Category: 31576-51-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31576-51-9, name is 2-(2-Methoxyethoxy)ethanamine, A new synthetic method of this compound is introduced below., Recommanded Product: 31576-51-9

In a round bottom flask under nitrogen 150 mg (0.35 mmol) of intermediate Awas dissolved in 5 mL ofCH2Ch and 0.18g of DIPEA (1.4 mmol) was added followed by 125 mg (1.05 mmol) of2-(2-Methoxy-ethoxy)-ethylamine. The mixture was allowed to stirovernight and then condensed in vacuo. The residue was dissolved in 20 mL of EtOAc andwashed with 2x 20 mL of water, 20 mL of brine, dried over Na2S04 and condensed in vacuo.Purification by biotage flash chromatography (Si02, MeOH/CH2Ch/Et3N gradient) affords 99mg of the title compound as a clear oil

The synthetic route of 31576-51-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZAFGEN, INC.; ZAHLER, Robert; VATH, James, F.; WO2013/169860; (2013); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31576-51-9, name is 2-(2-Methoxyethoxy)ethanamine, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(2-Methoxyethoxy)ethanamine

2.55 g (20 mmol) of oxalyl chloride are added to 10 g (16.5 mmol) of the title compound from Example 1a in 100 ml of dichloromethane and the mixture is stirred at room temperature for 14 h. It is evaporated to dryness in vacuo, the residue is dissolved in 100 ml of dichloromethane, 3.93 g (33 mmol) of 2-(methoxyethoxy)ethylamine (Whitesides et al., JACS, 1994, 5057-5062) are added and the mixture is subsequently stirred at room temperature for 4 h. The reaction solution is treated with 100 ml of 1 N hydrochloric acid, and thoroughly stirred for 15 min. The organic phase is separated off, dried over magnesium sulphate and evaporated to dryness in vacuo. The residue is chromatographed on silica gel (eluent: ethyl acetate/hexane 1:1). Yield: 11.2 g (96% of theory) of a colourless wax

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Platzek, Johannes; Schirmer, Heiko; Weinmann, Hanns-Joachim; Misselwitz, Bernd; Zorn, Ludwig; US2008/159954; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 31576-51-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 31576-51-9 name is 2-(2-Methoxyethoxy)ethanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(i) 3-Ami no-5-bromo-N-(2-(2-methoxyethoxy)ethyl)benzamideA stirred mixture of 3-amino-5-bromobenzoic acid (800 mg, 3.59 mmol), 2-(2- methoxyethoxy)ethanamine (856 mg, 7.18 mmol) and Et3N (1.5 mL, 10.76 mmol) in DCM (13mL) was cooled in an ice bath. T3P (50 w/w in EtOAc, 3.2 mL, 5.38 mmol) was added dropwise, the ice bath was removed and the reaction mixture allowed to warm to room temperature. DMF (2 mL) was added to aid solubility and the reaction stirred at room temperature overnight. The reaction mixture was partitioned between sat. aq. NaHCO3 (50 mL) and DCM (50 mL). The aqueous phase was back extracted with fresh DCM (50 mL).The combined organic extracts were washed with water (100 mL), brine (100 mL), dried (MgSO4), filtered and concentrated in vacuo to afford an orange oil. The crude product was purified by chromatography on silica gel (40 g column, 0-5% MeOH) to afford the sub-title compound (880 mg) as an orange oil.1H NMR (DMSO-d6) 400 MHz, O: 8.36 (t, 1H), 7.07 (t, 1H), 7.00-6.99 (m, 1H), 6.84 (t, 1H),5.57 (s, 2H), 3.53-3.48 (m, 4H), 3.44-3.42 (m, 2H), 3.35 (q, 2H), 3.23 (s, 3H). LCMS m/z 317/319 (M¡ÂH) (ES)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2-Methoxyethoxy)ethanamine, and friends who are interested can also refer to it.

Reference:
Patent; TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED; FYFE, Matthew Colin Thor; WO2014/162121; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem