Category: 321-28-8

On September 16, 2016, Chen, Tao; Li, Yi-Fan; An, Yang; Zhang, Fu-Min published an article.Synthetic Route of 321-28-8 The title of the article was Iron-Catalyzed α-Arylation of Deoxybenzoins with Arenes through an Oxidative Dehydrogenative Approach. And the article contained the following:

A novel α-arylation of deoxybenzoins with non-prefunctionalized arenes is developed through an iron-catalyzed oxidative dehydrogenative approach. The reaction shows broad substrate scope and functional group tolerance and thus provides efficient access to synthetically useful 1,2,2-triarylethanones. A reasonable mechanism is also proposed. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Synthetic Route of 321-28-8

The Article related to deoxybenzoin arene iron regioselective oxidative arylation catalyst, triaryl ethanone preparation green chem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Synthetic Route of 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shiung, Kui Shiu; Yu, Dan; Tzeng, Sheng Yuan; Tzeng, Wen Bih published an article in 2012, the title of the article was Cation spectroscopy of o-fluoroanisole and p-fluoroanisole by two-color resonant two-photon mass-analyzed threshold ionization.Application In Synthesis of 1-Fluoro-2-methoxybenzene And the article contains the following content:

Two-color resonant 2-photon mass-analyzed threshold ionization spectroscopy was applied to record the cation spectra of o- and p-fluoroanisole isomers. The adiabatic ionization energies of these 2 structural isomers are 67,354 ± 5 and 66,437 ± 5 cm-1, resp. The observed active normal modes of the cations mainly result from the in-plane ring and substituent-sensitive vibrations. Probably the relative location of the F and OMe substituents can slightly influence the transition energy and mol. vibrations. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Application In Synthesis of 1-Fluoro-2-methoxybenzene

The Article related to fluoroanisole isomer resonant two photon color threshold ionization, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Electron, X-Ray, and Photoelectron Spectroscopy and other aspects.Application In Synthesis of 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 31, 2021, Li, Rui; Du, Tianshu; Liu, Jingxing; Aquino, Adelia J. A.; Zhang, Jianyu published an article.Reference of 1-Fluoro-2-methoxybenzene The title of the article was Theoretical Study of O-CH3 Bond Dissociation Enthalpy in Anisole Systems. And the article contained the following:

Understanding ubiquitous Me transfer reactions requires a systematic study of thermodynamical parameters that could reveal valuable information about the nature of the chem. bond and the feasibility of those processes. In the present study, the O-CH3 bond dissociation enthalpies (BDEs) of 67 compounds belonging to phenol/anisole systems were calculated employing the Gaussian-4 (G4) method. Those compounds contain different substituents including alkyl groups, electron-donating groups (EDGs), and electron-withdrawing groups (EWGs). The results show that the bigger branched alkyl groups and EDGs will destabilize the O-CH3 bond, while EWGs have the opposite effect. A combination of different effects including steric effects, hydrogen bonds, and substituents and their position can achieve around 20 kcal/mol difference compared to the basic Ph frame. Also, the linear correlation between σp+ and O-CH3 BDE can provide a reference for the O-CH3 BDE prediction. The present study represents a step forward to establish a comprehensive O-CH3 BDE database to understand the substituent effect and make its contribution to the rational design of inhibitors and drugs. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Reference of 1-Fluoro-2-methoxybenzene

The Article related to oxygen methyl bond dissociation enthalpy anisole substituent effect, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Reference of 1-Fluoro-2-methoxybenzene

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Ether – Wikipedia,
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Ding, Lanlan; Zheng, Wenrui; Wang, Yingxing published an article in 2015, the title of the article was Theoretical study on homolytic C(sp2)-O cleavage in ethers and phenols.Synthetic Route of 321-28-8 And the article contains the following content:

The C-O homolytic bond dissociation enthalpies (BDEs) of many ethers were calculated by high-level ab initio methods including G4, G3, CBS-Q, CBS-4M as well as 26 d. function theory (DFT) methods. Among the DFT methods, wB97 provided the most accurate results and the root mean square error (RMSE) is 9.3 kJ mol-1 for 72 C-O BDE calculations Therefore, extensive C(sp2)-O BDEs and the substituent effect of alkenyl ethers, para-position Ph ethers/phenols as well as several typical heterocyclic ethers were investigated in detail by wB97 methods, which is important for the understanding of the chem. process involved in the cross-coupling reactions. For alkenyl ethers, the different substituents exhibited significant effects on C(sp2)-O BDEs, especially, the conjugate effect of the substituents on the O atom can greatly decrease the C(sp2)-O BDEs. In addition, the NBO anal. produced good linear correlations between the C(sp2)-O BDEs and qC × qO values (the qC and qO values denoted the natural charge of C and O atoms of the C-O bond, resp.). For para-position Ph ethers and phenols, excellent linear relationships between the C(sp2)-O BDEs with substituent constant σp+ are found. Further discussion of the substituent effect separated into the ground effect and the radical effect can further help us to understand the essence. For several five-membered typical heterocyclic ethers, a larger bond angle change will lead to a smaller C-O BDE. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Synthetic Route of 321-28-8

The Article related to homolytic carbon sp oxide cleavage ether phenol dft wb97, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Synthetic Route of 321-28-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 26, 2020, Kang, Qi-Kai; Lin, Yunzhi; Li, Yuntong; Shi, Hang published an article.HPLC of Formula: 321-28-8 The title of the article was Ru(II)-Catalyzed Amination of Aryl Fluorides via η6-Coordination. And the article contained the following:

A Ru/hemilabile-ligand catalyzed nucleophilic aromatic substitution (SNAr) of aryl fluorides as the limiting reagents was developed. Significant ligand enhancement was demonstrated by the engagement of both electron-rich and neutral arenes in the SNAr amination without using excess arenes. Preliminary mechanistic studies revealed that the nucleophilic substitution proceeds on a η6-complex of the Ru-catalyst and the substrate, and the hemilabile ligand facilitated dissociation of products from the metal center. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).HPLC of Formula: 321-28-8

The Article related to fluorobenzene amine diphenyl phosphane ruthenium catalyst regioselective amination, aminobenzene preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.HPLC of Formula: 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On March 16, 2017, Lin, Yingyin; Li, Meng; Ji, Xinfei; Wu, Jingjing; Cao, Song published an article.Quality Control of 1-Fluoro-2-methoxybenzene The title of the article was n-Butyllithium-mediated synthesis of N-aryl tertiary amines by reactions of fluoroarenes with secondary amines at room temperature. And the article contained the following:

A simple and facile method for the synthesis of aromatic tertiary amines by amination of fluoroarenes with secondary amines in the presence of n-butyllithium at room temperature was reported. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Quality Control of 1-Fluoro-2-methoxybenzene

The Article related to fluoroarene secondary amine butyllithium amination room temperature, aryl tertiary amine preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Quality Control of 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 31, 2019, Ruffoni, Alessandro; Julia, Fabio; Svejstrup, Thomas D.; McMillan, Alastair J.; Douglas, James J.; Leonori, Daniele published an article.Recommanded Product: 1-Fluoro-2-methoxybenzene The title of the article was Practical and regioselective amination of arenes using alkyl amines. And the article contained the following:

The formation of carbon-nitrogen bonds for the preparation of aromatic amines is among the top five reactions carried out globally for the production of high-value materials, ranging from from bulk chems. to pharmaceuticals and polymers. As a result of this ubiquity and diversity, methods for their preparation impact the full spectrum of chem. syntheses in academia and industry. In general, these mols. are assembled through the stepwise introduction of a reactivity handle in place of an aromatic C-H bond (i.e., a nitro group, halogen or boronic acid) and a subsequent functionalization or cross-coupling. Here we show that aromatic amines can be constructed by direct reaction of arenes and alkyl amines using photocatalysis, without the need for pre-functionalization. The process enables the easy preparation of advanced building blocks, tolerates a broad range of functionalities, and multigram scale can be achieved via a batch-to-flow protocol. The merit of this strategy as a late-stage functionalization platform has been demonstrated by the modification of several drugs, agrochems., peptides, chiral catalysts, polymers and organometallic complexes. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Recommanded Product: 1-Fluoro-2-methoxybenzene

The Article related to aromatic amine photoredox synthesis regioselective amination arene alkylamine, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Recommanded Product: 1-Fluoro-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dal Poggetto, Guilherme; Favaro, Denize C.; Nilsson, Mathias; Morris, Gareth A.; Tormena, Claudio F. published an article in 2014, the title of the article was 19F DOSY NMR analysis for spin systems with nJFF couplings.Electric Literature of 321-28-8 And the article contains the following content:

NMR is a powerful method for identification and quantification of drug components and contaminations. These problems present themselves as mixtures, and here, one of the most powerful tools is DOSY. DOSY works best when there is no spectral overlap between components, so drugs containing fluorine substituents are well-suited for DOSY anal. as 19F spectra are typically very sparse. Here, the authors demonstrate the use of a modified 19F DOSY experiment (from the Oneshot sequences) for various fluorinated benzenes. For compounds with significant nJFF coupling constants, as is common, the undesirable J-modulation can be efficiently suppressed using the Oneshot45 pulse sequence. This study highlights 19F DOSY as a valuable and robust method for anal. of mol. systems containing fluorine atoms even where there are large fluorine-fluorine couplings. Copyright © 2014 John Wiley and Sons, Ltd. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Electric Literature of 321-28-8

The Article related to fluorine dosy nmr spin system njff coupling, 19f, dosy, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Electric Literature of 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Arai, Kenta; Ueda, Yoshihiro; Morisaki, Kazuhiro; Furuta, Takumi; Sasamori, Takahiro; Tokitoh, Norihiro; Kawabata, Takeo published an article in 2018, the title of the article was Intermolecular chemo- and regioselective aromatic C-H amination of alkoxyarenes promoted by rhodium nitrenoids.Product Details of 321-28-8 And the article contains the following content:

Intermol. aromatic C(sp2)-H amination promoted by neutral rhodium nitrenoids has been developed. The reactions proceeded with various oxygen-substituted arenes ROR1 (R = Me, Et, Bn, etc.; R1 = Ph, 2-fluorophenyl, 2-benzylphenyl, etc.) (1.5 equivalent) in a chemo- and regioselective manner. The aromatic C(sp2)-H amination took place at the para position of the oxygen substituent in the presence of benzylic C(sp3)-H bonds and/or C(sp3)-H bonds α to ethereal oxygen. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Product Details of 321-28-8

The Article related to aryl carbamate preparation chemoselective regioselective, alkoxyarene tosyl trichloroethoxycarbonyl hydroxylamine amination dirhodium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Product Details of 321-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pirzer, Anna S.; Alvarez, Eva-Maria; Friedrich, Heike; Heinrich, Markus R. published an article in 2019, the title of the article was Radical Carbofluorination of Alkenes with Arylhydrazines and Selectfluor: Additives, Mechanistic Pathways, and Polar Effects.Formula: C7H7FO And the article contains the following content:

Radical carbofluorination reactions starting from arylhydrazines and nonactivated alkenes, in which the C-F bond is formed through the use of Selectfluor, can be improved through the addition of anisole. Because direct trapping products could be detected only in trace amounts, anisole does primarily act as a reversible scavenger for the highly reactive ammonium radical dication released from Selectfluor in the C-F bond-forming step. As shown for three diverse substitution patterns, the main role of anisole is to prevent, or at least reduce, the undesired addition of the ammonium radical dication to the alkene, which in turn leads to an unfavorable consumption of the arylhydrazine-derived precursors required for carbofluorination. Moreover, besides the remarkable polar effects in radical trapping, this study shows that the Selectfluor-derived nitrogen-centered radical dication may add directly to alkenes, which has not been described so far. The experimental process involved the reaction of 1-Fluoro-2-methoxybenzene(cas: 321-28-8).Formula: C7H7FO

The Article related to radical carbofluorination alkene arylhydrazine selectfluor mechanism polar effect, selectfluor, alkenes, anisole, fluorination, radical reactions, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydroxylamines, Hydrazines, Triazenes, Azides, Azines, and Azo and Diazo Compounds and other aspects.Formula: C7H7FO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem