Category: 2944-47-0

Mastral, Ana Maria published the artcileFriedel-Crafts reaction. Comparative study of alkylation of anisole with diverse alkylation agents, Synthetic Route of 2944-47-0, the publication is Afinidad (1979), 36(363), 401-4, database is CAplus.

Alkylation of anisole was carried out with MeCH:CH₂, PrCl, PrOH, or ROCHMeCH₂HgBr (R = H, Me, Ac) in the presence AlCl₃, FeCl₃, or BF₃.Et₂O. Best results were achieved using the organomercury compounds, which gave mainly o– or p-MeOC₆H₄CH₂CHMeOR.

Afinidad published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Synthetic Route of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dubois, Jacques Emile published the artcileElectrophilic aromatic substitution. Bromination of methoxybenzenes. Evaluation of steric effect of bulky alkyl substituents, Synthetic Route of 2944-47-0, the publication is Nouveau Journal de Chimie (1981), 5(1), 33-8, database is CAplus.

Bulky alkyl group steric effects on substituted methoxybenzenes are quant. determined as the difference between exptl. bromination rate constants and those calculated by taking into account electronic effects only. Two kinds of results are observed For di- or trisubstituted compounds, no steric inhibition to the transmission of Me or MeO group electronic effects is observed when these substituents are flanked in a vicinal position by an Me₂CH or Me₃C group. In contrast, important steric effects are observed for 4,5,2-Me₂(Me₂CH)C₆H₂OMe and for the ortho position (to the OMe group) in o-Me₃C C₆H₄OMe.

Nouveau Journal de Chimie published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Synthetic Route of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Organ, Michael G. published the artcilePd-PEPPSI-IHept^Cl: A General Purpose, Highly Reactive Catalyst for the Selective Coupling of Secondary Alkyl Organozincs, Synthetic Route of 2944-47-0, the publication is Chemistry – A European Journal (2016), 22(41), 14531-14534, database is CAplus and MEDLINE.

Pd-PEPPSI-IHept^Cl, a new, very bulky yet flexible Pd-NHC complex was evaluated in the Negishi coupling of secondary alkylzinc reactants with a wide variety of oxidative addition partners in high yields and excellent selectivity. The desired, direct reductive elimination branched products I [Ar = 2-pyridyl, 5-indolyl, 3-benzo[b]thiophenyl, etc.], II and e.g., III, were obtained with no sign of migratory insertion across electron-rich and electron poor aromatics and all forms of heteroaromatics (5- and 6-membered). Impressively, there was no impact of substituents at the site of reductive elimination (i.e., ortho or even di-ortho), which was not yet been demonstrated by another catalyst system to date.

Chemistry – A European Journal published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Synthetic Route of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chiellini, Grazia published the artcileA high-affinity subtype-selective agonist ligand for the thyroid hormone receptor, Recommanded Product: 2-Isopropylanisole, the publication is Chemistry & Biology (1998), 5(6), 299-306, database is CAplus and MEDLINE.

Thyroid hormones regulate many different physiol. processes in different tissues in vertebrates. Most of the actions of thyroid hormones are mediated by the thyroid hormone receptor (TR), which is a member of the nuclear receptor superfamily of ligand-activated transcription regulators. There are two different genes that encode two different TRs, TRα and TRβ, and these two TRs are often co-expressed at different levels in different tissues. Most thyroid hormones do not discriminate between the two TRs and bind both with similar affinities. The authors have designed and synthesized a thyroid hormone analog that has high affinity for the TRs and is selective in both binding and activation functions for TRβ over TRα. The compound, GC-1, was initially designed to solve synthetic problems that limit thyroid hormone analog preparation, and contains several structural changes with respect to the natural hormone 3,5,3′-triiodo-L-thyronine (T₃). These changes include replacement of the three iodines with Me and iso-Pr groups, replacement of the biaryl ether linkage with a methylene linkage, and replacement of the amino-acid sidechain with an oxyacetic-acid sidechain. The result of this study show that GC-1 is a member of a new class of thyromimetic compounds that are more synthetically accessible than traditional thyromimetics and have potentially useful receptor binding and activation properties. The TRβ selectivity of GC-1 is particularly interesting and suggests that GC-1 might be a useful in vivo probe for studying the physiol. roles of the different thyroid hormone receptor isoforms.

Chemistry & Biology published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Nilsson, Aake published the artcileElectrolytically initiated selective aliphatic hydrogen exchange in 4-isopropylanisole, Product Details of C10H14O, the publication is Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry (1988), B42(6), 378-83, database is CAplus.

Anodic oxidation of 4-isopropylanisole in CF₃COOH-d was observed to promote the exchange of the Me H of the iso-Pr group. No aliphatic H exchange was detected when 2-isopropylanisole and 4-ethylanisole were treated in the same way. Oxidation products from constant potential electrolysis of 4-isopropylanisole and 2-isopropylanisole were identified.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Katoh, Takahiro published the artcileSynthesis of DL-standishinal and its related compounds for the studies on structure-activity relationship of inhibitory activity against aromatase, Related Products of ethers-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2007), 15(7), 2736-2748, database is CAplus and MEDLINE.

DL-Standishinal (I), an aromatase inhibitor isolated from Thuja standishii, was synthesized in 15 steps from p-formylanisole via an acid catalyzed aldol reaction of (±)-12-hydroxy-6,7-secoabieta-8,11,13-trien-6,7-dial (II). It was found that the aldol condensation of II proceeded in excellent yield with the protonic catalyst such as d-camphorsulfonic acid in CH₂Cl₂. Moreover, structure-activity relationship of I and its related compounds, such as (±)-O-methylferruginol (III), was studied, and it was revealed that the isomers having cis-configuration on the A/B-ring generally exhibited more potent inhibitory activities against aromatase than those with trans-configuration.

Bioorganic & Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem