2398-37-0 Archives - Page 8 of 12 - Ethers-buliding-blocks

Wang, Gongshu’s team published research in International Journal of Biological Macromolecules in 2022 | CAS: 2398-37-0

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Computed Properties of C7H7BrO

Computed Properties of C7H7BrOIn 2022 ,《Metal-organic framework grown in situ on chitosan microspheres as robust host of palladium for heterogeneous catalysis: Suzuki reaction and the p-nitrophenol reduction》 was published in International Journal of Biological Macromolecules. The article was written by Wang, Gongshu; Wang, Jiwei; Chen, Zhangpei; Hu, Jianshe. The article contains the following contents:

In this study, the metal-organic framework ZIF-8 has been successfully planted on the surface of chitosan microspheres (CS/PDA@ZIF-8) using polydopamine as connecting material for the first time, which avoids the use of expensive, non-renewable, and non-biodegradable polystyrene microspheres commonly used as templates to prepare core-shell structures. Moreover, the metal-organic framework ZIF-8 was prepared specially by three different methods and all characterized by SEM, TEM, and BET, and the ZIF-8 shell prepared at room temperature presents a regular morphol., uniform size, large sp. surface area (353.1 m2/g) than the shells prepared by the other methods including. The CS/PDA@ZIF-825@Pd with high catalytic activity and high stability was especially prepared by encapsulating Pd nanoparticles into the pores of CS/PDA@ZIF-825. Notably, the fabricated catalyst performed well in an array of reactions, for example the Kapp value of the p-nitrophenol reduction reaction reached 0.0426 s-1, and the TOF of the Suzuki coupling reaction reached 128 h-1. In addition, the ZIF-67, UiO-66, UiO-66-NH2, HKUST-1, and NH2-MIL-53(Al) were also grown on chitosan microcapsules successively to prepare the core-shell microspheres, which prove the universal applicability of this strategy. And beyond that, the introduction of chitosan microspheres endows the material with biodegradable properties and excellent recycling properties. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-3-methoxybenzene(cas: 2398-37-0Computed Properties of C7H7BrO)

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Caliskan, Melike’s team published research in International Journal of Biological Macromolecules in 2021 | CAS: 2398-37-0

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Name: 1-Bromo-3-methoxybenzene

Caliskan, Melike; Baran, Talat published their research in International Journal of Biological Macromolecules in 2021. The article was titled 《Decorated palladium nanoparticles on chitosan/δ-FeOOH microspheres: A highly active and recyclable catalyst for Suzuki coupling reaction and cyanation of aryl halides》.Name: 1-Bromo-3-methoxybenzene The article contains the following contents:

In this study, an eco-friendly and low cost magnetic nanocomposite consisting of chitosan/δ-FeOOH microspheres (CS/δ-FeOOH) was fabricated as a stabilizer by using a simple method. Pd Nanoparticles (Pd NPs) were decorated on designed CS/δ-FeOOH, and resulting Pd NPs@CS/δ-FeOOH microspheres were employed as a heterogeneous catalyst in construction of biaryls Ph-Ar [Ar = 4-MeC6H4, 4-NCC6H4, 3-O2N6H4, etc.] and benzonitriles ArCN [Ar = 3-Me6H4]. Pd NPs@CS/δ-FeOOH Microspheres efficiently catalyzed conversion of aryl iodides and bromides to desired biaryls within 3 h. Moreover, Pd NPs@CS/δ-FeOOH microspheres showed high catalytic potential against synthesis of benzonitriles by providing yields up to of 99% within 4 h. More importantly, it was proved that Pd NPs@CS/δ-FeOOH microspheres were able to be easily recycled and reused up to eight runs for both reactions. This study revealed that Pd NPs@CS/δ-FeOOH microspheres are useful and recyclable nanocatalysts, which catalyze synthesis of biaryl and benzonitriles with good reaction yields. The experimental process involved the reaction of 1-Bromo-3-methoxybenzene(cas: 2398-37-0Name: 1-Bromo-3-methoxybenzene)

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Cruz-Migoni, Abimael’s team published research in Proceedings of the National Academy of Sciences of the United States of America in 2019 | CAS: 2398-37-0

Recommanded Product: 1-Bromo-3-methoxybenzeneIn 2019 ,《Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds》 appeared in Proceedings of the National Academy of Sciences of the United States of America. The author of the article were Cruz-Migoni, Abimael; Canning, Peter; Quevedo, Camilo E.; Bataille, Carole J. R.; Bery, Nicolas; Miller, Ami; Russell, Angela J.; Phillips, Simon E. V.; Carr, Stephen B.; Rabbitts, Terence H.. The article conveys some information:

The RAS gene family is frequently mutated in human cancers, and the quest for compounds that bind to mutant RAS remains a major goal, as it also does for inhibitors of protein-protein interactions. We have refined crystallization conditions for KRAS169Q61H-yielding crystals suitable for soaking with compounds and exploited this to assess new RAS-binding compounds selected by screening a protein-protein interaction-focused compound library using surface plasmon resonance. Two compounds, referred to as PPIN-1 and PPIN-2, with related structures from 30 initial RAS binders showed binding to a pocket where compounds had been previously developed, including RAS effector protein-protein interaction inhibitors selected using an intracellular antibody fragment (called Abd compounds). Unlike the Abd series of RAS binders, PPIN-1 and PPIN-2 compounds were not competed by the inhibitory anti-RAS intracellular antibody fragment and did not show any RAS-effector inhibition properties. By fusing the common, anchoring part from the two new compounds with the inhibitory substituents of the Abd series, we have created a set of compounds that inhibit RAS-effector interactions with increased potency. These fused compounds add to the growing catalog of RAS protein-protein inhibitors and show that building a chem. series by crossing over two chem. series is a strategy to create RAS-binding small mols. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Recommanded Product: 1-Bromo-3-methoxybenzene)

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9/28/2021 News Share a compound : 2398-37-0

According to the analysis of related databases, 2398-37-0, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2398-37-0, name is 1-Bromo-3-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1-Bromo-3-methoxybenzene

Acetyl chloride (3.56 mL, 0.06 mol) is added dropwise to a stirred suspension of 3-bromoanisole (9.35 g, 0.05 mol) and AlCl3 (8.00 g, 0.06 mol) in dichloromethane (50 mL) at 0 C under argon. The resulting mixture is stirred at 0 0C for 40 min and then at room temperature for 1 h, and diluted with H2O (100 mL) and 2 N HCl (35 mL), and extracted with ethyl acetate (2 x 100 mL and 50 mL). The extract is washed (brine) and dried. After solvent removal at reduced pressure, the residue is purified on silica gel (12.5% to 14.3% ethyl acetate/hexane) to give 9.55 g (83%) of 2 as a colorless liquid. IR 2964, 1688, 1596, 1252 cm”1; 1H NMR (CDCI3) delta 2.66 (s, 3H, CH3CO), 3.88 (s, 3H, CH3O), 6.91 (dd, J= 8.4 Hz, 2.4 Hz, IH, 5-PhH), 7.19 (d, J= 2.4 Hz, IH, 3- PhH), 7.63 ppm (d, J= 8.4 Hz, IH, 6-PhH).

According to the analysis of related databases, 2398-37-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BURNHAM INSTITUTE FOR MEDICAL RESEARCH; MERCOLA, Mark; DAWSON, Marcia, I.; CASHMAN, John; WO2010/33643; (2010); A2;,
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18-Sep-2021 News Brief introduction of 2398-37-0

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 2398-37-0, A common heterocyclic compound, 2398-37-0, name is 1-Bromo-3-methoxybenzene, molecular formula is C7H7BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a reaction tube charged with NBS (1.5 equiv, 0.3 mmol), catalyst (10 mol%, 0.02 mmol) and CH3CN (1.0 mL),was added para-chloroanisole 1a (0.2 mmol). After being stirred at room temperature for 12 h in dark, the reaction was quenched by saturated aq. solution of Na2S2O3 (2 mL). The resulting mixture was extracted by ethyl acetate (3 5 mL). The combined organic extracts were washed by brine (10 mL), dried over Na2SO4 and filtered through a pad of Celite. The filtrate was concentrated under reduced pressure and the residuewas purified by flash chromatography on a silica gel column with petroleum ether/dichloromethane (5:1) as the eluent to give 4.3.1. 2-Bromo-4-chloroanisole (2a)

Reference:
Article; Pramanick, Pranab Kumar; Hou, Zhen-Lin; Yao, Bo; Tetrahedron; vol. 73; 50; (2017); p. 7105 – 7114;,
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9/2/2021 News A new synthetic route of 2398-37-0

The synthetic route of 2398-37-0 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2398-37-0, name is 1-Bromo-3-methoxybenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 2398-37-0

General procedure: Compound 6a was prepared by reacting 3-bromo-2-methyl-5-thienylboronic acid [50] (4.2 g, 19.0 mmol) with 1-bromo-2-methoxybenzene (3.91 g, 20.9 mmol) in the presence of Pd(PPh3)4 (0.73 g, 0.63 mmol) and Na2CO3 (2 mol L-1, 10 mL) in tetrahydrofuran (THF) (80 mL) for 18 h at 343 K. The reaction was allowed to cool to room temperature. After being extracted with ether, the organic layer was dried over MgSO4, filtered, and concentrated. The crude product was purified by column chromatography on silica gel using petroleum ether as eluent to afford 3.87 g of 6a visible as a buff solid with a 72% yield.

The synthetic route of 2398-37-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zheng, Chunhong; Pu, Shouzhi; Pang, Zhiyi; Chen, Bing; Liu, Gang; Dai, Yanfeng; Dyes and Pigments; vol. 98; 3; (2013); p. 565 – 574;,
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Brief introduction of 2398-37-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-methoxybenzene, other downstream synthetic routes, hurry up and to see.

Related Products of 2398-37-0, The chemical industry reduces the impact on the environment during synthesis 2398-37-0, name is 1-Bromo-3-methoxybenzene, I believe this compound will play a more active role in future production and life.

General procedure: Under an argon atmosphere a solution of the appropriate bromobenzene (1 equivalent) dissolved in anhydrous THF (approximately 30 mL per mmol bromobenzene) is cooled to -78 C using a nitrogen-ethanol-bath. A solution of 2.3 equivalents of n-butyllithium in hexane is added drop wise keeping the temperature below -78 C. After completion the mixture is stirred for one hour at this temperature. Then 1.5 equivalents of trimethyl borate are added slowly and the reaction mixture is stirred at -78 C for another hour. The cooling bath is then removed, the reaction mixture is stirred until room temperature is reached and quenched with a saturated solution of ammonium chloride. THF and the major part of the water is removed under reduced pressure, the residue is laced with 3M hydrochloric acid until a pH of 3 is reached. After extraction with DCM (3 x) the organic phases are collected, washed with brine, dried over sodium sulphate and filtered. DCM is removed under reduced pressure, the resulting solid is washed first with ice cold water and then with PE and dried.

Reference:
Article; Obermoser, Victoria; Mauersberger, Robert; Schuster, Daniela; Czifersky, Monika; Lipova, Marina; Siegl, Monika; Kintscher, Ulrich; Gust, Ronald; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 590 – 603;,
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Some tips on 2398-37-0

Intermediate 1 l-AUyl-3-methoxy-benzene (Ha)A solution of 3-bromoanisole (4Og, 0.2138mol) dissolved in dry THF (220 rnL) was added dropwise to a solution of magnesium (7.9g, 0.328mol) activated by pinch of iodine in dry THF (20 ml) and the reaction was shortly heated with a heat -gun to get the reaction started. After 1 hr, when the solution was gray and most of the magnesium was dissolved, allyl bromide (28.4 mL, 0.328 mol) was added. After 3 h the reaction was quenched by a saturated NH4Cl solution and the organic layer was extracted with diethyl ether. The organic phase was dried over anhydrous Na2SO4, the solvent was evaporated and the crude product was subjected to flash chromatography on silica gel (230-400 mesh) using 3-4% ethyl acetate in petroleum ether which gave the allyl compound as yellow viscous liquid (24 g, 76%).

Reference:
Patent; MEDIVIR AB; WO2008/135488; (2008); A1;,
Ether – Wikipedia,
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The important role of 1-Bromo-3-methoxybenzene

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2398-37-0, its application will become more common.

Some common heterocyclic compound, 2398-37-0, name is 1-Bromo-3-methoxybenzene, molecular formula is C7H7BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: ethers-buliding-blocks

General procedure: A typical procedure for Suzuki reaction is as follows: arylhalide (0.5mmol) was weighed in 25mL round bottom flask containing boronic acids (0.6mmol), and Pd(OAc)2(PPh3)2/MgCe-HDC (100mg). The reactants and catalyst were dispersed in water (4mL), the RB was mounted on an oil bath at 353K and the mixture was stirred for 2h. The reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the catalyst was separated by filtration. Then the solution was extracted with ethyl acetate and brine solution. The organic phase was dried over anhydrous Na2SO4 and concentrated under vacuum. The crude product was purified by column chromatography on silicagel to afford pure product. The pure product was analyzed using 1H- and 13C-NMR techniques and compared with literature NMR data.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2398-37-0, its application will become more common.

Reference:
Article; Tomar, Ravi; Singh, Nidhi; Kumar, Neeraj; Tomar, Vartika; Chandra, Ramesh; Catalysis Letters; (2019);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The important role of 2398-37-0

The synthetic route of 2398-37-0 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2398-37-0, name is 1-Bromo-3-methoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2398-37-0

1-Bromo-3-methoxybenzene (20 mmol), CH2Cl2 (50 mL) and CH3COCl (1.5 eq., 30 mmol) were added to a 250 mL round-bottom flask. After cooled to -20 oC, AlCl3 (3 eq., 8.0 g) was added to the mixture slowly. The reaction was stirred vigorously for 3 h at -20 oC. Ice water ( 80 mL ) was added to the flask and the mixture was extracted with CH2Cl2 (30 mL x 3), dried by anhydrous Na2SO4. Evaporation of the solvent followed by purification on silica gel provided 1-(2-bromo-4-methoxyphenyl)ethanone, yield 75%.

The synthetic route of 2398-37-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lou, Zhen-Bang; Pang, Xin-Long; Chen, Chao; Wen, Li-Rong; Li, Ming; Chinese Chemical Letters; vol. 26; 10; (2015); p. 1231 – 1235;,
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