Category: 1663-61-2

Reference of 1663-61-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1663-61-2, name is (Triethoxymethyl)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The 2-aminobenzamide (1 equiv), the orthoester (2?3 equiv) and absolute ethanol (2?3 mL) wereplaced in a 15-mL Chemglass screw-cap pressure tube (No. CG-1880-01, Chemglass, Vineland, NJ,USA). Glacial acetic acid (3 equiv) was added, N2 was introduced to the vessel and the cap wastightened. The vessel was heated at 110 ¡ãC for 12?72 h, then cooled and concentrated to give thequinazolinone, which was purified by crystallization from absolute ethanol or trituration from 5percentether in pentane. The following compounds were prepared:

The synthetic route of (Triethoxymethyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gavin, Joshua T.; Annor-Gyamfi, Joel K.; Bunce, Richard A.; Molecules; vol. 23; 11; (2018);,
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Synthetic Route of 1663-61-2,Some common heterocyclic compound, 1663-61-2, name is (Triethoxymethyl)benzene, molecular formula is C13H20O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The orthoester (1.5 equiv) was added to a mixture of the 2-aminobenzamide (1.0 equiv) in absoluteethanol (3 mL). Glacial acetic acid (2 equiv) was added and the reaction was heated at reflux for 12?24 h.The reaction mixture was cooled and concentrated under vacuum. If the crude product was pure by1H-NMR, it was triturated with 5percent ether in pentane. If it was not pure, it was recrystallized fromethanol. In some cases, it was necessary to remove excess orthoester under high vacuum at 50 ¡ãC prior to purification. The following compounds were prepared:

The synthetic route of 1663-61-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gavin, Joshua T.; Annor-Gyamfi, Joel K.; Bunce, Richard A.; Molecules; vol. 23; 11; (2018);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 1663-61-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1663-61-2, name is (Triethoxymethyl)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To asolution of hydrazide (0.73 mmol) in 10 mL of anhydrous ethanol, added triethyl orthoester (0.81 mmol) and ammonium chloride (0.219 mmol). The solution was stirred and heated to reflux until it complete (0.5-18 h). The reaction mass was cooled to room temperature and concentrated under vacuum. The crude product was made into slurry in a mixture of hexanes and ether (3:1), filtered,washed with deionized water or purified by column chromatography.

The synthetic route of (Triethoxymethyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gnanasekaran, Krishna Kumar; Nammalwar, Baskar; Murie, Maeghan; Bunce, Richard A.; Tetrahedron Letters; vol. 55; 50; (2014); p. 6776 – 6778;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1663-61-2, name is (Triethoxymethyl)benzene, A new synthetic method of this compound is introduced below., name: (Triethoxymethyl)benzene

General procedure: The starting hydrazide 5a,b (10.0 mmol) was added to a mixture of the triethyl orthoester (15.0 mmol) and glacial AcOH (10 mL). The mixture was kept under reflux until the starting hydrazide was fully consumed (monitored by TLC, 1?4 h). After cooling, the excess orthoester and AcOH were evaporated under reduced pressure. The crude product 7a?f was subjected to silica gel column chromatography (benzene?EtOAc, 1:3) or was crystallised (benzene?hexanemixtures).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Kudelko, Agnieszka; Jasiak, Karolina; Synthesis; vol. 45; 14; (2013); p. 1950 – 1954;,
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Adding a certain compound to certain chemical reactions, such as: 1663-61-2, name is (Triethoxymethyl)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1663-61-2, HPLC of Formula: C13H20O3

General procedure: The starting hydrazide 4, 8e-i (10 mmol) was added to a mixture of the appropriate triethyl orthoester (10 mol) and 0.1 g p-TsOH in 20 mL of xylene and kept under reflux for 3 h (TLC). After cooling, the mixture was washed with water (30 mL), dried over MgSO4 and then concentrated under reduced pressure. The oily residue was subjected to column chromatography (silica gel, eluent: hexane/AcOEt, 1:2 v/v) or crystallised from benzene/hexane mixture.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Triethoxymethyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kudelko, Agnieszka; Zielin?ski, Wojciech; Ejsmont, Krzysztof; Tetrahedron; vol. 67; 40; (2011); p. 7838 – 7845;,
Ether – Wikipedia,
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1663-61-2, name is (Triethoxymethyl)benzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 1663-61-2

EXAMPLE IV 1-acetyl-5-butyryl-3-(ethoxy-phenyl-methylidene)-2-indolinone 10 g (49 mmol) 5-butyryl-2-indolinone (Ex. 1.2) are stirred in 200 ml acetic anhydride for 5 h at 130¡ã C. Then 35 ml triethyl orthobenzoate are added and the mixture is stirred for a further 4 h at 100¡ã C. Then it is evaporated down and the resulting precipitate is suction filtered, washed and dried. Yield: 11.5 g (62percent of theory) Rf=0.79 (silica gel, ethyl acetate/cyclohexane/methanol 9:9:2) C23H23NO4 (MW=377.438) Mass spectrum: m/z=378 (M+H)+

The synthetic route of 1663-61-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Boehringer Ingelheim International GmbH; US2005/209302; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 1663-61-2, name is (Triethoxymethyl)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1663-61-2, Safety of (Triethoxymethyl)benzene

General procedure: The starting hydrazide 4, 8e-i (10 mmol) was added to a mixture of the appropriate triethyl orthoester (10 mol) and 0.1 g p-TsOH in 20 mL of xylene and kept under reflux for 3 h (TLC). After cooling, the mixture was washed with water (30 mL), dried over MgSO4 and then concentrated under reduced pressure. The oily residue was subjected to column chromatography (silica gel, eluent: hexane/AcOEt, 1:2 v/v) or crystallised from benzene/hexane mixture.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Kudelko, Agnieszka; Zielin?ski, Wojciech; Ejsmont, Krzysztof; Tetrahedron; vol. 67; 40; (2011); p. 7838 – 7845;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

These common heterocyclic compound, 1663-61-2, name is (Triethoxymethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C13H20O3

To a solution of compound 13 (57.1 mg, 0.245 mmol) in 2 mL CH3CN, triethylorthobenzotate (170 muL, 0.735 mmol) and camphorsulfonic acid (11.4 mg,0.049 mmol) were added. The mixture was refluxed at 85 C for 4 h afterwhich TLC indicated full conversion and quenched by adding Et3N. The mixture was concentrated and theresidue was re-dissolved in 1 mL pyridine and 0.5 mL Ac2O was added. The mixture was stirred at roomtemperature for 2 h after which TLC indicated full conversion. The mixture was concentrated underreduced pressure. The residue was dissolved in 2 mL CH3OH and 1 M HCl (1.5 mL) was added. Themixture was stirred for 5 min and extracted with CH2Cl2. The combined organic layers were dried overNa2SO4 and concentrated. The residue was purified by column chromatography to afford 14 as light yellowsyrup (79.1 mg, 85percent).

The synthetic route of (Triethoxymethyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Lihao; Fan, Fei; Wu, Haotian; Gao, Lei; Zhang, Ping; Sun, Tiantian; Yang, Chendong; Yu, Guangli; Cai, Chao; Synlett; vol. 29; 20; (2018); p. 2701 – 2706;,
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Ether | (C2H5)2O – PubChem

Application of 1663-61-2, A common heterocyclic compound, 1663-61-2, name is (Triethoxymethyl)benzene, molecular formula is C13H20O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of intermediate 2 (4 g, 15 mmol), acetic anhydride(5.8 g, 56.9 mmol), and triethyl orthobenzoate (10.1 g, 45 mmol)in toluene (25 mL) was stirred for 5 h at 110 C. After that time,the solvent was concentrated. The precipitate was filtered off,and dried to give 3 as a yellow solid (4.56 g, 76percent). 1H NMR(400 MHz, DMSO-d6) d 8.75 (d, J = 1.3 Hz, 1H), 8.11 (d, J = 8.1 Hz,1H), 7.93 (dd, J = 8.1, 1.6 Hz, 1H), 7.61?7.55 (m, 3H), 7.51 (dd,J = 7.7, 1.8 Hz, 2H), 4.86 (s, 2H), 4.03 (m, 2H), 3.89 (s, 3H), 1.36(t, J = 7.0 Hz, 3H). ESI-MS m/z: 400.0 [M+H]+.

The synthetic route of 1663-61-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Qin, Mingze; Yan, Shuang; Wang, Lei; Zhang, Haotian; Tian, Ye; Zhao, Yanfang; Gong, Ping; Bioorganic and Medicinal Chemistry; vol. 25; 6; (2017); p. 1778 – 1786;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

These common heterocyclic compound, 1663-61-2, name is (Triethoxymethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C13H20O3

Step B: To the solution 3-azidopropoxyl beta-D-mannopyranoside (1030 mg, 3.91 mmol) in acetonitrile (15 ml) was added triethyl orthobenzoate (2.352 ml, 10.17 mmol) followed by TFA (0.030 ml, 0.391 mmol) and in ACN (0.5 mL). The mixture was allowed to stir at room temperature for 1 hour. Rotavap to remove ACN. TFA (10percent in water) (4.28 ml, 5.55 mmol) was added. The mixture was stirred at rt for 2 hours. The residue was purified by column chromatography on silica gel eluting with Ether/CH2Cl2 to give above product as a white solid. 1H NMR (CDCl3, 500 MHz): delta 7.0-8.2 (m, 10H), 5.72 (dd, 1H, J=3.4 Hz, J=1.1 Hz), 5.44 (t, 1H, J=9.6 Hz), 4.79 (d, 1H, J=1.1 Hz), 4.16 (dd, 1H, J=3.4 Hz, J=1.1 Hz), 4.00 (m, 1H), 3.88 (m, 1H), 3.82 (m, 1H), 3.66 (m, 2H), 3.31 (m, 2H), 1.82 (m, 2H).

The synthetic route of (Triethoxymethyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Lin, Songnian; Yan, Lin; Kekec, Ahmet; Zhu, Yuping; Hunter, David N.; Huo, Pei; Feng, Danqing; Nargund, Ravi P.; Moyes, Christopher R.; Zhao, Zhiqiang; Pipik, Brenda; Pissarnitski, Dmitri; Duffy, Joseph L.; Guidry, Erin N.; US2015/105317; (2015); A1;,
Ether – Wikipedia,
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