Category: 17100-64-0

Lu, Biao; Cao, Hu; Cao, Jingsong; Huang, Song; Hu, Qiyue; Liu, Dong; Shen, Ru; Shen, Xiaodong; Tao, Weikang; Wan, Hong; Wang, Dan; Yan, Yinfa; Yang, Liuqing; Zhang, Jiayin; Zhang, Lei; Zhang, Lianshan; Zhang, Minsheng published the artcile< Discovery of EBI-907: A highly potent and orally active B-RafV600E inhibitor for the treatment of melanoma and associated cancers>, Product Details of C8H9BrO2, the main research area is pyrazolo isoquinoline derivative preparation oral BRaf inhibitor cancer structure; B-Raf(V600E); Cancer; Kinase; Pyrazolo[3,4-c]isoquinoline; Scaffold hopping.

A novel series of pyrazolo[3,4-c]isoquinoline derivatives was discovered as B-RafV600E inhibitors through scaffold hopping based on a literature lead PLX4720. Further SAR exploration and optimization led to the discovery of potent B-RafV600E inhibitors with good oral bioavailability in rats and dogs. One of the compounds EBI-907 (13g) demonstrated excellent in vivo efficacy in B-RafV600E dependent Colo-205 tumor xenograft models in mouse and is under preclin. studies for the treatment of melanoma and B-RafV600E associated cancers.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, Product Details of C8H9BrO2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Huber, Daniela; Loeber, Stefan; Huebner, Harald; Gmeiner, Peter published the artcile< Bivalent molecular probes for dopamine D2-like receptors>, Application of C8H9BrO2, the main research area is arylamidoalkyl substituted phenylpiperazine preparation D2 dopamine receptor structure activity.

Merging two arylamidoalkyl substituted phenylpiperazines as prototypical recognition elements for dopamine D 2-like receptors by oligoethylene glycol linkers led to a series of bivalent ligands. These dimers were investigated in comparison to their monomeric analogs for their dopamine D2long, D2short, D3 and D4 receptor binding. Radioligand binding experiments revealed strong bivalent effects for some para-substituted benzamide derivatives For the D3 subtype, the target compounds showed an up to 70-fold increase of affinity and a substantial enhancement of subtype selectivity when compared to the monovalent analog. Anal. of the binding curves displayed Hill slopes very close to one indicating that the bivalent ligands displace 1 equiv of radioligand. Obviously, the two pharmacophores occupy an orthosteric and an allosteric binding site rather than adopting a receptor-bridging binding mode.

Bioorganic & Medicinal Chemistry published new progress about Dopamine D2 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, Application of C8H9BrO2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gilmartin, Philip H.; Kozlowski, Marisa C. published the artcile< Vanadium-Catalyzed Oxidative Intramolecular Coupling of Tethered Phenols: Formation of Phenol-Dienone Products>, Formula: C8H9BrO2, the main research area is vanadium catalyzed oxidative intramol coupling tethered phenol dienone.

A mild and efficient method for the vanadium-catalyzed intramol. coupling of tethered free phenols is described. The corresponding phenol-dienone products are prepared directly in good yields with low catalyst loadings. Electronically diverse tethered phenol precursors are well tolerated, and the catalytic method was effectively applied as the key step in syntheses of three natural products and a synthetically useful morphinan alkaloid precursor.

Organic Letters published new progress about Biomimetic synthesis. 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, Formula: C8H9BrO2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Speicher, Andreas; Backes, Timo; Grosse, Stefan published the artcile< Syntheses of macrocyclic bisbibenzyls on solid support>, COA of Formula: C8H9BrO2, the main research area is macrocycle isoplagiochin CD solid phase synthesis Suzuki Wittig hydrogenation.

A route for the polymer supported total synthesis of the cyclic bisbibenzyls, isoplagiochins C (I) and D (II), found in liverworts is reported. TentaGel resins were used as solid support for a sequence involving Suzuki, Wittig and hydrogenation protocols. The polymer linked intermediates could be characterized by HR-MAS NMR. This route is to be extended to the synthesis of small libraries of differently halogenated derivatives

Tetrahedron published new progress about Hydrogenation. 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, COA of Formula: C8H9BrO2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Joseph, Akil I.; El-Ayle, Gracia; Boutin, Celine; Leonce, Estelle; Berthault, Patrick; Holman, K. Travis published the artcile< Rim-functionalized cryptophane-111 derivatives via heterocapping, and their xenon complexes>, Product Details of C8H9BrO2, the main research area is heterocapping cyclotriphenolene cyclotriguaiacylene bromocyclotriphenolene rim functionalized cryptophane synthesis; xenon complex rim functionalized cryptophane.

Capping of cyclotriphenolene (I) by the more available cyclotriguaiacylene (II) or trisbromocyclotriphenolene (III) gives the first rim-functionalized cryptophane-111 derivatives (IV, R = OMe, Br). Crystal structures of the xenon complexes reveal high cavity packing coefficients and unprecedentedly short Xe···C contacts. A polemic on regioselective bromination of 3-methoxybenzyl alc. (A. Speicher et al., 2005) is also included.

Chemical Communications (Cambridge, United Kingdom) published new progress about Bromination, regioselective (polemic on regioselective bromination of 3-methoxybenzyl alc.). 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, Product Details of C8H9BrO2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem