Category: 2398-37-0

Reference of 1-Bromo-3-methoxybenzeneIn 2020 ,《Synthesis of Tetrahydropyridazines via Pd-Catalyzed Carboamination of Alkenyl Hydrazones》 was published in Advanced Synthesis & Catalysis. The article was written by Guo, Yajing; Zhao, Jinbo; Zhang, Qian. The article contains the following contents:

Herein a facile approach to tetrahydropyridazines, a scaffold found in many natural products and biol. active entities, via Pd-catalyzed carboamination of readily available alkenyl hydrazones with aryl and alkenyl halides was reported. Preliminary studies showed its promise for enantioselective synthesis. This work offers an expedient access to the tetrahydropyridazine scaffold bearing substitution patterns, thus significantly increasing the availability of these derivatives for downstream evaluation. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-methoxybenzene(cas: 2398-37-0Reference of 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Reference of 1-Bromo-3-methoxybenzene

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Liang, Xinyu; Wen, Kaikai; Shi, Qinqin; Zhang, Bei-Bei; Pei, Shurui; Lin, Qijie; Ma, Bowei; Wang, Song; Zhang, Meng; Li, Xiang; Wang, Zhi-Xiang; Huang, Hui published an article in Chemistry – A European Journal. The title of the article was 《The Aryl Sulfide Synthesis via Sulfide Transfer》.Application of 2398-37-0 The author mentioned the following in the article:

Aryl sulfides are in great demands in drugs and materials sciences. To avoid using nucleophilic and noxious thiols, many efforts have been focused on exploring novel sulfide resources. Herein, a reductive Pd-catalyzed, Ni-mediated method to synthesize aryl sulfides via a sulfide transfer reaction is developed. The utility and scope of this reaction is exemplified by various aryl electrophiles and aryl sulfides. Mechanistic studies reveal two competing catalytic cycles of sulfide transfer and aryl transfer in this reaction, where the former one is favored over the later one because of the large energy barrier difference during the transmetalation. Moreover, two important chems. are late-stage functionalized by this method, exhibiting the potential applications in drugs and materials science. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-methoxybenzene(cas: 2398-37-0Application of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Application of 2398-37-0

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bai, Jin-Hua; Qi, Xiu-Juan; Sun, Wei; Yu, Tian-Yang; Xu, Peng-Fei published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Nickel-Catalyzed Intramolecular Decarbonylative Coupling of Aryl Selenol Esters》.Recommanded Product: 1-Bromo-3-methoxybenzene The article contains the following contents:

A method for Ni-catalyzed intramol. decarbonylative coupling, which enabled the conversion of areneselenol esters to diaryl selenides was described. The inexpensive and readily available catalyst was employed under mild reaction conditions for the construction of structurally diverse diaryl selenides, including heterocyclic and natural product derivatives After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Recommanded Product: 1-Bromo-3-methoxybenzene

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C7H7BrOIn 2021 ,《Visible Light Mediated Photocatalytic N-Radical Cascade Reactivity of γ,δ-Unsaturated N-Arylsulfonylhydrazones: A General Approach to Structurally Diverse Tetrahydropyridazines》 was published in Journal of Organic Chemistry. The article was written by Azzi, Emanuele; Ghigo, Giovanni; Parisotto, Stefano; Pellegrino, Francesco; Priola, Emanuele; Renzi, Polyssena; Deagostino, Annamaria. The article contains the following contents:

The photocatalytic synthesis of different tetrahydropyridazines I (R = H, Me; R1 = Me, Ph; R2 = Me, Ph, naphthalen-2-yl, pyridin-2-yl, etc.), II (Ar = Ph, 4-methylphenyl, 2,4,6-trimethylphenyl; R3 = H, Me), III and (7R)-2-(mesitylsulfonyl)-3,4,4,7-tetramethyl-2,3,4,4a,5,6,7,8-octahydrocinnoline starting from γ,δ-unsaturated N-arylsulfonylhydrazones ArS(O)2NHN=C(R2)CH2C(CH3)(R1)CH=CHR3 were described. Simple structural changes of substrates result into three different pathways beginning from a common N-hydrazonyl radical, which evolves through a domino carboamination/dearomatization, a HAT process, or a photoinduced radical Smiles rearrangement to afford diverse tetrahydropyridazines I, II, III and (7R)-2-(mesitylsulfonyl)-3,4,4,7-tetramethyl-2,3,4,4a,5,6,7,8-octahydrocinnoline. All reactions are carried out in very mild conditions, and the quite inexpensive [Ru(bpy)3]Cl2 is used as the catalyst. Preliminary mechanism studies about luminescence and electrochem. characterization of the involved species are presented. Computational studies allow to rationalize the mechanism in accord with the exptl. findings. In the experimental materials used by the author, we found 1-Bromo-3-methoxybenzene(cas: 2398-37-0Synthetic Route of C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Synthetic Route of C7H7BrO

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Kondoh, Azusa; Hirozane, Takayuki; Terada, Masahiro published an article in Chemistry – A European Journal. The title of the article was 《Formal umpolung addition of phosphites to 2-azaaryl Ketones under chiral Broensted base catalysis: enantioselective protonation utilizing [1,2]-phospha-Brook rearrangement》.Product Details of 2398-37-0 The author mentioned the following in the article:

The formal enantioselective umpolung addition of dialkyl phosphites to 2-azaaryl ketones was developed under Broensted base catalysis. The reaction involved the enantioselective protonation of the transient α-oxygenated (2-azaaryl)methyl anion generated through the 1,2-addition of the anion of dialkyl phosphite to the 2-azaaryl ketone and the subsequent [1,2]-phospha-Brook rearrangement. A chiral bis(guanidino)iminophosphorane organosuperbase efficiently catalyzed the reaction to provide enantio-enriched phosphates in high yields with good to high enantioselectivities. This is a rare example of the catalytic enantioselective protonation of transient carbanions other than enolates, constructing a trisubstituted stereogenic center α to 2-azaarenes. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Product Details of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Product Details of 2398-37-0

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Blue light enhanced Heck arylation at room temperature applied to allenes》 was written by Renzi, Polyssena; Azzi, Emanuele; Bessone, Enrico; Ghigo, Giovanni; Parisotto, Stefano; Pellegrino, Francesco; Deagostino, Annamaria. SDS of cas: 2398-37-0This research focused ontosyl alkdienylamine aryl bromide palladium catalyst Heck photochem arylation; arylvinyl tolylsulfonyl pyrrolidine preparation; aryl vinyl tolylsulfonyl piperidine preparation. The article conveys some information:

An unprecedented visible light enhanced room temperature Heck reaction between aryl halides and allenyl tosyl amines was here reported. A simple catalytic system (Pd(OAc)2/PPh3) was employed to afford arylated vinyl pyrrolidines and piperidines. A broad scope with high tolerance towards functional groups was observed Electronic effects play an important role in the efficiency of this process. Mechanistic studies, both exptl. and computational, indicated no evidence for a radical mechanism and a pivotal role of light in promoting the carbo-palladation step. The results came from multiple reactions, including the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0SDS of cas: 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.SDS of cas: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Huang, Huoming; Li, Xueping; Xie, Peng; Li, Xinwei; Xu, XueJun; Qian, Yuanyuan; Yuan, Congmin; Meng, Xiangguo; Chai, JingRui; Chen, Jing; Liu, Jing; Wang, Wenli; Li, Wei; Wang, YuJun; Fu, Wei; Liu, Jinggen published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic》.Synthetic Route of C7H7BrO The article contains the following contents:

Management of moderate to severe pain relies heavily on opioid analgesics such as morphine, oxycodone, and fentanyl in clinics. However, their prolonged use was associated with undesirable side effects. Many new strategies to reduce side effects have been proposed, but not without disadvantages. Using a hot plate model as a phenotypic screening method, our studies identified (3R,4S)-9d (I) with a new scaffold as a potent analgesic with ED50 values of 0.54 mg/kg and 0.021 mg/kg in hot plate and antiwrithing models, resp. Mechanistic studies showed that it elicited its analgesic effect via the active metabolite (3R,4S)-10a (II). The mechanism of (3R,4S)-10a-induced activation of the μ opioid receptor (MOR) was proposed by means of mol. dynamics (MD) simulation. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3-methoxybenzene(cas: 2398-37-0Synthetic Route of C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Synthetic Route of C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Zheng, Kaiting; Liu, Yaomei; Zheng, Chenggong; Yan, Fangpei; Xiao, Hua; Feng, Yi-Si; Fan, Shilu published an article in Advanced Synthesis & Catalysis. The title of the article was 《Palladium-Catalyzed Monofluoroalkylation of Aryl Iodides and Aryl Bromides with Nucleophilic Ethyl 2-Fluoro-2-(trimethylsilyl)acetate》.Recommanded Product: 2398-37-0 The author mentioned the following in the article:

A palladium-catalyzed monofluoroalkylation of aryl iodides and aryl bromides was developed using nucleophilic Et 2-fluoro-2-(trimethylsilyl)acetate as a monofluoroalkyl source. The transformation proceeded with excellent substrate scope to afford a range of monofluoroalkylated products ArCH(F)CO2Et [Ar = Ph, 2-naphthyl, 3-thienyl, etc.] in good yields under mild conditions, and it proved feasible in a gram-scale reaction. This protocol was successfully used in late-stage modification of an estrone derivative, providing a facile route for research on the discovery of biol. active compounds and high-performance materials. In the experimental materials used by the author, we found 1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Recommanded Product: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Zhou, Zongtao; Cai, Zongyu; Zhang, Congzi; Yang, Benhui; Chen, Lianru; He, Yepu; Zhang, Luyong; Li, Zheng published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold》.Product Details of 2398-37-0 The author mentioned the following in the article:

The free fatty acid receptor 1 (FFA1/GPR40) and peroxisome proliferator-activated receptor δ (PPARδ) have been widely considered as promising targets for type 2 diabetes mellitus (T2DM) due to their resp. roles in promoting insulin secretion and improving insulin sensitivity. Hence, the dual FFA1/PPARδ agonists may exert synergistic effects by simultaneously activating FFA1 and PPARδ. The present study performed systematic exploration around previously reported FFA1 agonist compound I (lead compound), leading to the identification of a novel dual FFA1/PPARδ agonist compound II (the optimal compound), which displayed high selectivity over PPARα and PPARγ. In addition, the docking study provided detailed binding modes of the optimal compound II in FFA1 and PPARδ. Furthermore, the optimal compound II exhibited greater glucose-lowering effects than lead compound I, which might attribute to its synergistic effects by simultaneously modulating insulin secretion and resistance. Moreover, the optimal compound II has an acceptable safety profile in the acute toxicity study at a high dose of 500 mg/kg therefore, the results provided a novel dual FFA1/PPARδ agonist with excellent glucose-lowering effects in vivo. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Product Details of 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Product Details of 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Palladium-Catalyzed Direct C-H Arylation of Arenes Promoted by Quaternary Ammonium Salt》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Yang, Sabyuk; Hong, Soon Hyeok. Computed Properties of C7H7BrO The article mentions the following:

A new Pd-based catalytic system for the direct C-H arylation of arenes was developed. The use of a substoichiometric amount of quaternary ammonium salt as an additive with a Pd source achieved the direct arylation of unactivated arenes under milder reaction conditions in moderate to high yields. The ammonium salt generated the anionic palladium complex, thereby facilitating arylation by a concerted metalation-deprotonation process. In the experiment, the researchers used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Computed Properties of C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Computed Properties of C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem