare facilities》, the research content is summarized as follows. Children are particularly vulnerable to many classes of the volatile organic compounds (VOCs) detected in indoor environments. The neg. health impacts associated with chronic and acute exposures of the VOCs might lead to health issues such as genetic damage, cancer, and disorder of nervous systems. In this study, 40 VOCs including aldehydes and ketones, aliphatic hydrocarbons, esters, aromatic hydrocarbons, cyclic terpenes, alcs., and glycol ethers were identified and qualified in different locations at the University of Missouri (MU) Child Development Laboratory (CDL) in Columbia, Missouri. Our results suggested that the concentrations of the VOCs varied significantly among classrooms, hallways, and playground. The VOCs emitted from personal care and cleaning products had the highest indoor levels (2-ethylhexanol-1, 3-carene, homomenthyl salicylate with mean concentration of 5.15 μg/m³, 1.57 μg/m³, and 1.47 μg/m³, resp.). A cancer risk assessment was conducted, and none of the 95th percentile dose estimates exceeded the age-specific no significant risk levels (NSRL) in all classrooms. Dimensionless toxicity index scores were calculated for all VOCs using a novel web-based framework called Toxicol. Prioritization Index (ToxPi), which integrates multiple sources of toxicity data. According to the method, homomenthyl salicylate, benzothiazole, 2-ethylhexyl salicylate, hexadecane, and tridecane exhibited diverse toxicity profiles and ranked as the five most toxic indoor VOCs. The findings of this study provide critical information for policy makers and early education professionals to mitigate the potentially neg. health impacts of indoor VOCs in the childcare facilities.

Product Details of C6H14O3, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Computed Properties of 111-90-0.

Bayoumi, Mahitab;Arafa, Mona G.;Nasr, Maha;Sammour, Omaima A. research published 《 Nobiletin-loaded composite penetration enhancer vesicles restore the normal miRNA expression and the chief defence antioxidant levels in skin cancer》, the research content is summarized as follows. Skin cancer is one of the most dangerous diseases, leading to massive losses and high death rates worldwide. Topical delivery of nutraceuticals is considered a suitable approach for efficient and safe treatment of skin cancer. Nobiletin; a flavone occurring in citrus fruits has been reported to inhibit proliferation of carcinogenesis since 1990s, is a promising candidate in this regard. Nobiletin was loaded in various vesicular systems to improve its cytotoxicity against skin cancer. Vesicles were prepared using the thin film hydration method, and characterized for particle size, zeta potential, entrapment efficiency, TEM, ex-vivo skin deposition and phys. stability. Nobiletin-loaded composite penetration enhancer vesicles (PEVs) and composite transfersomes exhibited particle size 126.70 ± 11.80 nm, 110.10 ± 0.90 nm, zeta potential + 6.10 ± 0.40 mV, + 9.80± 2.60 mV, entrapment efficiency 93.50% ±3.60, 95.60% ± 1.50 and total skin deposition 95.30% ± 3.40, 100.00% ± 2.80, resp. These formulations were selected for cytotoxicity study on epidermoid carcinoma cell line (A431). Nobiletin-loaded composite PEVs displayed the lowest IC₅₀ value, thus was selected for the in vivo study, where it restored skin condition in DMBA induced skin carcinogenesis mice, as delineated by histol. and immuno-histochem. anal., biochem. assessment of skin oxidative stress biomarkers, in addition to miRNA21 and miRNA29A. The outcomes confirmed that nobiletin- loaded composite PEVs is an efficient delivery system combating skin cancer.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Computed Properties of 111-90-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Electric Literature of 111-90-0.

Bondre, Ruchika M.;Kanojiya, Pranita S.;Wadetwar, Rita N.;Kangali, Priya S. research published 《 Sustained vaginal delivery of in situ gel containing Voriconazole nanostructured lipid carrier: formulation, in vitro and ex vivo evaluation》, the research content is summarized as follows. Voriconazole (VOZ) is an antifungal drug having poor aqueous solubility VOZ nanostructured lipid carrier (VNLC) was prepared by using melt emulsification followed by ultrasonication technique. The VNLCs were optimized by 32 full factorial design using Design-Expert software. The optimized VNLC had a particle size, ζ potential and entrapment efficiency of 205.8 nm, -27.1 mV and 78.85%, resp. The optimized VNLC was further loaded in thermosensitive in situ gel. In vitro release studies of VNLC gel showed sustained release of the drug (98.84 ± 1.26%) for up to 24 h. The ex vivo permeation studies showed higher penetration for the VNLC gel as compared to plain VOZ gel. The in vitro antifungal assay showed higher efficacy of VNLC than that of plain VOZ. The HET-CAM test of the VNLC gel showed no irritation and thus was found to be suitable for vaginal administration. Thus, it can be concluded that the developed VNLC gel showed a sustained release pattern with higher drug localization in the vaginal tissue and thus can offer improved treatment of vaginal candidiasis.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Electric Literature of 111-90-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Safety of Diethylene Glycol Monoethyl Ether.

Alshehri, Sultan;Shakeel, Faiyaz;Alam, Prawez;Pena, Angeles;Jouyban, Abolghasem;Martinez, Fleming research published 《 Effect of temperature and polarity on the solubility and preferential solvation of sinapic acid in aqueous mixtures of DMSO and Carbitol》, the research content is summarized as follows. Reported equilibrium mole fraction solubilities of sinapic acid (3) in {DMSO (1) + water (2)} and {Carbitol (1) + water (2)} mixtures at several temperatures were analyzed in terms of the Hildebrand solubility parameter of these aqueous mixtures Moreover, the preferential solvation parameters of sinapic acid in these aqueous saturated mixtures at (298.15 and 313.15) K were determined based on the inverse Kirkwood-Buff integrals (IKBI) as widely described in the literature. Sinapic acid is preferentially solvated by water in water-rich mixtures, i.e. (0.00 <x₁ < 0.21 in {DMSO (1) + water (2)}) and (0.00 <x₁ < 0.12 in {Carbitol (1) + water (2)}) but preferentially solvated by the cosolvents in the other mixtures composition In the former cases these results could be interpreted as a consequence of hydrophobic hydration around the non-polar moieties of sinapic acid. Moreover, in the last cases, the observed trends could be due to the Lewis acidic behavior of sinapic acid in front of DMSO or Carbitol mols. because both cosolvents exhibit higher Lewis basic character than water, as indicated by the resp. solvatochromic parameters. A single cosolvency model for representing the equilibrium solubility of sinapic acid in binary solvents at various temperatures was also provided based on a combination of Hansen solubility parameters and Jouyban-Acree model.

Safety of Diethylene Glycol Monoethyl Ether, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Category: ethers-buliding-blocks.

Alshehri, Sultan;Shakeel, Faiyaz;Alam, Prawez;Jouyban, Abolghasem;Martinez, Fleming research published 《 Solubility of 6-phenyl-4,5-dihydropyridazin-3(2H)-one in aqueous mixtures of Transcutol and PEG 400 revisited: Correlation and preferential solvation》, the research content is summarized as follows. Reported equilibrium mole fraction solubility values of 6-phenyl-4,5-dihydropyridazin-3(2H)-one (PDP-6) (3) in {Transcutol (1) + water (2)} and {PEG 400 (1) + water (2)} mixtures at five temperatures from T = (293.15 to 313.15) K were analyzed based on the Hildebrand solubility parameter of the resp. aqueous mixtures Cosolvency models for representing the equilibrium solubility of PDP-6 in both binary solvent systems at various temperatures were also provided for correlation/prediction purposes. Moreover, the preferential solvation parameters of PDP-6 in these aqueous-cosolvent mixtures at T = (298.15 and 313.15) K were determined by means of the “inverse Kirkwood-Buff integrals” (IKBI). PDP-6 is preferentially solvated by water in water-rich mixtures of {Transcutol (1) + water (2)} system but preferentially solvated by Transcutol in mixtures of 0.13 < x1 < 1.00. In the former case this result could be due to hydrophobic hydration around the non-polar moieties of PDP-6. Otherwise, PDP-6 is preferentially solvated by PEG 400 in all the aqueous mixtures Moreover, in the systems where preferentially solvation of PDP-6 by cosolvents are observed, these results could be due to the Lewis acidic behavior of PDP-6 in front of Transcutol or PEG 400 mols. because these cosolvents exhibit higher Lewis basic behavior than water.

Category: ethers-buliding-blocks, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Name: Diethylene Glycol Monoethyl Ether.

Abd-Elsalam, Wessam H.;Saber, Mona M.;Abouelatta, Samar M. research published 《 Trehalosomes: Colon targeting trehalose-based green nanocarriers for the maintenance of remission in inflammatory bowel diseases》, the research content is summarized as follows. The use of non-steroidal anti-inflammatory drugs (NSAIDs) in inflammatory bowel diseases (IBDs) are contradictory between their beneficial effect in alleviating inflammation, and injurious outcomes in aggravating the symptoms of colitis. The study aimed to formulate trehalosomes (THs); innovative green trehalose-based nanocarriers, to alleviate the inflammation symptoms that might be provoked by NSAIDs in IBDs; as trehalose was proved to lighten the inflammation and the oxidative stress response, besides its resistance to the acidic conditions that rises its potentiality as a means for colon targeting. THs were fabricated using L-α-phosphatidylcholine (PL), trehalose, and transcutol, in a single step circumventing the incorporation of any organic solvent and loaded with Tenoxicam (TXM) as a model anti-inflammatory medication. A full 23 factorial design, using Design-Expert software, was established to optimize the formulation variables. The optimized formulation composed of trehalose: PL at a weight ratio of 1:1, 377.72 mg transcutol, and sonicated for 4 min, possessed a spherical shape with a size of 268.61 nm and EE% of 97.83% and released 70.22% of its drug content over 24 h. The supreme protective action of TXM loaded THs compared to TXM suspension and drug-free THs was revealed by the suppression of the inflammatory biomarkers and the improved histopathol. of the colonic tissue in male New Zealand rabbits. IL-1ss, IL-6, and TNF-alpha levels were notably dampened with TXM loaded THs, and oxidative stress markers, measured as GSH and MDA, were significantly altered. The study indicates the successful role of green THs in colon targeting and its anti-inflammatory characteristics in protecting against possible NSAIDs-driven exacerbation of colitis.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Name: Diethylene Glycol Monoethyl Ether

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem