Category: 321-28-8

On August 31, 2015, Sun, Kai; Li, Yan; Zhang, Qian published an article.Name: 1-Fluoro-2-methoxybenzene The title of the article was Copper-catalyzed arenes amination with saccharins. And the article contained the following:

Synthesis of N-arylsaccharins I [R = 4-C6H5C6H4, C6H5, 1-naphthyl, etc.] and N-arylisothioazolones e.g. II [R1 = CH3, R2 = 4-ClC6H4] via copper-catalyzed direct C-N bond formation of simple arenes with saccharins/isothiazolones under relatively mild conditions was developed. This work provided a new method for oxidative coupling of aromatic C(sp2)-H bonds and N-H bonds by using arenes as limiting reagents. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Name: 1-Fluoro-2-methoxybenzene

The Article related to arylsaccharin regioselective preparation mechanism, saccharin arene copper catalyst amination regioselective, arylisothiazolone regioselective preparation mechanism, isothiazolone arene copper catalyst amination regioselective and other aspects.Name: 1-Fluoro-2-methoxybenzene

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Ether – Wikipedia,
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On March 17, 2017, Huang, He; Wu, Yang; Zhang, Wen; Feng, Chun; Wang, Bi-Qin; Cai, Wan-Fei; Hu, Ping; Zhao, Ke-Qing; Xiang, Shi-Kai published an article.SDS of cas: 321-28-8 The title of the article was Copper-Catalyzed Regioselective C-H Sulfonyloxylation of Electron-Rich Arenes with p-Toluenesulfonic Acid and Sulfonyloxylation of Aryl(mesityl)iodonium Sulfonates. And the article contained the following:

Copper-catalyzed regioselective C-H sulfonyloxylation of electron-rich arenes with p-toluenesulfonic acid has been developed. Electron-rich benzene derivatives and heteroarenes can undergo this C-H sulfonyloxylation reaction to generate aryl tosylates. Furthermore, sulfonyloxylation of aryl(mesityl)iodonium sulfonates has also been investigated. Both aryl(mesityl)iodonium tosylates and triflates can react smoothly to get aryl sulfonates. The formed aryl sulfonates, e.g., I, can be converted to phenols, as well as used as good partners of cross-coupling reactions. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).SDS of cas: 321-28-8

The Article related to toluenesulfonic acid electron rich arene regioselective ch sulfonyloxylation copper, arylmesityliodonium sulfonate electron rich arene regioselective ch sulfonyloxylation, aryl sulfonate regioselective preparation, copper regioselective ch sulfonyloxylation catalyst and other aspects.SDS of cas: 321-28-8

Referemce:
Ether – Wikipedia,
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On September 6, 2021, Kang, Qi-Kai; Lin, Yunzhi; Li, Yuntong; Xu, Lun; Li, Ke; Shi, Hang published an article.Application of 321-28-8 The title of the article was Catalytic SNAr Hydroxylation and Alkoxylation of Aryl Fluorides. And the article contained the following:

A reliable method for accessing phenols ArOH (Ar = C6H5, 4-CH3OC6H4, 9H-fluoren-2-yl, etc.) and Ph alkyl ethers Ar1OR (Ar1 = 4-CH3C6H4, 9H-fluoren-2-yl, 1-methyl-2-oxo-2,3-dihydro-1H-indol-5-yl, etc.; R = Me, cyclohexylmethyl, oxan-4-yl, etc.) via catalytic SnAr reactions has been described. The method is applicable to a broad array of electron-rich and neutral aryl fluorides ArF and Ar1F, which are inert under classical SnAr conditions. Although the mechanism of SNAr reactions involving metal arene complexes is hypothesized to involve a stepwise pathway (addition followed by elimination), exptl. data that support this hypothesis is still under exploration. Mechanistic studies and DFT calculations suggest either a stepwise or stepwise-like energy profile. Notably, a rhodium η5-cyclohexadienyl complex intermediate with an sp3-hybridized carbon bearing both a nucleophile and a leaving group was isolated. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Application of 321-28-8

The Article related to phenol preparation dft mechanistic study, water aryl fluoride hydroxylation rhodium catalyst, ester preparation dft mechanistic study, aryl fluoride alc alkoxylation rhodium catalyst, c−o bond formation, meisenheimer-type intermediate, rhodium, η6-coordination and other aspects.Application of 321-28-8

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Ether – Wikipedia,
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On July 19, 2021, Xin, Hai-Long; Rao, Xiaofeng; Ishitani, Haruro; Kobayashi, Shu published an article.HPLC of Formula: 321-28-8 The title of the article was Sequential Continuous-Flow Synthesis of 3-Aryl Benzofuranones. And the article contained the following:

A sequential continuous-flow system to produce 3-aryl benzofuranones was developed. Starting from 2,4-di-tert-butylphenol and glyoxylic acid monohydrate, both the initial cyclocondensation and the subsequent Friedel-Crafts alkylation were catalyzed by the same heterogeneous catalyst, Amberlyst-15H. The catalyst has a promising life-time for these two steps, and it was able to be recovered and reused for several runs without deactivation. By using the established flow system, 5,7-di-tert-butyl-3-(3,4-dimethylphenyl)-3H-benzofuran-2-one (Irganox HP-136), which is a com. antioxidant, was prepared in 88% two-step yield. Reactions with various aromatic compounds proceeded well under flow conditions to afford 3-aryl benzo-furanone derivatives in high yields with good functional group compatibility. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).HPLC of Formula: 321-28-8

The Article related to tert butylphenol glyoxylic acid cyclocondensation friedel crafts amberlyst, hydroxy benzofuranone arene sequential continuous flow, aryl benzofuranone preparation, 3-aryl benzofuranones, amberlyst-15h, continuous-flow, heterogeneous catalyst, irganox hp-136 and other aspects.HPLC of Formula: 321-28-8

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Ether – Wikipedia,
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On April 28, 2021, Nilova, Aleksandra; Sibbald, Paul A.; Valente, Edward J.; Gonzalez-Montiel, Gisela A.; Richardson, H. Camille; Brown, Kevin S.; Cheong, Paul Ha-Yeon; Stuart, David R. published an article.Synthetic Route of 321-28-8 The title of the article was Regioselective Synthesis of 1,2,3,4-Tetrasubstituted Arenes by Vicinal Functionalization of Arynes Derived from Aryl(Mes)iodonium Salts. And the article contained the following:

Herein, the synthesis of 1,2,3,4-tetrasubstituted benzenoid rings, motifs found in pharmaceutical, agrochem., and natural products, is described. In the past, the regioselective syntheses of such compounds have been a significant challenge. This work reports a method using substituted arynes derived from aryl(Mes)iodonium salts to access a range of densely functionalized 1,2,3,4-tetrasubstituted benzenoid rings. Significantly, it was found that halide substituents are compatible under these conditions, enabling post-synthetic elaboration via palladium-catalyzed coupling. This concise strategy is predicated on two regioselective events: 1) ortho-deprotonation of aryl(Mes)iodonium salts to generate a substituted aryne intermediate, and 2) regioselective trapping of said arynes, thereby improving previously reported reaction conditions to generate arynes at room temperature and in shorter reaction times. D. functional theory (DFT) computations and linear free energy relationship (LFER) anal. suggest the regioselectivity of deprotonation is influenced by both proximal and distal ring substituents on the aryne precursor. A competition experiment further reveals the role of arene substituents on relative reactivity of aryl(Mes)iodoniums as aryne precursors. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Synthetic Route of 321-28-8

The Article related to tetrasubstituted arene preparation regioselective transition state structure dft, aryl mesyl iodonium tosylate aryne arylation, substituent effect linear free energy relationship regioselectivity aryne formation, arylation, aryne, deprotonation, diaryliodonium salt, hypervalent iodine and other aspects.Synthetic Route of 321-28-8

Referemce:
Ether – Wikipedia,
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Dong, Jinhuan; Xin, Shuang; Wang, Yanqing; Pan, Ling; Liu, Qun published an article in 2017, the title of the article was In situ generation and reactions of p-(trifluoromethyl)benzyl electrophiles: an efficient access to p-(trifluoromethyl)benzyl compounds.Recommanded Product: 1-Fluoro-2-methoxybenzene And the article contains the following content:

A new three-component reaction, namely condensation-anti-Michael addition-aromatization, enabling the construction of benzylic compounds was disclosed. This reaction not only acted as an alternative approach to regioselective Csp2-H trifluoromethylation of arenes through an “aromatic to be” strategy, but also provided a simple, convenient, step-economic and practical strategy for the in-situ generation of electrophilic p-(trifluoromethyl)benzyl species under extremely mild conditions. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Recommanded Product: 1-Fluoro-2-methoxybenzene

The Article related to trifluoromethyl trimethylsilyloxycyclohexadienone ketone sulfonamide indium triflate catalyst tandem reaction, trifluoromethylbenzylamine regioselective preparation arene, methane diaryl preparation regioselective, arene trifluoromethyl trimethylsilyloxycyclohexadienone ketone indium triflate catalyst tandem reaction, diarylmethane preparation regioselective and other aspects.Recommanded Product: 1-Fluoro-2-methoxybenzene

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Ether – Wikipedia,
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On June 18, 2021, Selmani, Aymane; Schoenebeck, Franziska published an article.Recommanded Product: 321-28-8 The title of the article was Transition-Metal-Free, Formal C-H Germylation of Arenes and Styrenes via Dibenzothiophenium Salts. And the article contained the following:

We report an operationally simple, selective, and transition-metal-free germylation of arenes and styrenes at room temperature, using a robust and bench-stable Ge source (R3Ge-SiR3) and dibenzothiophenium salts as enabling intermediates. The first direct engagement in cross-coupling of the newly made E-alkenyl germanes is also presented, allowing the chemoselective arylation under air-tolerant nanoparticle catalysis. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Recommanded Product: 321-28-8

The Article related to dibenzothiophenylation arene styrene stereoselective germylation, dibenzothiophenium salt preparation intermediate silylgermane germylation stereoselective, alkenyl germane preparation coupling arylation chemoselective nanoparticle palladium catalyst, mol structure optimized dft germylation dibenzothiophenium salt energy regioselective and other aspects.Recommanded Product: 321-28-8

Referemce:
Ether – Wikipedia,
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Roesner, Stefan; Buchwald, Stephen L. published an article in 2016, the title of the article was Continuous-Flow Synthesis of Biaryls by Negishi Cross-Coupling of Fluoro- and Trifluoromethyl-Substituted (Hetero)arenes.Reference of 1-Fluoro-2-methoxybenzene And the article contains the following content:

A continuous-flow method for the regioselective arylation of fluoroarenes and fluoropyridines has been developed. The telescoped procedure reported here consists of a three-step metalation, zincation, and Negishi cross-coupling sequence, providing efficient access to a variety of functionalized 2-fluorobiaryl products. Precise temperature control of the metalation step, made possible by continuous-flow technol., allowed for the efficient preparation of the arylated products in high yields and short residence times. Addnl., several examples of the regioselective arylation of benzotrifluoride derivatives are also provided. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Reference of 1-Fluoro-2-methoxybenzene

The Article related to fluorinated biaryl continuous flow synthesis sonication regioselective arylation, metalation zincation negishi coupling sequence fluoroarene bromoarene sonication, fluoropyridine metalation zincation negishi coupling sequence bromoarene sonication, biaryls, cross-coupling, flow chemistry, palladium, synthetic methods and other aspects.Reference of 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem