Category: 2398-37-0

Li, Han; Sheng, Jie; Wu, Bing-Bing; Li, Yan; Wang, Xi-Sheng published an article in 2021. The article was titled 《Nickel-Catalyzed Cross-Coupling of Ethyl Chlorofluoroacetate with Aryl Bromides》, and you may find the article in Chemistry – An Asian Journal.Computed Properties of C7H7BrO The information in the text is summarized as follows:

A combinatorial nickel-catalyzed monofluoroalkylation of aryl bromides with the industrial raw regent Et chlorofluoroacetate has been developed. The two key factors to successful conversion are the combination of nickel with readily available nitrogen and phosphine ligands and the using of a mixture of different solvents. Mechanistic investigations indicated a new zinc regent might generated in situ and be involved in the reaction process. The experimental process involved the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0Computed Properties of C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Computed Properties of C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Chen; Ma, Na-Na; Yu, Zi-Lun; Shen, Chuanji; Zhou, Xiaocong; Chu, Xue-Qiang; Rao, Weidong; Shen, Zhi-Liang published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Palladium-catalyzed direct reductive cross-coupling of aryltrimethylammonium salts with aryl bromides》.COA of Formula: C7H7BrO The article contains the following contents:

An efficient palladium-catalyzed direct reductive cross-coupling of aryltrimethylammonium salts with aryl bromides was developed. The reactions proceeded smoothly in the presence of a palladium catalyst, magnesium turnings, LiCl, and TMEDA in THF at room temperature, leading to the corresponding biaryl compounds in moderate to good yields with reasonable functional group tolerance. The one-pot reaction using cheap and readily available aryl bromide as a coupling partner were simple to handle, thereby avoiding the use of pre-prepared organometallic reagents. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-methoxybenzene(cas: 2398-37-0COA of Formula: C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.COA of Formula: C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Transition-Metal-Free Borylation of Aryl Bromide Using a Simple Diboron Source》 was published in Journal of Organic Chemistry in 2020. These research results belong to Lim, Taeho; Ryoo, Jeong Yup; Han, Min Su. COA of Formula: C7H7BrO The article mentions the following:

The authors developed a simple and atom-economic transition-metal-free borylation reaction of aryl bromides. An atom-economic and com. available diboron source, bis-boronic acid (BBA), was used, and the borylation reaction was performed using a simple procedure at a mild temperature Under mild conditions, aryl bromides were converted to arylboronic acids directly without any deprotection steps, and the functional group tolerance was considerably high. The mechanism study suggested that this borylation reaction proceeds via a radical pathway. This simple borylation reaction will be useful for the synthesis of valuable arylboronic acids. The experimental process involved the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0COA of Formula: C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.COA of Formula: C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Li, Wen-Xin; Yang, Bo-Wen; Ying, Xuan; Zhang, Zhuo-Wen; Chu, Xue-Qiang; Zhou, Xiaocong; Ma, Mengtao; Shen, Zhi-Liang published an article in Journal of Organic Chemistry. The title of the article was 《Nickel-Catalyzed Direct Cross-Coupling of Diaryl Sulfoxide with Aryl Bromide》.Recommanded Product: 2398-37-0 The author mentioned the following in the article:

The direct cross-couplings of diaryl sulfoxides with aryl bromides via C-S bond cleavage could be readily accomplished using nickel(II) as the catalyst, 1,2-bis(diphenylphosphino)ethane (dppe) as the ligand, and magnesium turnings as the reducing metal in THF, leading to the corresponding biaryls RR1 [R = Ph, 4-MeC6H4, 2-naphthyl, etc.; R1 = 4-MeOC6H4, 2-pyridyl, benzofuran-5-yl, etc.] in moderate to good yields. The reaction exhibited a broad substrate scope and could be applied to a gram-scale synthesis. The ”one-pot” reaction, which avoided the utility of presynthesized and moisture-labile organometallic compounds, was operationally simple and step-economic.1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 2398-37-0) was used in this study.

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Recommanded Product: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Huang, Huoming; Li, Xinwei; Guo, Wei; Zhu, Chen; Qian, Yuanyuan; Shen, Qing; Xu, Xuejun; Li, Wei; Wang, Yujun; Fu, Wei published an article in 2021. The article was titled 《Design, Synthesis, and Structure-Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective μ Opioid Receptor Agonists》, and you may find the article in ACS Chemical Neuroscience.Application of 2398-37-0 The information in the text is summarized as follows:

Pain was implicated in many diseases. Despite effectiveness to treat moderate to severe pain, opioid analgesics elicited many side effects, greatly limiting their prescription in clinics. Based on M1, an active metabolite of tramadol, 3-((dimethylamino)methyl)-4-(3-hydroxyphenyl)piperidin-4-ol analogs were designed, synthesized, and evaluated in vitro. Among all the compounds tested, compound 23 was found to be a novel, highly selective, and potent MOR agonist (Ki MOR = 0.0034 nM, EC50 MOR = 0.68 nM, Emax = 206.5%; Ki DOR = 41.67 nM; Ki KOR = 7.9 nM). Structure-activity relationship exploration showed that the linker between the piperidine ring and the Ph ring as well as substituent pattern of the Ph ring played a pivotal role in binding affinity and selectivity. (3R, 4S)-23(I) (Ki MOR = 0.0021 ± 0.0001 nM, EC50 MOR = 0.0013 ± 0.0001 nM, Emax = 209.1 ± 1.4%; Ki DOR = 18.4 ± 0.7 nM, EC50 DOR = 74.5 ± 2.8 nM, Emax = 267.1 ± 1.4%; Ki KOR = 25.8 ± 0.2 nM, EC50 DOR = 116.2 ± 4.4 nM, Emax = 209.5 ± 1.4%) had more potent activity for opioid receptors than its enantiomer (3S, 4R)-23 and was found to be a potent, highly selective MOR agonist with novel scaffold. High binding affinity and selectivity of (3R, 4S)-23 for MOR over KOR and DOR and its mechanism of activating MOR were proposed by docking and mol. dynamics simulations, resp. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-methoxybenzene(cas: 2398-37-0Application of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Application of 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Vankar, H. P.; Rana, V. A. published their research in Materials Today: Proceedings in 2021. The article was titled 《Density, viscosity and ultrasonic velocity study: Binary mixtures of 3-bromoanisole and methanol at different temperatures》.COA of Formula: C7H7BrO The article contains the following contents:

The values of d., viscosity and ultrasonic velocity at three different temperatures (303.15, 313.15 and 323.15 K) of the prepared binary mixture solutions with different compositions of 3-bromoanisole (3-BA) and methanol (MeOH) are exptl. determined and presented. Moreover, the excess values of molar volume, viscosity and ultrasonic velocity have been determined These determined excess properties are fitted to the Redlich-Kister equation. Deviations from the linearity are found in the exptl. measured parameters with variation in mixture composition and are interpreted in terms of mol. interaction. Moreover, thermodn. properties are evaluated to understand the dynamic behavior of the system. In the experimental materials used by the author, we found 1-Bromo-3-methoxybenzene(cas: 2398-37-0COA of Formula: C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.COA of Formula: C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Wu; Shu, Xiaomin; Huan, Leitao; Cheng, Buqing; Huo, Haohua published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Enantioselective β-C(sp3)-H arylation of amides via synergistic nickel and photoredox catalysis》.Reference of 1-Bromo-3-methoxybenzene The article contains the following contents:

An enantioselective benzylic β-C(sp3)-H arylation of amides RC(O)CH2CH2Ar (R = Me, phenylaminyl, [3-(trifluoromethyl)phenyl]aminyl, Ph, etc.; Ar = Ph, 4-methoxyphenyl, 3-chlorophenyl, etc.) via synergistic nickel and photoredox catalysis is reported. The C-H bond is activated by a bromine-radical-mediated C-H cleavage. This mild yet straightforward protocol provides arylation products (S)-RC(O)CH2CH(R1)Ar (R1 = 4-(trifluoromethyl)phenyl, 4-cyanophenyl, 3-bromophenyl, 1-benzothiophen-5-yl, etc.) in up to 96% yield and with up to 95% ee. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Reference of 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Reference of 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sands, Kai N.; Gelfand, Benjamin S.; Back, Thomas G. published their research in Journal of Organic Chemistry in 2021. The article was titled 《One-Pot Synthesis of Aryl Selenonic Acids and Some Unexpected Byproducts》.Electric Literature of C7H7BrO The article contains the following contents:

The synthesis of aryl selenonic acids was achieved from diverse aryl bromides via a one-pot method involving metalation, selenation, and oxidation with hydrogen peroxide followed by ion exchange to afford the pure products in 77-90% yield. An o-hydroxymethyl derivative was found to dehydrate readily, affording the first example of a cyclic selenonic ester, while two minor byproducts were isolated and shown by X-ray crystallog. to be mixed salts of aryl selenonic acids with either the corresponding aryl seleninic or selenious acid. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Electric Literature of C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Electric Literature of C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Miao, Shi-Xing; Wan, Lin-Xi; He, Zhen-Xiang; Zhou, Xian-Li; Li, Xiaohuan; Gao, Feng published their research in Journal of Natural Products in 2021. The article was titled 《Pd-Catalyzed Direct Diversification of Natural Anti-Alzheimer’s Disease Drug: Synthesis and Biological Evaluation of N-Aryl Huperzine A Analogues》.SDS of cas: 2398-37-0 The article contains the following contents:

The first systematic direct diversification of a complex natural product by metal-catalyzed N-H functionalization was carried out. A new series of N-(hetero)aryl analogs I (Ar = Ph, 2-naphthyl, 4-methylpyridin-2-yl, etc.) of the natural anti-Alzheimer’s disease drug huperzine A (HPA) was prepared via palladium-catalyzed Buchwald-Hartwig cross-coupling reactions of HPA with various aryl bromides ArBr in good yields. Most of the N-aryl-huperzine A (N-aryl-HPA) analogs showed good acetylcholinesterase (AChE) inhibitory activity in in vitro experiments Three arylated huperzine A analogs I (Ar = 4-FC6H4, 4-methoxy-2,6-dimethylphenyl, 5-methoxypyridin-2-yl) exhibited stronger anti-AChE activity than HPA. The 5-methoxy-2-pyridyl analog I (Ar = 5-methoxypyridin-2-yl) displayed the most potent AChE inhibition activity, with an IC50 value of 1.5μM, which was 7.6-fold more active than HPA. Compound I (Ar = 5-methoxypyridin-2-yl) also exhibited better neuroprotective activity for H2O2-induced damage in SH-SY5Y cells than HPA. Structure-activity relationship anal. suggested that the electron d. of the installed aromatic ring or heteroaromatic ring played a significant role in inducing the AChE inhibition activity. Overall, compound I (Ar = 5-methoxypyridin-2-yl) showed the advantages of easy synthesis, high potency and selectivity, and improved neuroprotection, making it a potential huperzine-type lead compound for Alzheimer’s disease drug development. In the experimental materials used by the author, we found 1-Bromo-3-methoxybenzene(cas: 2398-37-0SDS of cas: 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.SDS of cas: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis, Photophysics and Theoretical Calculation of (E)-2-(benzo[d] thiazol-2-yl)-3-(3-methoxyphenyl)acrylonitrile》 was published in Letters in Organic Chemistry in 2020. These research results belong to Wu, Pei-Chieh; Chen, Chih-Hsien. Recommanded Product: 2398-37-0 The article mentions the following:

A new type of luminogen with aggregation-induced-emission (AIE) behavior was designed and synthesized. The result of single-crystal x-ray structure showed a planar structure in which the dihedral angle between two aromatic rings is < 30o. Also, two different intermol. H bond interactions supported the stability of the crystal structure. After the formation of organic nanoparticles in poor solubility solvent, the emission intensity of the desired product was increased and the enhancement achieved was 14-fold. This new design of luminogen provided further understanding of the AIE mechanism. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Recommanded Product: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem