Category: 1484-26-0

1484-26-0, Adding a certain compound to certain chemical reactions, such as: 1484-26-0, name is 3-Benzyloxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1484-26-0.

A mixture OF TRIETHYL ORTHOFORMATE (92 mL, 0.55 mol) and 2, 2-DIMETHYL- [1, 3] – dioxane-4,6-dione (75.3 g, 0.522 mol) (MELDRUMS acid) was heated at 55 ¡ãC for 90 minutes and then cooled to 45 ¡ãC. A solution of 3-benzyloxyaniline (100.2 g, 0.5029 mol) in methanol (200 mL) was slowly added to the reaction over a period 45 minutes while maintaining the reaction temperature below 50 ¡ãC. The reaction was then heated at 45 ¡ãC for one hour, allowed to cool to room temperature, and stirred overnight. The reaction mixture was cooled to 1 ¡ãC, and the product was isolated by filtration and washed with cold ethanol (-400 mL) until the filtrate was colorless. 5-1 [ (3- Benzyloxy) phenylimino] methyl}-2, 2-DIMETHYL- [1, 3] -dioxane-4,6-dione (170.65 g) was isolated as a tan, powdery solid. IH NMR (300 MHz, DMSO-d6) 8 11.21 (d, J= 14. 2 Hz, 1H), 8.61 (d, J= 14. 2 Hz, 1H), 7.49-7. 30 (M, 7H), 7.12 (dd, J= 8.1, 1.96 Hz, 1H), 6.91 (dd, J= 8.4, 2.1 Hz, 1H), 5.16 (s, 2H), 1.68 (s, 6H).

According to the analysis of related databases, 1484-26-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2005/32484; (2005); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

1484-26-0, Adding some certain compound to certain chemical reactions, such as: 1484-26-0, name is 3-Benzyloxyaniline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1484-26-0.

2-Ohtoeroethyl isothiocyanate (293 ing, 2.4 mroot) was added io a solution of 3~bepsilonnzy)oxy~pheny)amine (398 mg, 2,0 mmoi) in dicMoromethane (4 mL), The reaction mixture was stirred at room temperature overnight It was quenched with water (30 mL), followed by extraction with diehloromethane OO mL x 3 ), The organic layers were combined, washed with brine, and concentrated under vacuum. The residue thus obtained was subjected to column chromatography on silica gel to give l -(3-benlambda’ioxy-plienyl)-3-{2-chloro-ethyl)-{hioufea (627 mg, 1.96 mmoi. yield; 98percent) as colorless oil.Tricihylarmne (2.0 mL, excess) was added to a solution of i ~(3-be”zyloxy- phctty.)-3-(2-chloro-ethyl)-mionrea ( S 87 mg, 0.58 mmol} in dry THF (3 mL). The reaction mixture was stirred at refluxiog temperature for 6 hours. It was then quenched with a saturated ammonium chloride aqueous solution {30 niL), followed by extraction with ethyl acetate (30 mL x 3), The organic layers were combined, washed with brine, and concentrated under vacuum. The residue thus obtained was subjected Jo column chromatography on silica gei to give l-(3-benz.yloxy~phenyl>- imidazoiidine-2-thione (compound 76) as a white solid (150 mg. 0.52 mmoi, yield: 90percent).Fi-MS (M-M ): 285.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1484-26-0.

Reference:
Patent; NATIONAL HEALTH RESEARCH INSTITUTES; WO2008/22204; (2008); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

1484-26-0, These common heterocyclic compound, 1484-26-0, name is 3-Benzyloxyaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of amine (1 mmol) in 3 mL of pyridine at 0¡ãC was slowly added the appropriate benzenesulfonyl chloride (1.1 mmol, 1.1 equiv). The mixture was stirred for 12 h at 25¡ãC. The mixture was quenched with 2N HCl, extracted with EtOAc, dried over anhydrous MgSO4, and concentrated in vacuum. The crude product was purified by recrystallization and/or chromatography as noted below.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1484-26-0.

Reference:
Article; Kril, Liliia M.; Vilchez, Valery; Jiang, Jieyun; Turcios, Lilia; Chen, Changguo; Sviripa, Vitaliy M.; Zhang, Wen; Liu, Chunming; Spear, Brett; Watt, David S.; Gedaly, Roberto; Bioorganic and Medicinal Chemistry Letters; vol. 25; 18; (2015); p. 3897 – 3899;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

1484-26-0, Name is 3-Benzyloxyaniline, 1484-26-0, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

Example 18; Preparation of Intermediate Compound 18C; Step A – Synthesis of Compound 18B; Compound 18A (commercially available) (10.0 g, 50.25 mmol) was dissolved in water at room temperature and to resulting suspension K2CO3 ( 3.8 g, 27.64 mmol) was added. 3- Chloro propionylchloride (7.0 g, 55.28 mmol) was added dropwise for 30 minutes and stirred ffoorr 22 hhoouurrss aatt RRTT.. TThhee pprreecciippiittaattee wwaass f fiilltteerreedd aanndd wwaasshheedc with water, 1 N HCl, dried at 500C under vacuum overnight to give 7.2 g of the product 18B.

Statistics shows that 3-Benzyloxyaniline is playing an increasingly important role. we look forward to future research findings about 1484-26-0.

Reference:
Patent; SCHERING CORPORATION; WO2009/32125; (2009); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A common compound: 1484-26-0, name is 3-Benzyloxyaniline, belongs to ethers-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 1484-26-0

General procedure: BSB-Cl 2 (314 mg, 1.2 mmol) and aniline 1 (1mmol) were premixed in THF (10 ml) at0 C to which was added LiHMDS (2 ml, 2 mmol). The resulting mixture was stirred for2 h at this temperature. Upon reaction completion, the solution was concentrated. Theresidue was purified with basic alumina flash chromatography to afford pure product

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1484-26-0, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lu, Erhu; Yadav, Arun; Weaver, Donald F.; Reed, Mark A.; Synlett; vol. 24; 17; (2013); p. 2259 – 2262;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some common heterocyclic compound, 1484-26-0, name is 3-Benzyloxyaniline, molecular formula is C13H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1484-26-0

A mixture of triethyl orthoformate (92 milliliters (mL), 0.55 mole (mol)) and 2,2-dimethyl-[1,3]-dioxane-4,6-dione (75.3 g, 0.522 mol) (Meldrum’s acid) was heated at 55¡ã C. for 90 minutes and then cooled to 45¡ã C. A solution of 3-benzyloxyaniline (100.2 g, 0.5029 mol) in methanol (200 mL) was slowly added to the reaction over a period of 45 minutes while maintaining the reaction temperature below 50¡ã C. The reaction was then heated at 45¡ã C. for one hour, allowed to cool to room temperature, and stirred overnight. The reaction mixture was cooled to 1¡ã C., and the product was isolated by filtration and washed with cold ethanol (400 mL) until the filtrate was colorless. 5-{[(3-benzyloxy)phenylimino]methyl}-2,2-dimethyl-[1,3]-dioxane-4,6-dione (170.65 g) was isolated as a tan, powdery solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1484-26-0, its application will become more common.

Reference:
Patent; Zarraga, Isidro Angelo E.; US2007/166384; (2007); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1484-26-0, name is 3-Benzyloxyaniline, A new synthetic method of this compound is introduced below., 1484-26-0

Example 37; Preparation of Intermediate Compound 37C; Step A ~ Synthesis of Compound 37B; Compound 37A (commercially available) (10.0 g, 50.25 mmol) was dissolved in water at room temperature and to resulting suspension K2CO3 ( 3.8 g, 27.64 mmol) was added. 3- Chloro propionylchloride (7.0 g, 55.28 mmol) was added dropwise for 30 minutes and stirred for 2 hours at RT. The precipitate was filtered and washed with water, 1 N HCl, dried at 50 0C under vacuum overnight to give 7.2 g of the product 37B.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SCHERING CORPORATION; WO2009/32123; (2009); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1484-26-0 as follows. 1484-26-0

A mixtureof triethyl orthoformate (92 mL, 0.55 mol) and 2,2-dimethyl- [1, 3] – dioxane-4,6-dione (75.3 g, 0.522 mol) (Meldrum’s acid) was heated at55 C for 90 minutes and then cooled to45 C. A solution of 3-benzyloxyaniline (100.2 g, 0.5029 mol) in methanol (200 mL) was slowly added to the reaction over a period 45 minutes while maintaining the reaction temperature below50 C. The reaction was then heated at45 C for one hour, allowed to cool to room temperature, and stirred overnight. The reaction mixture was cooled to 1 C, and the product was isolated by filtration and washed with cold ethanol (-400 mL) until the filtrate was colorless.5-{[(3- Benzyloxy) phenylimino]methyl}-2,2-dimethyl- [1, 3] -dioxane-4,6-dione (170.65 g) was isolated as a tan, powdery solid. ‘H NMR (300MHz, DMSO-d6) : 8 11.21 (d, J= 14.2 Hz, 1H), 8. 61 (d, J= 14.2 Hz, 1H), 7.49-7. 30 (m, 7H), 7.12 (dd, J= 8. 1,1. 96 Hz, 1H), 6.91 (dd, J= 8.4, 2.1 Hz, 1H), 5.16 (s, 2H), 1. 68 (s, 6H).

According to the analysis of related databases, 1484-26-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2005/48933; (2005); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

1484-26-0, A common heterocyclic compound, 1484-26-0, name is 3-Benzyloxyaniline, molecular formula is C13H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

B. 3-Benzyloxyphenyl isocyante. To a stirred solution of 3-benzyloxyaniline (507 mg, 2.54 mmol) in toluene (5 mL) containing TEA (740 muL, 5.34 mmol) was added 20percent phosgene in toluene (1.5 mL, 2.83 mmol). The reaction was stirred for 20 h at rt. The organic layer was washed with H2O (20 mL), dried (MgSO4) and concentrated to give a clear brown oil (497 mg, 87percent). The material was used in subsequent steps without charaterization.

The synthetic route of 1484-26-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Butler, Christopher R.; Edwards, James P.; Fourie, Anne M.; Grice, Cheryl A.; Karlsson, Lars; Savall, Brad M.; Tays, Kevin L.; Wei, Jianmei; US2006/223792; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem