Category: 2380-78-1

Intelligent detection of flavor changes in ginger during microwave vacuum drying based on LF-NMR was written by Sun, Yanan;Zhang, Min;Bhandari, Bhesh;Yang, Peiqiang. And the article was included in Food Research International in 2019.Category: ethers-buliding-blocks The following contents are mentioned in the article:

Low-field NMR (LF-NMR) and electronic nose combined with Gas chromatog. mass spectrometry (GC-MS) were used to collect the data of moisture state and volatile substances to predict the flavor change of ginger during drying. An back propagation artificial neural network (BP-ANN) model was established with the input values of LF-NMR parameters and the output values of sensors for different flavor substances obtained from electronic nose. The results showed that fresh ginger contained three water components: bound water (T₂₁), immobilized water (T₂₂) and free water (T₂₃), with the corresponding peak areas of A₂₁, A₂₂ and A₂₃, resp. During drying, the changes of A₂₁ and A₂₂ were not significant, while A₂₃ and A_Total decreased significantly (p < .05). Linear discriminant anal. (LDA) of electronic nose data showed that samples with different drying time can be well distinguished. Hierarchical clustering anal. (HCA) confirmed that the electronic nose characteristic sensor data S₄, S₅, S₈ and S₁₃ corresponded with the data measured by GC-MS. The correlation anal. between LF-NMR parameters and characteristic sensors showed that A₂₃ and A_Total were significantly correlated with the volatile components (p < .05). The results of the BP-ANN prediction showed that the model fitted well and had strong approximation ability (R > 0.95 and error < 3.65%) and stability, which indicated that the ANN model can accurately predict the flavor change during ginger drying based on LF-NMR parameters. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Category: ethers-buliding-blocks).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Microwave-assisted lignin liquefaction in hydrazine and ethylene glycol: Reaction pathways via response surface methodology was written by Nde, Divine B.;Barekati-Goudarzi, Mohamad;Muley, Pranjali D.;Khachatryan, Lavrent;Boldor, Dorin. And the article was included in Sustainable Materials and Technologies in 2021.Synthetic Route of C9H12O3 The following contents are mentioned in the article:

Microwave assisted liquefaction (MAL) of alkali lignin in ethylene glycol (EG) in the presence of hydrazine was carried out using response surface methodol. Dielec. properties of mixtures of lignin/EG at different hydrazine concentrations were determined to enhance the understanding of the MAL process. MAL parameters were hydrazine concentration (1-3%), temperature (100-180 °C), time (5-45 min) with the maximum microwave heating power limited to 750 W. Lignin/EG ratio was fixed at 1 g:10 mL. Dielec. properties were significantly influenced by hydrazine concentration and temperature Major products from the liquefaction process (as % of peak areas) were grouped into guaiacol and derivatives (17-42%), Nitrogen compounds (0-27%), and Hydroxylated products (8-22%), and their yields were modelled with polynomial equations. Product yields were significantly influenced by process parameters. Optimum parameters for maximizing yields of guaiacol and nitrogen containing compounds were 0.5%, 180 °C, 25 min and 2.5%, 130, 25 min for hydrazine concentration, temperature, and time, resp. Low hydrazine concentration increases guaiacol yield at higher temperatures, indicating that at high temperatures hydrazine behaves as a hydrogen donor for lignin liquefaction. The yield of nitrogen containing compounds increases at relatively low temperatures and high concentration of hydrazine. Apart from playing the resp. roles of liquefaction solvent and hydrogen donor, EG and hydrazine also take part in the reaction thereby significantly modifying the composition of reaction products. A mechanistic reaction mechanism was proposed to explain the formation of the liquefaction products. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Synthetic Route of C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C9H12O3

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Ether – Wikipedia,
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Biodegradation of lignin and the associated degradation pathway by psychrotrophic Arthrobacter sp. C2 from the cold region of China was written by Jiang, Cheng;Cheng, Yi;Zang, Hailian;Chen, Xi;Wang, Yue;Zhang, Yuting;Wang, Jinming;Shen, Xiaohui;Li, Chunyan. And the article was included in Cellulose (Dordrecht, Netherlands) in 2020.Product Details of 2380-78-1 The following contents are mentioned in the article:

Degradation of most of the lignocellulose-rich agricultural residue in the cold regions of China is limited due to the cold climate. Lignin is the main component of lignocellulose, and the effective degradation of lignin is one of the most crucial processes in degrading lignocellulose. Psychrotrophic lignin-degrading bacteria and cold adapted ligninolytic enzymes have promising potential for the degradation and transformation of lignin, which are conducive to the resource utilization of lignocelluloses and energy-saving production under cold conditions. In this study, a newly psychrotrophic bacterial strain, Arthrobacter sp.C2, was isolated. The optimal enzyme activity conditions and lignin degradation pathways of C2 were investigated using sodium lignin sulfonate as substrate. The optimal conditions for enzyme activity included an initial pH of 6.74, a temperature of 14.9°C, an incubation time of 6.87 days, and an inoculum size of 2.24%. Under the optimal conditions, the lignin peroxidase and manganese peroxidase activities and the degradation rate reached 29.8 U/L, 56.4 U/L and 40.1%, resp. The biodegradation products including acids, phenols, aldehydes and alcs. were analyzed by gas chromatog.-mass spectrometry and Fourier transform IR spectroscopy. Further, the potential degradation pathways were proposed according to the results obtained in this study and those presented in the relevant literature. This study not only provides valuable psychrotrophic strain resources for the sustainable utilization of lignocellulose in cold regions, but also supplies potential application options for energy-saving production of useful chems. using cold adapted enzymes. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Product Details of 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Product Details of 2380-78-1

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Catalytic pyrolysis of lignin using low-cost materials with different acidities and textural properties as catalysts was written by Han, Tong;Ding, Saiman;Yang, Weihong;Joensson, Paer. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2019.Formula: C9H12O3 The following contents are mentioned in the article:

Catalytic fast pyrolysis of lignin was performed using low-cost materials with different acidities and textural properties as catalysts in the present work. The main focus is to understand the role of low-cost catalysts in the fast pyrolysis of lignin. The four most commonly used low-cost catalysts, ilmenite (FeTiO₃), bentonite (Al-Si-OH), activated carbon (AC) and red mud (RM), were selected. The results show that bentonite, red mud and activated carbon effectively enhance the dehydration reaction, which is regarded as the dominant way to eliminate oxygen during the pyrolysis process, due to the existence of strong acidic sites. However, only activated carbon is found to be effective in promoting the production of monocyclic aromatic hydrocarbons (MAHs). Two metallic catalysts, i.e., bentonite and red mud, have strong acidities but quite low surface areas and less porous structures. Therefore, the dehydrated intermediates produced are especially easy to repolymerize to form char or coke without the restriction of obtaining a porous structure during the pyrolysis process. Activated carbon has not only a certain acidity but also a rich porous structure. Lignin fast pyrolysis-derived oxygenates can diffuse and react on the well-dispersed active sites within the pores of activated carbons. The catalytic performance of the activated carbon are supposed to be determined by the pore size. Only pores of similar size to lignin fast pyrolysis-derived oxygenates (0.6-1 nm) seems to be effective for the production of MAHs. Pores larger or smaller than lignin fast pyrolysis-derived oxygenates both tend to cause coke deposition rather than MAHs formation. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Formula: C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Formula: C9H12O3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Catalytic level identification of ZSM-5 on biomass pyrolysis and aromatic hydrocarbon formation was written by Chen, Wei-Hsin;Cheng, Ching-Lin;Lee, Kuan-Ting;Lam, Su Shiung;Ong, Hwai Chyuan;Ok, Yong Sik;Saeidi, Samrand;Sharma, Amit K.;Hsieh, Tzu-Hsien. And the article was included in Chemosphere in 2021.Synthetic Route of C9H12O3 The following contents are mentioned in the article:

Zeolite socony mobil-5 (ZSM-5) is a common catalyst used for biomass pyrolysis. Nevertheless, the quant. information on the catalytic behavior of ZSM-5 on biomass pyrolysis is absent so far. This study focuses on the catalytic pyrolysis phenomena and mechanisms of biomass wastes using ZSM-5 via thermogravimetric analyzer and pyrolysis-gas chromatog./mass spectrometry, with particular emphasis on catalytic level identification and aromatic hydrocarbons (AHs) formation. Two biomass wastes of sawdust and sorghum distillery residue (SDR) are investigated, while four biomass-to-catalyst ratios are considered. The anal. suggests that biomass waste pyrolysis processes can be divided into three zones, proceeding from a heat-transfer dominant zone (zone 1) to catalysis dominant zones (zones 2 and 3). The indicators of the intensity of difference (IOD), catalytic effective area, catalytic index (CI), and aromatic enhancement index are conducted to measure the catalytic effect of ZSM-5 on biomass waste pyrolysis and AHs formation. The maximum IOD occurs in zone 2, showing the highest intensity of the catalytic effect. The CI values of the two biomass wastes increase with increasing the biomass-to-catalyst ratio. However, there exists a threshold for sawdust pyrolysis, indicating a limit for the catalytic effect on sawdust. The higher the catalyst addition, the higher the AHs proportion in the vapor stream. When the biomass-to-catalyst ratio is 1/10, AHs formation is intensified significantly, especially for sawdust. Overall, the indexes conducted in the present study can provide useful measures to identify the catalytic pyrolysis dynamics and levels. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Synthetic Route of C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C9H12O3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The impact of olive oil compounds on the metabolic reprogramming of cutaneous melanoma cell models was written by Brito, Cheila;Tomas, Ana;Silva, Sandra;Bronze, Maria Rosario;Serra, Ana Teresa;Pojo, Marta. And the article was included in Molecules in 2021.Synthetic Route of C9H12O3 The following contents are mentioned in the article:

Cutaneous melanoma is the deadliest type of skin cancer, characterized by a high mol. and metabolic heterogeneity which contributes to therapy resistance. Despite advances in treatment, more efficient therapies are needed. Olive oil compounds have been described as having anti-cancer properties. Here, we clarified the cytotoxic potential of oleic acid, homovanillyl alc., and hydroxytyrosol on melanoma cells. Metabolic viability was determined 48 h post treatment of A375 and MNT1 cells. Metabolic gene expression was assessed by qRT-PCR and Mitogen-Activated Protein Kinase (MAPK) activation by Western blot. Hydroxytyrosol treatment (100 and 200μM) significantly reduced A375 cell viability (p = 0.0249; p < 0.0001) which, based on the expression anal. performed, is more compatible with a predominant glycolytic profile and c-Jun N-terminal kinase (JNK) activation. By contrast, hydroxytyrosol had no effect on MNT1 cell viability, which demonstrates an enhanced oxidative metabolism and extracellular signal-regulated kinase (ERK) activation. This compound triggered cell detoxification and the use of alternative energy sources in A375 cells, inhibiting JNK and ERK pathways. Despite oleic acid and homovanillyl alc. demonstrating no effect on melanoma cell viability, they influenced the MNT1 glycolytic rate and A375 detoxification mechanisms, resp. Both compounds suppressed ERK activation in MNT1 cells. The distinct cell responses to olive oil compounds depend on the metabolic and mol. mechanisms preferentially activated. Hydroxytyrosol may have a cytotoxic potential in melanoma cells with predominant glycolytic metabolism and JNK activation. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Synthetic Route of C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Influence of L. thermotolerans and S. cerevisiae commercial yeast sequential inoculation on aroma composition of red wines (Cv Trnjak, Babic, Blatina and Frankovka) was written by Korenika, Ana-Marija Jagatic;Tomaz, Ivana;Preiner, Darko;Lavric, Marina;Simic, Branimir;Jeromel, Ana. And the article was included in Fermentation in 2021.Reference of 2380-78-1 The following contents are mentioned in the article:

Even though Saccharomyces cerevisiae starter cultures are still largely used nowadays, the non-Saccharomyces contribution is re-evaluated, showing pos. enol. characteristics. Among them, Lachancea thermotolerans is one of the key yeast species that are desired for their contribution to wine sensory characteristics. The main goal of this work was to explore the impact of L. thermotolerans com. yeast strain used in sequential inoculation with S. cerevisiae com. yeast on the main enol. parameters and volatile aroma profile of Trnjak, BabiC, Blatina, and Frankovka red wines and compare it with wines produced by the use of S. cerevisiae com. yeast strain. In all sequential fermented wines, lactic acid concentrations were significantly higher, ranging from 0.20 mg/L in Trnjak up to 0.92 mg/L in Frankovka wines, while reducing alc. levels from 0.1% volume/volume in Trnjak up to 0.9% volume/volume in Frankovka wines. Among volatile compounds, a significant increase of Et lactate and iso-Bu acetate, geraniol, and geranyl acetate was detected in all wines made by use of L. thermotolerans. In BabiC wines, the strongest influence of sequential fermentation was connected with higher total terpenes and total ester concentrations, while Trnjak sequentially fermented wines stood up with higher total aldehyde, volatile phenol, and total lactone concentrations Control wines, regardless of variety, stood up with higher concentrations of total higher alcs., especially isoamyl alc. The present work contributed to a better understanding of the fermentation possibilities of selected non-Saccharomyces strains in the overall red wine quality modeling. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Reference of 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 2380-78-1

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Suppression of Oxidative Stress and Proinflammatory Cytokines Is a Potential Therapeutic Action of Ficus lepicarpa B. (Moraceae) against Carbon Tetrachloride (CCl4)-Induced Hepatotoxicity in Rats was written by Vun-Sang, Senty;Rodrigues, Kenneth Francis;Dsouza, Urban J. A.;Iqbal, Mohammad. And the article was included in Molecules in 2022.Recommanded Product: 2380-78-1 The following contents are mentioned in the article:

Local tribes use the leaves of Ficus lepicarpa B. (Moraceae), a traditional Malaysian medicine, as a vegetable dish, a tonic, and to treat ailments including fever, jaundice and ringworm. The purpose of this study was to look into the possible therapeutic effects of F. lepicarpa leaf extract against carbon tetrachloride (CCl4)-induced liver damage in rats. The DPPH test was used to measure the antioxidant activity of plants. Gas chromatog.-mass spectrometry was used for the phytochem. anal. (GCMS). Six groups of male Sprague-Dawley rats were subjected to the following treatment regimens: control group, CCl4 alone, F. lepicarpa 400 mg/kg alone, CCl4 + F. lepicarpa 100 mg/kg, CCl4 + F. lepicarpa 200 mg/kg and CCl4 + F. lepicarpa 400 mg/kg. The rats were euthanized after two weeks, and biomarkers of liver function and antioxidant enzyme status were assessed. To assess the extent of liver damage and fibrosis, histopathol. and immunohistochem. examinations of liver tissue were undertaken. The total phenolic content and the total flavonoid content in methanol extract of F. lepicarpa leaves were 58.86 ± 0.04 mg GAE/g and 44.31 ± 0.10 mg CAE/g, resp. F. lepicarpa′s inhibitory concentration (IC50) for free radical scavenging activity was reported to be 3.73 mg/mL. In a dose-related manner, F. lepicarpa was effective in preventing an increase in serum ALT, serum AST and liver MDA. Histopathol. alterations revealed that F. lepicarpa protects against the oxidative stress caused by CCl4. The immunohistochem. results showed that proinflammatory cytokines (tumor necrosis factor-α, interleukin-6, prostaglandin E2) were suppressed. The antioxidative, anti-inflammatory, and free-radical scavenging activities of F. lepicarpa can be related to its hepatoprotective benefits. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Recommanded Product: 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 2380-78-1

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Ether | (C2H5)2O – PubChem

Chemical and sensory characterization of Kalecik Karasi wines produced from two different regions in Turkey using chemometrics was written by Darici, Merve;Cabaroglu, Turgut. And the article was included in Journal of Food Processing and Preservation in 2022.COA of Formula: C9H12O3 The following contents are mentioned in the article:

Kalecik Karasi (KK) is one of the important native grape varieties of Turkey used in red wine production As an extension of a previous project that profiled the sensory characteristics of KK wines from different geog. regions of Turkey, this study aimed to investigate the chem. composition and sensory properties of KK wines belonging to different vintages from two different regions (Kalecik/Ankara and Gueney/Denizli) using the chemometric technique. Identification and quantification of aroma, aroma-active compounds, and sensory evaluations were carried out by GC/MS/FID, GC-O, and Descriptive Analyses. PLSR was used for determining the correlation between chem. and sensory data. A total of 26 aroma-active compounds have been identified for both regions. Based on PLSR, red fruit attribute in wines was pos. correlated with isoamylacetate, ethyl-hexadecanoate, ethyl-4-hydroxybutanoate, and 2-phenylethyl acetate. Dried fruit attribute has shown a significant pos. correlation with ethyl-2-methyl-propanoate, ethyl-2-methylbutanoate, and ethyl-3-methylbutanoate. The cotton candy attribute was pos. correlated with 2-phenylethanol, 2-phenylethyl acetate, ethyl-4-hydroxybutanoate, and gamma-butyrolactone. This is the first study in the literature to determine the correlation between chem. and sensory data in Kalecik Karasi wines. The study determined that common aroma descriptors of KK wines include red fruit (strawberry, raspberry, and apple), dried fruit, cotton candy, flower, and spice (sweet spices and nutmeg) odors. The characterization of the wines using chemometrics is an important tool. The findings obtained may constitute a source for quality Kalecik Karasi wines in transition to the Geog. Indication system. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1COA of Formula: C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.COA of Formula: C9H12O3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Scientific opinion on Prosmoke BW 01 was written by EFSA Panel on Food Additives and Flavourings;Younes, Maged;Aquilina, Gabriele;Castle, Laurence;Engel, Karl-Heinz;Fowler, Paul J.;Frutos Fernandez, Maria Jose;Fuerst, Peter;Gundert-Remy, Ursula;Guertler, Rainer;Husoey, Trine;Manco, Melania;Moldeus, Peter;Passamonti, Sabina;Shah, Romina;Waalkens-Berendsen, Ine;Wolfle, Detlef;Wright, Matthew;Benigni, Romualdo;Bolognesi, Claudia;Cordelli, Eugenia;Chipman, Kevin;Degen, Gisela;Noerby, Karin;Svendsen, Camilla;Carfi, Maria;Martino, Carla;Tard, Alexandra;Vianello, Giorgia;Mennes, Wim. And the article was included in EFSA Journal in 2022.HPLC of Formula: 2380-78-1 The following contents are mentioned in the article:

The EFSA Panel on Food Additives and Flavorings (FAF) was requested to evaluate the safety of Prosmoke BW 01 as a new smoke flavoring primary product, in accordance with Regulation (EC) No 2065/2003. Prosmoke BW01 is produced by pyrolysis of beechwood (Fagus sylvatica L.) sawdust. Its water content is estimated at 56 wt%, the total identified volatile fraction accounts for 28 wt% of the primary product, corresponding to 64% of the solvent-free mass, while the unidentified fraction amounts to 16 wt% of the primary product. Anal. data provided for three batches demonstrated that their batch-to-batch-variability was sufficiently low. However, for the batch used for the toxicol. studies, there were substantial deviations in the concentration of nearly all the constituents compared to the other three batches. The dietary exposure of Prosmoke BW 01 was estimated to be between 6.2 and 9.2 mg/kg body weight (bw) per day, resp., using SMK-EPIC and SMK-TAMDI. Using the FAIM tool, the 95th percentile exposure estimates ranged from 3.2 mg/kg bw per day for the elderly to 17.9 mg/kg bw per day for children. The Panel noted that furan-2(5H)-one is present in all batches of the primary product at an average concentration of 0.88 wt%. This substance was evaluated by the FAF Panel as genotoxic in vivo after oral exposure. The Panel considered that the (geno)toxicity studies available on the whole mixture were not adequate to support the safety assessment, due to limitations in these studies and because they were performed with a batch which may not be representative for the material of commerce. Considering that the exposure estimates for furan-2(5H)-one are above the TTC value of 0.0025 μg/kg bw per day (or 0.15 μg/person per day) for DNA-reactive mutagens and/or carcinogens, the Panel concluded that Prosmoke BW 01 raises a concern with respect to genotoxicity. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1HPLC of Formula: 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 2380-78-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem